Organization of the genes encoding the human proteasome activators PA28α and β

Immunogenetics

Volumn 49, Issue 5, 1999, Pages 438-445

  McCusker, Derek ^a   Wilson, Michael ^a   Trowsdale, John ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Evolution; Gene structure; Human; PA28; Proteasome

Indexed keywords

ALPHA INTERFERON; GLUTAMINE; LYSINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; EXON; GENE DUPLICATION; GENE SEQUENCE; GENE STRUCTURE; HUMAN; HUMAN CELL; INTRON; MOLECULAR CLONING; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; BASE SEQUENCE; EXPRESSED SEQUENCE TAGS; GENOMIC LIBRARY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LINKAGE (GENETICS); MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

EID: 0032897363     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002510050517     Document Type: Article

References (38)

1. Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, Chung CH, Shibmara N, Willy PJ, Mott JD, Slaughter CA, De Martino GN (1995) Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20 S proteasome. FEBS Lett 366:37-42
2. Altschul S, Gish W, Miller W, Myers E, Lipman D (1990) Basic local allignment search tool. J Mol Biol 215:403-410
3. Brodsky JL, McCracken AA (1997) Er-associated and proteasome-mediated protein-degradation: how 2 topologically restricted events came together. Trends Cell Biol 7:151-156
4. Cresswell P, Howard JC (1997) Antigen recognition. Curr Opin Immunol 9:71-74
5. Dick TP, Ruppert T, Groettrup M, Kloetzel PM, Kuehn L, Koszinowski UH, Stevanovic S, Schild H, Rammensee HG (1996) Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell 86:253-262
6. Dietrich C, Bartsch T, Schanz F, Oesch F, Wieser RJ (1996) p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts. Proc Natl Acad Sci USA 93:10815-10819
7. Dubiel W, Pratt G, Ferrell K, Rechsteiner M (1992) Purification of an 11s Regulator of the Multicatalytic Protease. J Biol Chem 267:22369-22377
8. Fehling HJ, Swat W, Laplace C, Kuhn R, Rajewsky K, Muller U, von Boehmer H (1994) MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265:1234-1237
9. Glynne R, Powis SH, Beck S, Kelly A, Kerr L-A, Trowsdale J (1991) A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature 353:357-360
10. Groettrup M, Kraft R, Kostka S, Standera S, Stohwasser R, Kloetzel PM (1996a) A third interferon-gamma-induced subunit exchange in the 20S proteasome. Eur J Immunol 26:863-869
11. Groettrup M, Soza M, Eggers L, Kuehn T, Dick H, Schild HG, Rammensee UH, Koszinowski 8 n, Kloetzel PM (1996b) A role for the proteasome regulator PA 28 alpha in antigen presentation. Nature 381:166-168
12. Groll M, Ditzel L, Lowe L, Stock D, Bochtler M, Bartwink HD, Huber R (1997) Structure of 20s proteasome from yeast at 2.4-angstrom resolution. Nature 386:463-471
13. Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J (1998) Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. Eur J Immunol 28:459-467
14. Kandil E, Kohda K, Ishibashi T, Tanaka K, Kasahara M (1997) PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes. Immunogenetics 46:337-344
15. Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J (1991) Second proteasome-related gene in the human MHC class II region. Nature 353:667-668
16. Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang ZG, Rechsteiner M, Hill CP (1997) Structure of the proteasome activator reg-alpha (PA28-alpha). Nature 390:639-643
17. Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M (1998) Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the 150-kb region containing the alpha and beta subunit genes. J Immunol 160:4923-4935
18. Kuehn L, Dahlmann B (1996) Reconstitution of proteasome activator PA28 from isolated subunits: optimal activity is associated with an alpha,beta-heteromultimer. FEBS Lett 394:183-186
19. Larsen F, Solheim J, Kristensen T, Kolsto AB, Prydz H (1993) A tight cluster of five unrelated human genes on chromosome 16q22.1. Hum Mol Genet 2:1589-1595
20. Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996) The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression. Genomics 33:151-152
21. Ma CP, Slaughter CA, DeMartino GN (1992) Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain). J Biol Chem 267:10515-10523
22. Ma CP, Willy PJ, Slaughter CA, DeMartino GN (1993) PA28, an activator of the 20 S proteasome, is inactivated by proteolytic modification at its carboxyl terminus. J Biol Chem 268:22514-22519
23. Martinez CK, Monaco JJ (1991) Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. Nature 353:664-667
24. McCusker D, Jones T, Sheer D, Trowsdale J (1997) Genetic-relationships of the genes encoding the human proteasome beta-subunits and the proteasome PA28 complex. Genomics 45:362-367
25. Nandi D, Jiang H, Monaco JJ (1996) Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunit. J Immunol 156:2361-2364
26. Neefjes J, Momburg F, Hammerling G (1993) Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261:769
27. Ortiz Navarrete V, Seelig A, Gernold M, Frentzel S, Kloetzel PM, Hammerling GJ (1991) Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature 353:662-664
28. Paesen GC, Nuttall PA (1996) A tick homolog of the human ki nuclear autoantigen. Biochim Biophys Acta [Gene Struct Express] 1309:9-13
29. Peters JM, Franke WW, Kleinschmidt JA (1994) Distinct 19 s and 20 s subcomplexes of the 26 s proteasome and their distribution in the nucleus and the cytoplasm. J Biol Chem 269:7709-7718
30. Realini C, Scott WR, Rechsteiner M (1994) KEKE motifs: Proposed roles in protein-protein association and presentation of peptides by MHC class I receptors. FEBS Lett 348:109-113
31. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-771
32. Song X, Mott JD, von Kampen J, Pramanik B, Tanaka K, Slaughter CA, DeMartino GN (1996) A model for the quaternary structure of the proteasome activator PA28. J Biol Chem 271:26410-26417
33. Tanahashi N, Tsurumi C, Tamura T, Tanaka K (1993) Molecular structure of 20 S and 26 S proteasomes. Enz Prot 47:241-251
34. Tanahashi N, Yokota K, Ahn JY, Chung CH, Fujiwara T, Takahashi E, DeMartino GN, Slaughter CA, Toyonaga T, Yamamura K, Shimbara N, Tanaka K (1997) Molecular properties of the proteasome activator PA28 family proteins and gamma interferon regulation. Genes Cells 2:195
35. Tanaka K, Tanahashi N, Tsurumi C, Yokota KY, Shimbara N (1997) Proteasomes and antigen-processing. Adv Immunol 64:1-38
36. Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S (1994) Altered peptidase and viral specific T cell response in LMP2 mutant mice. Immunity 1:533-541
37. Willems AR, Lanker S, Patton EE, Craig KL, Nason TF, Mathias N, Kobayashi R, Wittenberg C, Tyers M (1996) Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway. Cell 86:453-463
38. Zwickl P, Grziwa A, Puhler G, Dahlmann B, Lottspeich F, Baumeister W (1992) Primary structure of the thermoplasma proteasome and its implications for the structure, function, and evolution of the multicatalytic proteinase. Biochemistry 31:964-972