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Volumn 189, Issue 1, 1999, Pages 75-87

Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice

Author keywords

B cell development; Bone marrow; Immunoglobulin gene rearrangement

Indexed keywords

DNA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LEUKOSIALIN;

EID: 0033521627     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.1.75     Document Type: Article
Times cited : (67)

References (56)
  • 1
    • 0019846013 scopus 로고
    • Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chains
    • Alt, F., N. Rosenberg, S. Lewis, E. Thomas, and D. Baltimore. 1981. Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: rearrangement of heavy but not light chains. Cell. 27:381-390.
    • (1981) Cell , vol.27 , pp. 381-390
    • Alt, F.1    Rosenberg, N.2    Lewis, S.3    Thomas, E.4    Baltimore, D.5
  • 2
    • 0021933994 scopus 로고
    • Regulated progression of a cultured pre-B-cell line to the B-cell stage
    • Reth, M.G., P. Ammirati, S. Jackson, and F.W. Alt. 1985. Regulated progression of a cultured pre-B-cell line to the B-cell stage. Nature. 317:353-355.
    • (1985) Nature , vol.317 , pp. 353-355
    • Reth, M.G.1    Ammirati, P.2    Jackson, S.3    Alt, F.W.4
  • 3
    • 0021047154 scopus 로고
    • Immunoglobulin gene rearrangement during pre-B cell differentiation
    • Coffman, R.L., and I.L. Weissman. 1983. Immunoglobulin gene rearrangement during pre-B cell differentiation. J. Mol. Cell. Immunol. 1:31-38.
    • (1983) J. Mol. Cell. Immunol. , vol.1 , pp. 31-38
    • Coffman, R.L.1    Weissman, I.L.2
  • 4
    • 0025193047 scopus 로고
    • preB and λ5 preB cell-specific genes can associate with each other and with μ heavy chain
    • preB and λ5 preB cell-specific genes can associate with each other and with μ heavy chain. J. Exp. Med. 172:969-972.
    • (1990) J. Exp. Med. , vol.172 , pp. 969-972
    • Karasuyama, H.1    Kudo, A.2    Melchers, F.3
  • 7
    • 0026753294 scopus 로고
    • Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus
    • Tsubata, T., R. Tsubata, and M.G. Reth. 1992. Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus. Int. Immunol. 4:637-641.
    • (1992) Int. Immunol. , vol.4 , pp. 637-641
    • Tsubata, T.1    Tsubata, R.2    Reth, M.G.3
  • 8
    • 0028068082 scopus 로고
    • Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination
    • Schlissel, M.S., and T. Morrow. 1994. Ig heavy chain protein controls B cell development by regulating germ-line transcription and retargeting V(D)J recombination. J. Immunol. 153:1645-1657.
    • (1994) J. Immunol. , vol.153 , pp. 1645-1657
    • Schlissel, M.S.1    Morrow, T.2
  • 9
    • 0019494043 scopus 로고
    • Aberrrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
    • Coleclough, C., R.P. Perry, K. Karjalainen, and M. Weigert. 1981. Aberrrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature. 290: 372-378.
    • (1981) Nature , vol.290 , pp. 372-378
    • Coleclough, C.1    Perry, R.P.2    Karjalainen, K.3    Weigert, M.4
  • 10
    • 0025439518 scopus 로고
    • The protection: The unit of humoral immunity selected by evolution
    • Cohn, M., and R.E. Langman. 1990. The protection: the unit of humoral immunity selected by evolution. Immunol. Rev. 115:11-147.
    • (1990) Immunol. Rev. , vol.115 , pp. 11-147
    • Cohn, M.1    Langman, R.E.2
  • 11
    • 0024435908 scopus 로고
    • Activation of immunoglobulin kappa gene rearrangement correlates with induction of kappa gene transcription
    • Schlissel, M.S., and D. Baltimore. 1989. Activation of immunoglobulin kappa gene rearrangement correlates with induction of kappa gene transcription. Cell. 58:1001-1007.
    • (1989) Cell , vol.58 , pp. 1001-1007
    • Schlissel, M.S.1    Baltimore, D.2
  • 13
    • 0027739352 scopus 로고
    • Rearrangement and expression of K light chain genes can occur without μ heavy chain expression during differentiation of pre-B cells
    • Grawunder, U., D. Haasner, F. Melchers, and A. Rolink. 1993. Rearrangement and expression of K light chain genes can occur without μ heavy chain expression during differentiation of pre-B cells. Int. Immunol. 5:1609-1618.
    • (1993) Int. Immunol. , vol.5 , pp. 1609-1618
    • Grawunder, U.1    Haasner, D.2    Melchers, F.3    Rolink, A.4
  • 14
    • 0024553137 scopus 로고
    • Light chain gene expression before heavy chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus
    • Kubagawa, H., M.D. Cooper, A.J. Carroll, and P.D. Burrows. 1989. Light chain gene expression before heavy chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus. Proc. Natl. Acad. Sci. USA. 86:2356-2360.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2356-2360
    • Kubagawa, H.1    Cooper, M.D.2    Carroll, A.J.3    Burrows, P.D.4
  • 15
    • 0026629839 scopus 로고
    • Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development
    • Benatar, T., L. Tkalec, and M.J.H. Ratcliffe. 1992. Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development. Proc. Natl. Acad. Sci. USA. 89: 7615-7619.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7615-7619
    • Benatar, T.1    Tkalec, L.2    Ratcliffe, M.J.H.3
  • 16
    • 0029063042 scopus 로고
    • The status of Ig loci rearrangements in single cells from different stages of B cell development
    • ten Boekel, E., F. Melchers, and A. Rolink. 1995. The status of Ig loci rearrangements in single cells from different stages of B cell development. Int. Immunol. 7:1013-1019.
    • (1995) Int. Immunol. , vol.7 , pp. 1013-1019
    • Ten Boekel, E.1    Melchers, F.2    Rolink, A.3
  • 17
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    • Ehlich, A., S. Schaal, H. Gu, D. Kitamura, W. Müller, and K. Rajewsky. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell. 72:695-704.
    • (1993) Cell , vol.72 , pp. 695-704
    • Ehlich, A.1    Schaal, S.2    Gu, H.3    Kitamura, D.4    Müller, W.5    Rajewsky, K.6
  • 19
    • 0025852445 scopus 로고
    • A B cell deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
    • Kitamura, D., J. Roes, R. Kühn, and K. Rajewsky. 1991. A B cell deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature. 350:423-426.
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kühn, R.3    Rajewsky, K.4
  • 20
    • 0027280936 scopus 로고
    • Independent control of Ig switch recombination at individual switch regions evidenced through cre-loxP mediated gene targeting
    • Gu, H., Y. Zou, and K. Rajewsky. 1993. Independent control of Ig switch recombination at individual switch regions evidenced through cre-loxP mediated gene targeting. Cell. 73:1155-1164.
    • (1993) Cell , vol.73 , pp. 1155-1164
    • Gu, H.1    Zou, Y.2    Rajewsky, K.3
  • 21
    • 0030249394 scopus 로고    scopus 로고
    • A prematurely expressed Igκ transgene, but not a VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice
    • Pelanda, R., S. Schaal, R.M. Torres, and K. Rajewsky. 1996. A prematurely expressed Igκ transgene, but not a VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice. Immunity. 5:229-239.
    • (1996) Immunity , vol.5 , pp. 229-239
    • Pelanda, R.1    Schaal, S.2    Torres, R.M.3    Rajewsky, K.4
  • 22
    • 0023150598 scopus 로고
    • HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonisation by cultured cells
    • Hooper, M., K. Hardy, A. Handyside, S. Hunter, and M. Monk. 1987. HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonisation by cultured cells. Nature. 326:292-295.
    • (1987) Nature , vol.326 , pp. 292-295
    • Hooper, M.1    Hardy, K.2    Handyside, A.3    Hunter, S.4    Monk, M.5
  • 23
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213-1225.
    • (1991) J. Exp. Med. , vol.173 , pp. 1213-1225
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, K.5
  • 24
    • 0025216585 scopus 로고
    • High gradient magnetic cell separation with MACS
    • Miltenyi, S., W. Müller, W. Weichel, and A. Radbruch. 1990. High gradient magnetic cell separation with MACS. Cytometry. 11:231-238.
    • (1990) Cytometry , vol.11 , pp. 231-238
    • Miltenyi, S.1    Müller, W.2    Weichel, W.3    Radbruch, A.4
  • 25
    • 0018082103 scopus 로고
    • Monoclonal xenogeneic antibodies to murine cell surface antigens: Identification of novel leukocyte differentiation antigens
    • Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1978. Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. Eur. J. Immunol. 8:539-551.
    • (1978) Eur. J. Immunol. , vol.8 , pp. 539-551
    • Springer, T.1    Galfre, G.2    Secher, D.S.3    Milstein, C.4
  • 26
    • 0023906071 scopus 로고
    • Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation
    • Gulley, M.L., L.C. Ogata, J.A. Thorson, M.O. Dailey, and J.D. Kemp. 1988. Identification of a murine pan-T cell antigen which is also expressed during the terminal phases of B cell differentiation. J. Immunol. 140:3751-3757.
    • (1988) J. Immunol. , vol.140 , pp. 3751-3757
    • Gulley, M.L.1    Ogata, L.C.2    Thorson, J.A.3    Dailey, M.O.4    Kemp, J.D.5
  • 28
    • 0027691148 scopus 로고
    • Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus
    • Taki, S., M. Meiering, and K. Rajewsky. 1993. Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus. Science. 262:1268-1271.
    • (1993) Science , vol.262 , pp. 1268-1271
    • Taki, S.1    Meiering, M.2    Rajewsky, K.3
  • 29
    • 0028466384 scopus 로고
    • Analysis of the B cell progenitor compartment at the level of single cells
    • Ehlich, A., V. Martin, W. Müller, and K. Rajewsky. 1994. Analysis of the B cell progenitor compartment at the level of single cells. Curr. Biol. 4:573-583.
    • (1994) Curr. Biol. , vol.4 , pp. 573-583
    • Ehlich, A.1    Martin, V.2    Müller, W.3    Rajewsky, K.4
  • 30
    • 0029886467 scopus 로고    scopus 로고
    • Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development
    • Löffert, D., A. Ehlich, W. Müller, and K. Rajewsky. 1996. Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity. 4:133-144.
    • (1996) Immunity , vol.4 , pp. 133-144
    • Löffert, D.1    Ehlich, A.2    Müller, W.3    Rajewsky, K.4
  • 32
    • 0024496450 scopus 로고
    • Complexity, polymorphism, and connectivity of mouse Vκ gene families
    • Kofler, R., M.A. Duchosal, and F.J. Dixon. 1989. Complexity, polymorphism, and connectivity of mouse Vκ gene families. Immunogenetics. 29:65-74.
    • (1989) Immunogenetics , vol.29 , pp. 65-74
    • Kofler, R.1    Duchosal, M.A.2    Dixon, F.J.3
  • 34
    • 0019442186 scopus 로고
    • Heavy chain variable region contribution to the NPb family of antibodies: Somatic mutation evident in a gamma-2a variable region
    • Bothwell, A.L., M. Paskind, M. Reth, T. Imanishi-Kari, K. Rajewsky, and D. Baltimore. 1981. Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma-2a variable region. Cell. 24: 625-637.
    • (1981) Cell , vol.24 , pp. 625-637
    • Bothwell, A.L.1    Paskind, M.2    Reth, M.3    Imanishi-Kari, T.4    Rajewsky, K.5    Baltimore, D.6
  • 36
    • 0021678303 scopus 로고
    • Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells
    • Reth, M.G., and F.W. Alt. 1984. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature. 312:418-423.
    • (1984) Nature , vol.312 , pp. 418-423
    • Reth, M.G.1    Alt, F.W.2
  • 37
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee, D.A., and K. Burki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature. 337:562-566.
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Burki, K.2
  • 38
    • 0029930417 scopus 로고    scopus 로고
    • Assembly of the truncated immunoglobulin heavy chain Dμ into antigen receptor-like complexes in pre-B cells but not in B cells
    • Horne, M.C., P.E. Roth, and A.L. DeFranco. 1996. Assembly of the truncated immunoglobulin heavy chain Dμ into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 4:145-158.
    • (1996) Immunity , vol.4 , pp. 145-158
    • Horne, M.C.1    Roth, P.E.2    DeFranco, A.L.3
  • 39
    • 0032473486 scopus 로고    scopus 로고
    • Regulation of B lymphocyte development by the truncated immunoglobulin heavy chain protein Dμ
    • Tornberg, U.C., I. Bergqvist, M. Haury, and D. Holmberg. 1998. Regulation of B lymphocyte development by the truncated immunoglobulin heavy chain protein Dμ. J. Exp. Med. 187:703-709.
    • (1998) J. Exp. Med. , vol.187 , pp. 703-709
    • Tornberg, U.C.1    Bergqvist, I.2    Haury, M.3    Holmberg, D.4
  • 40
    • 0022557584 scopus 로고
    • H joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production
    • H joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature. 322:840-842.
    • (1986) Nature , vol.322 , pp. 840-842
    • Reth, M.G.1    Gehrmann, P.2    Petrac, E.3    Wiese, P.4
  • 41
    • 0022502863 scopus 로고
    • Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma
    • Kleinfield, R., R.R. Hardy, D. Tarlinton, J. Dangl, L.A. Herzenberg, and M. Weigert. 1986. Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphoma. Nature. 322:843-846.
    • (1986) Nature , vol.322 , pp. 843-846
    • Kleinfield, R.1    Hardy, R.R.2    Tarlinton, D.3    Dangl, J.4    Herzenberg, L.A.5    Weigert, M.6
  • 42
    • 0024474722 scopus 로고
    • H segments after the loss of μ-chain expression in μ-positive pre-B cells
    • H segments after the loss of μ-chain expression in μ-positive pre-B cells. J. Immunol. 142:3652-3656.
    • (1989) J. Immunol. , vol.142 , pp. 3652-3656
    • Maeda, T.1    Sugiyama, H.2    Tani, Y.3    Kishimoto, S.4
  • 43
    • 0028942622 scopus 로고
    • H expression in young rabbit bone marrow
    • H expression in young rabbit bone marrow. Eur. J. Immunol. 25:700-707.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 700-707
    • Fitts, M.G.1    Mage, R.G.2
  • 44
    • 0028828269 scopus 로고
    • Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
    • Grawunder, U., T.M.J. Leu, D.G. Schatz, A. Werner, A.G. Rolink, F. Melchers, and T.H. Winkler. 1995. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity. 3:601-608.
    • (1995) Immunity , vol.3 , pp. 601-608
    • Grawunder, U.1    Leu, T.M.J.2    Schatz, D.G.3    Werner, A.4    Rolink, A.G.5    Melchers, F.6    Winkler, T.H.7
  • 45
  • 47
    • 0026071128 scopus 로고
    • The expression of the IgH chain repertoire in developing bone marrow B lineage cells
    • Decker, D.J., N.E. Boyle, J.A. Koziol, and N.R. Klinman. 1991. The expression of the IgH chain repertoire in developing bone marrow B lineage cells. J. Immunol. 146:350-361.
    • (1991) J. Immunol. , vol.146 , pp. 350-361
    • Decker, D.J.1    Boyle, N.E.2    Koziol, J.A.3    Klinman, N.R.4
  • 48
    • 0027275497 scopus 로고
    • The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver
    • Li, Y.S., K. Hayakawa, and R.R. Hardy. 1993. The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver. J. Exp. Med. 178:951-960.
    • (1993) J. Exp. Med. , vol.178 , pp. 951-960
    • Li, Y.S.1    Hayakawa, K.2    Hardy, R.R.3
  • 49
    • 0030765923 scopus 로고    scopus 로고
    • Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor
    • ten Boekel, E., F. Melchers, and A.G. Rolink. 1997. Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity. 7:357-368.
    • (1997) Immunity , vol.7 , pp. 357-368
    • Ten Boekel, E.1    Melchers, F.2    Rolink, A.G.3
  • 51
    • 0029983727 scopus 로고    scopus 로고
    • Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
    • Sleckman, B.P., J.R. Gorman, and F.W. Alt. 1996. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 14: 459-481.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 459-481
    • Sleckman, B.P.1    Gorman, J.R.2    Alt, F.W.3
  • 54
    • 0021216208 scopus 로고
    • Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
    • Desiderio, S.V., G.D. Yancopoulos, M. Paskind, E. Thomas, M.A. Boss, N. Landau, F.W. Alt, and D. Baltimore. 1984. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature. 311:752-755.
    • (1984) Nature , vol.311 , pp. 752-755
    • Desiderio, S.V.1    Yancopoulos, G.D.2    Paskind, M.3    Thomas, E.4    Boss, M.A.5    Landau, N.6    Alt, F.W.7    Baltimore, D.8
  • 55
    • 0024791338 scopus 로고
    • Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V(D)J joining
    • Lafaille, J.J., A. DeCloux, M. Bonneville, Y. Takagaki, and S. Tonegawa. 1989. Junctional sequences of T cell receptor γδ genes: implications for γδ T cell lineages and for a novel intermediate of V(D)J joining. Cell. 59:859-870.
    • (1989) Cell , vol.59 , pp. 859-870
    • Lafaille, J.J.1    DeCloux, A.2    Bonneville, M.3    Takagaki, Y.4    Tonegawa, S.5


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