메뉴 건너뛰기




Volumn 98, Issue 3, 1996, Pages 741-749

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs

Author keywords

adipose tissue; free fatty acids; hepatic glucose output; insulin action; lipolysis

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; INSULIN; LIPOSYN; SOMATOSTATIN;

EID: 0029861999     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118846     Document Type: Article
Times cited : (272)

References (49)
  • 1
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin, K., G.M. Steil, L. Getty, and R.N. Bergman. 1995. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes. 44:1038-1045.
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 2
    • 0025297310 scopus 로고
    • Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
    • Ader, M., and R.N. Bergman. 1990. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am. J. Physiol. 258: E1020-E1032.
    • (1990) Am. J. Physiol. , vol.258
    • Ader, M.1    Bergman, R.N.2
  • 3
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca, A., S.J. Fisher, Z. Quing Shi, R. Gupta, H.L.A. Lickley, and M. Vranic. 1992. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J. Clin. Invest. 90:1769-1777.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.J.2    Quing Shi, Z.3    Gupta, R.4    Lickley, H.L.A.5    Vranic, M.6
  • 4
    • 0023546855 scopus 로고
    • Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects
    • Prager, R., P. Wallace, and J.M. Olefsky. 1987. Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes. 36:607-611.
    • (1987) Diabetes , vol.36 , pp. 607-611
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 5
    • 0027526476 scopus 로고
    • Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo
    • Bradley, D.C., R.A. Poulin, and R.N. Bergman. 1993. Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes. 42:296-306.
    • (1993) Diabetes , vol.42 , pp. 296-306
    • Bradley, D.C.1    Poulin, R.A.2    Bergman, R.N.3
  • 6
    • 0023245416 scopus 로고
    • Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates
    • Finegood, D.T., R.N. Bergman, and M. Vranic. 1987. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Comparison of unlabeled and labeled exogenous glucose infusates. Diabetes. 36:914-924.
    • (1987) Diabetes , vol.36 , pp. 914-924
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 8
    • 0028097682 scopus 로고
    • Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph
    • Poulin, R.A., G.M. Steil, D.M. Moore, M. Ader, and R.N. Bergman. 1994. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. Diabetes. 43:180-190.
    • (1994) Diabetes , vol.43 , pp. 180-190
    • Poulin, R.A.1    Steil, G.M.2    Moore, D.M.3    Ader, M.4    Bergman, R.N.5
  • 9
    • 0027520659 scopus 로고
    • On insulin action in vivo: The single gateway hypothesis
    • Bergman, R.N., D.C. Bradley, and M. Ader. 1993. On insulin action in vivo: the single gateway hypothesis. Adv. Exp. Med. Biol. 334:181-198.
    • (1993) Adv. Exp. Med. Biol. , vol.334 , pp. 181-198
    • Bergman, R.N.1    Bradley, D.C.2    Ader, M.3
  • 10
    • 0027319705 scopus 로고
    • Analysis of techniques to obtain plasma for measurement of levels of free fatty acids
    • Zambon, A., S.I. Hashimoto, and J.D. Brunzell. 1993. Analysis of techniques to obtain plasma for measurement of levels of free fatty acids. J. Lipid Res. 34:1021-1028.
    • (1993) J. Lipid Res. , vol.34 , pp. 1021-1028
    • Zambon, A.1    Hashimoto, S.I.2    Brunzell, J.D.3
  • 13
    • 0028276676 scopus 로고
    • Insulin regulation of renal glucose metabolism in conscious dogs
    • Cersosimo, E., R.L. Judd, and J.M. Miles. 1994. Insulin regulation of renal glucose metabolism in conscious dogs. J. Clin. Invest. 93:2584-2589.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2584-2589
    • Cersosimo, E.1    Judd, R.L.2    Miles, J.M.3
  • 14
    • 0029936779 scopus 로고    scopus 로고
    • Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans
    • Lewis, G.F., B. Zinman, Y. Groenewoud, M. Vranic, and A. Giacca. 1996. Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes. 45:454-462.
    • (1996) Diabetes , vol.45 , pp. 454-462
    • Lewis, G.F.1    Zinman, B.2    Groenewoud, Y.3    Vranic, M.4    Giacca, A.5
  • 15
    • 0019493609 scopus 로고
    • Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog
    • Cherrington, A.D., P.E. Williams, G.I. Shulman, and W.W. Lacy. 1981. Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog. Diabetes. 30:180-187.
    • (1981) Diabetes , vol.30 , pp. 180-187
    • Cherrington, A.D.1    Williams, P.E.2    Shulman, G.I.3    Lacy, W.W.4
  • 16
    • 0030034219 scopus 로고    scopus 로고
    • Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog
    • Pagliassotti, M.J., L.C. Holste, M.C. Moore, D.W. Neal, and A.D. Cherrington. 1996. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J. Clin. Invest. 97:81-91.
    • (1996) J. Clin. Invest. , vol.97 , pp. 81-91
    • Pagliassotti, M.J.1    Holste, L.C.2    Moore, M.C.3    Neal, D.W.4    Cherrington, A.D.5
  • 19
    • 0016739930 scopus 로고
    • Modulation of fatty acid metabolism by glucagon in man. I. Effects in normal subjects
    • Schade, D.S., and R.P. Eaton. 1975. Modulation of fatty acid metabolism by glucagon in man. I. Effects in normal subjects. Diabetes. 24:502-509.
    • (1975) Diabetes , vol.24 , pp. 502-509
    • Schade, D.S.1    Eaton, R.P.2
  • 22
    • 0027168778 scopus 로고
    • Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus
    • Jeng, C.Y., W.H.H. Sheu, J.B. Jaspan, K.S. Polonsky, Y.-D.I. Chen, and U.M. Reaven. 1993. Glucagon does not increase plasma free fatty acid and glycerol concentrations in patients with noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. & Metab. 77:6-10.
    • (1993) J. Clin. Endocrinol. & Metab. , vol.77 , pp. 6-10
    • Jeng, C.Y.1    Sheu, W.H.H.2    Jaspan, J.B.3    Polonsky, K.S.4    Chen, Y.-D.I.5    Reaven, U.M.6
  • 23
    • 0026320561 scopus 로고
    • Growth hormone and lipids
    • Keller, U., and J.M. Miles. 1991. Growth hormone and lipids. Horm. Res. 36(Suppl. 1):36-40.
    • (1991) Horm. Res. , vol.36 , Issue.1 SUPPL. , pp. 36-40
    • Keller, U.1    Miles, J.M.2
  • 24
    • 0028206903 scopus 로고
    • Acute growth hormone effects on aminoacid and lipid metabolism
    • Copeland, K.E., and K.S. Nair. 1994. Acute growth hormone effects on aminoacid and lipid metabolism. J. Clin. Endocrinol & Metab. 78:1040-1047.
    • (1994) J. Clin. Endocrinol & Metab. , vol.78 , pp. 1040-1047
    • Copeland, K.E.1    Nair, K.S.2
  • 26
    • 0026587584 scopus 로고
    • Mechanism of regulation of glucose production by lipolysis in humans
    • Jahoor, F., S. Klein, and R.R. Wolfe. 1992. Mechanism of regulation of glucose production by lipolysis in humans. Am. J. Physiol. 262:E353-E358.
    • (1992) Am. J. Physiol. , vol.262
    • Jahoor, F.1    Klein, S.2    Wolfe, R.R.3
  • 27
    • 0023026312 scopus 로고
    • Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans
    • Nurjhun, N., P.J. Campbell, F.P. Kennedy, J.M. Miles, and J.E. Gerich. 1986. Insulin dose-response characteristics for suppression of glycerol release and conversion to glucose in humans. Diabetes. 35:1326-1331.
    • (1986) Diabetes , vol.35 , pp. 1326-1331
    • Nurjhun, N.1    Campbell, P.J.2    Kennedy, F.P.3    Miles, J.M.4    Gerich, J.E.5
  • 29
    • 0028342686 scopus 로고
    • Mechanism of fatty acid-induced inhibition of glucose uptake
    • Boden, G., X. Chen, J. Ruiz, J.V. White, and L. Rossetti. 1994. Mechanism of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93:2438-2446.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 30
    • 0026518355 scopus 로고
    • Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus
    • Nurjhan, N., A. Consoli, and J.E. Gerich. 1992. Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 89:169-175.
    • (1992) J. Clin. Invest. , vol.89 , pp. 169-175
    • Nurjhan, N.1    Consoli, A.2    Gerich, J.E.3
  • 31
  • 32
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson, J.R., R.A. Kreisberg, and P.W. Felts. 1966. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc. Natl. Acad. Sci. USA. 56:247-254.
    • (1966) Proc. Natl. Acad. Sci. USA , vol.56 , pp. 247-254
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 33
    • 0027515569 scopus 로고
    • Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM
    • Puhakaincn, I., and H. Yki-Jarvinen. 1993. Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM. Diabetes. 42: 1694-1699.
    • (1993) Diabetes , vol.42 , pp. 1694-1699
    • Puhakaincn, I.1    Yki-Jarvinen, H.2
  • 34
    • 0024542178 scopus 로고
    • Sleep-associated fall in glucose disposal and hepatic glucose output in normal humans
    • Clore, J.N., J.E. Nestler, and W.G. Blackard. 1989. Sleep-associated fall in glucose disposal and hepatic glucose output in normal humans. Diabetes. 38: 285-290.
    • (1989) Diabetes , vol.38 , pp. 285-290
    • Clore, J.N.1    Nestler, J.E.2    Blackard, W.G.3
  • 35
    • 0025911738 scopus 로고
    • Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men
    • Clore, J.N., P.S. Glickman, S.T. Helm, J.E. Nestler, and W.G. Blackard, 1991. Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men. Diabetes: 40:1033-1040.
    • (1991) Diabetes , vol.40 , pp. 1033-1040
    • Clore, J.N.1    Glickman, P.S.2    Helm, S.T.3    Nestler, J.E.4    Blackard, W.G.5
  • 37
    • 0025089269 scopus 로고
    • On the determination of basal glucose production rate in patients with type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glueose infusion
    • Hother-Nielsen, O., and H. Beck-Nielsen. 1990. On the determination of basal glucose production rate in patients with type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glueose infusion. Diabetologia. 33:603-610.
    • (1990) Diabetologia , vol.33 , pp. 603-610
    • Hother-Nielsen, O.1    Beck-Nielsen, H.2
  • 38
    • 0028558591 scopus 로고
    • Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM
    • Jeng, C.Y., W.H.H. Sheu, M.M.T. Fuh, Y.-D.I. Chen, and G.M. Reaven. 1994. Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM. Diabetes. 43:1440-1444.
    • (1994) Diabetes , vol.43 , pp. 1440-1444
    • Jeng, C.Y.1    Sheu, W.H.H.2    Fuh, M.M.T.3    Chen, Y.-D.I.4    Reaven, G.M.5
  • 39
    • 0025677464 scopus 로고
    • Acute changes in plasma non-esterified fatly acid concentration do not change hepatic glucose production in people with type 2 diabetes
    • Johnston, P., C. Hollenheck, W. Sheu, Y.-D.I. Chen, and G.M. Reaven. 1990. Acute changes in plasma non-esterified fatly acid concentration do not change hepatic glucose production in people with type 2 diabetes. Diabetic Med. 7:871-875.
    • (1990) Diabetic Med. , vol.7 , pp. 871-875
    • Johnston, P.1    Hollenheck, C.2    Sheu, W.3    Chen, Y.-D.I.4    Reaven, G.M.5
  • 40
    • 0026644792 scopus 로고
    • Metabolic effects of suppression of nonesterified fatty acid levels with Acipimox in obese NIDDM subjects
    • Fulcher, G.R., M. Walker, C. Catalano, L. Agius, and K.G.M.M. Alberti. 1992. Metabolic effects of suppression of nonesterified fatty acid levels with Acipimox in obese NIDDM subjects. Diabetes. 41:1400-1408.
    • (1992) Diabetes , vol.41 , pp. 1400-1408
    • Fulcher, G.R.1    Walker, M.2    Catalano, C.3    Agius, L.4    Alberti, K.G.M.M.5
  • 41
    • 0025994801 scopus 로고
    • No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients
    • Puhakainen, I., V.A. Koivisto, and H. Yki-Jarvinen. 1991. No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients. Diabetes. 40:1319-1327.
    • (1991) Diabetes , vol.40 , pp. 1319-1327
    • Puhakainen, I.1    Koivisto, V.A.2    Yki-Jarvinen, H.3
  • 43
    • 0023153344 scopus 로고
    • Resistance to insulin suppression of plasma free fatly acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus
    • Chen, Y.-D.I., A. Golay, A.L.M. Swislocki, and G.M. Reaven. 1987. Resistance to insulin suppression of plasma free fatly acid concentrations and insulin stimulation of glucose uptake in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. & Metab. 64:17-21.
    • (1987) J. Clin. Endocrinol. & Metab. , vol.64 , pp. 17-21
    • Chen, Y.-D.I.1    Golay, A.2    Swislocki, A.L.M.3    Reaven, G.M.4
  • 44
    • 0022459307 scopus 로고
    • Effect of differences in glucose tolerance on insulin's ability to regulate carbohydrate and free fatty acid metabolism in obese individuals
    • Golay, A., Y.-D.I. Chen, and G.M. Reaven. 1986. Effect of differences in glucose tolerance on insulin's ability to regulate carbohydrate and free fatty acid metabolism in obese individuals. J Clin. Endocrinol. & Metab. 62:1081-1088.
    • (1986) J Clin. Endocrinol. & Metab. , vol.62 , pp. 1081-1088
    • Golay, A.1    Chen, Y.-D.I.2    Reaven, G.M.3
  • 45
    • 0028947949 scopus 로고
    • The fourth musketeer - From Alexandre Dumas to Claude Bernard
    • Reaven, G.M. 1995. The fourth musketeer - from Alexandre Dumas to Claude Bernard. Diabetologia. 38:3-13.
    • (1995) Diabetologia , vol.38 , pp. 3-13
    • Reaven, G.M.1
  • 46
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
    • Groop, L.C., R.C. Bonadonna, S. Del Prato, K. Ratheiser, K. Zyck, E. Ferrannini, and R.A. DeFronzo. 1989. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J. Clin. Invest. 84:205-213.
    • (1989) J. Clin. Invest. , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    Del Prato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6    DeFronzo, R.A.7
  • 47
    • 0021890981 scopus 로고
    • Multiple disturbances of free fatfy acid metabolism in non-insulin-dependent diabetes
    • Taskinen, M.R., C. Bogardus, A. Kennedy, and B.V. Howard. 1985. Multiple disturbances of free fatfy acid metabolism in non-insulin-dependent diabetes. j. Clin. Invest. 76:637-644.
    • (1985) J. Clin. Invest. , vol.76 , pp. 637-644
    • Taskinen, M.R.1    Bogardus, C.2    Kennedy, A.3    Howard, B.V.4
  • 48
    • 0025963777 scopus 로고
    • The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus
    • Groop, L.C., C. Saloranta, M. Shank, R.C. Bonadonna, E. Ferrannini, and R.A. DeFronzo. 1991. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. & Metab. 72:96-107.
    • (1991) J. Clin. Endocrinol. & Metab. , vol.72 , pp. 96-107
    • Groop, L.C.1    Saloranta, C.2    Shank, M.3    Bonadonna, R.C.4    Ferrannini, E.5    DeFronzo, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.