Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism

Journal of Clinical Investigation

Volumn 100, Issue 9, 1997, Pages 2243-2253

  Arreaza, Guillermo A ^a   Cameron, Mark J ^a,b   Jaramillo, Andrés ^a   Gill, Bruce M ^a   Hardy, Dan ^a   Laupland, Kevin B ^a   Rapoport, Micha J ^a   Zucker, Peter ^a   Chakrabarti, Subrata ^b   Chensue, Stephen W ^c   Qin, Hui Yu ^b   Singh, Bhagirath ^b   Delovitch, Terry L ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Diabetes mellitus; Insulin dependent; Islets of Langerhans; Mice, inbred NOD; Th1 cells; Th2 cells

Indexed keywords

CD28 ANTIGEN; INTERLEUKIN 4; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CLONAL ANERGY; CONTROLLED STUDY; ETIOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0030671243     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119762     Document Type: Article

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