Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast

EMBO Journal

Volumn 17, Issue 21, 1998, Pages 6144-6154

  Enenkel, Cordula ^a   Lehmann, Andrea ^a   Kloetzel, Peter Michael ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

ER network; GFP; NE; Yeast 26S proteasome

Indexed keywords

ADENOSINE TRIPHOSPHATASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PROTEASOME; PROTEIN SUBUNIT;

ARTICLE; CELL NUCLEUS MEMBRANE; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; YEAST;

ADENOSINE TRIPHOSPHATASES; BIOLOGICAL MARKERS; DNA-BINDING PROTEINS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; NUCLEAR ENVELOPE; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA;

EID: 0032476655     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.21.6144     Document Type: Article

References (55)

1. Amsterdam, A., Pitzer, F. and Baumeister, W. (1993) Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control. Proc. Natl Acad. Sci. USA, 90, 99-103.
2. Arendt, C.S. and Hochstrasser, M. (1997) Identification of the yeast proteasome catalytic centers and subunit interactions required for active-site formation. Proc. Natl Acad. Sci. USA, 94, 7156-7161.
3. Ausubel, F.M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. and Struhl, K. (1995) Short Protocols in Molecular Biology. Wiley & Sons, New York, NY.
4. Belgareh, N. and Doye, V. (1997) Dynamics of nuclear pore distribution in nucleoporin mutant yeast cells. J. Cell Biol., 136, 747-759.
5. Biederer, T., Volkwein, C. and Sommer, T. (1997) Role of Cuelp in ubiquitination and degradation at the ER surface. Science, 278, 1806-1808.
6. Bucci, M. and Wente, S.R. (1997) In vivo dynamics of nuclear pore complexes in yeast. J. Cell Biol., 136, 1185-1199.
7. Chen, P. and Hochstrasser, M. (1996) Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly. Cell, 86, 961-972.
8. Confalonieri, F. and Duguet, M. (1995) A 200-amino acid ATPase module in search of a basic function. BioEssays, 17, 639-650.
9. Coux, O., Tanaka, K. and Goldberg, A.L. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem., 65, 801-847.
10. Cubitt, A.B., Heim, R., Adams, S.R., Boyd, A.E., Gross, L.A. and Tsien, R.Y. (1995) Understanding, improving and using green fluorescent proteins. Trends Biochem. Sci., 20, 448-455.
11. Dai, R.-M., Chen, E., Longo, D.L., Gorbea, C.M. and Li, C.-C.H. (1998) Involvement of valosin-containing protein, an ATPase co-purified with IκBα and 26S proteasome, in ubiquitin-proteasome-mediated degradation of IκBα. J. Biol Chem., 273, 3562-3573.
12. Deveraux, Q., Ustrell, C., Pickart, C. and Rechsteiner, M. (1994) A 26S protease subunit that binds ubiquitin conjugates. J. Biol. Chem., 269, 7059-7061.
13. Dubiel, W., Ferrell, K. and Rechsteiner, M. (1995) Subunits of the regulatory complex of the 26S protease. Mol. Biol Rep., 21, 27-34.
14. Enenkel, C., Lehmann, H., Kipper, J., Guckel, R., Hilt, W. and Wolf, D.H. (1994) PRE3, highly homologous to the human major histo compatibility complex-linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activity. FEBS Lett., 341, 193-196.
15. Fraser, R.A., Rossignol, M., Heard, D.J., Egly, J.M. and Chambon, P. (1997) SUG1, a putative transcriptional mediator and subunit of the PA700 proteasome regulatory complex, is a DNA helicase. J. Biol. Chem., 272, 7122-7126.
16. Friedman, H. and Snyder, M. (1994) Mutations in PRG1, a yeast proteasome-related gene, cause defects in nuclear division and are suppressed by deletion of a mitotic cyclin gene. Proc. Natl Acad. Sci. USA, 91, 2031-2035.
17. 2/metaphase. Nature, 366, 358-362.
18. Gilon, T., Chomsky, O. and Kulka, R.G. (1998) Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae. EMBO J., 17, 2759-2766.
19. Glickman, M.H., Rubin, D.M., Fried, V.A. and Finley, D. (1998) The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol. Cell. Biol., 18, 3149-3162.
20. Gordon, C., McGurk, G., Dillon, P., Rosen, C. and Hastie, N.D. (1993) Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Nature, 366, 355-357.
21. Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H.D. and Huber, R. (1997) Structure of 20S proteasome from yeast at 2.4 Å resolution. Nature, 386, 463-471.
22. Guthrie, C. and Fink, G.R. (1991) Guide to Yeast Genetics and Molecular Biology. Methods in Enzymology Vol 194. Academic Press Inc., San Diego, CA.
23. Hampton, R.Y., Gardner, R.G. and Rine, J. (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol. Cell 7, 2029-2044.
24. Heinemeyer, W., Trondle, N., Albrecht, G. and Wolf, D.H. (1994) PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core. Biochemistry, 33, 12229-12237.
25. Heinemeyer, W., Fischer, M., Krimmer, T., Stachon, U. and Wolf, D.H. (1997) The active sites of the eucaryotic 20S proteasome and their involvement in subunit precursor processing. J. Biol. Chem., 272, 25200-25209.
26. Hershko, A. and Ciechanover, A. (1992) The ubiquitin system for protein degradation. Annu. Rev. Biochem., 61, 761-807.
27. Hiller, M.M., Finger, A., Schweiger, M. and Wolf, D.H. (1996) ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science, 273, 1725-1728.
28. Hilt, W. and Wolf, D.H. (1996) Proteasomes: destruction as a programme. Trends Biochem. Sci., 21, 96-102.
29. Hilt, W., Heinemeyer, W. and Wolf, D.H. (1994) Studies on the yeast proteasome uncover its basic structural features and multiple in vivo functions. Enzyme Protein, 47, 189-201.
30. Hochstrasser, M. (1995) Ubiquitin, proteasomes and the regulation of intracellular protein degradation. Curr. Opin. Cell Biol., 7, 215-223.
31. Jones, J.S. and Prakash, L. (1990) Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast, 6, 363-366.
32. Klein, U., Gernold, M. and Kloetzel, P.-M. (1990) Cell-specific accumulation of Drosophila proteasomes (MCP) during early development. J. Cell Biol., 111, 2275-2282.
33. Kominami, K. et al. (1995) Nin1p, a regulatory subunit of the 26S proteasome, is necessary for the activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J., 14, 3105-3115.
34. Kominami, K. et al. (1997) Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. Mol. Biol. Cell. 8, 171-187.
35. Lam, Y.A., Xu, W., DeMartino, G.N. and Cohen, R.E. (1997) Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome. Nature, 385, 737-740.
36. Latterich, M. and Schekman, R. (1994) The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion. Cell, 78, 87-98.
37. Latterich, M., Fröhlich, K.-U. and Schekman, R. (1995) Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes. Cell. 82, 885-893.
38. Lin, L., DeMartino, G.N. and Greene, W.C. (1998) Cotranslational biogenesis of NF-κB p50 by the 26S proteasome. Cell, 92, 819-828.
39. McDonald, H.B. and Byers, B. (1997) A proteasome cap subunit required for spindle pole body duplication in yeast. J. Cell Biol., 137, 539-553.
40. Palmer, A., Rivett, A.J., Thomson, S., Hendil, K.B., Butchers, G.W., Fuertes, G. and Knecht, E. (1996) Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol. Biochem. J., 316, 401-407.
41. Peters, J.M., Franke, W.W. and Kleinschmidt, A. (1994) Distinct 19S and 20S subcomplexes of the 26S proteasome and their distribution in the nucleus and the cytoplasm. J. Biol. Chem., 269, 7709-7718.
42. Plemper, R.K., Böhmler, S., Bordallo, J., Sommer, T. and Wolf, D.H. (1997) Mutant analysis links the translocon and Bip to retrograde protein transport for ER degradation. Nature, 388, 891-895.
43. Reits, E.A.J., Benham, A.M., Plougastel, B., Neefjes, J. and Trowsdale, J. (1997) Dynamics of proteasome distribution in living cells. EMBO J., 16, 6087-6094.
44. Rose, M.D., Misra, L.M. and Vogel, J.P. (1989) KAR2, a karyogamy gene, is the yeast homolog of the mammalian Bip/GRP78 gene. Cell, 57, 1211-1221.
45. Rout, M.P. and Blobel, G. (1993) Isolation of the yeast nuclear pore complex. J. Cell Biol., 123, 771-783.
46. Russell, S.J., Sathyanarayana, U.G. and Johnston, S.A. (1996) Isolation and characterization of SUG2. A novel ATPase family component of the yeast 26S proteasome. J. Biol. Chem., 271, 32810-32817.
47. Sato, S., Ward, C.L. and Kopito, R.R. (1998) Cotranslational ubiquitination of cystic fibrosis transmembane regulator in vitro. J. Biol. Chem., 273, 7189-7192.
48. Schmidtke, G., Kraft, R., Kostka, S., Henklein, R. Frommel, C., Lowe, J., Huber, R., Kloetzel, P.M. and Schmidt, M. (1996) Analysis of mammalian 20S proteasome biogenesis: the maturation of β-subunits is an ordered two-step mechanism involving autocatalysis. EMBO J., 15, 6887-6898.
49. Seeger, M., Gordon, C., Ferrell, K. and Dubiel, W. (1996) Characteristics of 26S proteases from fission yeast mutants, which arrest in mitosis. J. Mol. Biol., 263, 423-431.
50. Seeger, M., Kraft, R., Ferrell, K., Bech-Otschir, D., Dumdey, R., Schade, R., Gordon, C., Naumann, M. and Dubiel, W. (1998) A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J., 12, 469-478.
51. Seemueller, E., Lupas, A. and Baumeister, W. (1996) Autocatalytic processing of the 20S proteasome. Nature, 382, 468-471.
52. Seufert, W., Futcher, B. and Jentsch, S. (1995) Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature. 373, 78-81.
53. Strambio-de-Castillia, C., Blobel, G. and Rout, M.P. (1995) Isolation and characterization of nuclear envelopes from the yeast Saccharomyces. J. Cell Biol., 131, 19-31.
54. Tanaka, K. and Tsurumi, C. (1997) The 26S proteasome: subunits and functions. Mol, Biol. Rep., 24, 3-11.
55. Wilkinson, C.R.M., Wallace, M., Seeger, M., Dubiel, W. and Gordon, C. (1997) Mts4, a non-ATPase subunit of the 26S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2. J. Biol. Chem., 272, 25768-25777.