Retinoid-X receptor signalling in the developing spinal cord

Nature

Volumn 395, Issue 6700, 1998, Pages 398-402

  Solomin, Ludmila ^a   Johansson, Clas B ^b   Zetterström, Rolf H ^b   Bissonnette, Reid P ^c   Heyman, Richard A ^c   Olson, Lars ^b   Lendahl, Urban ^b   Frisén, Jonas ^b   Perlmann, Thomas ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL) 1,3 DIOXOLAN 2 YL]BENZOIC ACID; ALITRETINOIN; BETA GALACTOSIDASE; DNA; LG 100849; LIGAND; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; EMBRYO; LIGAND BINDING; MOTONEURON; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; BETA-GALACTOSIDASE; CULTURE TECHNIQUES; EXTREMITIES; GENES, REPORTER; HUMANS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; SIGNAL TRANSDUCTION; SPINAL CORD; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0032563863     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/26515     Document Type: Article

References (31)

1. Manglesdorf, D. J. & Evans, R. M. The RXR heterodimers and orphan receptors. Cell 83, 841-850 (1995).
2. Kastner, P., Mark, M. & Chambron, P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83, 859-869 (1995).
3. Marshall, H. et al. A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1. Nature 370, 567-571 (1994).
4. Kastner, P. et al. Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development. Development 124, 313-326 (1997).
5. Dupé, V. et al. In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE). Development 124, 399-410 (1997).
6. Wagner, M., Thaller, C., Jessell, T. M. & Eichele, G. Polarizing activity and retinoid synthesis in the floorplate of the neural tube. Nature 345, 819-822 (1990).
7. Horton, C. & Maden, M. Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. Dev. Dynam. 202, 312-323 (1995).
8. Durand, B. et al. Activation function 2 (AF2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activation domain and influence of the nature of the response element on AF-2 activity. EMBO J. 13, 5370-5382 (1994).
9. Yang, Y., Minucci, S., Ozato, K., Heyman, R. A. & Ashwell, J. D. Efficient inhibition of activation-induced Fas ligand up-regulation and T cell apoptosis by retinoids requires occupancy of both retinoid X receptors and retinoic acid receptors. J. Biol. Chem. 270, 18672-18677 (1995).
10. Roy, B., Taneja, R. & Chambon, P. Synergistic activation of retinoic acid (RA)-responsive genes and induction of embryonal carcinoma cell differentiation by an RA receptor α (RARα)-, RARβ-, or RARγ-selective ligand in combination with a retinoid X receptor-specific ligand. Mol. Cell. Biol. 15, 6481-6487 (1995).
11. Bissonnette, R. P. et al. 9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation. Mol. Cell. Biol 15, 5576-5585 (1995).
12. Botling, J., Castro, D. S., Ösberg, F., Nilsson, K. & Perlmann, T. RAR/RXR heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. J. Biol. Chem. 272, 9443-9449 (1997).
13. Minucci, S. et al. Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol. Cell. Biol. 17, 644-655 (1997).
14. Lu, H.-C., Eichele, G. & Thaller, C. Ligand-bound RXR can mediate retinoid signal transduction during embryogenesis. Development 124, 195-203 (1997).
15. Allenby, G. et al. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc. Natl Acad. Sci. USA 90, 30-34 (1993).
16. Zimmerman, L. et al. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron 12, 11-24 (1994).
17. Rossant, J., Zirngibl, R., Cado, D., Shago, M. & Giguère, V. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev. 5, 1333-1344 (1991).
18. Reynolds, K., Mezey, E. & Zimmer, A. Activity of the β-retinoic acid receptor promoter in transgenic mice. Mech. Dev. 36, 15-29 (1991).
19. Mendelsohn, C., Ruberte, E., LeMeur, M., Morriss-Kay, G. & Chambon, P. Developmental analysis of the retinoic acid-inducible RAR-β2 promoter in transgenic animals. Development 113, 723-734 (1991).
20. Wagner, M. & Jessell, T. M. Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development 116, 55-66 (1992).
21. Colbert, M. C., Linney, E. & LaMantia, A.-S. Local sources of retinoic acid coincide with retinoid-mediated transgene activity during embryonic development. Proc. Natl Acad. Sci. USA 90, 6572-6576 (1993).
22. Sockanathan, S. & Jessell, T. M. Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell 94, 503-514 (1998).
23. McCaffery, P. & Dräger, U. C. Hot spots of retinoic acid synthesis in the developing spinal cord. Proc. Natl Acad. Sci. USA 91, 7194-7197 (1994).
24. Wang, X., Penzes, P. & Napoli, J. L. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. J. Biol. Chem. 271, 16288-16293 (1996).
25. Zhao, D. et al. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. Eur. J. Biochem. 240, 15-22 (1996).
26. Niederreither, K., McCaffery, P., Dräger, U. C., Chambon, P. & Dollé, P. Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech. Dev. 62, 67-78 (1997).
27. Perlmann, T. & Jansson, L. A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and Nurr1. Genes Dev. 9, 769-782 (1995).
28. Nilsson, E. & Lendahl, U. Transient expression of a human β-actin promoter/lacZ gene introduced into mouse embryos correlates with a low degree of methylation. Mol. Repr. Dev. 34, 149-157 (1993).
29. Lumsden, A. G. S. & Davies, A. M. Earliest sensory nerve fibres are guided to peripheral targets by attractants other than nerve growth factor. Nature 306, 786-788 (1983).
30. Zetterström, R., Solomin, L., Mitsiadis, T., Olson, L. & Perlmann, T. RXR heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1 and Nor1. Mol. Endocrinol. 10, 1656-1666 (1996).
31. Mascrez, B. et al. The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse development. Development (in the press).