Strategies and potential molecular targets for obesity treatment

Science

Volumn 280, Issue 5368, 1998, Pages 1383-1387

  Campfield, L Arthur ^a   Smith, Françoise J ^a   Burn, Paul ^a  

^a Hoffman La Roche Department of Metabolic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; ANTIOBESITY AGENT; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BOMBESIN; CARBOXYPEPTIDASE H; CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR STIMULATING AGENT; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; DEXFENFLURAMINE; FEN PHEN; FENFLURAMINE; GALANIN; GLUCAGON LIKE PEPTIDE 1; GROWTH HORMONE; LEPTIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; PHENTERMINE; PROOPIOMELANOCORTIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN; UROCORTIN;

ARTICLE; BODY FAT; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENERGY BALANCE; HUMAN; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; APPETITE DEPRESSANTS; ENERGY INTAKE; ENERGY METABOLISM; HORMONES; HUMANS; LEPTIN; NEUROPEPTIDES; OBESITY; PROTEINS; RECEPTORS, CELL SURFACE;

EID: 0032577350     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5368.1383     Document Type: Article

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57. We thank J. F. R. Curtis for assistance with the artwork; K. Yagaloff, S. Fisher, W. Danho, J. Kochan, D. Hartman, J. Grippo, R. Sarabu, S. Wertheimer, A. Olivier, R. Garippa, J. Coffey, B. Oemar, and J. Guenot for insightful discussions; I. Rivera, J. Yu, M. Renzetti, and G. Mackie for technical assistance; and D. Loh for support, encouragement, and helpful comments. Because of space limitations, it was not possible to include a comprehensive list of references for all of the work discussed.