-
1
-
-
0026723417
-
Chicken erythroid cells transformed by the gag-myb-ets-encoding E26 leukemia virus are multipotent
-
Graf T, Mcnagny K, Brady G, Frampton J Chicken erythroid cells transformed by the gag-myb-ets-encoding E26 leukemia virus are multipotent. Cell. 70:1992;201-213.
-
(1992)
Cell
, vol.70
, pp. 201-213
-
-
Graf, T.1
McNagny, K.2
Brady, G.3
Frampton, J.4
-
2
-
-
0032146794
-
PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors
-
Nerlov and Graf have transduced multi-potential chicken cells with inducible forms of PU.1 to confirm a role for this protein in myeloid commitment. The authors also demonstrate that the transactivation domain of PU.1 is necessary for its function in biasing differentiation, and that transient expression of PU.1 can lead to an immature eosinophil-like phenotype.
-
Nerlov C, Graf T PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors. Genes Dev. 12:1998;2403-2412. Nerlov and Graf have transduced multi-potential chicken cells with inducible forms of PU.1 to confirm a role for this protein in myeloid commitment. The authors also demonstrate that the transactivation domain of PU.1 is necessary for its function in biasing differentiation, and that transient expression of PU.1 can lead to an immature eosinophil-like phenotype.
-
(1998)
Genes Dev
, vol.12
, pp. 2403-2412
-
-
Nerlov, C.1
Graf, T.2
-
3
-
-
0028136726
-
Requirement of the transcription factor PU.1 in the development of multiple hematopoietic lineages
-
Scott EW, Simon MC, Anastasi J, Singh H Requirement of the transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265:1994;1573-1577.
-
(1994)
Science
, vol.265
, pp. 1573-1577
-
-
Scott, E.W.1
Simon, M.C.2
Anastasi, J.3
Singh, H.4
-
4
-
-
0030611964
-
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors
-
Scott EW, Fisher RC, Olson MC, Kehrli EW, Simon MC, Singh H PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity. 6:1997;437-447.
-
(1997)
Immunity
, vol.6
, pp. 437-447
-
-
Scott, E.W.1
Fisher, R.C.2
Olson, M.C.3
Kehrli, E.W.4
Simon, M.C.5
Singh, H.6
-
5
-
-
0242549003
-
Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
-
McKercher S, Torbett B, Anderson K, Henkel G, Vestal D, Garibault H, Klemsz M, Feeney A, Wu G, Paige C, Maki R Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:1996;5647-5658.
-
(1996)
EMBO J
, vol.15
, pp. 5647-5658
-
-
McKercher, S.1
Torbett, B.2
Anderson, K.3
Henkel, G.4
Vestal, D.5
Garibault, H.6
Klemsz, M.7
Feeney, A.8
Wu, G.9
Paige, C.10
Maki, R.11
-
6
-
-
0032145528
-
Distinct C/EBP functions are required for eosinophil lineage commitment and maturation
-
••], the authors propose a model in which PU.1 and C/EBP stimulate, and GATA-1 opposes, myeloid and eosinophil differentiation.
-
••], the authors propose a model in which PU.1 and C/EBP stimulate, and GATA-1 opposes, myeloid and eosinophil differentiation.
-
(1998)
Genes Dev
, vol.12
, pp. 2413-2423
-
-
Nerlov, C.1
McNagny, K.M.2
Doderlein, G.3
Kowenz-Leutz, E.4
Graf, T.5
-
7
-
-
0030665673
-
Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
-
Heemskerk MHM, Blom B, Nolan G, Stegmann APA, Bakker AQ, Weijer K, Res PCM, Spits H Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J Exp Med. 186:1997;1597-1602.
-
(1997)
J Exp Med
, vol.186
, pp. 1597-1602
-
-
Heemskerk, M.H.M.1
Blom, B.2
Nolan, G.3
Stegmann, A.P.A.4
Bakker, A.Q.5
Weijer, K.6
Res, P.C.M.7
Spits, H.8
-
8
-
-
0033577695
-
Disruption of αβ but not γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors
-
•].
-
•].
-
(1999)
EMBO J
, vol.18
, pp. 2793-2802
-
-
Blom, B.1
Heemskerk, M.H.M.2
Verschuren, M.C.M.3
Van Dongen, J.J.M.4
Stegmann, A.P.A.5
Bakker, A.Q.6
Couwenberg, F.7
Res, P.C.M.8
Spits, H.9
-
10
-
-
0033136288
-
Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
-
Pallard et al. test the effect of inhibition of the IL7/STAT 5 signaling pathway, through forced expression of dominant negative forms of both STAT 5 and a chimeric IL-7 receptor on T-cell development, in their FTOC differentiation assay. Differentiation of αβ T-cells is blocked by the disruption of signaling through IL7/STAT 5. The authors also identify a role for signaling through phosphatidylinositol 3-kinase and protein kinase B in thymocyte proliferation and survival.
-
Pallard C, Stegmann APA, van Kleffens T, Smart F, Venkitaraman A, Spits H Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity. 10:1999;525-535. Pallard et al. test the effect of inhibition of the IL7/STAT 5 signaling pathway, through forced expression of dominant negative forms of both STAT 5 and a chimeric IL-7 receptor on T-cell development, in their FTOC differentiation assay. Differentiation of αβ T-cells is blocked by the disruption of signaling through IL7/STAT 5. The authors also identify a role for signaling through phosphatidylinositol 3-kinase and protein kinase B in thymocyte proliferation and survival.
-
(1999)
Immunity
, vol.10
, pp. 525-535
-
-
Pallard, C.1
Stegmann, A.P.A.2
Van Kleffens, T.3
Smart, F.4
Venkitaraman, A.5
Spits, H.6
-
11
-
-
0027992622
-
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
-
Bain G, Maandag E, Izon D, Amsen D, Kruisbeek A, Weintraub B, Krop I, Schlissel M, Feeney A, van Roon Met al. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 79:1994;885-892.
-
(1994)
Cell
, vol.79
, pp. 885-892
-
-
Bain, G.1
Maandag, E.2
Izon, D.3
Amsen, D.4
Kruisbeek, A.5
Weintraub, B.6
Krop, I.7
Schlissel, M.8
Feeney, A.9
Van Roon, M.10
-
12
-
-
0028148938
-
The helix-loop-helix gene E2A is required for B cell formation
-
Zhuang Y, Soriano P, Weintraub H The helix-loop-helix gene E2A is required for B cell formation. Cell. 79:1994;875-884.
-
(1994)
Cell
, vol.79
, pp. 875-884
-
-
Zhuang, Y.1
Soriano, P.2
Weintraub, H.3
-
13
-
-
0029045161
-
Failure of B-cell differentiation in mice lacking the transcription factor EBF
-
Lin H, Grosschedl R Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature. 376:1995;263-267.
-
(1995)
Nature
, vol.376
, pp. 263-267
-
-
Lin, H.1
Grosschedl, R.2
-
14
-
-
0032541471
-
Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12
-
Kee and Murre provide evidence that E2A functions upstream of EBF on the basis of the ability of these factors to convert the 70Z/3 macrophage line to a pre-B-like phenotype.
-
Kee BL, Murre C Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med. 188:1998;699-713. Kee and Murre provide evidence that E2A functions upstream of EBF on the basis of the ability of these factors to convert the 70Z/3 macrophage line to a pre-B-like phenotype.
-
(1998)
J Exp Med
, vol.188
, pp. 699-713
-
-
Kee, B.L.1
Murre, C.2
-
15
-
-
0027083415
-
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split
-
Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev. 6:1992;2620-2634.
-
(1992)
Genes Dev
, vol.6
, pp. 2620-2634
-
-
Sasai, Y.1
Kageyama, R.2
Tagawa, Y.3
Shigemoto, R.4
Nakanishi, S.5
-
16
-
-
0031723955
-
The notch pathway intermediate HES-1 silences CD4 gene expression
-
Kim HK, Siu G The notch pathway intermediate HES-1 silences CD4 gene expression. Mol Cell Biol. 18:1998;7166-7175.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7166-7175
-
-
Kim, H.K.1
Siu, G.2
-
17
-
-
0029188455
-
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to upregulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
-
Ishibashi M, Ang S-L, Shiota K, Nakanishi S, Kageyama R, Guillemot F Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to upregulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 9:1995;3136-3148.
-
(1995)
Genes Dev
, vol.9
, pp. 3136-3148
-
-
Ishibashi, M.1
Ang, S.-L.2
Shiota, K.3
Nakanishi, S.4
Kageyama, R.5
Guillemot, F.6
-
19
-
-
0025821494
-
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
-
Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott JWJ, Potter SS A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 65:1991;677-689.
-
(1991)
Cell
, vol.65
, pp. 677-689
-
-
Mucenski, M.L.1
McLain, K.2
Kier, A.B.3
Swerdlow, S.H.4
Schreiner, C.M.5
Miller, T.A.6
Pietryga, D.W.7
Scott, J.W.J.8
Potter, S.S.9
-
20
-
-
0033135877
-
C-Myb is essential for early T cell development
-
••]. Hes-1 was found to be required for the differentiation and expansion of DN thymocytes, whereas thymocytes deficient for c-Myb express markers arrested at the earliest defined stage of T-cell commitment. The c-Myb-null ES cells also failed to contribute to the B-cell or macrophage lineages.
-
••]. Hes-1 was found to be required for the differentiation and expansion of DN thymocytes, whereas thymocytes deficient for c-Myb express markers arrested at the earliest defined stage of T-cell commitment. The c-Myb-null ES cells also failed to contribute to the B-cell or macrophage lineages.
-
(1999)
Genes Dev
, vol.13
, pp. 1073-1078
-
-
Allen, R.D.1
Bender, T.P.2
Siu, G.3
-
22
-
-
0033602163
-
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
-
•] demonstrate the requirement for Ets-1 and Id2 in the development of NK cells. Mice deficient in Id2 were also found to lack lymph nodes and Peyer's patches.
-
•] demonstrate the requirement for Ets-1 and Id2 in the development of NK cells. Mice deficient in Id2 were also found to lack lymph nodes and Peyer's patches.
-
(1999)
Nature
, vol.397
, pp. 702-706
-
-
Yokota, Y.1
Mansouri, A.2
Mori, S.3
Sugawara, S.4
Adachi, S.5
Nishikawa, S.-I.6
Gruss, P.7
-
23
-
-
0028276834
-
The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin-6 induced myeloid differentiation
-
Voronova AF, Lee F The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin-6 induced myeloid differentiation. Proc Natl Acad Sci USA. 91:1994;5952-5956.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5952-5956
-
-
Voronova, A.F.1
Lee, F.2
-
24
-
-
0025804491
-
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins
-
Hsu H-L, Cheng JT, Chen Q, Baer R Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol Cell Biol. 11:1991;3037-3042.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 3037-3042
-
-
Hsu, H.-L.1
Cheng, J.T.2
Chen, Q.3
Baer, R.4
-
25
-
-
0031466610
-
Genetics of erythropoiesis: Induced mutations in mice and zebrafish
-
Orkin SH, Zon LI Genetics of erythropoiesis: induced mutations in mice and zebrafish. Annu Rev Genet. 31:1997;33-60.
-
(1997)
Annu Rev Genet
, vol.31
, pp. 33-60
-
-
Orkin, S.H.1
Zon, L.I.2
-
26
-
-
0026673933
-
The SCL gene product: A positive regulator of erythroid differentiation
-
Aplan PD, Nakahara K, Orkin SH, Kirsch IR The SCL gene product: a positive regulator of erythroid differentiation. EMBO J. 11:1992;4073-4081.
-
(1992)
EMBO J
, vol.11
, pp. 4073-4081
-
-
Aplan, P.D.1
Nakahara, K.2
Orkin, S.H.3
Kirsch, I.R.4
-
27
-
-
0032520080
-
Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
-
Visvader et al. find that although the early hematopoietic defect of SCL could be rescued by a transgene that placed a SCL cDNA under control of the GATA-1 promoter, vitelline vessel formation was defective and the embryos died by E9.5
-
Visvader JE, Fujiwara Y, Orkin SH Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development. Genes Dev. 12:1998;473-479. Visvader et al. find that although the early hematopoietic defect of SCL could be rescued by a transgene that placed a SCL cDNA under control of the GATA-1 promoter, vitelline vessel formation was defective and the embryos died by E9.5.
-
(1998)
Genes Dev
, vol.12
, pp. 473-479
-
-
Visvader, J.E.1
Fujiwara, Y.2
Orkin, S.H.3
-
29
-
-
0032032466
-
SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish
-
••] find that the hematopoietic and angiogenic defects of cloche are corrected by enforced expression of SCL, thus demonstrating that SCL acts downstream of cloche. More work is needed to resolve whether SCL actually functions to specify the formation of a hemangioblast stem cell in mice and zebrafish, or whether it only acts separately in the development of both lineages.
-
••] find that the hematopoietic and angiogenic defects of cloche are corrected by enforced expression of SCL, thus demonstrating that SCL acts downstream of cloche. More work is needed to resolve whether SCL actually functions to specify the formation of a hemangioblast stem cell in mice and zebrafish, or whether it only acts separately in the development of both lineages.
-
(1998)
Genes Dev
, vol.12
, pp. 621-626
-
-
Liao, E.C.1
Paw, B.H.2
Oates, A.C.3
Pratt, S.J.4
Postlethwait, J.H.5
Zon, L.I.6
-
30
-
-
0028278325
-
The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
-
Warren AJ, Colledge WH, Carlton MBL, Evans MJ, Smith AJH, Rabbitts TH The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 78:1994;45-58.
-
(1994)
Cell
, vol.78
, pp. 45-58
-
-
Warren, A.J.1
Colledge, W.H.2
Carlton, M.B.L.3
Evans, M.J.4
Smith, A.J.H.5
Rabbitts, T.H.6
-
32
-
-
0030999645
-
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb/NL1 proteins
-
Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A, Rabbitts TH The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb/NL1 proteins. EMBO J. 16:1997;3145-3157.
-
(1997)
EMBO J
, vol.16
, pp. 3145-3157
-
-
Wadman, I.A.1
Osada, H.2
Grutz, G.G.3
Agulnick, A.D.4
Westphal, H.5
Forster, A.6
Rabbitts, T.H.7
-
33
-
-
0344784406
-
Chromatin immunoselection defines a TAL-1 target gene
-
•] characterized the sequences bound by complexes defined in erythroid cells as containing SCL and LMO2
-
•] characterized the sequences bound by complexes defined in erythroid cells as containing SCL and LMO2.
-
(1998)
EMBO J
, vol.17
, pp. 5151-5160
-
-
Cohen-Kaminsky, S.1
Maouche-Chretien, L.2
Vitelli, L.3
Vinit, M.-A.4
Blanchard, I.5
Yamamoto, M.6
Peschle, C.7
Romeo, P.-H.8
-
34
-
-
0029073944
-
Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A Pediatric Oncology Group study
-
Bash RO, Hall S, Timmons CF, Crist WM, Amylon M, Smith RG, Baer R Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A Pediatric Oncology Group study. Blood. 86:1995;666-676.
-
(1995)
Blood
, vol.86
, pp. 666-676
-
-
Bash, R.O.1
Hall, S.2
Timmons, C.F.3
Crist, W.M.4
Amylon, M.5
Smith, R.G.6
Baer, R.7
-
35
-
-
0031051552
-
Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL
-
Ono Y, Fukuhara N, Yoshie O Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. J Biol Chem. 272:1997;4576-4581.
-
(1997)
J Biol Chem
, vol.272
, pp. 4576-4581
-
-
Ono, Y.1
Fukuhara, N.2
Yoshie, O.3
-
36
-
-
0032168564
-
LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes
-
Rabbitts TH LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Genes Dev. 12:1998;2651-2657.
-
(1998)
Genes Dev
, vol.12
, pp. 2651-2657
-
-
Rabbitts, T.H.1
-
38
-
-
0032479872
-
Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells
-
•]
-
•].
-
(1998)
J Exp Med
, vol.188
, pp. 439-450
-
-
Krosl, G.1
He, G.2
Lefrancois, M.3
Charron, F.4
Romeo, P.-H.5
Jolicoeur, P.6
Kirsch, I.R.7
Nemer, M.8
Hoang, T.9
-
39
-
-
0031724589
-
TAL1 and LIM-only proteins synergistically induce retinaldehyde degydrogenease 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
-
•].
-
•].
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6939-6950
-
-
Ono, Y.1
Fukuhara, N.2
Yoshie, O.3
-
40
-
-
0028290697
-
Positive and negative transcriptional control by the TAL1 helix-loop-helix protein
-
Hsu H-L, Wadman I, Tsan JT, Baer R Positive and negative transcriptional control by the TAL1 helix-loop-helix protein. Proc Natl Acad Sci USA. 91:1994;5947-5951.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5947-5951
-
-
Hsu, H.-L.1
Wadman, I.2
Tsan, J.T.3
Baer, R.4
-
41
-
-
0032549655
-
The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition
-
Park ST, Sun X-H The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition. J Biol Chem. 273:1998;7030-7037.
-
(1998)
J Biol Chem
, vol.273
, pp. 7030-7037
-
-
Park, S.T.1
Sun, X.-H.2
-
42
-
-
0030752361
-
E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
-
Bain G, Engel I, Maandag ECR, te Riele HPJ, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol. 17:1997;4782-4791.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4782-4791
-
-
Bain, G.1
Engel, I.2
Maandag, E.C.R.3
Te Riele, H.P.J.4
Voland, J.R.5
Sharp, L.L.6
Chun, J.7
Huey, B.8
Pinkel, D.9
Murre, C.10
-
43
-
-
0030666853
-
High Incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
-
Yan W, Young AZ, Soares VC, Kelley R, Benezra R, Zhuang Y High Incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol Cell Biol. 17:1997;7317-7327.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 7317-7327
-
-
Yan, W.1
Young, A.Z.2
Soares, V.C.3
Kelley, R.4
Benezra, R.5
Zhuang, Y.6
-
45
-
-
0033514377
-
Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas
-
•]. We observe that either E2A-encoded protein act to kill these lines, but unlike Park et al., find no effect on cell-cycle progression.
-
•]. We observe that either E2A-encoded protein act to kill these lines, but unlike Park et al., find no effect on cell-cycle progression.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 996-1001
-
-
Engel, I.1
Murre, C.2
-
47
-
-
0032191170
-
Aiolos regulates B cell activation and maturation to effector state
-
•].
-
•].
-
(1998)
Immunity
, vol.9
, pp. 543-553
-
-
Wang, J.-H.1
Avitahl, N.2
Cariappa, A.3
Friedrich, C.4
Ikeda, T.5
Renold, A.6
Andrikopoulos, K.7
Liang, L.8
Pillai, S.9
Morgan, B.A.10
Georgopoulos, K.11
-
48
-
-
0031437119
-
Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin
-
Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell. 91:1997;845-854.
-
(1997)
Cell
, vol.91
, pp. 845-854
-
-
Brown, K.E.1
Guest, S.S.2
Smale, S.T.3
Hahm, K.4
Merkenschlager, M.5
Fisher, A.G.6
-
50
-
-
0033103374
-
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
-
note
-
•] find that both Ikaros and Aiolos are associated with chromatin-remodeling and histone deacetylation complexes in T-cells.
-
(1999)
Immunity
, vol.10
, pp. 345-355
-
-
Kim, J.1
Sif, S.2
Jones, B.3
Jackson, A.4
Koipally, J.5
Heller, E.6
Winandy, S.7
Viel, A.8
Sawyer, A.9
Ikeda, T.10
-
51
-
-
0032511196
-
Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts
-
Geiger et al. use tranplantation of embryonic/fetal and adult HSCs into adult and blastocyst host environments, respectively, to examine the influence of microenvironment on the expression of a transgenic human globin locus. They find that both adult and embryonic hosts function in a dominant fashion to reprogram gene expression of the transplanted HSCs.
-
Geiger H, Sick S, Bonifer C, Muller AM Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts. Cell. 93:1998;1055-1065. Geiger et al. use tranplantation of embryonic/fetal and adult HSCs into adult and blastocyst host environments, respectively, to examine the influence of microenvironment on the expression of a transgenic human globin locus. They find that both adult and embryonic hosts function in a dominant fashion to reprogram gene expression of the transplanted HSCs.
-
(1998)
Cell
, vol.93
, pp. 1055-1065
-
-
Geiger, H.1
Sick, S.2
Bonifer, C.3
Muller, A.M.4
-
53
-
-
0032412441
-
Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
-
•] find that differentiation of naïve T-helper populations into different polarized T-helper subsets (i.e. Th1 and Th2) is associated with changes in chromatin structure at the appropriate gene loci, as determined by Dnase hypersensitivity.
-
•] find that differentiation of naïve T-helper populations into different polarized T-helper subsets (i.e. Th1 and Th2) is associated with changes in chromatin structure at the appropriate gene loci, as determined by Dnase hypersensitivity.
-
(1998)
Immunity
, vol.9
, pp. 765-775
-
-
Agarwal, S.1
Rao, A.2
|