Presenilins: Structural aspects and posttranslational events

Molecular Neurobiology

Volumn 19, Issue 3, 1999, Pages 255-265

  Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Alzheimer's disease; Apoptosis; A peptide; Caspases; Development; Embryogenesis; Maturation; Mutations; Presenilins; APP processing

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA CATENIN; CALCIUM BINDING PROTEIN; CASEIN KINASE I; CASEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; PRESENILIN 1; PRESENILIN 2; PROTEIN KINASE C;

ALZHEIMER DISEASE; ARTICLE; CHROMOSOME MUTATION; NERVE DEGENERATION; SENILE PLAQUE;

EID: 0032872131     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02821716     Document Type: Article

References (90)

1. 1. Tanzi R. E., St. George-Hyslop P., and Gusella J. F. (1991) Molecular genetics of Alzheimer disease amyloid. J. Biol. Chem. 266, 20579-20582.
2. 2. Tanzi R. E., Kovacs D. M., Kim T-W., Moir R. D., Guenette S. Y., and Wasco W. (1996) The gene defects responsible for familial Alzheimer's disease. Neurobiol. Disease 3, 159-168.
3. 3. Mullan M and Crawford F. (1993) Genetic and molecular advances in Alzheimer's disease. Trends Neurosci. 16, 398-403.
4. 4. Schellenberg G. D. (1995) Genetic dissection of Alzheimer disease, a heterogeneous disorder. Proc. Natl. Acad. Sci. USA 92, 8552-8559.
5. 5. Kang J., Lemaire H-G., Unterbeck A., Salbaum J. M., Masters C. L., Grzeschik K-H., Multhaup G, Beyreuther K., and Müller-Hill B. (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325, 733-736.
6. 6. Tanzi R. E., Gusella J. F., Watkins P. C., Bruns G. A. P., St. George-Hyslop P., Van Keuren M. L., Patterson D., Pagan S., Kurnit D. M., Neve R. L. (1987) Amyloid β protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235, 880-884.
7. 7. Goldgaber D., Lerman M. I., McBride O. W., Saffiotti U., and Gajdusek D. C. (1987) Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235, 887-880.
8. 8. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G, Ikeda M, Chi H, Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J. F., Bruni A. C., Montesi M. P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinski R. J., Wasco W., Da Silva HAR, Haines J. L., Pericak-Vance M. A., Tanzi R. E., Roses A. D., Fraser P. E., Rommens J. M., and St George-Hyslop P. H. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760.
9. 9. Levy-Lahad E., Wasco W., Poorkaj P., Romano D. M., Oshima J., Pettingell W. H., Yu C., Jondro P. D., Schmidt S. D., Wang K., Crowley A. C., Fu Y. H., Guenette S. Y., Galas D., Nemens E., Wisjman E. M., Bird T. D., Schellenberg G. D., and Tanzi R. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269, 973-977.
10. 10. Rogaev E. I., Sherrington R., Rogaeva E. A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., Mar L., Sorbi S., Nacmias B., Piacentini S., Amaducci L., Chumakov I., Cohen D., Lannfelt L., Fraser P. E., Rommens J. M., and St Georges-Hyslop P. H. (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778.
11. 11. Alzheimer's Disease Collaborative Group (1996) The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset A. D. families. Nature Genet. 11, 219-222.
12. 12. Mitsuda N., Roses A. D., and Vitek M. P. (1997) Transcriptional regulation of the mouse presenilin-1 gene. J. Biol. Chem. 272, 23,489-23,497.
13. 13. Nishiyama K., Murayama S., Suzuki T., Mitsui Y., Sakaki Y., and Kanazawa I. (1996) Presenilin 1 mRNA expression in hippocampi of sporadic Alzheimer's disease patients. Neurosci. Res. 26, 75-78.
14. 14. Tanimukai H., Sato K., Kudo T., Kashiwagi Y., Tohyama M., and Takeda M. (1999) Regional distribution of presenilin-1 messenger RNA in the embryonic rat brain: comparison with β-amyloid precursor protein messenger RNA localization. Neuroscience 90, 27-39.
15. 15. Hardy J. (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20, 154-159.
16. 16. Campion D., Brice A., Dumanchin C., Puel M., Baulac M., De La Sayette V., Hannequin D., Duyckaerts C., Michon A., Martin C., Moreau V., Penet C., Martinez M., Clerget-Darpoux F., Agid Y., and Frobourg T. (1996) A novel presenilin 1 mutation resulting in familial Alzheimer's disease with an onset age of 29 years. Neuroreport 7, 1582-1584.
17. 17. Wisniewski T., Dowjat W. K., Buxbaum J. D., Khorkova O., Efthimiopoulos S., Kulczycki J., Lojkowska W., Wegiel J., Wisniewski H. M., and Frangione B. (1998) A novel polish presenilin-1 mutation (P117L) is associated with Alzheimer's disease and leads to death as early as the age of 28 years. NeuroReport 9, 217-221.
18. 18. Perez-Tur J., Froelich S., Prihar G., Crook R., Baker M., Duff K., Wragg M., Busfield F., Lendon C., Clark R. F., Roques P., Fuldner R. A., Johnston J., Cowburn R., Forsell C., Axelman K., Lilius L., Houlden H., Karran E., Roberts G. W., Rossor M., Adams M. D., Hardy J., Goate A., Lannfelt L., and Hutton M. (1995) A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. NeuroReport 7, 297-301.
19. 19. Levy-Lahad E., Poorkaj P., Wang K., Fu Y. H., Oshima J., Mulligan J., and Schellenberg G. D. (1996) Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene. Genomics 34, 198-204.
20. 20. Prihar G., Fuldner R. A., Perez-Tur J., Lincoln S., Duff K., Crook R., Hardy J., Philips C. A., Venter C., Talbot C., Clark R. F., Goate A., Li J., Potter H., Karran E., Roberts G. W., Hutton M., and Adams M. D. (1996) Structure and alternative splicing of the presenilin-2 gene. NeuroReport 7, 1680-1684.
21. 21. Levy-Lahad E., Wijsman E. M., Nemens E., Anderson L., Goddard A. B., Weber J. L., Bird T. D., and Schellenberg G. D. (1995) A familial Alzheimer's disease locus on chromosome 1. Science 269, 970-973.
22. 22. Sherrington R., Froelich S., Sorbi S., Campion D., Chi H., Rogaeva E. A., Levesque G., Rogaev E. I., Lin C., Liang Y., Ikeda M., Mar L., Brice A., Agid Y., Percy M. E., Clerget-Darpoux F., Piacentini S., Marcon G., Nacmias B., Amaducci L., Frebourg T., Lannfelt L., Rommens J. M., and St George-Hyslop P. (1996) Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum. Mol. Genet. 5, 985-988.
23. 23. Doan A., Thinakaran C., Borchelt D. R., Slunt H. H., Ratovitsky T., Podlisny M., Selkoe D. J., Seeger M., Gandy S. E., Price D. L., and Sisodia S. S. (1996) Protein topology of presenilin 1. Neuron 17, 1023-1030.
24. 24. Lehmann S., Chiesa R., and Harris D. A. (1997) Evidence for a six-transmembrane domain structure of presenilin 1. J. Biol. Chem. 272, 12,047-12,051.
25. 25. Li X. and Greenwald I. (1996) Membrane topology of the C-elegans SEL-12 presenilin. J. Biol. Chem. 17, 1015-1021.
26. 26. De Strooper B., Beullens M., Contreras B., Levesque L., Craessaerts K., Cordell B., Moechars D., Bollen M., Fraser P., St. George-Hyslop P., and Van Leuven F. (1997) Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem. 272, 3590-3598.
27. 27. Dewji N. N. and Singer S. J. (1997) The seven-transmembrane spanning topography of the Alzheimer disease-related presenilin proteins in the plasma membranes of cultured cells. Proc. Natl. Acad. Sci. USA 94, 14,025-14,030.
28. 28. Elder G. A., Tezapsidis N., Carter J., Shioi J., Bouras C., Li H-C., Johnston J. M., Efthimiopoulos S., Friedrich V. L., and Robakis N. K. (1996) Identification and neuron specific expression of the S182/presenilin 1 protein in human and rodent brains. J. Neurosci. Res. 45, 308-320.
29. 29. Moussaoui S., Czech C., Pradier L., Blanchard V., Bonici B., Gohin M., Imperato A., and Revah F. (1996) Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Letts. 383, 219-222.
30. 30. Kim K. S., Wegiel J., Sapienza V., Chen J., Hong H., and Wisniewski H. M. (1997) Immunoreactivity of presenilin-1 in human, rat and mouse brain. Brain Res. 757, 159-163.
31. 31. Huynh D. P., Vinters H. V., Ho D. H. D., Ho V. V., and Pulst S-M. (1997) Neuronal expresion and intracellular localization of presenilins in normal and Alzheimer's disease. J. Neuropathol. Exp. Neurol. 56, 1009-1017.
32. 32. Culvenor J. G., Maher F., Evin G., Malchiodi-Albedi F., Cappai R., Underwood J. R., Davis J. B., Karran E. H., Roberts G. W., Beyreuther K., and Masters C. L. (1997) Alzheimer's disease-associated presenilin 1 in neuronal cells: evidence for localization to the endoplasmic reticulum-golgi intermediate compartment. J. Neurosci. Res. 49, 719-731.
33. 33. Cook D. G., Sung J. C., Golde T. E., Felsenstein K. M., Wojczyk B. S., Tanzi R. E., Trojanowski J. Q., Lee V. M-Y., and Doms R. W. (1996) Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proc. Natl. Acad. Sci. USA 93, 9223-9228.
34. 34. Capell A., Saffrich R., Olivo J-C., Meyn L., Walter J., Grünberg J., Mathews P., Nixon R., Dotti C., and Haass C. (1997) Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. J. Neurochem. 69, 2432-2440.
35. 35. Busciglio J., Hartmann H., Lorenzo A., Wong C., Baumann K., Sommer B., Staufenbiel M., and Yankner B. A. (1997) Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J. Neurosci. 17, 5101-5107.
36. 36. Kovacs D. M., Fausett H. J., K. J. P., Kim T. W., Moir R. D., Merriam D. E., Hollister R. D., Hallmark O. G., Mancini R., Felsenstein K. M., Hyman B. T., Tanzi R. E., and Wasco W. (1996) Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature. Med. 2, 224-229.
37. 37. Blanchard V., Czech C., Bonici B., Clavel N., Gohin M., Dalet K., Revah F., Pradier L., Imperato A., and Moussaoui S. (1997) Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein. Brain Res. 758, 209-217.
38. 38. Takashima A., Sato M., Mercken M., Tanaka S., Honda T., Sato K., Murayama M., Noguchi K., Nakazato Y., and Takahashi H. (1996) Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells. Biochem. Biophys. Res. Commun. 227, 423-426.
39. 39. Walter J., Capell A., Grünberg J., Pesold B., Schindzielorz A., Prior R., Podlisny M. B., Fraser P., St. George Hyslop P., Selkoe D. J., and Haass C. (1996) The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2, 673-691.
40. 40. Dewji N. N. and Singer S. J. (1997) Cell surface expression of the Alzheimer disease-related presenilin proteins. Proc. Natl. Acad. Sci. USA 94, 9926-9931.
41. 41. Dewji N. N. and Singer S. J. (1998) Specific intercellular binding of the Ξ-amyloid precursor protein to the presenilins induces intercellular signalling: its significance for Alzheimer's disease. Proc. Natl. Acad. Sci. USA 93, 15,055-15,060.
42. 42. Li J., Xu M., Zhou H., and Ma J., Potter H. (1997) Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome seggregation. Cell 90, 917-927.
43. 43. Walter J., Schindzielorz A., Grünberg J., and Haass C. (1999) Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proc. Natl. Acad. Sci. USA 96, 1391-1396.
44. 44. Ward R. V., Davis J. B., Gray C. W., Barton A. J. L., Bresciani L. G., Caivano M., Murphy V. F., Duff K., Hutton M., Hardy J., Roberts G. W., and Karran E. H. (1996) Presenilin-1 is processed into two major cleavage products in neuronal cell lines. Neurodegeneration 5, 293-298.
45. 45. Thinakaran G., Borchelt D. R., Lee M. K., Slunt H. H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A. I., Gandy S. E., Jenkins N. A., Copeland N. G., Price D. L., and Sisodia S. (1996) Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17, 181-190.
46. 46. Kim T. W., Pettingell W. H., Hallmark O. G., Moir R. D., Wasco W., and Tanzi R. E. (1997) Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells. J. Biol. Chem. 272, 11,006-11,010.
47. 47. Baumann K., Paganetti P. A., Sturchler-Pierrat C., Wong C., Hartmann H., Cescato R., Frey P., Yankner B. A., Sommer B., and Staufenbiel M. (1997) Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol. Aging 18, 181-189.
48. 48. Shirotani K., Takahashi K., Ozawa K., Kunishita T., and Tabira T. (1997) Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines. Biochem. Biophys. Res. Commun. 240, 728-731.
49. 49. Capell A., Grünberg J., Pesold B., Diehlmann A., Citron M., Nixon R., Beyreuther K., Selkoe D. J., and Haass C. (1998) The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass. J. Biol. Chem. 273, 3205-3211.
50. 50. Ratovitski T., Slunt H. H., Thinakaran G., Price D. L., Sisodia S. S., and Borchelt D. R. (1997) Endoproteolytic processing and stabilization of wild-type and mutant presenilin. J. Biol. Chem. 272, 24,536-24,541.
51. 51. Okochi M, Ishii K., Usami M., Sahara N., Kametani F., Tanaka K., Frazer P. E., Ikeda M., Saunders A. M., Hendriks L., Shoji S-I., Nee L. E., Martin J-J., Van Broeckhoven C., St. George-Hyslop P., Roses A. D., and Mori H. (1997) Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations. FEBS Lett. 418, 162-166.
52. 52. Hendriks L., Thinakaran G., Harris C. L., De Jonghe C., Martin J. J., Sisodia S. S., and Van Broeckoven C. (1997) Processing of presenilin 1 in brains of patients with Alzheimer's disease and controls. NeuroReport 8, 1717-1721.
53. 53. Murayama O., Honda T., Mercken M., Murayama M., Yasutake K., Nihonmatsu N., Nakazato Y., Michel G., Song S., Sato K., Takahashi H., and Takashima A. (1997) Different effects of Alzheimer-associated mutations of presenilin 1 on its processing. Neurosci. Lett. 229, 61-64.
54. 54. Mercken M., Takahashi H., Honda T., Sato K., Murayama M., Nakazato Y., Noguchi K., Imahori K., and Takashima A. (1996) Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: evidence that Alzheimer mutations affect proteolytic processing. FEBS Lett. 389, 297-303.
55. 55. Lee M. K., Borchelt D. R., Kim G., Thinakaran G., Slunt H. H., Ratovitski T., Martin L. J., Kittur A., Gandy S., Levey A. I., Jenkins N., Copeland N., Price D. L., and Sisodia S. S. (1997) Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Med. 3, 756-760.
56. 56. Seeger M., Nordstedt C., Petanceska S., Kovacs D. M., Gouras G. K., Hahne S., Fraser P., Levesque L., Czernik A. J., St-George-Hyslop P., Sisodia S. S., Thinakaran G., Tanzi R. E., Greengard P., and Gandy S. (1997) Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. USA 94, 5090-5094.
57. 57. Walter J., Grünberg J., Capell A., Pesold B., Schindzielorz A., Citron M., Mendla K., StGeorge-Hyslop P., Multhaup G., Selkoe D. J., and Haass C. (1997) Proteolytic processing of the Alzheimer disease associated presenilin-1 generates an in vivo substrate for protein kinase C. Proc. Natl. Acad. Sci. USA 94, 5349-5354.
58. 58. Loetscher H., Deuschle U., Brockhaus M., Reinhard D., Nelboeck P., Mous J., Grünberg J., Haass C., and Jacobsen H. (1997) Presenilins are processed by caspase-like proteases. J. Biol. Chem. 272, 20,655-20,659.
59. 59. Kim T-W., Pettingell W. H., Jung Y-K., Kovacs D. M., and Tanzi R. E. (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376.
60. 60. Grünberg J., Walter J., Loetscher H., Deuschle U., Jacobsen H., and Haass C. (1998) Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry 37, 2263-2270.
61. 61. van de Craen M., de Jonghe C., van den Brande I., Declercq W., van Gassen G., van Criekinge W., Vanderhoeven I., Fiers W., van Broeckhoven C., Hendricks L., and Vandenabeele P. (1999) Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases. Neurosci. Lett. 260, 149-154.
62. 62. Dewji N. N., Do C., and Singer S. J. (1997) On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues. Proc. Natl. Acad. Sci. USA 94, 14,031-14,036.
63. 63. Marambaud P., Ancolio K., Lopez-Perez E., and Checler F. (1998) Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and trigger increased Aβ42 secretion by human cells. Mol. Med. 4, 146-156.
64. 64. Honda T., Yasutake K., Nihonmatsu N., Mercken M., Takahashi H., Murayama O., Sato K., Omori A., Tsubuki S., Saido T. C., and Takashima A. (1999) Dual roles of proteasome in the metabolism of presenilin 1. J. Neurochem. 72, 255-261.
65. 65. Steiner H., Capell A., Pesold B., Citron M., Kloetzel P. M., Selkoe D. J., Romig H., Mendla K., and Haass C. (1998) Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. J. Biol. Chem. 273, 32,322-32,331.
66. 66. Fraser P. E., Levesque G., Yu G., Mills L. R., Thirwell J., Frantseva M., Gandy S. E., Seeger M., Carlen P. L., and St George-Hyslop P. (1998) Presenilin 1 is actively degraded by the 26S proteasome. Neurobiol. Aging 19, S19-S21.
67. 67. Marambaud P., Alves da Costa C., Ancolio K., and Checler F. (1998) Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPα secretion: control by the proteasome. Biochem. Biophys. Res. Commun. 252, 134-138.
68. 68. Alves da Costa C., Ancolio K., and Checler F. (1999) C-terminal maturation fragments of presenilin 1 and 2 control secretion of APPα and Aβ by human cells and are degraded by the proteasome. Mol. Med. 5, 160-168.
69. 69. Levitan D. and Greenwald I. (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377, 351-354.
70. 70. Levitan D., Doyle T. G., Brousseau D., Lee M. K., Thinakaran G., Slunt H. H., Sisodia S. S., and Greenwald I. (1996) Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 93, 14,940-14,944.
71. 71. Ray W. J., Yao M., Nowotny P., Mumm J., Zhang W., Wu J., Kopan R., and Goate A. (1999) Evidence for a physical interaction between presenilin and Notch. Proc. Natl. Acad. Sci. USA 96, 3263-3268.
72. 72. De strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J. S., Schroeter E. H., Schrijvers V., Wolfe M. S., Ray W. J., Goate A., and Kopan R. (1999) A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518-522.
73. 73. Ye Y., Lukinova N., and Fortini M. E. (1999) Neurogenic phenotypes and altered Notch processing in drosophila presenilin mutants. Nature 398, 525-529.
74. 74. Struhl G. and Greenwald I. (1999) Presenilin is required for activity and nuclear access of Notch in drosophila. Nature 398, 522-525.
75. 75. De Strooper B., Saftig P., Craessaerts K., Vanderstichele H., Guhde G., Von Figura K., and Van Leuven F. (1998) Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390.
76. 76. Wolfe M. S., Xia W., Ostaszewski B. L., Diehl T. S., Kimberly W. T., and Selkoe D. J. (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature 398, 513-517.
77. 77. Naruse S., Thinakaran G., Luo J-J., Kusiak J. W., T. T., Twatsubo T., Qian X., Ginty D. D., Price D. L., Borchelt D. R., Wong P. C., and Sisodia S. S. (1998) Effects of PS1 deficiency on membrane protein trafficking in neurons. Neuron 21, 1213-1221.
78. 78. Nishimura M., Yu G., Levesque G., Zhang D. M., Ruel L., Chen F., Milman P., Holmes E., Liang Y., Kawarai T., Jo E., Supala A., Rogaeva E., Xu D-M., Janus C., Levesque L., Bi Q., Duthie M., Rozmahel R., Mattila K., Lannfelt L., Westaway D., Mount H. T. J., Woodgett J., Fraser P. E., and St George-Hyslop P. (1999) Presenilin mutations associated with Alzheimer's disease cause defective intracellular trafficking of β-catenin, a component of the presenilin protein complex. Nature Med. 5, 164-169.
79. 79. Yu G., Chen F., Levesque G., Nishimura M., Zhang D-M., Levesque L., Rogaeva E., Xu D., Liang Y., Duthie M., St George-Hyslop P. H., and Fraser P. E. (1998) The presenilin 1 protein is component of a high molecular weight intracellular complex that contains β-catenin. J. Biol. Chem. 273, 16,470-16,475.
80. 80. Tesco G., Kim T-W., Dielhmann A., Beyreuther K., and Tanzi R. (1998) Abrogation of the presenilin 1/β-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J. Biol. Chem. 273,33,909-33,914.
81. 81. Zhang Z., Hartmann H., Do V. M., Abramowski D., Sturchler-Pierrat C., Staufenbiel M., Sommer B., van de wetering M., Clevers H., Saftig P., De Strooper B., He X., and Yankner B. A. (1998) Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702.
82. 82. Levesque G., Yu G., Nishimura M., Zhang D. M., Levesque L., Yu H., Xu D., Liang Y., Rogaeve E., Ikeda M., Duthie M., Murgolo N., Wang L., Vander Vere P., Bayne M. L., Strader C. D., Rommens J. M., Fraser P. E., and St. George-Hyslop P. (1999) Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and β-catenin. J. Neurochem. 72, 999-1008.
83. 83. Haass C. (1997) Presenilins, genes for life and death. Neurons 18,687-690.
84. 84. Hutton M. and Hardy J. (1997) The presenilins and Alzheimer's disease. Human Mol. Genet. 6, 1639-1646.
85. 85. Mattson M. P., Gue Q., Furukawa K., and Pedersen W. A. (1998) Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease. J. Neurochem. 70, 1-14.
86. 86. Checler F. (1999) Presenilins: multifunctional proteins involved in Alzheimer's disease Pathology. LIFE, in press.
87. 87. Smine A., Xu X., Nishiyama K., Katada T., Gambetti P., Yadav S. P., Wu X., Shi Y-C., Yasuhara S., Homburger V., and Okamoto T. (1998) Regulation of brain G-protein Go by Alzheimer's disease gene presenilin-1. J. Biol. Chem. 273, 16,281-16,288.
88. 88. Dumanchin C., Czech C., Campion D., Cuif M-H., Poyot T., Charbonnier F., Coud B., Pradier L., and Frebourg T. (1999) Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport. Hum. Mol. Genet. 8, 1263-1269.
89. 89. Buxbaum J. D., Choi E-K., Luo Y., Lilliehook C., Crowley A. C., Merriam D. E., and Wasco W. (1998) Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nature Med. 4, 1177-1181.
90. 90. Takashima A., Murayama M., Murayama O., Kohno T., Honda T., Yasutake K., Nihonmatsu N., Mercken M., Yamaguchi H., Sugihara S., and Wolozin B. (1998) Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc. Natl. Acad. Sci. USA 95, 9637-9641.