Role and distribution of retinoic acid during CNS development

International Review of Cytology

Volumn 209, Issue , 2001, Pages 1-77

  Maden, M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Central nervous system; Hox genes; Neuronal differentiation; Retinoic acid; Retinoid receptors

Indexed keywords

CYTOPLASM PROTEIN; GENE PRODUCT; HOX PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID BINDING PROTEIN; RETINOID RECEPTOR; RETINOL; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; AUTOCRINE EFFECT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOPLASM; EMBRYONAL CARCINOMA; ENZYME SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; REVIEW; RHOMBENCEPHALON; SIGNAL TRANSDUCTION;

EID: 0034802030     PISSN: 00747696     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7696(01)09010-6     Document Type: Review

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238. Retinoid-binding proteins in the developing vertebrate nervous system
239. Vitamin A-deficient quail embryos have half a hindbrain and other neural defects
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241. Retinoic acid as a chemotactic molecule in neuronal development
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243. The role of vitamin A in the development of the central nervous system
244. Segmental identity can change independently in the hindbrain and rhombencephalic neural crest
245. Retinoic acid affects the organization of reticulospinal neurons in developing Xenopus
246. Functional and physical interactions between mammalian achete-scute homolog 1 and myocyte enhancer factor 2A
247. A novel brain-specific mRNA exnoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells
248. Two rhombomeres are altered in Hoxa-1 mutant mice
249. Retinoic acid is necessary for development of the ventral retina in zebrafish
250. Retinoic acid in the anteroposterior patterning of the zebrafish trunk
251. Retinoic acid alters hindbrain Hox code and induces trasformation of rhombomeres 2/3 into a 4/5 identity
252. A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1
253. Cholinergic differentiation of clonal rat pheochromocytoma cells (PCl2) induced by retinoic acid: Increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase
254. Differential and coordinated regulation of expression of norepinephrine transporter in catecholaminergic cells in culture
255. The GABAa receptor is expressed in human neurons derived from a teratocarcinoma cell line
256. Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line
257. Differentiation and maturation of embryonal carcinoma-derived neurons in cell culture
258. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system
259. Hot spots of retinoic acid synthesis in the developing spinal cord
260. Retinoic acid synthesizing enzymes in the embryonic and adult vertebrate
261. Aldehyde dehydrogenase is a positional marker in the retina
262. Asymmetrical retinoic acid synthesis in the dorsoventral axis of the retina
263. Changing patterns of the retinoic acid system in the developing retina
264. Dorsal and ventral territories defined by retinoic acid synthesis, break-down and nuclear receptor expression
265. The deaf Kreisler mouse: A hindbrain segmentation mutant
266. Regulation of UDP-N-acetylglucosamine: Dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase by retinoic acid in P19 cells
267. Developmental analysis of the retinoic acid-inducible RAR-β2 promoter in transgenic animals
268. Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants
269. Retinoic acid increases BDNF-dependent regeneration of chick retinal ganglion cells in vitro
270. Retinoic acid synthesis in the developing chick retina
271. RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development
272. SHP-1 is induced in neuronal differentiation of P19 embryonic carcinoma cells
273. 2+ -dependent protein phosphorylation in cholinergic differentiation of clonal rat pheochromocytoma cells (PCl2) induced by glioma-conditioned medium and retinoic acid
274. Tissue-specific expression of retinoic acid receptor isoform transcripts in the mouse embryo
275. Developmental changes in the expression and distribution of cellular retinoic acid binding protein CRABP in the central nervous system of the chick embryo
276. Activin synergistically increased c-jun mRNA in P19 embryonal carcinoma cells in the presence of retinoic acid
277. High expression of the G5 isoform of G protein in neuroepithelial cells and its replacement of the g2 isoform during neuronal differentiation in the rat brain
278. Retinoic acid induces changes in the rhombencephalic neural crest cells migration and extracellular matrix composition in chick embryos
279. In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer
280. Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A
281. Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segementation in the hindbrain of mouse embryos
282. Effect of retinoic acid on N-glycosylation and mRNA stability of the liver/bone/kidney alkaline phosphatase in neuronal cells
283. EX-1, a surface antigen of mouse neuronal progenitor cells and mature neurons
284. Purification of recombinant midkine and examination of its biological activities: Functional comparison of new heparin binding factors
285. Midkine, a retinoic acid-inducible growth/differentiation factor: Immunochemical evidence for the function and distribution
286. Midkine (MK), the product of a retinoic acid responsive gene, and pleitrophin constitute a new protein family regulating growth and differentiation
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288. Ectopic expression of DAN enhances the retinoic acid-induced neural differentiation in human neuroblastoma cells
289. Expression of mRNA encoding neurotrophic factors and its regulation in a hybrid neuronal cell line
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304. Activation of the mouse inositol 1,4,5-triphosphate receptor type 1 promoter by AP-2
305. Bc1-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells
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308. Meis2, a novel mouse Pbx-related homoebox gene induced by retinoic acid during differentiation of P19 embryonal carcinoma cells
309. Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-B superfamily
310. Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element
311. Retinoic acid-induced differentiation of cultured human neuroblastoma cells: A comparison with phorbol ester-induced differentiation
312. The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions
313. A posteriorising factor, retinoic acid, reveals that anteroposterior patterning controls the timing of neuronal differentiation in Xenopus neurectoderm
314. Retinoic acid causes abnormal development and segmental patterning of the anterior hindbrain in Xenopus embryos
315. Cholinergic properties of neurons differentiated from an embryonal carcinoma cell-line (P19)
316. Stimulated astrocytes release high-mobility group 1 protein, an inducer of LAN-5 neuroblastoma cell differentiation
317. Regulation of neurofilament L, M and H gene expression during retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells
318. Retinoic acid acts during peri-implantational development to alter axial and brain formation
319. Trigeminal sensory neurons require extrinsic signals to switch neurotrophin dependence during the early stages of target field innervation
320. Spatial and temporal pattern of expression of the cellular retinoic acid-binding protein and the cellular retinol-binding protein during mouse embryogensis
321. A role for SOX1 in neural determination
322. Regional specificity of RARg isoforms in Xenopus development
323. Cell type-specific regulation of expression of transcription factor AP-2 in neuroectodermal cells
324. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
325. Neuronal differentiation of NT2/D1 teratocarcinoma cells is accompanied by a loss of lamin A/C expression and an increase in lamin B1 expression
326. Pure, postmitotic, polarized human neurons derived from NTera2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons
327. All-trans retinoic acid stimulates and maintains neurite outgrowth in nerve growth factor-supported developing chick embryonic sympathetic neurons
328. Stimulation of the myelin basic protein gene expression by 9-cis-retinoic acid and thyroid hormone: Activation in the context of its native promoter
329. Retinoic acid rapidly decreases phosphatidyinositol turnover during neuroblastoma cell differentiation
330. Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene
331. Retinoic acid inhibits migration of cranial neural crest cells in the cultured mouse embryo
332. A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell
333. Enhanced neuronal regeneration by retinoic acid of murine dorsal root ganglia and of fetal murine and human spinal cord in vitro
334. A requirement for the POU transcription factor Brn-2, in corticotrophin-releasing hormone expression in a neuronal cell line
335. A new heparin binding protein regulate by retinoic acid from chick embryo
336. Retinoic acid signalling is necessary for the development of the organ of Corti
337. Differential effects of transforming growth factor-bs and glial cell line-derived neurotrophic factor on gene expression of presenilin-1 in human post-mitotic neurons and astrocytes
338. Neurons derived in vitro from ES cells express homeoproteins characteristic of motoneurons and interneurons
339. Developmental expression of functional GABAa receptors containing the g2 subunit in neurons derived from embryonal carcinoma (P19) cells
340. Activity of the β-retinoic acid receptor promoter in transgenic mice
341. A mediator role of ceramide in the regulation of neuroblastoma Neuro2a cell differentiation
342. An analysis of the effects of retinoic acid and other retinoids on the development of adrenergic cells from the avian neural crest
343. Thyroid hormone decreases the number of adrenergic cells that develop in neural crest cultures and can inhibit the stimulatory action of retinoic acid
344. Retinoic acid induces NGF-dependent survival response and high-affinity NGF receptors in immature chick sympathetic neurons
345. The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid
346. Teratogen update: Vitamin A congeners
347. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis
348. Up-regulation of the integrin α1/β1 in human nueroblastoma cells differentiated by retinoic acid: Correlation with increased neurite outgrowth responses to laminin
349. A member of the RXR nuclear receptor family is expressed in neural-crest-derived cells of the developing chick peripheral nervous system
350. Development of the spatial pattern of retinoic acid receptor-β transcripts in embryonic chick facial primordia
351. Synergistic activation of retinoic acid (RA)- responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor α (RARα)-, RARβ-, or RARγ-selective ligand in combination with a retinoid X receptor-specific ligand
352. Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis
353. Retinoic acid receptors and cellular retinoid binding proteins. II. Their differential pattern of transcription during early morphogenesis in mouse embryos
354. Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis
355. Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development
356. Age-dependent retinoic acid regulation of gene expression distinguishes the cervical, thoracic, lumbar, and sacral spinal cord regions during development
357. Retinoic acid modifies mesodermal patterning in early Xenopus embryos
358. Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos
359. Neuronal differentiation of P19 embryonal cells exhibits cell-specific regulation of neurotrophin receptors
360. Differential gene expression between human neurons and neuronal progenitor cells in culture: An analysis of arrayed cDNA clones in NTera2 human embryonal carcinoma cell line as a model system
361. Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues
362. Retinoic acid regulates both the expression of the nerve growth factor receptor and sensitivity to nerve growth factor
363. v-erbA and citral reduce the teratogenic effects of all-trans-retinoic acid and retinol, respectively, in Xenopus embryogenesis
364. Morphological differences elicited by two weak acids, retinoic acid and valproic acid, in rat embryos grown in vitro
365. Characterisation of a neurotransmitter phenotype during neuronal differentiation of embryonal carcinoma cells
366. Retinoic acid can mimic endogenous signals involved in transformation of the Xenopus nervous system
367. Retinoid receptors promote primary neurogenesis in Xenopus
368. Effect of retinoic acid on growth and morphological differentiation of mouse NB2a neuroblastoma cells in culture
369. Embryonic stem cells stably transfected with mRARb2-lacZ exhibit specific expression in chimeric embryos
370. Morphogenesis of malformations in hamsters caused by retinoic acid: Relation to dose and stage at treatment
371. The development of interneurons in the chick embryo spinal cord following in vivo treatment with refinoic acid
372. Identification of a novel type II activin receptor type IIA-N2 induced during the neural differentiation of murine P19 embryonal carcinoma cells
373. Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo
374. Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro
375. Effects of retinoic acid (RA) on the growth and phenotypic expression of several human neuroblastoma cell lines
376. Regulation of acetylcholinesterase acvitity by retinoic acid in a human neuroblastoma cell line
377. Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells
378. Differential regulation by retinoic acid of the homeobox genes of the four Hox loci in human embryonal carcinoma cells
379. Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system
380. Retinoic acid perturbs the expression of Xhox.lab genes and laters mesodermal determination in Xenopus laevis
381. Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis
382. Retinoic acid receptor isoform β2 is an early marker for alimentary tract and central nervous system positional specification in the chicken
383. Temporal and regional differences in the expression pattern of distinct retionic acid receptor-β transcripts in the chick embryo
384. Effects of isotretinoin on the behavior of neural crest cells in vitro
385. Regulated expression of Wnt family members during neuroectodermal differentiation of P19 embryonal carcinoma cells: Overexpression of Wnt-1 perturbs normal differentiation-specific properties
386. Motor neuron-derived retinoid signalling specifies the subtype identity of spinal motor neurons
387. Retinoid-X receptor signalling in the developing spinal cord
388. Mouse embryonal carcinoma cell lines stably transfected with retinoic acid receptor B2 promoter-lacZ: Sensitive system for measuring levels of active retinoids
389. Retinoic acid hydroxylase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells
390. Neurons derived from P19 embryonal carcinoma cells have varied morphologies and neurotransmitters
391. The RNA biding protein HUD: Rat cDNA and analysis of the alternative spliced mRNA in neuronal differentiating cell lines P19 and PC12
392. Retinoid effects in purified cultures of chick embryo retina neurons and photoreceptors
393. Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons
394. Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1
395. Altered segmental identity and abnormal migration in mice lacking Hoxb-1
396. Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning
397. Teratogenicity of low doses of all-trans retinoic acid in presomite mouse embryos
398. An early marker of axial pattern in the chick embryo and its respecification by retinoic acid
399. Complementary domains of retinoic acid production and degradation in the early chick embryo
400. Acetylcholine and acetyl-CoA metabolism in differentiating SN56 septal cell line
401. Role of the Xlim-1 and Xbra genes in antero-posterior patterning of neural tissue by the head and trunk organiser
402. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures
403. Regulation of glial cell line-derived neurotrophic factor responsiveness in developing rat sympathetic neurons by retinoic acid and bone morphogenetic protein-2
404. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma
405. Regulation of c-myb expression in human neuro-blastoma cells during retinic acid-induced differentiation
406. Vitamin A in development of the embryo
407. Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid
408. Effects of vitamin A on the behaviour of migratory neural crest cells in vitro
409. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells
410. An analysis of the early events when oligodendrocyte precursor cells are triggered to differentiate by thyroid hormone, retinoic acid or PDGF withdrawal
411. Expression of Ras-GRF in the SK-N-BE neuroblastoma accelerates retinoic-acid-induced neuronal differentiation and increases the functional expression of the IRK1 potassium channel
412. Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation
413. Patterns of CYP26 expression in human prenatal cepahlic and hepatic tissues indicate an important role during early brain development
414. Transfectable and transplantable postmitotic human neurons: A potential "platform" for gene therapy of nervous system diseases
415. Down-regulation of mu-opioid receptor expression in rat oligodendrocytes during their development in vitro
416. Glutamate receptor-mediated surrents and toxicity in embryonal carcinoma cells
417. Brn-3.2: A Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid
418. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: Important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid
419. Preferential expression of cellular retinoic acid binding protein in a subpopulation of neural cells in the developing mouse embryo
420. The cellular retinoic acid-binding protein is expressed in tissues associated with retinoic acid-induced malformations
421. Accumulation of microtubule-associated protein 1A (MAP1A) in differentiating P19 embryonal carcinoma cells
422. Retinoic acid regulates the developmental expression of dopamine D2 receptors in rat striatal primary cultures
423. Human aldehyde dehydrogenase: Mechanism of inhibition by disulphiram
424. Differentiation of aggregated murine P19 embryonal carcinoma cells is induced by a novel visceral endoderm-specific FGF-like factor and inhibited by activin A
425. Inhibition of retinoic acid receptor-mediated signalling alters positional identity in the developing hindbrain
426. Retinoic acid-mediated increase in TrkA expression is sufficient to elicit NGF-dependent survival of sympathetic neurons
427. Trka expression levels of sympathetic neurons correlate with NGF-dependent survival during development and after treatment with retinoic acid
428. The role of receptor protein tyrosine phosphatase a in neuronal differentiation of embryonic stem cells
429. Regulation of neuronal differentiation by retinoic acid alone and in cooperation with thyroid hormone or hydrocortisone
430. Retinoic acid in the formation of the dorsoventral retina and its central projections
431. Polarizing activity and retinoid synthesis in the floor plate of the neural tube
432. Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay
433. MAL mRNA is induced during the differentiation of human embryonal carcinoma cells into neurons and is also localised within specific regions of the human brain
434. Human Wnt-13 is developmentally regulated during the differentiation of NTER-2 pluripotent human embryonal carcinoma cells
435. Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells
436. Retinoic acid up-regulates ciliary neurotrophic factor receptors in cultured chick neurons and cardiomyocytes
437. Retinoic acid regulates the expression of the cacium binding protein, calbindin-D28K
438. Manifestations of prenatal nutritional deficiency
439. pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk)2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells
440. Isotretinoin embryopathy and the cranial neural crest: An in vivo and in vitro study
441. Identification of the retinoic acid-inducible all- trans-retinoic acid 4-hydroxylase
442. cDNA cloning of human retinoic acid-metabolizing enzyme (hp450RAI) identifies a novel family of cytochromes P450 (CYP26)
443. Defects in embryonic hindbrain development and fetal resorption resulting from vitamin A deficiency in the rat are prevented by feeding pharmacological levels of all-trans-retinoic acid
444. Vitamin A deficiency results in the dose-dependent acquisition of anterior character and shortening of the caudal hindbrain of the rat embryo
445. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation
446. Retinoic acid increases the expression of NGF gene in mouse L cells
447. Retinoic acid enhances neuronal proliferation and astroglial differentiation in cultures of CNS stem cell-derived precursors
448. Positional information and the spatial pattern of cellular differentiation
449. Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3′ HoxB gene expression domains
450. Induction of axon-like and dendrite-like processes in neuroblastoma cells
451. Differential susceptibilities of spinal cord neurons to retinoic acid-induced survival and differentiation
452. Retinoids increase perinatal spinal cord neuronal survival and astroglial differentiation
453. Retinoic acid upregulates nuclear retinoic acid receptor-a expression in human neuroblastoma cells
454. Embryonic expression of epithelial membrane protein 1 in early neurons
455. NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons
456. Regulation of neurotrophin receptor expression by retinoic acid in mouse sympathetic neuroblasts
457. Influence of the choroid plexus on cerebellar development: Analysis of retinoic acid synthesis
458. Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injections: Disruption of hindbrain and craniofacial morphogenesis in zebrafish embryos
459. Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species
460. Developmental anomalies induced by all-trans retinoic acid in fetal mice: I. Macroscopic findings
461. Aberrant differentiation of neuroepithelial cells in developing mouse brains subsequent to retinoic acid exposure in utero
462. 9-cis-retinoic acid induces neuronal differentiation of retinoi acid-nonresponsive embryonal carcinoma cells
463. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line
464. PKCe, via its regulatory domain and independently of its catalytic domain, induced neurite-like processes in neuroblastoma cells
465. Cloning of the mouse class IV alcohol dehydrogenase (retinol dehydrogenase) cDNA and tissue-specific expression patterns of the murine ADH gene family
466. Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain
467. Specific teratogenic effects of different retinoic acid isomers and analogs in the developing anterior central nervous system of zebrafish
468. Molecular identification of a major retinoic acid-synthesising enzyme, a retinaldehyde-specific dehydrogenase