Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias

Cancer Research

Volumn 58, Issue 12, 1998, Pages 2500-2503

  Larry Maxwell, G ^a   Risinger, John I ^b   Gumbs, Curtis ^a   Shaw, Heather ^a   Bentley, Rex C ^a   Barrett, J Carl ^b   Berchuck, Andrew ^a   Andrew Futreal, P ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; DNA SEQUENCE; ENDOMETRIUM BIOPSY; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; EXON; FEMALE; GENE DELETION; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ENDOMETRIAL HYPERPLASIA; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; MUTATION; NEOPLASM PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE-PHOSPHATASE; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 2642643720     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Wingo, P. A., Tong, T., and Bolden, S. Cancer statistics, 1995. CA Cancer J. Clin., 45: 8-30, 1995.
2. Lukes, A. S., Kohler, M. F., Pieper, C. F., Kerns, B. J., Bentley, R., Rodriguez, G. C., Soper, J. T., Clarke-Pearson, D. L., Bast, R. C., Jr., and Berchuck, A. Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer (Phila.), 73: 2380-2385, 1994.
3. Sasaki, H., Nishii, H., Tada, A., Furusato, M., Terashima, Y., Siegal, G. P., Parker, S. L., Kohler, M. F., Berchuck, A., and Boyd, J. Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. Cancer Res., 53: 1906-1910, 1993.
4. Risinger, J. I., Berchuck, A., Kohler, M. F., Watson, P., Lynch, H. T., and Boyd, J. Genetic instability of microsatellites in endometrial carcinoma. Cancer Res., 53: 5100-5103, 1993.
5. Burks, R. T., Kessis, T. D., Cho, K. R., and Hedrick, L. Microsatellite instability in endometrial carcinoma. Oncogene, 9: 1163-1166, 1994.
6. Kurman, R. J., Kaminski, P. F., and Norris, H. J. The behavior of endometrial hyperplasia: a long term study of "untreated" hyperplasia in 170 patients. Cancer (Phila.), 56: 403-412, 1985.
7. Kohler, M. F., Nishii, H., Humphrey, P. A., Saski, H., Marks, J., Bast, R. C., Clarke-Pearson, D. L., Boyd, J., and Berchuck, A. Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias. Am. J. Obstet. Gynecol., 169: 690-694, 1993.
8. Peiffer, S. L., Herzog, T. J., Tribune, D. J., Mutch, D. G., Gersell, D. J., and Goodfellow, P. J. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers. Cancer Res., 55: 1922-1926, 1995.
9. Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., Li, J., Parsons, R., and Hedrick Ellenson, L. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecologic malignancies. Cancer Res., 57: 3935-3940, 1997.
10. Risinger, J. I., Hayes, S. K., Berchuck, A., and Barrett J. C. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res., 57: 4736-4738, 1997.
11. Kong, D., Suzuki, A., Zou, T. T., Sakurada, A., Kemp, L. W., Wakatsuki, S., Yokoyama, T., Yamakawa, H., Furukawa, T., Sato, M., Ohuchi, N., Sato, S., Yin, J., Wang, S., Abraham, J. M., Souza, R. F., Smolinski, K. N., Meltzer, S. J., and Horii, A. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat. Genet., 17: 143-144, 1997.
12. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington, D.C.), 275: 1943-1947, 1997.
13. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H., and Tavtigian, S.V. Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
14. Teng, D. H., Rong, H., Lin, H., Davis, T., Iliev, D., Frye, C., Swedlund, B., Hansen, K. L., Vinson, V. L., Gumpper, K. L., Ellis, L., El-Naggar, A., Frazier, M., Jasser, S., Langford, L. A., Lee, J., Gordon, B. M., Perhouse, M. A., Pollack, R. E., Tornos, C., Troncoso, P., Yung, W. K. A., Fujii, G., Berson, A., Bookstein, R., Bolen, J. B., Tavtigian, S. V., and Steck, P. A. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res., 57: 5221-5225, 1997.
15. Guldberg, P., thor Straten, P., Birck, A., Ahrenkiel, V., Kirkin, A. F., and Zeuthen, J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res., 57: 3660-3663, 1997.
16. Rasheed, B. K., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., Bigner, D. D., and Bigner, S. H. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res., 57: 4187-4190, 1997.
17. Suzuki, H., Freije, D., Nusskern, D. R., Okami, K., Cairns, P., Sidransky, D., Isaacs, W. B., and Bova, G. S. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res., 58: 204-209, 1998.
18. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L. M., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16:64-67, 1997.
19. Myers, M. P. and Tonks, N. K. PTEN: sometimes taking it off can be better than putting it on. Am. J. Hum. Genet., 61: 1234-1238, 1997.
20. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R., and Tonks, N. K. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA, 94: 9052-9057, 1997.
21. Katabuchi, H., van Rees, B., Lumbers, A. R., Ronnett, B. M., Blazes, M. S., Leach, F. S., Cho, K. R., and Hedrick, L. Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res., 55: 5556-5560, 1995.
22. Mutter, G. L., Boynton, K. A., Faquin, W. C., Ruiz, R. E., and Jovanovic, A. S. Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer. Cancer Res., 56: 4483-4486, 1996.