Suppressor T cells - They're back and critical for regulation of autoimmunity!

Immunological Reviews

Volumn 182, Issue , 2001, Pages 149-163

  Chatenoud, Lucienne ^a   Salomon, Benoît ^b   Bluestone, Jeffrey A ^c  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELLULAR IMMUNITY; DIABETES MELLITUS; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SUPPRESSOR CELL;

ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DIABETES MELLITUS, TYPE 1; HUMANS; MICE; MICE, INBRED NOD; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH2 CELLS;

EID: 0035187182     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1820112.x     Document Type: Review

References (139)

1. Regulatory T cells in autoimmunity
2. Regulatory T cells: Key controllers of immunologic self-tolerance
3. Control of immune pathology by regulatory T cells
4. Tolerance to islet autoantigens and type I diabetes
5. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation
6. Infectious tolerance
7. Cell interactions in the induction of tolerance: The role of thymic lymphocytes
8. Infectious immunological tolerance
9. Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients
10. Enhancement of the antibody response to type 3 pneumococcal polysaccharide in mice treated with antilymphocyte serum
11. Regulation of the antibody response to type 3 pneumococcal polysaccharide. II. Mode of action of thymic-derived suppressor cells
12. Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response
13. Contrasuppression. A novel immunoregulatory activity
14. Contrasuppression: The second law of thymodynamics, revisited
15. The I-J puzzle
16. Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex
17. Suppressor cells and immunoregulation
18. A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression
19. RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex
20. Purification and analysis of an antigen-specific suppressor factor from a T cell hybridoma specific for phenyltrimethylamino hapten
21. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
22. Insulin-dependent diabetes mellitus as an autoimmune disease
23. Pancreatic islet-specific T-cell clones from nonobese diabetic mice
24. + Th1 and Th2 cells derived from the spleens of diabetic NOD mice
25. The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
26. + T cells secreting Th1 or Th2 cytokines
27. Systemic antigen in the treatment of T-cell-mediated autoimmune diseases
28. Antigen-specific therapy for autoimmune disease
29. Induction of glutamic acid decarboxylase 6S-specific Th2 cells and suppression of autoimmune diabetes at late stages of disease is epitope dependent
30. + T cells that prevent diabetes onset in nonobese diabetic mice
31. Curtailment of autoimmunity following parabiosis with a normal partner
32. Breeding of a non-obese, diabetic strain of mice
33. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
34. Analysis of the spontaneous T cell response to insulin in NOD mice
35. Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice
36. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
37. Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy
38. Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
39. A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice
40. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
41. Glutamic acid decarboxylase 67-reactive T cells: A marker of insulin-dependent diabetes
42. Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes
43. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
44. Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes
45. Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2
46. T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus
47. Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes
48. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen
49. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
50. Vaccination against autoimmune mouse diabetes svith a T-cell epitope of the human 65-kDa heat shock protein
51. Peptide therapy for diabetes in NOD mice
52. A role of hsp60 in autoimmune diabetes: Analysis in a transgenic model
53. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
54. null mice
55. Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice
56. B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice
57. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes
58. Antibodies to ICA512/IA-2 in rodent models of IDDM
59. Prevention of diabetes in NOD mice treated with antibody to murine IFN-γ
60. Interferon-γ impacts at multiple points during the progression of autoimmune diabetes
61. Organ-specific autoimmunity
62. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice
63. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
64. Neonatal activation of CD 28 signaling overcomes T cell allergy and prevents autoimmune diabetes by an IL-4-dependent mechanism
65. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
66. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
67. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
68. The activity of immunoregulatory T cells mediating active tolerance is potentiated in non obese diabetic mice by an IL4-based retroviral gene therapy
69. CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes
70. Recombinant human IL- 10 prevents the onset of diabetes in the nonobese diabetic mouse
71. Interleukin-13 prevents autoimmune diabetes in NOD mice
72. Antigen-driven tissue-specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse
73. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
74. Mouse CD1-specific NK1 T cells: Development, specificity, and function
75. +-like thymocytes in the NOD mouse
76. Overexpression of natural killer T cells protects V α 14-J α 281 transgenic nonobese diabetic mice against diabetes
77. + thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse
78. Accessory molecules
79. Interleukin 4 deficiency does not exacerbate disease in NOD mice
80. Protection from autoimmune diabetes by adjuvant therapy in the non-obese diabetic mouse: The role of interleukin-4 and interleulkin-10
81. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice
82. Th1 to Th2 cytokine shifts in nonobese diabetic mice: Sometimes an outcome, rather than the cause, of diabetes resistance elicited by immunostimulation
83. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice
84. The transfer of autoimmune diabetes in NOD mice can be inhibited or accelerated by distinct cell populations present in normal splenocytes taken from young males
85. Ontogeny of regulatory and effector T-cells in autoimmune NOD mice
86. Lack of L-selectin expression by cells transferring diabetes in NOD mice: Insights into the mechanisms involved in diabetes prevention by Mel-14 antibody treatment
87. + immunoregulatory T cells that control autoimmune diabetes
88. + T cells
89. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice
90. + regulatory T cells in the non-obese diabetic male mouse
91. Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide which do not affect antibody responses
92. Experimental allergic encephalomyelitis in the Lewis rat. A model of predictable relapse by cyclophosphamide
93. Reinduction of experimental allergic encephalomyelitis in convalescent Lewis rats with cyclophosphamide
94. Studies on the mechanism of suppression of experimental allergic encephalomyelitis induced by myelin basic protein-cell conjugates
95. Experimental allergic encephalomyelitis in Lewis rats: Immunoregulation of disease by a single amino acid substitution in the disease-inducing determinant
96. Cyclophosphamide-induced diabetes in NOD/WEHI mice. Evidence for suppression in spontaneous autoimmune diabetes meilitus
97. Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning
98. + T cell subsets: A subset (Thy0) that secretes diverse cytokines and overexpresses the Vβ8 T cell receptor gene family
99. - single positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vβ family
100. Induction of intefienkin 2 receptor β chain expression by self-recognition in the thymus
101. + T cells: A new family of T cells
102. Spontaneous thyroiditis in thymectomized and irradiated Wistar rats
103. Thyroiditis in T cell-depleted rats. Influence of strain, radiation dose, adjuvants and antilymphocyte serum
104. - thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer
105. - subpopulations
106. Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice
107. Experimental autoimmune orchitis after neonatal thymectomy in the mouse
108. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis
109. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
110. lowsubset
111. + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
112. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients
113. Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice
114. T helper cell subsets in insulin-dependent diabetes
115. - thymocytes
116. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
117. Peripheral-antigen-expressing cells in thymic medulla: Factors in self-tolerance and autoimmunity
118. + regulatory T cells induced by an agonist self-peptide
119. Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
120. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
121. - murine thymocytes positively selected by dass I molecules
122. + naturally anergic and suppressive T cells: Induction of autoimmune disease by breaking their anergic/suppressive state
123. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
124. Interception of the development of self tolerance in fetal lambs
125. The significance of immune suppression in normal self tolerance
126. Acquisition of immunological self-recognition by the fetal rat
127. Experimental autoimmune prostatitis after neonatal thymectomy in the mouse
128. An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus
129. + T cells
130. An essential role for interlenkin 10 in the function of regulatory T cells that inhibit intestinal inflammation
131. + regulatory cells that control intestinal inflammation
132. Lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous
133. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes
134. T cell suppression in transplantation tolerance through linked recognition
135. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice
136. CD3 antibody-reduced dominant self tolerance in overtly diabetic NOD mice
137. Identification of a monoclonal antibody specific for a murine T3 polypeptide
138. + immunoregulatory T cells is antigen nonspecific
139. + regulatory T cells down-regulate costimulatory molecules on antigen-presenting cells