Differentiated human NT2-N neurons possess a high intracellular content of myo-inositol

Journal of Neurochemistry

Volumn 72, Issue 4, 1999, Pages 1431-1440

  Novak, James E ^a,b   Turner, R Scott ^b   Agranoff, Bernard W ^a,b   Fisher, Stephen K ^a,b,c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Inositol efflux; Inositol synthase; Inositol uptake; Neuronal differentiation; Osmotic stress; Phlorizin

Indexed keywords

INOSITOL; MYOINOSITOL 1 PHOSPHATE SYNTHASE; RETINOIC ACID;

ANIMAL CELL; ARTICLE; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NONHUMAN; OSMOREGULATION; OSMOTIC STRESS; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; ASTROCYTOMA; BIOLOGICAL TRANSPORT; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; INOSITOL; MYO-INOSITOL-1-PHOSPHATE SYNTHASE; NEUROBLASTOMA; NEURONS; PHLORHIZIN; STEM CELLS; TERATOCARCINOMA; TRETINOIN; WATER; WATER-ELECTROLYTE BALANCE;

ANIMALIA;

EID: 0033037909     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.721431.x     Document Type: Article

References (57)

1. Acevedo L. D., Holloway H. W., Rapoport S. I., and Shetty H. U. (1997) Application of stable isotope tracer combined with mass spectrometric detection for studying myo-inositol uptake by cultured neurons from fetal mouse: effect of trisomy 16. J. Mass Spectrom. 32, 395-400.
2. Andrews P. W. (1984) Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro. Dev. Biol. 103, 285-293.
3. Andrews P. W., Damjanov I., Simon D., Banting G. S., Carlin C., Dracopoli N. C., and Fogh J. (1984) Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Lab. Invest. 50, 147-162.
4. Batty I. H., Michie A., Fennel M., and Downes C. P. (1993) The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. Biochem. J. 294, 49-55.
5. Baxter M. A., Bunce C. M., Lord J. M., French P. J., Michell R. H., and Brown G. (1991) Changes in inositol transport during DMSO-induced differentiation of HL60 cells towards neutrophils. Biochim. Biophys. Acta 1091, 158-164.
6. Berridge M. J. and Irvine R. F. (1989) Inositol phosphates and cell signalling. Nature 341, 197-205.
7. Berridge M. J., Downes C. P., and Hanley M. R. (1989) Neural and developmental actions of lithium: a unifying hypothesis. Cell 59, 411-419.
8. +/ myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21. Genomics 25, 507-513.
9. Brand A., Richter-Landsberg C., and Leibfritz D. (1993) Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev. Neurosci. 15, 289-298.
10. Carpenter C. L. (1996) Intracellular signals and the cytoskeleton: the interactions of phosphoinositide kinases and small G proteins in adherence, ruffling and motility. Cell Dev. Biol. 7, 691-697.
11. Cockroft D. L. (1988) Changes with gestational age in the nutritional requirements of postimplantation rat embryos in culture. Teratology 38, 281-290.
12. +) cells. J. Bacteriol. 126, 232-242.
13. del Río E., Shinomura T., van der Kaay J., Nicholls D. G., and Downes C. P. (1998) Disruption by lithium of phosphoinositide signalling in cerebellar granule cells in primary culture. J. Neurochem. 70, 1662-1669.
14. Einat H., Kofman O., Itkin O., Lewitan R. J., and Belmaker R. H. (1998) Augmentation of lithium's behavioral effect by inositol uptake inhibitors. J. Neural Transm. 105, 31-38.
15. Eisenberg F. Jr. (1967) D-Myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis. J. Biol. Chem. 242, 1375-1382.
16. Fisher S. K., Figueiredo J. C., and Bartus R. T. (1984) Differential stimulation of inositol phospholipid turnover in brain by analogs of oxotremorine. J. Neurochem. 43, 1171-1179.
17. 3H]inositol uptake by dissociated brain cells and cultured fibroblasts from fetal mice. Neurochem. Res. 16, 913-918.
18. Glanville N. T., Byers D. M., Cook H. W., Spence M. W., and Palmer F. B. St. C. (1989) Differences in the metabolism of inositol and phosphoinositides by cultured cells of neuronal and glial origin. Biochim. Biophys. Acta 1004, 169-179.
19. Godfrey D. A., Hallcher L. M., Laird M. H., Matschinsky F. M., and Sherman W. R. (1982) Distribution of myo-inositol in the cat cochlear nucleus. J. Neurochem. 38, 939-947.
20. Godfrey P. P. (1989) Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol. Biochem. J. 258, 621-624.
21. + channel blockers of the volume-activated, diffusional mechanism of inositol transport in primary astrocytes in culture. Neurochem. Res. 20, 895-900.
22. Greene N. D. and Copp A. J. (1997) Inositol prevents folate-resistant neural tube defects in the mouse. Nat. Med. 3, 60-66.
23. Gullans S. R. and Vcrbalis J. G. (1993) Control of brain volume during hyperosmolar and hypoosmolar conditions. Annu. Rev. Med. 44, 289-301.
24. Honegger P. and Richelson E. (1976) Biochemical differentiation of mechanically dissociated mammalian brain in aggregating cell culture. Brain Res. 109, 335-354.
25. Hwang P. M., Bredt D. S., and Snyder S. H. (1990) Autoradiographic imaging of phosphoinositide turnover in the brain. Science 249, 802-804.
26. Iacovitti L. and Stull N. D. (1997) Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT). Neuroreport 8, 1471-1474.
27. +/MYO-inositol cotransporter mRNA in the rat brain. Neuroreport 7, 1195-1198.
28. Isaacks R. E., Bender A. S., Kim C. Y., Prieto N. M., and Norenberg M. D. (1994) Osmotic regulation of myo-inositol uptake in primary astrocyte cultures. Neurochem. Res. 19, 331-338.
29. Jackson P. S. and Strange K. (1993) Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. Am. J. Physiol. 265, C1489-C1500.
30. Karihaloo A. K., Joshi K., and Chopra J. S. (1997) Effect of sorbinil and ascorbic acid on myo-inositol transport in cultured rat Schwann cells exposed to elevated extracellular glucose. J. Neurochem. 69, 2011-2018.
31. Kletzien R. F., Pariza M. W., Becker J. E., and Potter V. R. (1975) A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture. Anal. Biochem. 68, 537-544.
32. Lee J. H., Arcinue E., and Ross B. D. (1994) Brief report: organic osmolytes in the brain of an infant with hypernatremia. N. Engl. J. Med. 331, 439-442.
33. Lee V. M.-Y. and Andrews P. W. (1986) Differentiation of NTERA-2 clonal human embryonal carcinoma cells into neurons involves the induction of all three neurofilament proteins. J. Neurosci. 6, 514-521.
34. Mauck L. A., Wong Y.-H., and Sherman W. R. (1980) L-myo-Inositol-1-phosphate synthase from bovine testis: purification to homogeneity and partial characterization. Biochemistry 19, 3623-3629.
35. Nakanishi T., Turner R. J., and Burg M. B. (1989) Osmoregulatory changes in myo-inositol transport by renal cells. Proc. Natl. Acad. Sci. USA 86, 6002-6006.
36. Novak J. E., Turner R. S., Agranoff B. W., and Fisher S. K. (1998) myo-Inositol homeostasis in differentiated NT2-N neurons. Soc. Neurosci. Abstr. 24, 113.
37. Palmano K. P., Whiting P. H., and Hawthorne J. N. (1977) Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes. Biochem. J. 167, 229-235.
38. Patishi Y., Lubrich B., Berger M., Kofman O., van Calker D., and Belmaker R. H. (1996) Differential uptake of myo-inositol in vivo into rat brain areas. Eur. Neuropsychopharmacol. 6, 73-75.
39. Pleasure S. J., Page C., and Lee V. M.-Y. (1992) Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. J. Neurosci. 12, 1802-1815.
40. Pouwels P. J. W. and Frahm J. (1998) Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn. Reson. Med. 39, 53-60.
41. Reeves R. E. and Cammarata P. R. (1996) Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 5: Mechanism of the myo-inositol efflux pathway. Invest. Ophthalmol. Vis. Sci. 37, 619-629.
42. Sherman W. R., Packman P. M., Laird M. H., and Boshans R. L. (1977) Measurement of myo-inositol in single cells and defined areas of the nervous system by selected ion monitoring. Anal. Biochem. 78, 119-131.
43. Sima A. A. F., Dunlap J. A., Davidson E. P., Wiese T. J., Lightle R. L. F., Greene D. A., and Yorek M. A. (1997) Supplemental myo-inositol prevents L-fucose-induced diabetic neuropathy. Diabetes 46, 301-306.
44. 2+ in response to muscarinic and glutamate receptor agonists during the differentiation of NTERA2 human embryonal carcinoma cells into neurons. Eur. J. Neurosci. 8, 783-793.
45. Stewart M. A., Rhee V., Kurien M. M., and Sherman W. R. (1969) Gas chromatographic analysis of myo-inositol in microgram samples of brain. Biochim. Biophys. Acta 192, 361-363.
46. Stokes C. E., Gillon K. R. W., and Hawthorne J. N. (1983) Free and total lipid myo-inositol concentrations decrease with age in human brain. Biochim. Biophys. Acta 753, 136-138.
47. Strange K., Morrison R., Heilig C. W., DiPietro S., and Gullans S. R. (1991) Upregulation of inositol transport mediates inositol accumulation in hyperosmolar brain cells. Am. J Physiol 260, C784-C790.
48. +/myo-inositol cotransport in rat cortical astrocytes. Glia 12, 35-43.
49. Stubbs E. B. Jr. and Agranoff B. W. (1993) Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells. J. Neurochem. 60, 1292-1299.
50. Toker A. and Cantley L. C. (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387, 673-676.
51. Wiesinger H. (1991) myo-Inositol transport in mouse astroglia-rich primary cultures. J. Neurochem. 56, 1698-1704.
52. Wolf B. A., Wertkin A. M., Jolly Y. C., Yasuda R. P., Wolfe B. B., Konrad R. J., Manning D., Ravi S., Williamson J. R., and Lee V. M.-Y. (1995) Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid β-protein production in human neuronal NT2N cells. J. Biol. Chem. 270, 4916-4922.
53. Wong Y.-H. H., Kalmbach S. J., Hartman B. K., and Sherman W. R. (1987) Immunohistochemical staining and enzyme activity measurements show myo-inositol-1-phosphate synthase to be localized in the vasculature of brain. J. Neurochem. 48, 1434-1442.
54. Yorek M. A., Dunlap J. A., and Ginsberg B. H. (1986) Myoinositol uptake by four cultured mammalian cell lines. Arch. Biochem. Biophys. 246, 801-807.
55. Yorek M. A., Dunlap J. A., Stefani M. R., Davidson E. P., Zhu X., and Eichberg J. (1994) Decreased myo-inositol uptake is associated with reduced bradykinin-stimulated phosphatidylinositol synthesis and diacylglycerol content in cultured neuroblastoma cells exposed to L-fucose. J. Neurochem. 62, 147-158.
56. Younkin D. P., Tang C.-M., Hardy M., Reddy U. R., Shi Q.-Y., Pleasure S. J., Lee V. M.-Y., and Pleasure D. (1993) Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proc. Natl. Acad. Sci. USA 90, 2174-2178.
57. Zeller M. and Strauss W. L. (1995) Retinoic acid induces cholinergic differentiation of NTera 2 human embryonal carcinoma cells. Int. J. Dev. Neurosci. 13, 437-445.