The pharmacological profile of L-glutamate transport in human NT2 neurones is consistent with excitatory amino acid transporter 2

European Journal of Pharmacology

Volumn 360, Issue 2-3, 1998, Pages 249-256

  Dunlop, John ^a   Beal McIlvain, H ^a   Lou, Zhuangwei ^a   Franco, Rod ^a  

^a PFIZER INC   (United States)

Author keywords

Excitatory amino acid transporter; L glutamate; NT2 N cell

Indexed keywords

CARRIER PROTEIN; CHOLINE; DIHYDROKAINIC ACID; EXCITATORY AMINO ACID; GLUTAMIC ACID; KAINIC ACID; MESSENGER RNA; RETINOIC ACID; SODIUM ION;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CARCINOMA CELL; CELL DIFFERENTIATION; CELL TRANSPORT; CONTROLLED STUDY; LONG TERM EXPOSURE; MAMMAL CELL; MESSENGER RNA SYNTHESIS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; TERATOCARCINOMA;

ANIMALS; BIOLOGICAL TRANSPORT; DOGS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMIC ACID; HUMANS; KAINIC ACID; NEURONS; RECEPTORS, NEUROTRANSMITTER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEREOISOMERISM; TUMOR CELLS, CULTURED;

EID: 0032491474     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00675-X     Document Type: Article

References (46)

1. Andrews P.W. Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 103:1984;285-293.
2. Arriza J.L., Fairman W.A., Wadiche J.I., Murdoch G.H., Kavanaugh M.P., Amara S.G. Functional comparisons of three glutamate transporter subtypes cloned from human cortex. J. Neurosci. 14:1994;5559-5569.
3. Arriza J.L., Eliasof S., Kavanaugh M.P., Amara S.G. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA. 94:1997;4155-4160.
4. Chaudhry F.A., Lehre K.P., van Lookeren Campagne M., Ottersen O.P., Danbolt N.C., Storm-Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localisations revealed by quantitative ultrastructural immunocytochemistry. Neuron. 15:1995;711-720.
5. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
6. Choi D.W. Ionic dependence of glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7:1987;369-379.
7. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
8. +-dependent glutamate transport activity in synaptosomes, C6 glioma and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1). Mol. Pharmacol. 49:1996;465-473.
9. Dunlop J., Lou Z., Zhang Y., Kadakia N., Briggs-Schultz H., Zaleska M. Pharmacological characterisation of the human glutamate transporters EAAT1 and EAAT2 expressed in mammalian cell lines. J. Neurochem. (Abstr.). 70(Suppl. 1):1998;S69B.
10. Fairman W.A., Vandenberg R.J., Arriza J.L., Kavanaugh M.P., Amara S.G. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 375:1995;599-603.
11. +-dependent excitatory amino acid uptake mechanisms in rat brain. J. Neurosci. Res. 16:1986;491-503.
12. 3H ]glutamate transport in glial cultures J. Neurochem. 64:1995;2572-2580.
13. 2+ of N-methyl-D-aspartate and quisqualate neurotoxicity in young rat hippocampal slices. Neurosci. Lett. 97:1989;316-322.
14. Garthwaite G., Hajos F., Garthwaite J. Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices. Neuroscience. 18:1986;437-447.
15. Gegelashvili G., Civenni G., Racagni G., Danbolt N.C., Schousboe I., Schousboe A. Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. NeuroReport. 8:1996;261-265.
16. Gegelashvili G., Danbolt N., Schousboe A. Neuronal soluble factors differentially regulate the expression of the GLT-1 and GLAST glutamate transporters in cultured astroglia. J. Neurochem. 69:1997;2612-2615.
17. Gegelashvili G., Schousboe A. High affinity glutamate transporters: regulation of expression and activity. Mol. Pharmacol. 52:1997;6-15.
18. Hardy M., Younkin D., Tang C.-M., Pleasure J., Shi Q.Y., Williams M., Pleasure D. Expression of non-NMDA glutamate receptor channel genes by clonal human neurons. J. Neurochem. 63:1994;482-489.
19. Kanai Y., Hediger M.A. Primary structure and functional characterisation of a high-affinity glutamate transporter. Nature. 360:1992;467-471.
20. Kanai Y., Smith C.P., Hediger M.A. The elusive transporters with a high affinity for glutamate. Trends Neurosci. 16:1993;365-370.
21. Kanner B.I. Glutamate transporters from brain. A novel neurotransmitter transporter family. FEBS Lett. 325:1993;95-99.
22. Kanner B.I., Schuldiner S. Mechanism of transport and storage of neurotransmitters. CRC Crit. Rev. Biochem. 22:1987;1-38.
23. Kondoh T., Nishizaki T., Tamaki N., Matsuoka T., Akiyama H., Mori M., Okada Y. Expression of neurotransmitter receptor and grafting of human neurons derived from NT2 cells. Soc. Neurosci. Abstr. 23:1997;140.7.
24. Lee V.M.-Y., Andrews P.W. Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins. J. Neurosci. 6:1986;514-521.
25. Meldrum B., Garthwaite J. Excitatory amino acid neurotoxicity and neurodegenrative disease. Trends Pharmacol. Sci. 11:1990;379-387.
26. Mennerick S., Dhond R.P., Benz A., Xu W., Rothstein J.D., Danbolt N.C., Isenberg K.E., Zorumski C.F. Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures. J. Neurosci. 18:1998;4490-4499.
27. Munir M., Lu L., McGonigle P. Excitotoxic cell death and delayed rescue in human neurons derived from NT2 cells. J. Neurosci. 15:1995;7847-7860.
28. Munir M., Lu L., Wang Y.-H., Luo J., Wolfe B.B., McGonigle P. Pharmacological and immunological characetrisation of N-methyl-D-aspartate receptors in human NT2-N neurons. J. Pharmacol. Exp. Ther. 276:1996;819-828.
29. Nicholls D., Attwell D. The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11:1990;462-468.
30. Olney J.W., Price M.T., Samson L., Labruyere J. The role of specific ions in glutamate neurotoxicity. Neurosci. Lett. 65:1986;65-71.
31. Palos T.P., Ramachandran B., Boado R., Howard B.D. Rat C6 and human astrocytic tumor cells express a neuronal type of glutamate transporter. Mol. Brain Res. 37:1996;297-303.
32. Pines G., Danbolt N.C., Bjoras M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., Kanner B.I. Cloning and expression of a rat brain L-glutamate transporter. Nature. 360:1992;464-467.
33. Pleasure S.J., Page C., Lee V.M.-Y. Pure, post-mitotic, polarised human neurons derived from Ntera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J. Neurosci. 12:1992;1802-1815.
34. + currents and the capacity for regenerative responses. Exp. Cell Res. 180:1989;580-584.
35. 3H ]glutamate transport processes in rat brain Brain Res. 544:1991;196-202.
36. + J. Neurochem. 60:1993;167-179.
37. Rothstein J.D., Martin L., Levey A.I., Dykes-Hoberg M., Jin L., Wu D., Nash N., Kuncl R.W. Localisation of neuronal and glial glutamate transporters. Neuron. 13:1994;713-725.
38. Rothstein J.D., Dykes-Hoberg M., Pardo C.A., Bristol L.A., Jin L., Kuncl R.W., Kanai Y., Hediger M.A., Wang Y., Schielke J.P., Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
39. Schousboe A. Transport and metabolism of glutamate and GABA in neurones and glial cells. Int. Rev. Neurobiol. 22:1981;1-45.
40. +-dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. USA. 89:1992;10955-10959.
41. Swanson R.A., Liu J., Miller J.W., Rothstein J.D., Farrell K., Stein B.A., Longuemare M.C. Neuronal regulation of glutamate transporter subtype expression in astrocytes. J. Neurosci. 17:1997;932-940.
42. +-dependent glutamate transporter. Soc. Neurosci. Abstr. 23:1997;585.7.
43. Tanaka K., Watase K., Manabe T., Yamada K., Watanabe M., Takahashi K., Iwama H., Nishikawa T., Ichihara N., Kikuchi T., Okuyama S., Kawashima N., Hori S., Takimoto M., Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 276:1997;1699-1702.
44. Wang G.J., Chung H.J., Schnuer J., Pratt K., Zable A.C., Kavanaugh M.P., Rosenberg P.A. High affinity glutamate transport in rat cortical neurones in culture. Mol. Pharmacol. 53:1998;88-96.
45. Watkins J.C., Evans R.H. Excitatory amino acid transmitters. Ann. Rev. Pharmacol. Toxicol. 21:1981;165-204.
46. Younkin D.P., Tang C.M., Hardy M., Reddy U.R., Shi Q.Y., Pleasure S.J., Lee V.M., Pleasure D. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc. Natl. Acad. Sci. USA. 90:1993;2174-2178.