In vivo modulation of Hmgic reduces obesity

Nature Genetics

Volumn 24, Issue 4, 2000, Pages 377-380

  Anand, Ashim ^a   Chada, Kiran ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN DERIVATIVE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DISRUPTION; GENE FUNCTION; GENE MUTATION; GENOTYPE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; DIET; DIETARY FATS; GENE DOSAGE; GENE TARGETING; HIGH MOBILITY GROUP PROTEINS; HMGA2 PROTEIN; LEPTIN; MICE; MICE, KNOCKOUT; MICE, OBESE; OBESITY;

ANIMALIA; RODENTIA;

EID: 0034069653     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/74207     Document Type: Article

References (29)

1. Grosschedl, R., Giese, K. & Pagel, J. HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. Trends Genet. 10, 94-100 (1994).
2. Bustin, M., Lehn, D. & Landsman, D. Structural features of the HMG chromosomal proteins and their genes. Biochem. Biophys. Acta 1049, 231-243 (1990).
3. Wolffe, A. Architectural transcription factors. Science 264, 1100-1101 (1994).
4. Zhou, X. & Chada, K. HMGI family proteins: architectural transcription factors in mammalian development and cancer. Keio J. Med. 47, 73-77 (1998).
5. Mantovani, F. et al. NF-κB mediated transcriptional activation is enhanced by the architectural factor HMGI-C. Nucleic Acids Res. 26, 1433-1439 (1998).
6. Thanos, D. & Maniatis, T. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell 83, 1091-1100 (1995).
7. Carey, M. The enhancesome and transcriptional synergy. Cell 92, 5-8 (1998).
8. Zhou, X., Benson, K., Ashar, H. & Chada, K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376, 771-774 (1995).
9. Hirning-Folz, U., Wilda, M., Rippe, V., Bullerdiek, J. & Hameister, H. The expression pattern of the Hmgic gene during development. Genes Chrom. Cancer 23, 350-357 (1998).
10. Schoenmakers, E. et al. Recurrent rearrangements in the high mobility group protein gene, HMGI-C. in benign mesenchymal tumors. Nature Genet. 10, 436-443 (1995).
11. Tkachenko, A., Ashar, H.R., Meloni, A.M., Sandberg, A.A. & Chada, K.K. Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis. Cancer Res. 57, 2276-2280 (1997).
12. Ashar, H.R. et al. Disruption of the architectural factor HMGI-C: DMA-binding A-T hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82, 57-65 (1995).
13. Benson, K. & Chada, K. Minimouse: phenotypic characterization of a transgenic insertions I mutant allelic to pygmy Genet. Res. 64, 27-33 (1994).
14. West, D., Boozer, C., Moody, D. & Atkinson, R. Dietary obesity in the mouse: interaction of strain with diet composition. Am. J. Physiol. 262, R1025-R1032 (1992).
15. Rogalla, P. et al. HMGI-C expression patterns in human tissues. Am. J. Pathol. 149, 775-779 (1996).
16. Green, M. in Genetic Variants and Strains of the Laboratory Mouse (eds Lyon, M. & Searle, A.) 265-266 (Oxford University Press, Oxford and New York, 1989).
17. Herberg, L. & Coleman, D, Laboratory animals exhibiting obesity and diabetes syndromes. Metabolism 26, 59-99 (1977).
18. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-431 (1994).
19. Bates, M., Nauss, S., Hagman, N. & Mayer, J. Fat metabolism in three forms of experimental obesity. Am. J. Physiol. 180, 301-303 (1955).
20. Johnson, P. & Hirsch, J. Cellularity of adipose depots in six strains of genetically obese mice. J. Lipid Res. 13, 2-11 (1972).
21. Frankel, W. & Schork, N. Who's afraid of epistasis? Nature Genet, 14, 371-373 (1996).
22. Reeves, R., Langan, T. & Nissen, M. Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase reduction of binding affinity. Proc. Natl Acad. Sci. USA 88, 1671-1675 (1991).
23. 1 serum response genes and identification of a subset regulated by conditional myc expression. Mol. Biol. Cell 5, 375-388 (1994).
24. Klyde, S. & Hirsch, J. Increased cellular proliferation in adipose tissue of adult rats fed a high-fat diet. J. Lipid Res. 20, 705-715 (1979).
25. Ailhaud, G., Grimaldi, P. & Negrel, R. Cellular and molecular aspects of adipose tissue development. Annu. Rev. Nutr. 12, 207-233 (1992).
26. Flier, J. & Maratos-Flier, E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 92, 437-440 (1998).
27. Pi-Sunyer, F.X. Medical hazards of obesity. Ann. Intern. Med. 119, 655-670 (1993).
28. Flegal, K., Carrol, W., Kuczmarski, R. & Johnson, C. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int. J. Obes. Relat. Metab. Disord. 22, 39-47 (1998).
29. Cummings, D.E. et al. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A. Nature 382, 622-626 (1996).