13C/31P NMR studies on the mechanism of insulin resistance in obesity

Diabetes

Volumn 47, Issue 3, 1998, Pages 381-386

  Petersen, Kitt Falle ^a   Hendler, Rosa ^a   Price, Thomas ^a   Perseghin, Gianluca ^a   Rothman, Douglas L ^a   Held, Nancy ^a   Amatruda, John M ^b   Shulman, Gerald I ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER CORPORATION   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE 6 PHOSPHATE; GLYCOGEN; INSULIN;

ADULT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HUMAN; INSULIN RESISTANCE; MUSCLE METABOLISM; OBESITY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; BLOOD; CAUCASIAN; COHORT ANALYSIS; COMPARATIVE STUDY; GLUCOSE CLAMP TECHNIQUE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN; HUMANS; INSULIN RESISTANCE; MAGNETIC RESONANCE SPECTROSCOPY; OBESITY;

EID: 0031594368     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.3.381     Document Type: Article

References (47)

1. Barner AH, Eff C, Leslie RD, Pyke DA: Diabetes in identical twins: a study of 2 pairs. Diabetotogia 20:87-93, 1981
2. DeFronzo R: The triumvirate: B-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37:667-683, 1988
3. HafEner SM, Stern MP, Mitchell BD, Hazuda HP, Pattereon JK Incidence of type II diabetes mellitus in Mexican Americans predicted by fasting insulin and glucose levels, obesity and body fat distribution. Diabetes 39:283-288, 1980
4. Kolterman OG, Gray RS, Griffin J, Burstein P, Insel J, Scarlett JA, Olefsky JM: Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Invest 68:957-969, 1981
5. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP: The effect of insulin on the disposal of intravenous glucose: results from indirect cal crime try and hepatic and femoral venous catheterization. Diabetes 30:1000-1007, 1981
6. Yki-Jarvinen H, Young AA, Lamkin C, Foley JE: The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest 79:1713-1719, 1987
7. 13C nuclear magnetic resonance spectroscopy. N Engt J Med 322:223-228, 1990
8. 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulindependent muscle glucose transport or phosphorylation activity in noninsulin-dependent diabetes mellitus. J Clin Invest 89:1069-1075, 1992
9. Webb P: 24-hour energy expenditure and the menstrual cycle. Am J Clin Nutr 44:614-619, 1986
10. Hohorst HJ: L-(+)-lacLate determination with lactic dehydrogenase. In Methods of Enzymatic Analysis, Bergmeyer HU, Ed. Basel, Verlag Chemie, 1965, p. 266-270
11. Miles J, Glasscock R, Aikens J, Gerich J, Haymond M: A microfluorometric method for the determination of free fatty acids in plasma. J Lipid Res 24:96-99, 1983
12. Wolfe RR: Radioactive and Stable Isotope Tracers in Biorriedidne: Prtndr plea and Practice of Kinetic Analysis. New York, Wiley-Liss, 1992
13. Lusk G: Animal calorimetry: analysis of the oxidation of mixtures of carbohydrates and fat a correction. J But Chem 59:4142, 1924
14. Harris RC, Hultman E, Nordesjo LO: Glycogen, glycolytic intermediates and high energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Scand J Clin Lab Invest 33:109-120, 1974
15. 31P NMR measurement of glucose-6-phosphate in the rat muscle after exercise. Magn Reson Med 30:347-350, 1993
16. 13C NMR visibility of rabbit muscle glycogen in vivo. Magn Reson Med 20:327-332, 1991
17. 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples. Magn Rescm Med 27:13-20, 1992
18. Heitman BL Prediction of body water and fat in adult Danes from measurement of electrical impedance: a validation study. Int J Obes 14:789-802, 1990
19. Prager R, Wallace P, Olefsky JM: In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest 78:472-481, 1986
20. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45, 1983
21. DeFronzo RA: Insulin secretion, insulin resistance, and obesity. Int J Obes 6 (Suppl l):73-82, 1982
22. Caprio S, Hyman LD, Limb C, McCarthy S, Lange R, Sherwin RS, Shulman G, Tamborlane WV: Central adiposity and its metabolic correlates in obese adolescent girls. Am J Physiol 269:E118-E126, 1995
23. DeFronzo RA, Soman V, Sherwin RS, Hendler R, Felig P: Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding. J Clin Invest 62:204-213, 1978
24. Kolterman OG, Reaven GM, Olefsky JM: Relationship between in vivo insulin resistance and decreased insulin receptors in obese man. J Clin Endocrinol Metab 48:487-194, 1979
25. Yki-Jarvinen H, Koivisto VA: Effects of body composition on insulin sensitivity. Diabetes 32:965-969, 1983
26. Bogardus C, Lillioja S, Mott D, Reaven GR, Kashiwagi A, Foley JE: Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. J Clin Invest 73:800-805, 1984
27. Hollenbeck CB, Chen YD, Reaven GM: A comparison of the relative effects of obesity and non-insulin-dependent diabetes mellitus on in vivo insulinstimulated glucose utilization. Diabetes 33:622-626, 1984
28. Bogardus C, Lillioja S, Mon DM, Hollenbeck C, Reaven G: Relationship between degree of obesity and in vivo insulin action in man. Am J Physiol 248:E286-E291, 1985
29. Bonadonna RC, Groop L, Kraemer N, Ferrannini E, Del Prato S, DeFronzo RA: Obesity and insulin resistance in humans: a dose-response study. Metabolism 39:452-159, 1990
30. Ludvik B, Nolan JJ, Baloga J, Sacks D, Olefsky J: Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes 44:1121-1125, 1995
31. Clausen JO, Borch-Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K, Pedersen O: Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young, healthy Caucasians: analysis of the impact of gender, body fat, physical fitness, and life-style factors. J Clin Invest 98:1195-1209, 1996
32. Rabinowitz D, Zierler KL: Forearm metabolism in obesity and its response to intra-arterial insulin: evidence for adaptative hyperinsulinism. J Clin Invest 41:2173-2181, 1962
33. Laakso M, Edelman SV, Brechtel G, Baron AD: Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest 85:1844-1852, 1990
34. Laakso M, Edelman SV, Olefsky JM, Brechtel G, Wallace P, Baron AD: Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity. Diabetes 39:965-974, 1990
35. Colberg SR, Simoneau JA, Thaete FL, Kelley DE: Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95:1846-1853, 1995
36. Felber JP, Ferrannini E, Golay A, Meyer HU, Theibaud D, Curchod B, Maeder E, Jequier E, DeFronzo RA: Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes 36:1341-1350, 1987
37. Conn SH, Vartsky D, Yasumura S, Sawitsky A, Zanri I, Vaswani A, Ellis KJ: Compartmental body composition based on total-body nitrogen, potassium, and calcium. Am J Physiol 239:E524-E530, 1980
38. Clarys JP, Marin AF, Frinkwater DT: Gross tissue weights in the human body by cadaver dissection. Hum Biol 56:459-573, 1984
39. Golay A, Munger R, Felber J-P: Obesity and NIDDM: the retrograde regulation concept. Diabetes Rev 5:69-82, 1997
40. Rothman DL, Magnusson I, Cline G, Gerard D, Kahn CR, Shulman RG, Shulman GI: Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 92:983-987, 1995
41. Felber J-P, Golay A: Regulation of nutrient metabolism and energy expenditure. Metabolism 44:4-9, 1995
42. Friedman JE, Caro JF, Pories WJ, Azevedo JL Jr, Dohm GL: Glucose metabolism in incubated human muscle: effect of obesity and non-insulin-dependent diabetes mellitus. Metabolism 43:1047-1054, 1994
43. Dohm GL, Tapscott EB, Pories WJ, Dabbs DJ, Flickinger EG, Meelheim D, Fushiki T, Atkinson SM, Elton CW, Caro JF: An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest 82:486-194, 1988
44. Kelley DE, Mintun MA, Watkins SC, Simoneau JA, Jadali F, Fredrickson A, Beattie J, Theriault R: The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. J Clin Invest 97:2705-2713, 1996
45. 3H]2-deoxyglucose incorporation into neurons and glial cells in invertebrate ganglia: histological processing of nervous tissue for selective marking of glycogen. J Neurocytol 10:693-708, 1981
46. 3H]2-deoxyglucose into glycogen in nervous tissues. Neuroscience 7:759-767, 1982
47. Nelson T, Kaufrnan EE, Sokoloff L: 2-Deoxyglucose incorporation into rat brain glycogen during measurement of local cerebral glucose utilization by the 2deoxyglucose method. J Neurochem 43:949-956, 1984