Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

Journal of Clinical Investigation

Volumn 106, Issue 3, 2000, Pages 329-333

  Cavaghan, Melissa K ^a   Ehrmann, David A ^a   Polonsky, Kenneth S ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

DISEASE PREDISPOSITION; GENE EXPRESSION; GLUCOSE INTOLERANCE; HUMAN; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

EID: 0033842027     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI10761     Document Type: Review

References (38)

1. Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
2. The influence of generic background on the expression of the obese (Ob) gene in the mouse
3. Quantitative study of insulin secretion and clearance in normal and obese subjects
4. Alterations in the glucose-stimulated insulin secretory dose-reponse curve and in insulin clearance in nondiabetic insulin-resistant individuals
5. Quantification of the relationship between insulin sensitivity and β-cell function in human subjects. Evidence for a hyperbolic function
6. Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
7. Pancreatic β-cells in obesity
8. Overexpression of hexokinase I in isolated islets of Langerhans via recombinant adenovirus. Enhancement of glucose metabolism and insulin secretion at basal but not sdmulatory glucose levels
9. Differential effects o foverexpressed glucokinase and hexokinase I in isolated islets
10. Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes
11. Evolution of β-cell dysfunction in the male Zucker diabetic fatty rat
12. Disruption of IRS-2 causes type 2 diabetes in mice
13. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
14. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
15. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured β-cell lines
16. Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways
17. Insuhn receptor signaling in the β-cell influences insulin gent expression and insulin content
18. Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes
19. Defects in insulin secretion and action in women with a history of gestational diabetes
20. Elevated plasma glucose 2 h postchallenge predicts defects in β-cell function
21. Lack of control of ultradian insulin secretory oscillations in impaired glucose tolerance and in non-insulin-dependent diabetes mellitus
22. Defects in β cell function and insulin action in functional ovarian hyperandrogenism
23. Insulin secretory defects in polycystic ovary syndrome: Relationship to insulin sensitivity and Family history of non-insulin dependent diabetes mellitus
24. Strategies and prospects for finding insulin resistance genes
25. An approach to the prediction of diabetes mellitus by modification of the glucose tolerance test with cortisone
26. Risk and mechanism ofdexamethasone-induced deterioration of glucose tolerance in non-diabetic first-degree relatives of NIDDM patients
27. Treatment with the oral antidiabetic agent troglitazone improves β-cell responses to glucose in subjects with impaired glucose tolerance
28. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycysric ovary syndrome
29. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
30. Effects of lipid and basal carbohydrate metabolism in normal men
31. Cellular mechanisms of insulin resistance
32. Stimulation of insulin secretion by long-chain free fatty acids
33. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation
34. Essentiality o fcirculating Fatty acids for glucose-stimulated insulin secretion in the fasted rat
35. Defective fatty acid-mediated β-cell compensation in Zucker diabetic fatty rats
36. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation
37. Failure of β-cell compensation for insulin resistance induced by elevated free fatty acids in obese subjects