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Volumn 22, Issue 5, 2001, Pages 247-254

Pharmacotherapy of obesity: Targets and perspectives

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN BLOCKER; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; AMYLIN RECEPTOR AGONIST; ANTIOBESITY AGENT; BOMBESIN RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; CORTICOTROPIN RELEASING FACTOR RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; ENTEROSTATIN RECEPTOR AGONIST; GALANIN RECEPTOR ANTAGONIST; GLUCAGON LIKE PEPTIDE AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; LEPTIN RECEPTOR AGONIST; MELANIN CONCENTRATING HORMONE ANTAGONIST; MELANOCORTIN 4 RECEPTOR AGONIST; MU OPIATE RECEPTOR ANTAGONIST; NEUROMEDIN U AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; OREXIN RECEPTOR ANTAGONIST; SEROTONIN 2C AGONIST; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0035338157     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01664-3     Document Type: Review
Times cited : (81)

References (60)
  • 2
    • 0032434821 scopus 로고    scopus 로고
    • Sibutramine. A review of its contribution to the management of obesity
    • (1998) Drugs , vol.56 , pp. 1093-1124
    • McNeely, W.1    Goa, K.L.2
  • 4
    • 0032577350 scopus 로고    scopus 로고
    • Strategies and potential molecular targets for obesity treatment
    • (1998) Science , vol.280 , pp. 1383-1387
    • Campfield, L.A.1
  • 7
    • 0034611732 scopus 로고    scopus 로고
    • Central nervous system control of food intake
    • (2000) Nature , vol.404 , pp. 661-671
    • Schwartz, M.W.1
  • 10
    • 0033575993 scopus 로고    scopus 로고
    • Effects of recombinant leptin therapy in a child with congenital leptin deficiency
    • (1999) New Engl. J. Med. , vol.341 , pp. 879-884
    • Farooqi, I.S.1
  • 12
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1
  • 14
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • (1998) Mol. Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1
  • 16
    • 15844420659 scopus 로고    scopus 로고
    • A receptor subtype involved in neuropeptide-Y-induced food intake
    • (1996) Nature , vol.382 , pp. 168-171
    • Gerald, C.1
  • 19
    • 0031779336 scopus 로고    scopus 로고
    • 5 neuropeptide Y receptor in feeding and obesity
    • (1998) Nat. Med. , vol.4 , pp. 718-721
    • Marsh, D.J.1
  • 21
    • 0034192443 scopus 로고    scopus 로고
    • A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences
    • (2000) J. Neurosci. , vol.20 , pp. 3442-3448
    • Benoit, S.C.1
  • 22
    • 0033927916 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
    • (2000) J. Clin. Invest. , vol.106 , pp. 253-262
    • Vaisse, C.1
  • 23
    • 0343953074 scopus 로고    scopus 로고
    • Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
    • (2000) J. Clin. Invest. , vol.106 , pp. 271-279
    • Farooqi, I.S.1
  • 24
    • 0033818103 scopus 로고    scopus 로고
    • Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
    • (2000) Nat. Genet. , vol.26 , pp. 97-102
    • Chen, A.S.1
  • 25
    • 0032542294 scopus 로고    scopus 로고
    • Mice lacking melanin-concentrating hormone are hypophagic and lean
    • (1998) Nature , vol.39 , pp. 670-674
    • Shimada, M.1
  • 26
    • 0033566084 scopus 로고    scopus 로고
    • Molecular characterization of the melanin-concentrating hormone-receptor
    • (1999) Nature , vol.400 , pp. 265-269
    • Saito, Y.1
  • 27
    • 0033566128 scopus 로고    scopus 로고
    • Melanin-concentrating hormone is the cognate ligand for the orphan G-protein coupled receptor SLC-1
    • (1999) Nature , vol.400 , pp. 261-265
    • Chambers, J.1
  • 28
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G-protein coupled receptors that regulate feeding behaviour
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1
  • 29
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.1
  • 30
    • 0033588319 scopus 로고    scopus 로고
    • Narcolepsy: A key role for hypocretins (orexins)
    • (1999) Cell , vol.98 , pp. 409-412
    • Siegel, J.1
  • 31
    • 0032492893 scopus 로고    scopus 로고
    • Hypothalamic CART is a new anorectic peptide regulated by leptin
    • (1998) Nature , vol.393 , pp. 72-76
    • Kristensen, P.1
  • 32
    • 0031820785 scopus 로고    scopus 로고
    • CART peptides in the central control of feeding and interactions with neuropeptide Y
    • (1998) Synapse , vol.29 , pp. 293-298
    • Lambert, P.D.1
  • 33
    • 0034612519 scopus 로고    scopus 로고
    • Identification of receptors for neuromedin U and its role in feeding
    • (2000) Nature , vol.406 , pp. 70-74
    • Howard, A.D.1
  • 34
    • 85047684961 scopus 로고    scopus 로고
    • Editorial: The corticotropin-releasing hormone system and feeding behaviour - A complex web begins to unravel
    • (2000) Endocrinology , vol.141 , pp. 2713-2714
    • Cone, R.D.1
  • 35
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • (2000) Science , vol.289 , pp. 2122-2125
    • Brüning, J.C.1
  • 36
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • (2000) Science , vol.288 , pp. 2379-2381
    • Loftus, T.M.1
  • 39
    • 0034652302 scopus 로고    scopus 로고
    • The role of CNS glucagon-like peptide 1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    • (2000) J. Neurosci. , vol.20 , pp. 1616-1621
    • Seeley, R.J.1
  • 40
    • 0033914183 scopus 로고    scopus 로고
    • The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake
    • (2000) Nat. Med. , vol.6 , pp. 802-807
    • Tang-Christensen, M.T.1
  • 41
    • 0034048279 scopus 로고    scopus 로고
    • Transgenic approach to the study of body weight regulation
    • (2000) Pharmacol. Rev. , vol.52 , pp. 35-61
    • Inui, A.1
  • 42
    • 0033760587 scopus 로고    scopus 로고
    • Beacon: A novel gene involved in the regulation of energy balance
    • (2000) Diabetes , vol.49 , pp. 1766-1771
    • Collier, G.R.1
  • 43
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1
  • 44
    • 0033197543 scopus 로고    scopus 로고
    • Identification of the major intestinal fatty acid transport protein
    • (1999) Mol. Cell , vol.4 , pp. 299-308
    • Stahl, A.1
  • 45
    • 0034103658 scopus 로고    scopus 로고
    • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
    • (2000) Nat. Genet. , vol.25 , pp. 87-90
    • Smith, S.J.1
  • 48
    • 0032923340 scopus 로고    scopus 로고
    • Development of β-3 adrenoceptor agonists for the treatment of obesity - An update
    • (1999) Diabetes Metab. , vol.25 , pp. 11-21
    • Weyer, C.1
  • 50
    • 0033969421 scopus 로고    scopus 로고
    • Uncoupling protein 2 and 3: Potential regulators of mitochondrial energy metabolism
    • (2000) Diabetes , vol.49 , pp. 143-156
    • Boss, O.1
  • 51
    • 0032933115 scopus 로고    scopus 로고
    • Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima indians
    • (1999) Diabetes , vol.48 , pp. 146-149
    • Schrauwen, P.1
  • 52
    • 0032189845 scopus 로고    scopus 로고
    • Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
    • (1998) J. Clin. Invest. , vol.102 , pp. 1345-1351
    • Agyropoulos, G.1
  • 53
    • 0006877856 scopus 로고    scopus 로고
    • Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
    • (2000) Nature , vol.406 , pp. 415-418
    • Clapham, J.C.1
  • 54
    • 0034717074 scopus 로고    scopus 로고
    • Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
    • (2000) J. Biol. Chem. , vol.275 , pp. 16251-16257
    • Gong, D.W.1
  • 55
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-γ: Adipogenic regulator and thiazolidinedione receptor
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 56
    • 0033212964 scopus 로고    scopus 로고
    • PPAR-γmediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • (1999) Mol. Cell , vol.4 , pp. 597-609
    • Kubota, N.1
  • 59
    • 0034708580 scopus 로고    scopus 로고
    • Mechanism of insulin resistance in A-ZIP/F-1 fatless mice
    • (2000) J. Biol. Chem. , vol.275 , pp. 8456-8460
    • Kim, J.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.