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Volumn 6, Issue 7, 2000, Pages 802-807

The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN; GLUCAGON LIKE PEPTIDE; GLUCAGON LIKE PROTEIN 2; GLUCAGON RECEPTOR; NEUROPEPTIDE Y; PROGLUCAGON; PROTEIN C FOS; RECEPTOR BLOCKING AGENT; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 0033914183     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/77535     Document Type: Article
Times cited : (238)

References (40)
  • 1
  • 2
    • 0031936954 scopus 로고    scopus 로고
    • Glucagon-like peptides
    • Drucker, D.J. Glucagon-like peptides. Diabetes 47, 159-169 (1998).
    • (1998) Diabetes , vol.47 , pp. 159-169
    • Drucker, D.J.1
  • 3
    • 0029859220 scopus 로고    scopus 로고
    • Central administration of GLP-1(7-36)amide inhibits food and water intake in rats
    • Tang-Christensen, M. et al. Central administration of GLP-1(7-36)amide inhibits food and water intake in rats. Am. Jour. Phys. 271, 848-856 (1996).
    • (1996) Am. Jour. Phys. , vol.271 , pp. 848-856
    • Tang-Christensen, M.1
  • 4
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • Larsen, P.J., Tang-Christensen, M. & Jessop, D. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 138, 4445-4455 (1997).
    • (1997) Endocrinology , vol.138 , pp. 4445-4455
    • Larsen, P.J.1    Tang-Christensen, M.2    Jessop, D.3
  • 5
    • 0031924498 scopus 로고    scopus 로고
    • Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment
    • Tang-Christensen, M., Vrang, N. & Larsen, P.J. Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment. Diabetes 47, 530-537 (1998).
    • (1998) Diabetes , vol.47 , pp. 530-537
    • Tang-Christensen, M.1    Vrang, N.2    Larsen, P.J.3
  • 6
    • 0029933622 scopus 로고    scopus 로고
    • Central glucagon-like peptide-1 in the control of feeding
    • Gunn, I. et al. Central glucagon-like peptide-1 in the control of feeding. Biochem. Soc Trans. 24, 581-584 (1996).
    • (1996) Biochem. Soc Trans. , vol.24 , pp. 581-584
    • Gunn, I.1
  • 7
    • 0031891391 scopus 로고    scopus 로고
    • PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats
    • McMahon, L.R. & Wellman, P.J. PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats. Am. J. Physiol. 274, R23-R29 (1998).
    • (1998) Am. J. Physiol. , vol.274 , pp. R23-R29
    • McMahon, L.R.1    Wellman, P.J.2
  • 8
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton, M.D. et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379, 69-72 (1996).
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1
  • 9
    • 0032763050 scopus 로고    scopus 로고
    • functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia
    • Rinaman, L. A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia. Am. J. Physiol. 277, R1537-R1540 (1999).
    • (1999) Am. J. Physiol. , vol.277 , pp. R1537-R1540
    • Rinaman, L.A.1
  • 10
    • 0034652302 scopus 로고    scopus 로고
    • The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride
    • Seeley, R.J. et al. The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride. J. Neurosci. 20, 1616-1621 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 1616-1621
    • Seeley, R.J.1
  • 11
    • 13044286018 scopus 로고    scopus 로고
    • Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc
    • Munroe, D.G. et al. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2. Proc. Natl. Acad. Sci. USA 96, 1569-1573 (1999).
    • (1999) Natl. Acad. Sci. USA , vol.96 , pp. 1569-1573
    • Munroe, D.G.1
  • 12
    • 0031029936 scopus 로고    scopus 로고
    • Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
    • Larsen, P.J., Tang-Christensen, M., Holst, J.J. & Orskov, C. Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience 77, 257-270 (1997).
    • (1997) Neuroscience , vol.77 , pp. 257-270
    • Larsen, P.J.1    Tang-Christensen, M.2    Holst, J.J.3    Orskov, C.4
  • 13
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • Merchenthaler, I., Lane, M. & Shughrue, P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J. Comp. Neurol. 403, 261-280 (1999).
    • (1999) J. Comp. Neurol. , vol.403 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 15
    • 0027501184 scopus 로고
    • Insulin, neuropeptide Y, and food intake
    • Schwartz, M.W. et al. Insulin, neuropeptide Y, and food intake. Ann. N.Y. Acad. Sci. 692, 60-71 (1993).
    • (1993) Ann. N.Y. Acad. Sci. , vol.692 , pp. 60-71
    • Schwartz, M.W.1
  • 16
    • 0000555383 scopus 로고
    • Neuropeptide Y injected in the paraventricular hypothalamus: A powerful stimulant of feeding behavior
    • Stanley, B.G. & Leibowitz, S.F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. USA 82, 3940-3943 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 3940-3943
    • Stanley, B.G.1    Leibowitz, S.F.2
  • 17
    • 0027397282 scopus 로고
    • Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue
    • Valverde, I. et al. Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue. Endocrinology 132, 75-79 (1993).
    • (1993) Endocrinology , vol.132 , pp. 75-79
    • Valverde, I.1
  • 18
    • 0027425034 scopus 로고
    • Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
    • Thorens, B. et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42, 1678-1682 (1993).
    • (1993) Diabetes , vol.42 , pp. 1678-1682
    • Thorens, B.1
  • 19
    • 0030782159 scopus 로고    scopus 로고
    • Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2
    • Brubaker, P.L. et al. Circulating and tissue forms of the intestinal growth factor, glucagon-like peptide-2. Endocrinology 138, 4837-4843 (1997).
    • (1997) Endocrinology , vol.138 , pp. 4837-4843
    • Brubaker, P.L.1
  • 20
    • 0029829540 scopus 로고    scopus 로고
    • Oxyntomodulin: A cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2
    • Schepp, W. et al. Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7-36)NH2. Digestion 57, 398-405 (1996).
    • (1996) Digestion , vol.57 , pp. 398-405
    • Schepp, W.1
  • 21
    • 0029908224 scopus 로고    scopus 로고
    • Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain
    • Van Dijk, G. et al. Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am. J. Physiol. 271, R1096-R1100 (1996).
    • (1996) Am. J. Physiol. , vol.271 , pp. R1096-R1100
    • Van Dijk, G.1
  • 22
    • 0030944526 scopus 로고    scopus 로고
    • Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats
    • Thiele, T.E. et al. Central infusion of GLP-1, but not leptin, produces conditioned taste aversions in rats. Am. J. Physiol. 272, R726-R730 (1997).
    • (1997) Am. J. Physiol. , vol.272 , pp. R726-R730
    • Thiele, T.E.1
  • 23
    • 0032718059 scopus 로고    scopus 로고
    • Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor
    • Yusta, B. et al. Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor. J. Biol. Chem. 274, 30459-30467 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 30459-30467
    • Yusta, B.1
  • 24
    • 0028171996 scopus 로고
    • Exendin-4 and exendin-(9-39)NH2: Agonist and antagonist, respectively, at the rat parietal celt receptor for glucagon-like peptide-1-(7-36)NH2
    • Schepp, W. et al. Exendin-4 and exendin-(9-39)NH2: agonist and antagonist, respectively, at the rat parietal celt receptor for glucagon-like peptide-1-(7-36)NH2. Eur. J. Pharmacol. 269, 183-191 (1994).
    • (1994) Eur. J. Pharmacol. , vol.269 , pp. 183-191
    • Schepp, W.1
  • 25
    • 0031789874 scopus 로고    scopus 로고
    • Exendin (9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: Implications for basal intracellular cyclic adenosine 3′, 5′-monophosphate levels and beta-cell glucose competence
    • Serre, V. et al. Exendin (9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3′, 5′-monophosphate levels and beta-cell glucose competence. Endocrinology 139, 4448-4454 (1998).
    • (1998) Endocrinology , vol.139 , pp. 4448-4454
    • Serre, V.1
  • 26
    • 0024359370 scopus 로고
    • Complete sequences of glucagon-like peptide-1 from human and pig small intestine
    • Ørskov, C. et al. Complete sequences of glucagon-like peptide-1 from human and pig small intestine. J. Biol. Chem. 264, 1 2826-1 2829 (1989).
    • (1989) J. Biol. Chem. , vol.264 , pp. 12826-12829
    • ØRskov, C.1
  • 27
    • 0031856907 scopus 로고    scopus 로고
    • The dorsomedial hypothalamic nucleus revisited: 1998 update
    • Bernardis, L.L. & Bellinger, L.L. The dorsomedial hypothalamic nucleus revisited: 1998 update. Proc. Soc. Exp. Biol. Med. 218, 284-306 (1998).
    • (1998) Proc. Soc. Exp. Biol. Med. , vol.218 , pp. 284-306
    • Bernardis, L.L.1    Bellinger, L.L.2
  • 28
    • 0023109895 scopus 로고
    • Phaseolus vulgaris leuco-agglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat
    • Ter Horst, G.J. & Luiten, P.G. Phaseolus vulgaris leuco-agglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat. Brain Res. Bull. 18, 191-203 (1987).
    • (1987) Brain Res. Bull. , vol.18 , pp. 191-203
    • Ter Horst, G.J.1    Luiten, P.G.2
  • 29
    • 0031054014 scopus 로고    scopus 로고
    • Leptin activates neurons in ventrobasal hypothalamus and brainstem
    • Elmquist, J.K. et al. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138, 839-842 (1997).
    • (1997) Endocrinology , vol.138 , pp. 839-842
    • Elmquist, J.K.1
  • 30
    • 0025542173 scopus 로고
    • Ultrastructural localization of neuropeptide Y in the hypothalamus
    • Pelletier, G. Ultrastructural localization of neuropeptide Y in the hypothalamus. Ann. N.Y. Acad. Sci. 611, 232-246 (1990).
    • (1990) Ann. N.Y. Acad. Sci. , vol.611 , pp. 232-246
    • Pelletier, G.1
  • 31
    • 0031764960 scopus 로고    scopus 로고
    • The acute suckling stimulus induces expression of neuropeptide Y (NPY) in cells in the dorsomedial hypothalamus and increases NPY expression in the arcuate nucleus
    • Li, C., Chen, P. & Smith, M.S. The acute suckling stimulus induces expression of neuropeptide Y (NPY) in cells in the dorsomedial hypothalamus and increases NPY expression in the arcuate nucleus. Endocrinology 139, 1645-1652 (1998).
    • (1998) Endocrinology , vol.139 , pp. 1645-1652
    • Li, C.1    Chen, P.2    Smith, M.S.3
  • 32
    • 0032566823 scopus 로고    scopus 로고
    • Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH)
    • Li, C., Chen, P. & Smith, M.S. Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH). Regul. Pept. 75-76, 93-100 (1998).
    • (1998) Regul. Pept. , vol.75-76 , pp. 93-100
    • Li, C.1    Chen, P.2    Smith, M.S.3
  • 33
    • 0027220143 scopus 로고
    • Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat
    • Smith, M.S. Lactation alters neuropeptide-Y and proopiomelanocortin gene expression in the arcuate nucleus of the rat. Endocrinology 133, 1258-1265 (1993).
    • (1993) Endocrinology , vol.133 , pp. 1258-1265
    • Smith, M.S.1
  • 34
    • 0031047570 scopus 로고    scopus 로고
    • Additive effects of lactation and food restriction to increase hypothalamic neuropeptide Y mRNA in rats
    • Wilding, J.P., Ajala, M.O., Lambert, P.D. & Bloom, S.R. Additive effects of lactation and food restriction to increase hypothalamic neuropeptide Y mRNA in rats. J. Endocrinol. 152, 365-369 (1997).
    • (1997) J. Endocrinol. , vol.152 , pp. 365-369
    • Wilding, J.P.1    Ajala, M.O.2    Lambert, P.D.3    Bloom, S.R.4
  • 35
    • 0030894709 scopus 로고    scopus 로고
    • Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome
    • Kesterson, R.A. et al. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol. Endocrinol. 11, 630-637 (1997)
    • (1997) Mol. Endocrinol. , vol.11 , pp. 630-637
    • Kesterson, R.A.1
  • 36
    • 0032577534 scopus 로고    scopus 로고
    • Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast
    • Thim, L. et al. Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast. FEBS Lett. 428, 263-268 (1998).
    • (1998) FEBS Lett. , vol.428 , pp. 263-268
    • Thim, L.1
  • 37
    • 0025973566 scopus 로고
    • Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization
    • Kristensen, P., Eriksen, J. & Dano, K. Localization of urokinase-type plasminogen activator messenger RNA in the normal mouse by in situ hybridization. J. Histochem. Cytochem. 39, 341-349 (1991).
    • (1991) J. Histochem. Cytochem. , vol.39 , pp. 341-349
    • Kristensen, P.1    Eriksen, J.2    Dano, K.3
  • 38
    • 0029763995 scopus 로고    scopus 로고
    • mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor
    • Jensen, J. et al. mRNA profiling of rat islet tumors reveals nkx 6.1 as a beta-cell-specific homeodomain transcription factor. J. Biol. Chem. 271, 18749-18758 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 18749-18758
    • Jensen, J.1
  • 39
    • 0029943197 scopus 로고    scopus 로고
    • Prolonged induction of c-fos in neuropeptide Y-and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation
    • Woldbye, D.P. et al. Prolonged induction of c-fos in neuropeptide Y-and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation. Brain. Res. 720, 111-119 (1996).
    • (1996) Brain. Res. , vol.720 , pp. 111-119
    • Woldbye, D.P.1
  • 40
    • 0033561832 scopus 로고    scopus 로고
    • Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons
    • Vrang, N., Larsen, P.J., Clausen, J.T. & Kristensen, P. Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurons J. Neurosci. 19, RC5 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. RC5
    • Vrang, N.1    Larsen, P.J.2    Clausen, J.T.3    Kristensen, P.4


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