Cross-linking of B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of phosphatidylinositol 3-kinase

International Immunology

Volumn 8, Issue 8, 1996, Pages 1273-1285

  Kuwahara, Kazuhiko ^a,f   Kawai, Taro ^a   Mitsuyoshi, Saori ^b   Matsuo, Yoshinobu ^c   Kikuchi, Hidehiko ^d   Imajoh Ohmi, Shinobu ^e   Hashimoto, Eikichi ^a   Inui, Seiji ^b   Cooper, Max D ^c   Sakaguchi, Nobuo ^d  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Department of Immunology ^*  (United States)

^c TOTTORI UNIVERSITY   (Japan)

^d HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

B cell differentiation; Phosphatidylinositol 3 kinase; Pre B cell; Signal transduction

Indexed keywords

B LYMPHOCYTE ANTIGEN; CYTOPLASM PROTEIN; LYMPHOCYTE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN SUBUNIT;

ARTICLE; B LYMPHOCYTE; CALCIUM MOBILIZATION; CELL LINE; CELL TYPE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN PHOSPHORYLATION;

EID: 9544223185     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.8.1273     Document Type: Article

References (61)

1. Tonegawa, S. 1983. Somatic generation of antibody diversity. Nature 302:575.
2. Reth, M. G. and Alt., F. W. 1984. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangement in lymphoid cells. Nature 312:418.
3. Alt, F. W., Oltz, E. M., Young, F., Gorman, J., Taccioli, G. and Chen, J. 1992. VDJ recombination. Immunol. Today. 13:306.
4. Sakaguchi, N., Berger, C. N. and Melchers, F. 1986. Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells. EMBOJ. 5:2139.
5. Sakaguchi, N. and Melchers, F. 1986. X5, a new light-chain-related locus selectively expressed in pre-B lymphocytes. Nature 324:579.
6. Kudo, A. and Melchers, R 1987. A second gene, VpreB in the X5 locus of the mouse, which appears to be selectively expressed in pre-B lymphocytes. EMBO J. 6:2267.
7. Melchers, F., Karasuyama, H., Haasner, D., Bauer, S., Kudo, A., Sakaguchi, N., Jameson, B. and Rolink, A. 1993. The surrogate light chain in B-cell development. Immunol. Today. 14:60.
8. Kitamura, D., Kudo, A., Schaal, S., Mueller, W., Melchers, F. and Rajewsky, K. 1992. A critical role of Ä5 protein in B cell development. Cell 69:823.
9. Sakaguchi, N., Kashiwamura, S.-l., Kimoto, M., Thalmann, P. and Melchers, F. 1988. B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBOJ. 7:3457.
10. Matsuo, T., Kimoto, M. and Sakaguchi, N. 1991. Direct identification of the putative surface IgM receptor-associated molecule encoded by murine B cell-specific mb-1 gene. J. Immunol. 146:1584.
11. Hombach, J., Tsubata, T., Leclercq, L, Stappert, H. and Reth, M. 1990. Molecular components of the B-cell antigen receptor complex of the IgM class. Nature 343:760.
12. Campbell, K. S., Hager, E. J., Friedrich, R. J. and Cambier, J. C. 1991. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc. Natl Acad. Sci. USA 88:3982.
13. Hermanson, G. G., Eisenberg, D., Kincade, P. W. and Wall, R. 1988. B29: A member of the immunoglobulin gene superfamily exclusively expressed on B-lineage cells. Proc. Natl Acad. Sci. USA 85:6890.
14. Burkhardt, A. L., Brunswick, M., Bolen, J. B. and Mond, J. J. 1991. Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc. Natl Acad. Sci. USA 88:7410.
15. Clark, M. R., Campbell, K. S., Kazlauskas, A., Johnson, S. A., Hertz, M., Potter, T. A., Pleiman, C. and Gambier, J. C. 1992. The B cell antigen receptor complex: association of Ig-a and Ig-β with distinct cytoplasmic effectors. Science 258:123.
16. Yamanashi, Y., Kakiuchi, T., Mizuguchi, J., Yamamoto, T. and Toyoshima, K. 1991. Association of B cell antigen receptor with protein tyrosine kinase Lyn. Sc/ence251:192.
17. Campbell, M.-A. and Sefton, B. M. 1992. Association between B-lymphocyte membrane immunoglobulin and multiple members of the src-family of protein tyrosine kinases. Mol. Cell. Biol. 12:2315.
18. Gold, M. R., Chiu, R., Ingham, R. J., Saxton, T. M., van Oostveen, I., Watts, J. D., Affolter, M. and Aebersold, R. 1994. Activation and serine phosphorylation of the p56lck protein tyrosine kinase in response to antigen receptor cross-linking in B lymphocytes. J. Immunol. 153:2369.
19. Dymecki, S. M., Niederhuber, J. E. and Desiderio, S. V. 1990. Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science 247:332.
20. Taniguchi, T., Kobayashi, T., Kondo, J., Takahashi, K., Nakamura, H., Suzuki, J., Nagai, K., Yamada, T., Nakamura, S. I. and Yamamura, H. 1991. Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J. Biol. Chem. 266:15790.
21. Hutchcroft, J. E., Harrison, M. L. and Geahlen, R. L. 1992. Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J. Biol. Chem. 267:8613.
22. Yamanashi, Y, Fukui, Y, Wongsasant, B., Kinoshita, Y, Ichimori, Y, Toyoshima, K. and Yamamoto, T. 1992. Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling. Proc. Natl Acad. Sci. USA 89:1118.
23. Gold, M. R., Chan, V. W.-F., Turck, C. W. and DeFranco, A. L. 1992. Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes. J. Immunol. 148:2012.
24. Kuwahara, K., Matsuo, T., Nomura, J., Igarashi, H., Kimoto, M., Inui, S. and Sakaguchi, N. 1994. Identification of a 52-kDa molecule (p52) coprecipitated with the Ig receptor-related MB-1 protein that is inducibly phosphorylated by the stimulation with phorbol myristate acetate. J. Immunol. 152:2742.
25. Inui, S., Kuwahara, K., Mizutani, J., Maeda, K., Kawai, T., Nakayasu, H. and Sakaguchi, N. 1995. Molecular cloning of a cDNA clone encoding a phosphoprotein component related to the Ig receptor-mediated signal transduction. J. Immunol. 154:2714.
26. Saxton, T. M., van Oostveen, I., Bowtell, D., Aebersold, R. and Gold, M. R. 1994. B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein. J. Immunol. 153:623.
27. Sakaguchi, N., Matsuo, T., Nomura, J., Kuwahara, K., Igarashi, H. and Inui, S. 1993. Immunoglobulin receptor-associated molecules. Adv. Immunol. 54:337.
28. Pleiman, C. M., D'Ambrosio, D. and Gambier, J. C. 1994. The B-cell antigen receptor complex: structure and signal transduction. Immunol. Today 15:393.
29. Takata, M., Sabe, H., Hâta, A., Inazu, T., Homma, Y, Nukada, T., Yamamura, H. and Kurosaki, T. 1994. Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J. 13:1341.
30. c-src complexes, and PI3-kinase. Cell 65:91.
31. Miles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayotou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtneidge, S. A., Parker, P. J. and Waterfield, M. D. 1992. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419.
32. Cantley, L C., Anger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R. and Soltoff, S. 1991. Oncogenes and signal transduction. Cell 64:281.
33. Kuwahara, K., Igarashi, H., Kawai, T., Ichigi, Y, Muraguchi, A., Mason, D. Y, Kimoto, M., Inui, S. and Sakaguchi, N. 1993. Induction of tyrosine phosphorylation in human B lineage cells by cross-linking MB-1 molecule of B cell receptor-related heterodimer complex. Biochem. Biophys. Res. Commun. 197:1563.
34. Kudo, A., Bauer, S. R. and Melchers F. 1989. Structure, control of expression and putative function of the preB cell-specific genes VpreB and Xc. In Melchers, F., ed., Progress in Immunology, Vol. VII, p. 339. Springer-Verlag, Berlin.
35. Bossy, D., Salamero, J., Olive, D., Fougereau, M. and Schiff, C. 1993. Structure, biosynthesis, and transduction properties of the human n-yL complex: similar behavior of preB and intermediate preB-B cells in transducing ability. Int. Immunol. 5:467.
36. Lassoued, K., Nunez, C. A., Billips, L, Kubagawa, H., Monteiro, R. C., LeBien, T. W. and Cooper, M. D. 1993. Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation. Cell 73:73.
37. Matsuo, Y and Minowada, J. 1988. Human leukemia cell lines. Hum. Cell 1:263.
38. Findley, H. W., Cooper, M. D., Kim, J. H., Alvarado, C. and Ragab, A. H. 1982. Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes. B/ood60:1305.
39. Karasuyama, H., Relink, A. and Melchers, F. 1993. A complex of glycoprotein is associated with VpreBA.5 surrogate light chain on the surface of n heavy chain-negative early precursor B cell lines.J. Exp. Med. 178:469.
40. Law, C.-L, Sidorenko, S. P., Chandran, K. A., Graves, K. E., Chan, A. C., Weiss, A., Edelhoff, S., Disteche. C. M. and Clark, E. A. 1994. Molecular cloning of human Syk. J. Bio]. Chem. 269:12310.
41. Kikuchi, H., Imajoh-Ohmi, S. and Kanegasaki, S. 1993. Novel antibodies specific for proteolyzed forms of protein kinase C: production of anti-peptide antibodies available for in situ analysis of intracellular limited proteolysis. Biochim. Biophysics. Acta. 1162:171.
42. Kikuchi, H. and Imajoh-Ohmi, S. 1995. Antibodies specific for proteolyzed forms of protein kinase C a. Biochim. Biophys. Acta 1269:253.
43. Matsuo, T., Nomura, J., Kuwahara, K., Igarashi, H., Inui, S., Hamaguchi, M., Kimoto, M. and Sakaguchi, N. 1993. Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells. J. Immunol. 150:3766.
44. Nomura, J., Matsuo, T., Kubota, E., Kimoto, M. and Sakaguchi, N. 1991. Signal transmission through the B cell-specific MB-1 molecule at the pre-B cell stage. Int. Immunol. 3:117.
45. Igarashi, H., Kuwahara, K., Nomura, J., Matsuda, A., Kikuchi, K., Inui, S. and Sakaguchi, N. 1994. B cell Ag receptor mediates different types of signals in the protein kinase activity between immature B cell and mature B cell. J. Immunol. 153:2381.
46. Yamanashi, Y., Okada, M., Semba, T., Yamori, T., Umemori, H., Tsunasawa, S., Toyoshima, K., Kitamura, D., Watanabe, T. and Yamamoto, T. 1993. Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. Proc. Natl. Acad. USA 90:3631.
47. Yanagi, S., Sada, K., Tohyama, Y., Tsubokawa, M., Nagai, K., Yonezawa, K. and Yamamura, . 1994. Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation. Eur. J. Biochem. 224:329.
48. Sidorenko, S. P., Law, C.-L, Chandran, K. A. and Clark, E. A. 1995. Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/p56Lyn and a 120-kDa phosphoprotein. Proc. Natl Acad. Sci. USA 92:359.
49. Chen, 2. Z., Coggeshall, K. M. and Cambier, J. C. 1986. Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J. Immunol. 136:2300.
50. Hâta, A., Sabe, H., Kurosaki, T., Takata, M. and Hanafusa, H. 1994. Functional analysis of Csk in signal transduction through the B cell antigen receptor. Mol. Cell. Biol. 14:7306.
51. Melchers, F., Strasser, A., Bauer, S. R., Kudo, A., Thalmann, P. and Rolink, A. 1989. Cellular stages and molecular steps of murine B-cell development. Cold Spring Harbor Symp. Quant. Biol. 54:183.
52. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Müller, W. and Rajewsky, K. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
53. Karasuyama, H., Rolink, A., Shinkai, Y, Young, F., Alt, F. W. and Melchers, F. 1994. The expression of Vpre_B/X5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77:133.
54. Takemori, T., Mizuguchi, J., Miyazoe, I., Nakanishi, M., Shigemoto, K., Kimoto, H., Shirasawa, T., Maruyama, N. and Taniguchi, M. 1990. Two types of \i chain complexes are expressed during differentiation from pre-B to mature B cells. EMBO J. 9:2493.
55. Brauns, G. S., De Vries, E., Van Noesel, C. J., Mason, D. Y, Van Lier, R. A. W. and Borst, J. 1993. The structure of the n/pseudo light chain complex on human pre-B cells consistent with a function in signal transduction. Eur. J. Immunol. 23:1088.
56. Hibbs, M. L, Tarlington, D. M., Armes, J., Grail, D., Hodgson, G., Marglitto, R., Stacker, S. A. and Dünn, A. R. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83:301.
57. Nishizumi, H., Tahiuchi, I., Yamanashi, Y, Kitamura, D., Ilic, D., Mori, S., Watanabe, T. and Yamamoto, T. 1995. Impaired proliferation of peripheral B cells and indication of autoimmune disease in /yn-deficient mice. Immunity 3:549.
58. Turner, M., Mee, P. J., Costello, P. S., Williams, O., Price, A. A., Duddy, L. P., Furlong, M. T., Geahlen, R. L. and Tybulewicz, V. L. J. 1995. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298.
59. Cheng, A. M., Rowley, B., Pao, W., Hayday, A., Bolen, J. B. and Pawson, T. 1995. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378:303.
60. Aoki, Y, Isselbacher, K. J., Cherayil, B. J. and Pillai, S. 1994. Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutive in pre-B cells. Proc. Natl Acad. Sci. USA 91:4204.
61. Aoki, Y, Isselbacher, K. J. and Pillai, S. 1994. Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc. Natl Acad. Sci. USA 91:10606.