Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element

Development

Volumn 125, Issue 11, 1998, Pages 1991-1998

  Packer, Alan I ^a   Crotty, David A ^a,b   Elwell, Vivian A ^a   Wolgemuth, Debra J ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Autoregulation; Hoxa4; Retinoic acid; Retinoic acid response element; Transgenic mice

Indexed keywords

RETINOIC ACID; RETINOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; DEVELOPMENT; DNA FLANKING REGION; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENE SEQUENCE; GROWTH REGULATION; MOUSE; MUTATION; NEURAL TUBE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; REPORTER GENE; RHOMBENCEPHALON; TRANSGENIC MOUSE;

NON-PROGRAMMATIC;

ANIMALS; CENTRAL NERVOUS SYSTEM; CONSENSUS SEQUENCE; CROSSES, GENETIC; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC INDUCTION; FEEDBACK; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PREGNANCY; REGULATORY SEQUENCES, NUCLEIC ACID; RHOMBENCEPHALON; TIME FACTORS; TRETINOIN;

EID: 0031835078     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Awgulewitsch, A. and Jacobs, D. (1992). Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice. Nature 358, 341-344.
2. Behringer, R. R., Crotty, D. A., Tennyson, V. M., Brinster, R. L., Palmiter, R. D. and Wolgemuth, D. J. (1993). Sequences 5′ of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development. Development 117, 823-833.
3. Bergson, C. and McGinnis, W. (1990). The autoregulatory enhancer element of the Drosophila homeotic gene deformed.EMBO J. 9, 4287-4297.
4. Conlon, R. A. and Rossant, J. (1992). Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo. Development 116, 357-368.
5. Davis, A. P., Witte, D. P., Hsieh-Li, H. M., Potter, S. S. and Capecchi, M. R. (1995). Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-II Nature 375, 791-795.
6. Doerksen, L. F., Bhattacharya, A., Kannan, P., Pratt, D. and Tainsky, M. A. ( 1996). Functional interaction between a RARE and an AP-2 binding site in the regulation of the human HOXA-4 gene promoter. Nucleic Acids Res. 24, 2849-2856.
7. Duboule, D. and Morata, G. (1994). Colinearity and functional hierarchy among genes of the homeotic complexes. Trends Genet. 10, 358-364.
8. Dupé, V., Davenne, M., Brocard, J., Dolle, P., Mark, M., Dierich, A., Chambon, P. and Rijli, F. M. (1997). In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE). Development 124, 399-410.
9. Frasch, M., Chen, X. and Lufkin, T. (1995). Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila.Development 121, 957-974.
10. Galliot, B., Dolle, P., Vigneron, M., Featherstone, M., Baron, A. and Duboule, D. (1989). The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development. Development 107, 343-359.
11. Gerard, M., Duboule, D. and Zakany, J. (1993). Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. EMBO J. 12, 3539-3550.
12. Gould, A., Morrison, A., Sproat, G., White, R. A. H. and Krumlauf, R. (1997). Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. Genes Dev. 11, 900-913.
13. Horan, G. S. B., Wu, K., Wolgemuth, D. J. and Behringer, R. R. (1994). Homeotic transformation of cervical vertebrae in Hoxa-4 mutant mice. Proc. Natl. Acad. Sci. USA 91, 12644-12648.
14. Horan, G. S. B., Kovacs, E., Behringer, R. R. and Featherstone, M. (1995a). Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: Evidence for unique and redundant function. Dev. Biol. 169, 359-372.
15. Horan, G. S. B., Ramirez-Solis, R., Featherstone, M., Wolgemuth, D. J., Bradley, A. and Behringer, R. R. (1995b). Compound mutants for the paralogous Hoxa-4.Hoxb-4, and Hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev. 9, 1667-1677.
16. Hsieh-Li, H. M., Witte, D. P., Weinstein, M., Branford, W., Li, H., Small, K. and Potter, S. S. (1995). Hoxa-11 structure, extensive antisense transcription, and function in male and female fertility. Development 121, 1373-1385.
17. Keegan, L. P., Haerry, T. E., Crotty, D. A., Packer, A. I., Wolgemuth, D. J. and Gehring, W. J. (1997). A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginai discs. Mech. Dev. 63, 145-157.
18. Kessel, M. and Gruss, P. (1991). Homeotic transformations of murine prevertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67, 89-104.
19. Krumlauf, R. (1993). Hox genes and pattern formation in the branchial region of the vertebrate head. Trends Genet. 9, 106-112.
20. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
21. Langston, A. W. and Gudas, L. J. (1992). Identification of a retinoic acid-responsive enhancer 3′ of the murine homeobox gene Hox-1.6. Mech. Dev. 38, 217-228.
22. Langston, A. W., Thompson, J. R. and Gudas, L. J. (1997). Retinoic acid-responsive enhancers located 3′ of the HoxA and HoxB homeobox gene clusters. J. Biol. Chem. 272, 2167-2175.
23. Lohnes, D., Mark, M., Mendelsohn, C., Dolle, P., Dierich, A., Gorry, Ph., Gansmuller, A. and Chambon, P. (1994). Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants. Development 120, 2723-2748.
24. Lou, L., Bergson, C. and McGinnis, W. (1995). Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer. Nucleic Acids Res. 23, 3481-3487.
25. Maconochie, M., Nonchev, S., Morrison, A. and Krumlauf, R. (1996). Paralogous Hox genes: Function and regulation. Annu. Rev. Genet. 30, 529-556.
26. Malicki, J., Cianetti, L. C., Peschle, C. and McGinnis, W. (1992). A human HOX 4B regulatory element provides head-specific expression in Drosophila embryos. Nature 358, 345-347.
27. Manak, J. R. and Scott, M. P. (1994). A class act: Conservation of homeodomain protein function. Development supplement 61-71.
28. Manley, N. R. and Capecchi, M. R. (1995). The role of Hoxa-3 in mouse thymus and thyroid development. Development 121, 1989-2003.
29. Marshall, H., Studer, M., Popperl, H., Aparicio, S., Kuroiwa, A., Brenner, S. and Krumlauf, R. (1994). A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1.Nature 370, 567-571.
30. McGinnis, W. and Krumlauf, R. (1992). Homeobox genes and axial patterning. Cell 68, 283-302.
31. Means, A. L. and Gudas, L. J. (1995). The roles of retinoids in vertebrate development. Annu. Rev. Biochem. 64, 201-233.
32. Mendelsohn, C., Larkin, S., Mark, M., LeMeur, M., Clifford, J., Zelent, A. and Chambon, P. (1994a). RAR β isoforms: distinct transcriptional control by retinoic acid and specific spatial patterns of promoter activity during mouse development. Mech. Dev. 45, 227-241.
33. Mendelsohn, C., Lohnes, D., Decimo, D., Lufkin, T., LeMeur, M., Chambon, P. and Mark, M. (1994b). Function of the retinoic acid receptors (RARs) during development. (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120, 2749-2771.
34. Morrison, A., Moroni, M. C., Ariza-McNaughton, L., Krumlauf, R. and Mavilio, F. (1996). In vitro and transgenic analysis of a human HOXD4 retinoid-responsive enhancer. Development 122, 1895-1907.
35. Morrison, A., Ariza-McNaughton, L., Gould, A., Featherstone, M. and Krumlauf, R. (1997). HOXD4 and regulation of the group 4 paralog genes. Development 124, 3135-3146.
36. Ogura, T. and Evans, R. M. (1995). A retinoic acid-triggered cascade of HOXB1 gene activation. Proc. Natl. Acad. Sci. USA 92, 387-391.
37. Popperl, H. and Featherstone, M. (1992). An autoregulatory element of the murine Hox-4.2 gene. EMBO J. 11, 3673-3680.
38. Popperl, H. and Featherstone, M. (1993). Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene. Mol. Cell. Biol. 13, 257-265.
39. Popperl, H., Bienz, M., Studer, M., Chan, S. K., Aparicio, S., Brenner, S., Mann, R. S. and Krumlauf, R. (1995). Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/Pbx.Cell 81, 1031-1042.
40. Puschel, A., Balling, R. and Gruss, P. (1991). Position-specific activity of the Hoxl.1 promoter in transgenic mice. Development 112, 279-288.
41. Satre, M. A. and Kochhar, D. M. ( 1989). Elevations in the endogenous levels of the putative morphogen retinoic acid in embryonic mouse limb buds associated with limb dysmorphogenesis. Dev. Biol. 133, 529-536.
42. Schuger, L., Varani, J., Mitra, Jr., R. and Gilbride, K. (1993). Retinoic acid stimulates mouse lung development by a mechanism involving epithelialmesenchymal interaction and regulation of epidermal growth factor receptors. Dev. Biol. 159, 462-473.
43. Shashikant, C. S. and Ruddle, F. H. ( 1996). Combinations of closely situated cis-acting elements determine tissue-specific patterns and anterior extent of early Hoxc8 expression. Proc. Nat. Acad. Sci. USA 93, 12364-12369.
44. Studer, M., Popperl, H., Marshall, A., Kuroiwa, A. and Krumlauf, R. (1994). Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.Science 265, 1728-1732.
45. Subramanian, V., Meyer, B. I. and Gruss, P. (1995). Disruption of the murine homeobox gene cdx-1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell 83, 641-653.
46. Theiler, K. (1972). The House Mouse: Development and Normal Stages from Fertilization to 4 Weeks of Age.New York: Springer-Verlag.
47. Vilar, J., Gilbert, T., Moreau, E. and Merlet-Benichou, C. (1996). Metanephros organogenesis is highly stimulated by vitamin A derivatives in organ culture. Kidney Int. 49, 1478-1487.
48. Weiner, M. P. and Costa, G. L. (1996). Rapid PCR site-directed mutagenesis. In PCR Primer: A Laboratory Manual (ed. C. W. Dieffenbach and G. S. Dveksler), pp. 613-622. New York: Cold Spring Harbor.
49. Whiting, J., Marshall, H., Cook, M., Krumlauf, R., Rigby, P. W. J., Stott, D. and Allemann, R. K. (1991). Multiple spatially-specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 5, 2048-2059.
50. Wu, K. and Wolgemuth, D. J. (1993). Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron. J. Cell. Biochem. 52, 449-462.
51. Zhang, J., Hagopian-Donaldson, S., Serbedzija, G., Elsemore, J., Plehndujowich, D., McMahon, A. P., Flavell, R. A. and Williams, T. (1996). Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature 381, 238-241.
52. Zhang, F., Popperl, H., Morrison, A., Kovacs, E. N., Prideaux, V., Schwarz, L., Krumlauf, R., Rossant, J. and Featherstone, M. S. (1997). Elements both 5′ and 3′ to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm. Mech. Dev. 67, 49-58.