Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects

Journal of Biological Chemistry

Volumn 272, Issue 48, 1997, Pages 30208-30214

  Krook, Anna ^a,b,e   Whitehead, Jonathan P ^a,b   Dobson, Stephen P ^c   Griffiths, Matthew R ^c   Ouwens, Margrite ^d   Baker, Claire ^a,b   Hayward, Amanda C ^b   Sen, Sankhya K ^c   Maassen, J Antoine ^d   Siddle, Kenneth ^b   Tavaré, Jeremy M ^c   O'Rahilly, Stephen ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d LEIDEN UNIVERSITY   (Netherlands)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; INSULIN RECEPTOR; INSULIN RECEPTOR KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; POLYCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CHO CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE MUTATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CHO CELLS; CRICETINAE; ENZYME ACTIVATION; FEMALE; GLUTAMINE; HUMANS; INSULIN; INSULIN RESISTANCE; LEUCINE; MUTATION; PHOSPHOPROTEINS; PROTEINS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CERVUS ELAPHUS; CRICETINAE; CRICETULUS GRISEUS;

EID: 14444276528     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.48.30208     Document Type: Article

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