A novel mechanism for B cell repertoire maturation based on response by B cell precursors to pre-B receptor assembly

Journal of Experimental Medicine

Volumn 187, Issue 2, 1998, Pages 259-264

  Wasserman, R ^a,c   Li, Y S ^a,d   Shinton, S A ^a   Carmack, C E ^a,e   Manser, T ^b   Wiest, D L ^a   Hayakawa, K ^a   Hardy, R R ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^e Molecular Dynamics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN MU CHAIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; FETUS; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION;

ANIMALS; B-LYMPHOCYTE SUBSETS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; FETUS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN MU-CHAINS; LIVER; MICE; MICE, TRANSGENIC; PRECIPITIN TESTS; RECEPTORS, ANTIGEN, B-CELL; STEM CELLS; TRANSFECTION;

EID: 0031985545     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.2.259     Document Type: Article

References (32)

1. Sigal, N.H., A.R. Pickard, E.S. Metcalf, P.J. Gearhart, and N.R. Klinman. 1977. Expression of phosphorylcholine-specific B cells during murine development. J. Exp. Med. 146: 933-948.
2. Klinman, N., and P. Linton. 1988. The clonotype repertoire of B cell subpopulations. Adv. Immunol. 42:1-93.
3. H gene segments in pre-B-cell lines. Nature. 311:727-733.
4. Perlmutter, R.M. 1987. Programmed development of the antibody repertoire. Curr. Top. Microbiol. Immunol. 135:95-109.
5. H gene families. J. Exp. Med. 168:417-435.
6. H genes occurs in the newly generated repertoires of neonatal and adult mice. J. Exp. Med. 171:843-859.
7. H81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. J. Immunol. 147:1406-1411.
8. Decker, D.J., G.H. Kline, T.A. Hayden, S.N. Zaharevitz, and N.K. Klinman. 1995. Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition. J. Immunol. 154:4924-4935.
9. H repertoire maturation during B cell development in vitro: differential selection of Ig heavy chains by fetal and adult B cell progenitors. J. Immunol. 158:4282-4291.
10. H11 family. J. Immunol. 142: 3643-3651.
11. Hardy, R.R., and K. Hayakawa. 1994. CD5 B cells, a fetal B cell lineage. Adv. Immunol. 55:297-339.
12. Melchers, F., A. Strasser, S.R. Bauer, A. Kudo, P. Thalmann, and A. Rolink. 1989. Cellular stages and molecular steps of murine B-cell development. Cold Spring Harbor Symp. Quant. Biol. 1:183-189.
13. Karasuyama, H., A. Kudo, and F. Melchers. 1990. The proteins encoded by the VpreB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172:969-972.
14. Reichman-Fried, M., R.R. Hardy, and M.J. Bosma. 1990. Development of B-lineage cells in the bone marrow of scid mice following the introduction of functionally rearranged immunoglobulin transgenes. Proc. Natl. Acad. Sci. USA. 87: 2730-2739.
15. Spanopoulou, E., C.A. Roman, L.M. Corcoran, M.S. Schlissel, D.P. Silver, D. Nemazee, M.C. Nussenzweig, S.A. Shinton, R.R. Hardy, and D. Baltimore. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030-1042.
16. Kitamara, D., A. Kudo, S. Schaal, W. Muller, F. Melchers, and K. Rajewsky. 1992. A critical role of λ5 protein in B cell development. Cell. 69:823-831.
17. Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
18. Li, Y.S., K. Hayakawa, and R.R. Hardy. 1993. The regulated expression of B lineage-associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951-960.
19. Wasserman, R., Y.S. Li, and R.R. Hardy. 1997. Down-regulation of terminal deoxynucleotidyl transferase by Ig heavy chain in B lineage cells. J. Immunol. 158:1133-1138.
20. Chang, Y., G.C. Bosma, and M.J. Bosma. 1995. Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination. Immunity. 2:607-616.
21. Grawunder, U., T.M. Leu, D.G. Schatz, A. Werner, A.G. Rolink, F. Melchers, and T.H. Winkler. 1995. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity. 3:601-608.
22. Nussenzweig, M.C., A.C. Shaw, E. Sinn, D.B. Danner, K.L. Holmes, H.C. Morse, and P. Leder. 1987. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ. Science. 236:816-819.
23. Erikson, J., M.Z. Radic, S.A. Camper, R.R. Hardy, C. Carmack, and M. Weigert. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature. 349:331-334.
24. Cenciarelli, C., D. Hou, K.-C. Hsu, B.L. Rellahan, D.L. Wiest, H.T. Smith, V.A. Fried, and A.M. Weissman. 1992. Activation-induced ubiquitination of the T cell antigen receptor. Science. 257:795-797.
25. s poly(A) site usage and the Cμ4-to-M1 splice. Mol. Cell. Biol. 9:726-738.
26. Chen, X., F. Martin, K.A. Forbush, R.M. Perlmutter, and J.F. Kearney. 1997. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. Int. Immunol. 9:27-41.
27. Keyna, U., G.B. Beck-Engeser, J. Jongstra, S.E. Applequist, and H.M. Jack. 1995. Surrogate light chain-dependent selection of Ig heavy chain V regions. J. Immunol. 155:5536-5542.
28. H81X in newborns but not in adults. Mol. Immunol. 30:1473-1479.
29. + B cells. Immunol. Rev. 137:91-118.
30. Landau, N.R., D.G. Schatz, M. Rosa, and D. Baltimore. 1987. Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector. Mol. Cell. Biol. 7:3237-3243.
31. Gerstein, R.M., and M.R. Lieber. 1993. Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination. Nature. 363:625-627.
32. Karasuyama, H., A. Rolink, Y. Shinkai, F. Young, F.W. Alt, and F. Melchers. 1994. The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell. 77:133-143.