Protection from autoimmune diabetes by adjuvant therapy in the non- obese diabetic mouse: The role of interleukin-4 and interleukin-10

Immunology and Cell Biology

Volumn 75, Issue 5, 1997, Pages 467-471

  Calcinaro, Filippo ^a,b   Gambelunghe, Giovanni ^b   Lafferty, Kevin J ^a,c,d  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF PERUGIA   (Italy)

^c AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^d Biology and Environment   (Australia)

Author keywords

Autoimmunity; Cytokines; Diabetes; Th1 Th2 shift

Indexed keywords

FREUND ADJUVANT; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 4 ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CELL DESTRUCTION; CELL PROTECTION; DRUG EFFECT; FEMALE; GLUCOSE TOLERANCE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; PANCREAS ISLET BETA CELL; PATHOGENESIS;

ANIMALIA; CELL FUSING AGENT VIRUS;

EID: 0030726021     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1997.72     Document Type: Article

References (27)

1. Sadelain MWJ, Qin HY, Lauzon J, Sing B. Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. Diabetes 1990; 3: 583-9.
2. McInerney MF, Pek SB, Thomas DW. Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice. Diabetes 1991; 40: 715-25.
3. Shehadeh NN, LaRosa F, Lafferty KJ. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 1993; 6: 291-300.
4. Qin HY, Sadelain MWJ, Hitchon C, Lauzon J, Singh B. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 1993; 150: 2072-80.
5. Shehadeh NN, Calcinaro F, Bradley BJ, Bruchlim I, Vardi P, Lafferty KJ. Effect of adjuvant therapy on development of diabetes in mouse and man. Lancet 343: 706-7.
6. Wilson JD, Prowse SJ, Haynes SP. Pancreatic islet allograft function in nonimmunosuppressed conscious mice. Metabolism 1985; 34: 92-6.
7. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clones. I: Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 1986; 136: 2348-57.
8. Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR. Two types of mouse helper T cell clone. J. Exp. Med. 1987; 166: 1229-44.
9. Bottomly K, Luqman M, Greenbaum L et al. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur. J. Immunol. 1989; 19: 617-23.
10. Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989; 7: 145-73.
11. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV: Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 1989; 170: 2081-95.
12. Gajewski TF, Fitch FW. Anti-proliferative effect of IFN-γ in immune regulation: IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 1988; 140: 4245-52.
13. Abehsira-Amar O, Gibert M, Joliy M, Theze J, Jankovic DL. IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J. Immunol. 1992; 148: 3820-9.
14. Parish CR. The relationship between humoral and cell-mediated immunity. Transplant. Rev. 1972; 13: 35-66.
15. Sher A, Gazzinelli RT, Oswald IP et al. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol. Rev. 1992; 127: 185-204.
16. Heinzel FP, Sadick MD, Mutha SS, Locksley RM. Production of interferon γ, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl Acad. Sci. USA 1991; 88: 7011-15.
17. Silva JS, Morrissey PJ, Grabstein KH, Mohler KM, Anderson D, Reed SG. Interleukin 10 and interferon-γ regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 1992; 175: 169-74.
18. Nicoletti F, Meroni PL, Landolfo S et al. Prevention of diabetes in BB/Wor rats treated with monoclonal antibodies to interferon-γ (letter). Lancet 1990; 336: 319.
19. Sarvetnick N, Liggitt D, Pitts SL, Hansen SE, Stewart TA. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 1988; 52: 773-82.
20. Sarvetnick N, Shizuru J, Liggitt D et al. Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ. Nature 1990; 346: 844-7.
21. Foulis AK, McGill M, Farquharson MA. Insulitis in type I (insulin-dependent) diabetes mellitus in man - macrophages, lymphocytes, and interferon-γ containing cells. J. Pathol. 1991; 165: 97-103.
22. Debray-Sachs M, Carnaud C, Boitard C et al. Prevention of diabetes in NOD mice treated with antibody to murine IFN-γ. J. Autoimmun. 1991; 4: 237-48.
23. Stewart TA, Hultgren B, Huang X, Pitts-Meek S, Hully J, MacLachlan NJ. Induction of type I diabetes by interferon-α in transgenic mice. Science 1993; 260: 1942-6.
24. + T cells in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse. Int. Immunol. 1993; 5: 479-89.
25. + regulatory T cells in the non-obese diabetic male mouse. Diabetologia 1994; 37: 337-43.
26. Rabinovitch A, Sorensen O, Suarez-Pinzon WL, Power RF, Rajotte RV, Bleackley RC. Analysis of cytokine mRNA expression in syngeneic islet grafts of NOD mice: interleukin-2 and interferon-γ mRNA expression correlate with graft rejection and interleukin-10 with graft survival. Diabetologia 1994; 37: 833-7.
27. Rabinovitch A, Suarez-Pinzon WL, Sorensen O, Bleackley RC, Power RF. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 1995; 154: 4874-82.