Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional μ heavy chains

Journal of Immunology

Volumn 161, Issue 4, 1998, Pages 1608-1618

  Kline, Gregory H ^a   Hartwell, Laura ^b   Beck Engeser, Gabrielle B ^b   Keyna, Ulrike ^b   Zaharevitz, Samantha ^a   Klinman, Norman R ^a   Jäck, Hans Martin ^b,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL DIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE REARRANGEMENT; IMMUNOPRECIPITATION; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN FOLDING; QUALITY CONTROL; SEQUENCE ANALYSIS;

ANIMALS; B-LYMPHOCYTE SUBSETS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN J-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PERITONEAL CAVITY; RECEPTORS, ANTIGEN, B-CELL; SPLEEN; STEM CELLS;

EID: 0032529224     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Willerford, D. M., W. Swat, and F. W. Alt. 1996. Developmental regulation of V(D)J recombination and lymphocyte differentiation. Curr. Opin. Genet. Dev. 6:603.
2. Decker, D. J., N. E. Boyle, J. A. Koziol, and N. R. Klinman. 1991. The expression of the Ig H chain repertoire in developing bone marrow B lineage cells. J. Immunol. 146:350.
3. Karasuyama, H., A. Rolink, Y. Shinkai, F. Young, F. W. Alt, and F. Melchers. 1994. The expression of Vpre-B/λ 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77:133.
4. Rolink, A., U. Grawunder, T. H. Winkler, H. Karasuyama, and F. Melchers. 1994. IL-2 receptor α chain (CD25, TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257.
5. Kitamura, D., J. Roes, R. Kühn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350:423.
6. Mombaerts, P., J. Iacomini, R. S. Johnson, K. Herrup, S. Tonegawa, and V. E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
7. Shinkai Y., G. Rathbun, K. P. Lam. E. M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A. M. Stall, and F. W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68:855.
8. H locus. Int. Immunol. 5:647.
9. Ehlich A., S. Schaal, H. Gu, D. Kitamura, W. Müller, and K. Rajewsky. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
10. H81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. J. Immunol. 147:1406.
11. Keyna, U., G. B. Beck-Engeser, J. Jongstra, S. E. Applequist, and H.-M. Jäck. 1995. Surrogate light chain-dependent selection of Ig heavy chain V regions. J. Immunol. 155:5536.
12. Misener, V., J. Jongstra-Bilen, A. J. Young, M. J. Atkinson, G. E. Wu, and J. Jongstra. 1990. Association of Ig L chain-like protein λ5 with a 16-kilodalton protein in mouse pre-B cell lines is not dependent on the presence of Ig H chain protein. J. Immunol 145:905.
13. Karasuyama, H., A. Kudo, and F. Melchers. 1990. The proteins encoded by the VpreB and λ5 pre-B cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172:969.
14. Melchers, F., H. Karasuyama, D. Haasner, S. Bauer, A. Kudo, N. Sakaguchi, B. Jameson, and A. Rolink. 1993. The surrogate light chain in B cell development, Immunol. Today 14:60.
15. Li, Y.S., K. Hayakawa, and R. R. Hardy. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951.
16. Guelpa-Fonlupt, V., D. Bossy, P. Alzari, F. Fumoux, M. Fougereau, and C. Schiff. 1994. The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain. Mol. Immunol. 31:1099.
17. Pillai, S., and D. Baltimore. 1987. Formation of a disulphide-linked μ2-ω2 teramers in pre-B cells by the 18K to-immunoglobulin light chain. Nature 329:172.
18. Takemori, T., J. Mizuguchi, I. Miyazoe, M. Nakanishi, K. Shigemoto, H. Kimoto, T. Shirasawa, N. Maruyama, and M. Taniguchi. 1990. Two types of μ chain complexes are expressed during differentiation from pre-B to mature B cells. EMBO J. 9:2493.
19. Misener, V., G. P. Downey, and J. Jongstra. 1991. The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule. Int. Immunol. 3:1129.
20. Nishimoto, N., H. Kubagawa, T. Ohno, G. L. Gartland, A. K. Stankovic, and M. D. Cooper. 1991. Normal pre-B cells express a receptor complex of μ heavy chains and surrogate light-chain proteins. Proc. Natl. Acad. Sci. USA 88:6284.
21. Tsubata, T., R. Tsubata, and M. Reth. 1992. Crosslinking of the cell surface immunoglobulin (μ-surrogate light chain complex) on pre-B cells induces activation of V gene rearrangements at the κ locus. Int. Immunol. 4:637.
22. Nakamura, T., M. C. Sekar, H. Kubagawa, and M. D. Cooper. 1993. Signal transduction in human B cells initiated via Ig β ligation. Int. Immunol 5:1309.
23. Bossy, D., J. Salamero, D. Olive, M. Fougereau, and C. Schiff. 1993. Structure, biosynthesis, and transduction properties of the human μ-ψL complex: similar behavior of preB and intermediate preB-B cells in transducing ability. Int. Immunol. 5:467.
24. Krop, I., A. L. Shaffer, D. T. Fearon, and M. S. Schlissel. 1996. The signaling activity of murine CD19 is regulated during cell development. J. Immunol 157: 48.
25. Winkler, T., A. Rolink, F. Melchers, and H. Karasuyama. 1995. Precursor B cells of mouse bone marrow express two different complexes with the surrogate light chain on the surface. Eur. J. Immunol. 25:446.
26. Kitamura, D., A. Kudo, S. Schaal, W. Müller, F. Melchers, and K. Rajewsky. 1992. A critical role of λ5 protein in B cell development. Cell 69:823.
27. Ehlich, A., V. Martin, W. Müller, and K. Rajewsky. 1994. Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4:573.
28. H gene segments in pre-B cell lines. Nature 311:727.
29. H gene repertoire. Sem. Immunol. 2:207.
30. H7183 genes and evidence for stage-specific somatic diversification. Eur. J. Immunol. 22:71.
31. Huetz, F., L. Carlsson, U.-C. Tornberg, and D. Holmberg. 1993. V-region directed selection in differentiating B lymphocytes. EMBO J. 12:1819.
32. H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.
33. Jack, H.-M., G. B. Beck-Engeser, G. Lee, D. Wofsy, and M. Wabl. 1992. Tumorigenesis mediated by an antigen receptor. Proc. Natl. Acad. Sci. USA 89: 8482.
34. Jack, H.-M., G. B. Beck-Engeser, B. Sloan, M. L. Wong, and M. Wabl. 1992. A different sort of Mott cell. Proc. Acad. Sci. USA 89:11688.
35. Chen, X., F. Martin, K. A. Forbush, R. M. Perlmutter, and J. F. Kearney. 1997. Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone. Int. Immunol. 9:27.
36. H81X transgene-bearing B cells in fetus and adult: sites for expansion and deletion in conventional and CD5/B1 cells. Int. Immunol. 9:493.
37. Kearney, J. F., A. Radbruch, B. Liesegang, and K. Rajewsky. 1979. A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J. Immunol. 123:1548.
38. Schüppel R., J. Wilke, and E. Weiler. 1987. Monoclonal anti-allotype antibody towards BALB/c IgM: analysis of specificity and site of a V-C crossover in recombinant strain BALB-Igh-Va/Igh-Cb. Eur. J. Immunol. 17:739.
39. Sanger, F., S. Niklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 86:5463.
40. Falkner, F. G., and H. G. Zachau. 1984. Correct transcription of an immunoglobulin kappa gene requires an upstream fragment containing conserved sequence elements. Nature 310:71.
41. Chen, S. Z., and G. A. Evans. 1990. A simple screening method for transgenic mice using the PCR. Biotechniques 8:32.
42. Hogan, B., R. Beddington, F. Costantini, and E. Lacy, eds. 1994. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
43. Sambrook, J., E. F. Fritsch, and T. Maniatis (eds.). 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
44. Chen, J., M. Trounstine, C. Kurahara, F. Young, C.-C. Kuo, Y. Xu, J. F. Loring, F. W. Alt, and D. Huszar. 1993. B cell development in mice that lack one or both immunoglobulin κ light chain genes. EMBO J. 12:821.
45. Bornemann, K., J. Brewer, G. Beck-Engeser, R. Corley, I. Haas, and H.-M. Jäck. 1995. Roles of heavy and light chains in IgM polymerization. Proc. Natl. Acad. Sci. USA 92:4912.
46. Velardi, A., H. Kubagawa, and J. F. Kearney. 1984. Analysis of the reactivity of four anti-mouse IgM allotype antibodies with μ+ B lineage cells at various stages of differentiation. J. Immunol. 133:2098.
47. Schreier, P. H., S. Quester, and A. Bothwell. 1986. Allotypic differences in murine μ genes. Nucleic Acids Res. 14:2381.
48. Haas, I. G., and M. Wabl. 1983. Immunoglobulin heavy chain binding protein. Nature 306:387.
49. H gene segments. Cell 40:271.
50. Gerster, T., D. Picard, and W. Schaffner. 1986. During B-cell differentiation enhancer activity and transcription rate of immunoglobulin heavy chain genes are high before mRNA accumulation. Cell 45:45.
51. Lin, H., and R. Grosschedl. 1995. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376:263.
52. Hardy, R. R., C. E. Carmack, S. A. Shinton, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-B cell stages in normal mouse bone marrow. 3. Exp. Med. 173:1213.
53. Li, Y. S., R. Wasserman, K. Hayakawa, and R. R. Hardy. 1996. Identification of the earliest B lineage stage in mouse bone marrow. Immunity 5:527.
54. Chen, J., R. Lansford, V. Stewart, F. Young, and F. W. Alt. 1993. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. USA 90:4528.
55. Rolink, A., H. Karasuyama, U. Grawunder, D. Hassner, A. Kudo, and F. Melchers. 1993. B cell development in mice with a defective λ5 gene. Eur. J. Immunol 23:1284.
56. Löffert, D., S. Schaal, A. Ehlich, R. R. Hardy, Y. Zou, W. Müller, and K. Rajewsky. 1994. Early B-cell development in the mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137:135.
57. Rolink, A., H. Karasuyama, D. Haasner, U. Grawunder, I. L. Martensson, A. Kudo, and F. Melchers. 1994. Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol. Rev. 137:185.
58. Kitamura, D., and K. Rajewsky, 1992. Targeted disruption of ji chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154.
59. Papavasiliou, F., Z. Misulovin, H. Suh., and M. C. Nussenzweig. 1995. The role of Igβ in precursor B cell transition and allelic exclusion. Science 268:408.
60. Melchers, F., A. Strasser, S. R. Bauer, A. Kudo, Thalmann P., and A. Rolink. 1989, Cellular stages and molecular steps of murine B-cell development. Cold Spring Harb. Symp. Quant. Biol. 54:183.
61. Löffert, D., S. Schaal, A. Ehlich, R. R. Hardy, Y. Zou, W. Müller, and K. Rajewsky. 1994. Early B-cell development in the mouse: insights from mutations introduced by gene targeting, Immunol. Rev. 137:135.
62. Papavasiliou, F., M. Jankovic, and M. C. Nussenzweig. 1996. Surrogate or conventional light chains are required for membrane immunoglobulin μ to activate the precursor B cell transition. J. Exp. Med. 184:2025.
63. Pelanda, R., S. Schaal, R. M. Torres, and K. Rajewsky. 1996. A prematurely expressed Ig(κ) transgene, but not V(κ)J(κ) gene segment targeted into the Ig(k) locus, can rescue B cell development in λ5-deficient mice. Immunity 5:229.
64. H81X expressing IgM antibody on early B cell development. Ann. N. Y. Acad. Sci. 651:160.
65. Raaphorst, F. M., C. S. Raman, B. T. Nall, and J. M. Teale. 1997. Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes. Immunol. Today 18:37.
66. Wu, G. E., M. J. Atkinson, D. A., Ramsden, and C. J. Paige. 1990. VH gene repertoire. Semin. Immunol. 2:207.
67. H structure of the μsurrogate L chain receptor. EMBO J. 15:1524.
68. Corcos, D., O. Dunda, C. Butor, J. Y. Cesbron, P. Lores, D, Bicchini, and J. Jami 1995. Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. Curr. Biol. 5:1140.
69. Shaffer, A.L and M.S. SchlisseL 1997. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. J. immunol. 159:1265.
70. Nussenzweig, M. C., A. C. Shaw, E. Sinn, D. B. Danner, K. L. Holmes, H. C. Morse III, and P. Leder. I987. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ. Science 236:816.
71. Melchers, F., D. Haasner, U. Grawunder, C. Kalberer, H. Karasuyama, T. Winkler, and A. Rolink. 1994. Roles of IgH and L chains in the development of cells of the B lymphocyte lineage. Annu. Rev. Immunol. 12:209.
72. Spanopoulou, E., C. A. Roman, L. M. Corcoran, M. S. Schlissel, D. P. Silver, D. Nemazee, M. C. Nussenzweig, S. A. Shinton, R. R. Hardy, and D. Baltimore. (1994). Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030.