A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

Development

Volumn 122, Issue 1, 1996, Pages 243-252

  Ang, Siew Lan ^a   Jin, Ou ^b,c   Rhinn, Muriel ^a   Daigle, Nathalie ^a   Stevenson, Lois ^c   Rossant, Janet ^b,c  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Gastrulation; Gene targeting; Neural tube; Node; Notochord; Otx2; Patterning; Prechordal mesoderm

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GASTRULATION; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; GENETIC CONSERVATION; HOMEOBOX; MALE; MESODERM; MOUSE; NERVOUS TISSUE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; BRAIN; DNA PRIMERS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GASTRULA; GENE DELETION; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MALE; MESODERM; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NERVE TISSUE PROTEINS; OTX TRANSCRIPTION FACTORS; PHENOTYPE; PREGNANCY; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0030050751     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ang, S.-L. and Rossant, J. (1993). Anterior mesendoderm induces mouse Engrailed genes in explant cultures. Development 118, 139-149
2. Ang, S.-L. and Rossant, J. (1994). HNF-3ß is essential for node and notochord formation in mouse development. Cell 78, 561-574.
3. Ang, S.-L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J. and Zaret, K. S. (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF-3/forkhead proteins. Development 119, 1301-1315.
4. Ang, S.-L., Conlon, R. A., Jin, O. and Rossant, J. (1994). Positive and negative signals from mesoderm regulate the expression of mouse Orx2 in ectoderm explants. Development 120, 979-989.
5. Bailly-Cuif, L., Gulisano, M., Broccoli, V. and Boncinelli, E. (1995). c-otx2 is expressed in two different phases of gastrulation and is sensitive to retinoic acid treatment in chick embryo. Mech. Dev. 49, 49-63.
6. Barnes, Joseph D., Crosby, J. L., Jones, C. M., Wright, C. V. E. and Hogan, B. L. M. (1994). Embryonic expression of Lim-J, the mouse homolog of Xenopus XLim-I, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol. 161, 168-178
7. Beddington, R. S. P. (1994). Induction of a second neural axis by the mouse node. Development 120, 613-620.
8. Blitz, I. C. and Cho K. W. Y. (1995). Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle. Development 121, 993-1004.
9. Blum, M., Gaunt, S. J., Cho, K. W. Y., Steinbeisser, H., Blumberg, B., Bittner, D. and De Robertis, E. M. (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106.
10. Candia, A. H., Hu, J., Crosby, J., Lalley, P. A., Noden, D., Nadeau, J. H. and Wright, C. V. E. (1992) Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development 116, 1123-1136
11. Conlon, R. A. and Herrmann, B. G. (1993). Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts. In Methods in Enzyniology. Guides to Techniques in Mouse Development vol. 225. (ed. P. M. Wassarman and M L. DePamphilis), pp. 373-383. New York: Academic Press.
12. Dalton, D., Chadwick, R. and McGinnis, W. (1989). Expression and embryonic function of empty spiracles, a Drosophila homeobox gene with two patterning functions on the anterior-posterior axis of the embryo. Genes Der. 3, 1940-1956.
13. Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L. (1991). Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. Development 111, 287-298.
14. Dietrich, S., Schubert, F. R. and Gruss, P. (1993). Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite Mech. Der. 44, 189-207.
15. Doniach, T. (1993). Planar and vertical induction of anteropostenor pattern during the development of the amphibian central nervous system. J. Neurobiol. 24, 1256-1275
16. Finkelstein, R., Smouse, D., Theresa, M. C., Spradling, A. C. and Perrimon, N. (1990). The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev. 4, 1516-1527.
17. Finkelstein, R. and Boncinelli, E. (1994). From fly to mammalian forebrain: the story of otd and Otx. Trends Neurosci 9, 310-315.
18. Guillemot, F. and Joyner, A. L. (1993). Dynamic expression of the murine achaete-scute homolog (MASH-1) in the developing nervous system. Mech. Der 42, 171-185.
19. Herrmann, B. G. (1991). Expression pattern of the Brachyury gene in wholemount mutant embryos. Development 113, 913-917.
20. Krumlauf, R. (1994). Hox genes in vertebrate development. Cell 78, 191-201.
21. Lawrence, P. A. and Morata, G. (1994). Homeobox genes: Their function in Drosophila segmentation and pattern formation. Cell 78, 181-189.
22. Lawson, K. A., Meneses, J. J., and Pedersen, R. A. (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.
23. Lin, T.-P., Labosky, P.A., Grabel, L. B., Kozak, C. A., Pitman, J. L., Kleeman, J. and MacLeod, (1994). The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during murine development Dev. Biol. 166, 170-179
24. Monaghan, A. P., Kaestner, K. H., Grau, E. and Schutz, G. (1993). Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neurectoderm. Development 119, 567-578
25. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. and Roeder, J. C. (1993) Viable cell culture-derived mice from early passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428.
26. Pannese, M., Polo, C., Andreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G. and Boncinelli, E. (1995). The Xenopus homologue of Otx2 is a maternal homeobox gene that demarcates and specifies anterior body regions. Development 121, 707-720.
27. Rong, P. M., Teillet, M.-A., Ziller, C.and Le Douarin, N. M. (1992). The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation Development 115, 657-672.
28. Ruiz i Altaba, A. (1994). Pattern formation in the vertebrate neural plate. TINS 17, 233-243.
29. Sasaki, H. and Hogan, B. I. M. (1993). Differential expression of multiple fork head related genes during gastrulation and axial pattern in the mouse embryo. Development 118, 47-59.
30. Serafini, T., Kennedy, T., Galko, N., Mirzayan, C., Jesseli, T. and Tessier-Lavigne, M. (1994) The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424.
31. Shawlot, W. and Behringer, R. M. (1995). Requirement for Lim/ in head-organizer function. Nature 374, 425-430.
32. Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli, E. (1992a). Nested expression domains of four homeobox genes in developing brain. Nature 358, 687-690.
33. Simeone, A., Gulisano, M., Acampora, D., Stornaiuolo, A., Rambaldi, M. and Boncinelli, E. (1992b). Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 11, 2541-2550.
34. Simeone, A., Acampora D., Mallamaci, A., Stornaiuolo, A., D'Apice, M. R., Nigro, V. and Boncinelli, E. (1993). A vertebrate gene related to orthodenticle contains a homeodomam of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12, 2735-2747.
35. Simeone, A., Avantaggiato, V., Moroni, M. C., Mavillo, F., Arra, C., Cotelli, R., Nigro, V. and Acampora, D. (1995). Retinoic acid induces stage-specific antero-posterior transformation of rostral central nervous system. Mech. Dev. 51, 83-98
36. Slack, J. and Tannahill, D. (1992). Mechanism of anteropostenor axis specification in vertebrates. Lessons from amphibians. Development 114, 285-302.
37. Spemann,H. (1938). Embryonic Development and Induction. Yale University Press.
38. Tarn, P. P. L. (1989). Regionalization of the mouse embryonic ectoderm: allocation of prospective ectodermal tissues during gastrulation. Development 107, 55-67.
39. Tao, W. and Lai, E. (1992). Telencephalon restricted expression fo BF-1, a new member of the HNF-3/forkhead gene family, in the developing rat brain. Neuron 8, 957-966.
40. Teillet, M.-A. and Le Douarin, N. M. (1983). Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo. Dev. Biol. 98, 192-211.
41. Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., and Mulligan, R. C. (1991). Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1165.
42. Waddington, C. H. (1933). Induction by the primitive streak and its derivatives in the chick. J. Exp. Biol. 10, 38-46.
43. Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M., Darnell, J. E., Jr. (1994). The winged-helix transcription factor HNF-3ß is required for notochord development in the mouse embryo. Cell 78, 575-588.
44. Wilkinson, D. G., Bhatt, S., Cook, M., Boncinelli, E. and Krumlauf, R. (1989a). Segmental expression of Hox-2 homeobox genes in the developing mouse hindbram. Nature 341, 405-409.
45. Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R. and Charnay, P. (1989b). Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse. Nature 337, 461-464.
46. Wurst, W. and Joyner, A. L. (1992). Production of targeted embryonic stem cell lines In Gene Targeting: A Practical Approach, (ed. A. L. Joyner), pp 31-62. Oxford: Oxford University Press.
47. Yamaguchi, T. P., Dumont, D. J., Conlon, R. A., Breitman, M. L. and Rossant, J. (1993). flk-l, an flt-related receptor kinase is an early marker for endothelial cell precursors. Development 118, 489-498.