Caspase activation involves the formation of the aposome, a large (~700 kDa) caspase-activating complex

Journal of Biological Chemistry

Volumn 274, Issue 32, 1999, Pages 22686-22692

  Cain, Kelvin ^a   Brown, David G ^a   Langlais, Claudia ^a   Cohen, Gerald M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 9; CYTOCHROME C; PROTEASE ACTIVATING FACTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CASPASES; CELL COMPARTMENTATION; CELL FRACTIONATION; ENZYME ACTIVATION; HUMANS; MONOCYTES; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0033529634     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.32.22686     Document Type: Article

References (26)

1. Chinnaiyan, A. M., and Dixit, V. M. (1996) Curr. Biol. 6, 555-562
2. Nicholson, D. W. (1996) Nature Biotechnol. 14, 297-301
3. Takahashi, A., and Earnshaw, W. C. (1996) Curr. Opin. Genet. Dev. 6, 50-55
4. Nagata, S. (1997) Cell 88, 355-365
5. Cohen, G. M. (1997) Biochem. J. 326, 1-16
6. Thornberry, N. A., and Lazebnik, Y. (1998) Science 281, 1312-1316
7. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
8. Wilson, K. P., Black, J.-A. F., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A., and Livingston, D. J. (1994) Nature 370, 270-274
9. Zou, H., Henzel, W. J., Liu, X, Lutschg, A., and Wang, X. (1997) Cell 90, 405-413
10. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. (1997) Cell 91, 479-489
11. Hengartner, M. O. (1997) Nature 388, 714-715
12. MacFarlane, M., Cain, K., Sun, X-M., Alnemri, E. S., and Cohen, G. M. (1997) J. Cell Biol. 137, 469-479
13. Srinivasula, S. M., Fernandes-Alnemri, T., Zangrilli, J., Robertson, N., Armstrong, R. C., Wang, L., Trapani, J. A., Tomaselli, K. J., Litwack, G., and Alnemri, E. S. (1996) J. Biol. Chem. 271, 27099-27106
14. Takahashi, A., Alnemri, E. S., Lazebnik, Y. A., Fernades-Alnemri, T., Litwack, G., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H., and Earnshaw, W. C. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8395-8400
15. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. (1996) Cell 86, 147-157
16. Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., Munday, N. A., Raju, S. M., Smulson, M. E., Yamin, T.-T., Yu, V. L., and Miller, D. K. (1995) Nature 376, 37-43
17. Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A., and Tocci, M. J. (1992) Nature 356, 768-774
18. Lewis, V. A., Hynes, G. M., Zheng, D., Saibil, H., and Willison, K. (1992) Nature 358, 249-252
19. Hough, R., Pratt, G., and Rechsteiner, M. (1987) J. Biol. Chem. 262, 8303-8313
20. Lupas, A., Flanagan, J. M., Tamura, T., and Baumeister, W. (1997) Trends Biochem. Sci. 22, 399-404
21. Baumeister, W., Walz, J., Zuhl, F., and Seemuller, E. (1998) Cell 92, 367-380
22. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. (1998) Mol. Cell 1, 949-957
23. Liou, K. F., and Willison, K. R. (1997) EMBO J. 16, 4311-4316
24. Chandler, J. M., Cohen, G. M., and MacFarlane, M. (1998) J. Biol. Chem. 273, 10815-10818
25. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., and Schreiber, S. L. (1995) Science 268, 726-731
26. Drexler, H. C. A. (1998) Apoptosis 3, 1-7