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Volumn 92, Issue 4, 2000, Pages 659-670

Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after: Implantation of embryonal carcinoma- derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor

Author keywords

6 Hydroxydopamine; Cell implantation; Gene therapy; Neural progenitor cell; Parkinson's disease; Rat

Indexed keywords

COMPLEMENTARY DNA; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OXIDOPAMINE;

EID: 0034109787     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2000.92.4.0659     Document Type: Article
Times cited : (45)

References (48)
  • 1
    • 0024450903 scopus 로고
    • The functional anatomy of basal ganglia disorders
    • Albin RL, Young AB, Penney JB: The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366-375, 1989
    • (1989) Trends Neurosci , vol.12 , pp. 366-375
    • Albin, R.L.1    Young, A.B.2    Penney, J.B.3
  • 2
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • Beck KD, Valverde J, Alexi T, et al: Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373:339-341, 1995
    • (1995) Nature , vol.373 , pp. 339-341
    • Beck, K.D.1    Valverde, J.2    Alexi, T.3
  • 3
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease
    • Bilang-Bleuel A, Revah F, Colin P, et al: Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc Natl Acad Sci USA 94:8818-8823, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1    Revah, F.2    Colin, P.3
  • 4
    • 0016423020 scopus 로고
    • Dopamine in dendrites of substantia nigra neurons: Suggestions for a role in dendritic terminals
    • Björklund A, Lindvall O: Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals. Brain Res 83:531-537, 1975
    • (1975) Brain Res , vol.83 , pp. 531-537
    • Björklund, A.1    Lindvall, O.2
  • 5
    • 0030725572 scopus 로고    scopus 로고
    • Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • Björklund A, Rosenblad C, Winkler C, et al: Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol Dis 4:186-200, 1997
    • (1997) Neurobiol Dis , vol.4 , pp. 186-200
    • Björklund, A.1    Rosenblad, C.2    Winkler, C.3
  • 6
    • 0029053195 scopus 로고
    • Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons
    • Bowenkamp KE, Hoffmann AF, Gerhardt GA, et al: Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp Neurol 355: 479-489, 1995
    • (1995) J Comp Neurol , vol.355 , pp. 479-489
    • Bowenkamp, K.E.1    Hoffmann, A.F.2    Gerhardt, G.A.3
  • 7
    • 0031019795 scopus 로고    scopus 로고
    • Dopaminergic neurons protected from degeneration by GDNf gene therapy
    • Choi-Lundberg DL, Lin Q, Chang YN, et al: Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 275:838-841, 1997
    • (1997) Science , vol.275 , pp. 838-841
    • Choi-Lundberg, D.L.1    Lin, Q.2    Chang, Y.N.3
  • 8
    • 0025298139 scopus 로고
    • Primate models of movement disorders of basal ganglia origin
    • DeLong MR: Primate models of movement disorders of basal ganglia origin. Trends Neurosci 13:281-285, 1990
    • (1990) Trends Neurosci , vol.13 , pp. 281-285
    • DeLong, M.R.1
  • 9
    • 0031104731 scopus 로고    scopus 로고
    • Targets for gene therapy of Parkinson's disease: Growth factors, signal transduction, and promoters
    • During MJ, Leone P: Targets for gene therapy of Parkinson's disease: growth factors, signal transduction, and promoters. Exp Neurol 144:74-81, 1997
    • (1997) Exp Neurol , vol.144 , pp. 74-81
    • During, M.J.1    Leone, P.2
  • 10
    • 0028126942 scopus 로고
    • In vivo and ex vivo gene transfer to the brain
    • Fisher L, Ray J: In vivo and ex vivo gene transfer to the brain. Curr Opin Neurobiol 4:735-741, 1994
    • (1994) Curr Opin Neurobiol , vol.4 , pp. 735-741
    • Fisher, L.1    Ray, J.2
  • 11
    • 0037762415 scopus 로고
    • Genetically modified cells for intracerebral transplantation
    • Lindvall O (ed). Berlin: Springer-Verlag
    • Gage FH, Fisher L: Genetically modified cells for intracerebral transplantation, in Lindvall O (ed): Restoration of Brain Function by Tissue Transplantation. Berlin: Springer-Verlag, 1993, pp 51-60
    • (1993) Restoration of Brain Function by Tissue Transplantation , pp. 51-60
    • Gage, F.H.1    Fisher, L.2
  • 12
    • 0031662603 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative properties of GDNF
    • Gash DM, Zhang Z, Gerhardt G: Neuroprotective and neurorestorative properties of GDNF. Ann Neurol 44 (Suppl 3): 121-125, 1998
    • (1998) Ann Neurol , vol.44 , Issue.3 SUPPL. , pp. 121-125
    • Gash, D.M.1    Zhang, Z.2    Gerhardt, G.3
  • 13
    • 13344277993 scopus 로고    scopus 로고
    • Functional recovery in parkinsonian monkeys treated with GDNF
    • Gash DM, Zhang Z, Ovadia A, et al: Functional recovery in parkinsonian monkeys treated with GDNF. Nature 380:252-255, 1996
    • (1996) Nature , vol.380 , pp. 252-255
    • Gash, D.M.1    Zhang, Z.2    Ovadia, A.3
  • 14
    • 0017237701 scopus 로고
    • Release of dopamine from dendrites in rat substantia nigra
    • Geffen LB, Jessell TM, Cuello AC, et al: Release of dopamine from dendrites in rat substantia nigra. Nature 260:258-260, 1976
    • (1976) Nature , vol.260 , pp. 258-260
    • Geffen, L.B.1    Jessell, T.M.2    Cuello, A.C.3
  • 15
    • 0028109526 scopus 로고
    • Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo
    • Hoffer BJ, Hoffmann A, Bowenkamp K, et al: Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo. Neurosci Lett 182: 107-111, 1994
    • (1994) Neurosci Lett , vol.182 , pp. 107-111
    • Hoffer, B.J.1    Hoffmann, A.2    Bowenkamp, K.3
  • 16
    • 0028898505 scopus 로고
    • Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo
    • Hudson J, Granholm AC, Gerhardt GA, et al: Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo Brain Res Bull 36:425-432, 1995
    • (1995) Brain Res Bull , vol.36 , pp. 425-432
    • Hudson, J.1    Granholm, A.C.2    Gerhardt, G.A.3
  • 17
    • 0021022541 scopus 로고
    • Role of nigral dopamine in amphetamine-induced locomotor activity
    • Jackson EA, Kelly PH: Role of nigral dopamine in amphetamine-induced locomotor activity. Brain Res 278:366-369, 1983
    • (1983) Brain Res , vol.278 , pp. 366-369
    • Jackson, E.A.1    Kelly, P.H.2
  • 18
    • 0023174716 scopus 로고
    • Overview of morphological changes in Parkinson's disease
    • Jellinger K: Overview of morphological changes in Parkinson's disease. Adv Neurol 45:1-18, 1987
    • (1987) Adv Neurol , vol.45 , pp. 1-18
    • Jellinger, K.1
  • 19
    • 0030595815 scopus 로고    scopus 로고
    • 125I] glial cell line-derived neurotrophic factor to the rat CNS following osmotic blood-brain barrier modification
    • 125I] glial cell line-derived neurotrophic factor to the rat CNS following osmotic blood-brain barrier modification. Neurosci Lett 220: 187-190, 1996
    • (1996) Neurosci Lett , vol.220 , pp. 187-190
    • Jiao, S.1    Miller, P.J.2    Lapchak, P.A.3
  • 20
    • 0020326857 scopus 로고
    • Retinoic acid induces embryonal carcinoma cells 10 differentiate into neurons and glial cells
    • Jones-Villeneuve EMV, McBurney MW, Rogers KA, et al: Retinoic acid induces embryonal carcinoma cells 10 differentiate into neurons and glial cells. J Cell Biol 94:253-262, 1982
    • (1982) J Cell Biol , vol.94 , pp. 253-262
    • Jones-Villeneuve, E.M.V.1    McBurney, M.W.2    Rogers, K.A.3
  • 21
    • 0029061918 scopus 로고
    • Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain
    • Kleppner SR, Robinson KA, Trojanowski JQ, et al: Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain. J Comp Neurol 357:618-632, 1995
    • (1995) J Comp Neurol , vol.357 , pp. 618-632
    • Kleppner, S.R.1    Robinson, K.A.2    Trojanowski, J.Q.3
  • 22
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LFH, Doherty DH, Lile JD, et al: GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260:1130-1132, 1993
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.H.1    Doherty, D.H.2    Lile, J.D.3
  • 23
    • 0001109127 scopus 로고
    • Neural transplantation in Parkinson's disease
    • Dunnett SB, Björklund A (eds). New York: Raven Press
    • Lindvall O: Neural transplantation in Parkinson's disease, in Dunnett SB, Björklund A (eds): Functional Neural Transplantation. New York: Raven Press, 1994, pp 103-107
    • (1994) Functional Neural Transplantation , pp. 103-107
    • Lindvall, O.1
  • 24
    • 0343580476 scopus 로고    scopus 로고
    • Survival, integration, and differentiation of neural stem cell lines after transplantation to the adult rat striatum
    • Lundberg C, Martínez-Serrano A, Cattaneo E, et al: Survival, integration, and differentiation of neural stem cell lines after transplantation to the adult rat striatum. Exp Neurol 145: 342-360, 1997
    • (1997) Exp Neurol , vol.145 , pp. 342-360
    • Lundberg, C.1    Martínez-Serrano, A.2    Cattaneo, E.3
  • 25
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    • Mandel RJ, Spratt SK, Snyder RO, et al: Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc Natl Acad Sci USA 94: 14083-14088, 1997
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14083-14088
    • Mandel, R.J.1    Spratt, S.K.2    Snyder, R.O.3
  • 27
    • 0029905329 scopus 로고    scopus 로고
    • Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells
    • Martínez-Serrano A, Björklund A: Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. J Neurosci 16:4604-4616, 1996
    • (1996) J Neurosci , vol.16 , pp. 4604-4616
    • Martínez-Serrano, A.1    Björklund, A.2
  • 28
    • 0029123286 scopus 로고
    • CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: Complete rescue of axotomized cholinergic neurons after transplantation into the septum
    • Martínez-Serrano A, Lundberg C, Horellou P, et al: CNS-derived neural progenitor cells for gene transfer of nerve growth factor to the adult rat brain: complete rescue of axotomized cholinergic neurons after transplantation into the septum. J Neurosci 15:5668-5680, 1995
    • (1995) J Neurosci , vol.15 , pp. 5668-5680
    • Martínez-Serrano, A.1    Lundberg, C.2    Horellou, P.3
  • 29
    • 0020045043 scopus 로고
    • Isolation of male embryonal carcinoma cells and their chromosome replication pattern
    • McBurney MW, Rogers BJ: Isolation of male embryonal carcinoma cells and their chromosome replication pattern. Dev Biol 89:503-508, 1982
    • (1982) Dev Biol , vol.89 , pp. 503-508
    • McBurney, M.W.1    Rogers, B.J.2
  • 30
    • 0028203588 scopus 로고
    • Murine embryonal carcinoma-derived neurons survive and mature following transplantation into adult rat striatum
    • Morassutti DJ, Staines WA, Magnuson DSK, et al: Murine embryonal carcinoma-derived neurons survive and mature following transplantation into adult rat striatum. Neuroscience 58: 753-763, 1994
    • (1994) Neuroscience , vol.58 , pp. 753-763
    • Morassutti, D.J.1    Staines, W.A.2    Magnuson, D.S.K.3
  • 31
    • 0026697724 scopus 로고
    • NeuN: A neuronal specific nuclear protein in vertebrates
    • Mullen RJ, Buck CR, Smith AM: NeuN: a neuronal specific nuclear protein in vertebrates. Development 116:201-211, 1992
    • (1992) Development , vol.116 , pp. 201-211
    • Mullen, R.J.1    Buck, C.R.2    Smith, A.M.3
  • 32
    • 0028899401 scopus 로고
    • Overexpressed Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease
    • Nakao N, Frodl EM, Widner H, et al: Overexpressed Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nat Med 1:226-231, 1995
    • (1995) Nat Med , vol.1 , pp. 226-231
    • Nakao, N.1    Frodl, E.M.2    Widner, H.3
  • 33
    • 0031589730 scopus 로고    scopus 로고
    • Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro
    • Nakao N, Nakai K, Itakura T: Metabolic inhibition enhances selective toxicity of L-DOPA toward mesencephalic dopamine neurons in vitro. Brain Res 777:202-209, 1997
    • (1997) Brain Res , vol.777 , pp. 202-209
    • Nakao, N.1    Nakai, K.2    Itakura, T.3
  • 34
    • 0030041034 scopus 로고    scopus 로고
    • Fetal nigral transplantation as a therapy for Parkinson's disease
    • Olanow CW, Kordower JH, Freeman TB: Fetal nigral transplantation as a therapy for Parkinson's disease. Trends Neurosci 19:102-109, 1996
    • (1996) Trends Neurosci , vol.19 , pp. 102-109
    • Olanow, C.W.1    Kordower, J.H.2    Freeman, T.B.3
  • 35
    • 0030003264 scopus 로고    scopus 로고
    • Toward trophic treatment in parkinsonism: A primate step
    • Olson L: Toward trophic treatment in parkinsonism: a primate step. Nat Med 2:400-401, 1996
    • (1996) Nat Med , vol.2 , pp. 400-401
    • Olson, L.1
  • 37
    • 0032903988 scopus 로고    scopus 로고
    • Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats
    • Philips MF, Muir JK, Saatman KE, et al: Survival and integration of transplanted postmitotic human neurons following experimental brain injury in immunocompetent rats. J Neurosurg 90:116-124, 1999
    • (1999) J Neurosurg , vol.90 , pp. 116-124
    • Philips, M.F.1    Muir, J.K.2    Saatman, K.E.3
  • 38
    • 0025991037 scopus 로고
    • Characterization of dopamine release in the substantia nigra by in vivo microdialysis in freely moving rats
    • Robertson GS, Damsma G, Fibiger HC: Characterization of dopamine release in the substantia nigra by in vivo microdialysis in freely moving rats. J Neurosci 11:2209-2216, 1991
    • (1991) J Neurosci , vol.11 , pp. 2209-2216
    • Robertson, G.S.1    Damsma, G.2    Fibiger, H.C.3
  • 39
    • 0024458006 scopus 로고
    • Evidence that L-DOPA-induced rotational behavior is dependent on both striatal and nigral mechanisms
    • Robertson GS, Robertson HA: Evidence that L-DOPA-induced rotational behavior is dependent on both striatal and nigral mechanisms. J Neurosci 9:3326-3331, 1989
    • (1989) J Neurosci , vol.9 , pp. 3326-3331
    • Robertson, G.S.1    Robertson, H.A.2
  • 40
    • 0023896463 scopus 로고
    • Evidence that the substantia nigra is a site of action of L-DOPA
    • Robertson GS, Robertson HA: Evidence that the substantia nigra is a site of action of L-DOPA. Neurosci Lett 89: 204-208, 1988
    • (1988) Neurosci Lett , vol.89 , pp. 204-208
    • Robertson, G.S.1    Robertson, H.A.2
  • 41
    • 0030884756 scopus 로고    scopus 로고
    • Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease
    • Rosenblad C, Martínez-Serrano A, Björklund A: Intrastriatal glial cell line-derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic afferents and induces recovery of function in a rat model of Parkinson's disease. Neuroscience 82:129-137, 1998
    • (1998) Neuroscience , vol.82 , pp. 129-137
    • Rosenblad, C.1    Martínez-Serrano, A.2    Björklund, A.3
  • 43
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde and immunocytochemical study in the rat
    • Sauer H, Oertel WH: Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde and immunocytochemical study in the rat. Neuroscience 59:401-415, 1994
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 44
    • 0029047329 scopus 로고
    • Glial cell line-derived neurotrophic factor but not transforming growth factor β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion
    • Sauer H, Rosenblad C, Björklund A: Glial cell line-derived neurotrophic factor but not transforming growth factor β3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion. Proc Natl Acad Sci USA 92:8935-8939, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8935-8939
    • Sauer, H.1    Rosenblad, C.2    Björklund, A.3
  • 45
    • 0030779097 scopus 로고    scopus 로고
    • The use of nonneuronal cells for gene delivery
    • Snyder EY, Senut MC: The use of nonneuronal cells for gene delivery. Neurobiol Dis 4:69-102, 1997
    • (1997) Neurobiol Dis , vol.4 , pp. 69-102
    • Snyder, E.Y.1    Senut, M.C.2
  • 46
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A, Lindqvist E, Lin LFH, et al: Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373:335-339, 1995
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.H.3
  • 47
    • 0031031008 scopus 로고    scopus 로고
    • GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine
    • Tseng JL, Baetge EE, Zurn AD, et al: GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. J Neurosci 17:325-333, 1997
    • (1997) J Neurosci , vol.17 , pp. 325-333
    • Tseng, J.L.1    Baetge, E.E.2    Zurn, A.D.3
  • 48
    • 0029803454 scopus 로고    scopus 로고
    • Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
    • Winkler C, Sauer H, Lee CS, et al: Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. J Neurosci 16: 7206-7215, 1996
    • (1996) J Neurosci , vol.16 , pp. 7206-7215
    • Winkler, C.1    Sauer, H.2    Lee, C.S.3


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