Direct evidence for the contribution of B cells to the progression of insulitis and the development of diabetes in non-obese diabetic mice

International Immunology

Volumn 9, Issue 8, 1997, Pages 1159-1164

  Akashi, Moyuki ^a,b   Nagafuchi, Seiho ^a   Anzai, Keizo ^c   Kondo, Shiori ^a   Kitamura, Daisuke ^f   Wakana, Shigeharu ^e   Ono, Junko ^c   Kikuchi, Masahiro ^c,d   Niho, Yoshiyuki ^a   Watanabe, Takeshi ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

^d TOKYO UNIVERSITY OF SCIENCE   (Japan)

^e CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^f NONE

Author keywords

Autoimmunity; B lymphocytes; Diabetes; Knockout; Rodent

Indexed keywords

INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HYPERGLYCEMIA; INSULIN RESPONSE; INSULITIS; MALE; MOUSE; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; B-LYMPHOCYTES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GLUCOSE TOLERANCE TEST; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; PANCREATIC DISEASES; TIME FACTORS;

EID: 8544271680     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.8.1159     Document Type: Article

References (30)

1. Makino, S., Kunimoto, K., Muraoka, Y., Mizushima, Y., Katagiri, K. and Tochino, Y. 1980. Breeding of a non-obese, diabetic strain of mice. Exp. Anim. 29:1.
2. Bach, J.-F. 1995. Insulin-dependent diabetes mellitus as a β-cell targeted disease of Immunoregulation. J. Autoimmun. 8:439.
3. Tisch, R. and McDevitt, H. 1996. Insulin-dependent diabetes mellitus. Cell 85:291.
4. Makino, S., Harada, M., Kishimoto, Y., Hayashi, Y. 1986. Absence of insulitis and overt diabetes in athymic nude mice with NOD genetic background. Exp. Anim. 35:495.
5. Ogawa, M., Maruyama, T., Hasegawa, T., Kanaya, T., Kobayashi, F., Tochino, Y. and Uda, H. 1985. The inhibitory effect of neonatal thymectomy on the incidence of insulitis in non-obese diabetes (NOD) mice. Biomed. Res. 6:103.
6. Miyazaki, A., Hanafusa, T., Yamada, K., Miyagawa, J., Fujino-Kurihara, H., Nakajima, H., Nonaka, K. and Tarui, S. 1985. Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study. Clin. Exp. Immunol. 60:622.
7. Signore, A., Pozzilli, P., Gale E. A. M., Andreani D. and Beverley, P. C. L. 1989. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Diabetologia 32:282.
8. Harada, M., Makino, S. 1986. Suppression of overt diabetes in NOD mice by anti-thymocyte serum or anti-Thy-1.2 antibody. Exp. Anim. 35:501
9. Koike, T., Itoh, Y, Ishii, T., Ito, I., Takabayashi, K., Maruyama, N., Tomioka, H. and Yoshida, S. 1987. Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice. Diabetes 36:539.
10. Hayward, A. R., Schreiber, M. 1989. Neonatal injection of CD3 antibody into nonobese diabetic mice reduces the incidence of insulitis and diabetes. J. Immunol. 143:1555
11. Bendelac, C., Carnaud, C., Boitard, C. and Bach, J.-F. 1987. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. J. Exp. Med. 16:823.
12. Haskins, K., Portas, M., Bergman, B., Lafferty, K. and Bradley B. 1989. Pancreatic islet-specific T-cell clones from nonobese diabetic mice. Proc. Natl Acad. Sci. USA 86:8000.
13. + islet-specific T cell clone. Science 249:1433.
14. Katz, J. D., Wang, B., Haskins, K., Benoist, C. and Mathis, D. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74:1089.
15. Bendelac, A., Boitard, C., Bedossa, P., Bazin, H., Bach, J.-F. and Carnaud, C. 1988. Adoptive T cell transfer of autoimmune nonobese diabetic mouse diabetes does not require recruitment of host B lymphocytes. J. Immunol. 141:2625.
16. Reddy, S., Bibby, N. J. and Ellio, R. B. 1988. Ontogeny of islet cell antibodies, insulin autoantibodies and insulin in the non-obese diabetic mouse. Diabetologia 31:322.
17. Elias, D., Markovits, D., Reshef, T., Zee R. V. D., Cohen I. R. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc. Natl Acad. Sci. USA 87:1576.
18. Sumida, T., Furukawa, M., Sakamoto, A., Namekawa, T., Maeda, T., Zijlstra, M., Iwamoto, I., Koike, T., Yoshida, S., Tomioka, H. and Taniguchi, M. 1994. Prevention of insulitis and diabetes in β2-microglobulin-deficient non-obese diabetic mice. Int. Immunol. 6:1445.
19. Kitamura, D., Roes, J., Kuhn, R. and Rajewsky, K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423.
20. Miyazaki T., Uno, M., Uehira, M., Kikutani, H., Kishimoto, T., Kimoto, M., Nishimoto, H., Miyazaki. J. and Yamamura, K. 1990. Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice. Nature 345:722.
21. Serreze D. V., Chapman, H. D., Varnum, D. S., Hanson, M. S., Reifsnyder, P. C., Richard, S. D., Fleming, S. A., Leiter, E. H. and Shultz, L. D. 1996. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes, analysis of a new 'speed congenic' stock of NOD.lg μ null mice. J. Exp. Med. 184:2049.
22. Epstein, M. M., Rosa, F. D., Jankovic, D., Sher, A. and Matzinger, P. 1995. Successful T cell priming in B cell-deficient mice. J. Exp. Med. 182:915.
23. + T cell activation and tolerance induction in B cell knockout mice. J. Exp. Med. 183:1339.
24. Vella, A. T., Scherer, M. T., Shultz, L., Kappler, J. W. and Marrack, P. 1996. B cells are not essential for peripheral T-cell tolerance. Proc. Natl Acad. Sci. USA 93:951.
25. Liu, Y., Wu, Y., Ramarathinam, L., Guo, Y., Huszar, D., Trounstine, M. and Zhao, M. 1995. Gene-targeted B-deficient mice reveal a critical role for B cells in the CD4 T cell response. Int. Immunol. 7:1353.
26. Lenschow, D. J., Ho, S. C., Sattar, H., Rhee, L., Gray, G., Nabavi, N., Herold, K. C. and Bluestone, J. A. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J. Exp. Med. 181:1145.
27. Thompson, C. B. 1995. Distinct roles for the costimulatory ligand B7-1 and B7-2 in T helper cell differentiation? Cell 81:979.
28. Hollander, G. A., Castigli, E., Kulbacki, R., Su, M., Burakoff, S. J., Gutierrez-Ramos, J.-C. and Geha, R. S. 1996. Induction of alloantigen-specific tolerance by B cells from CD40-deficient mice. Proc. Natl Acad. Sci. USA 93:4994.
29. Nakano, N., Kikutani, H., Nishimoto, H. and Kishimoto, T. 1991. T cell receptor V gene usage of islet β cell-reactive T cells is not restricted in non-obese diabetic mice. J. exp. Med. 173:1091.
30. Yang, Y., Charlton, B., Shimada, A., Canto, R. D. and Fathman, C. G. 1996. Monoclonal T cells identified in early NOD islet infiltrates. Immunity 4:189.