Biased V(H) gene usage in early lineage human B cells: Evidence for preferential Ig gene rearrangement in the absence of selection

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2732-2740

  Rao, Sambasiva P ^a   Riggs, Jeffrey M ^a   Friedman, David F ^b   Scully, Michael S ^b   LeBien, Tucker W ^c   Silberstein, Leslie E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; CELL SELECTION; COMPLEMENTARITY DETERMINING REGION; FETUS; FREQUENCY ANALYSIS; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC SELECTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; ONTOGENY; PRIORITY JOURNAL; STEM CELL; ADULT; BONE MARROW CELL; CELL DIFFERENTIATION; COMPARATIVE STUDY; GENE FREQUENCY; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; LIVER; METABOLISM; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE;

ADULT; B-LYMPHOCYTES; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; FETUS; GENE FREQUENCY; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LIVER; MULTIGENE FAMILY; READING FRAMES; STEM CELLS;

EID: 0033181326     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Hardy, R. R., C. C. Carmack, S. A. Shinton, J. D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
2. Rolink, A., U. Grawunder, T. H. Winkler, H. Karasuyama, and F. Melchers. 1994. IL-2 receptor α chain (CD25,TAC) expression defines a crucial stage in pre-B cell development. Int. Immunol. 6:1257.
3. Ghia, P., E. ten Boekel, E. Sanz, A. de la Hera, A. Rolink, and F. Melchers. 1996. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analysis of the rearrangement status of the immunoglobulin H and L chain gene loci. J. Exp. Med 184:2217.
4. Melchers, F., H. Karasuyama, D. Haasner, S. Bauer, A. Kudo, N. Sakaguchi, B. Jameson, and A. Rolink. 1993. The surrogate light chain in B-cell development. Immunol. Today 14:60.
5. Matsuda, F., K. Ishii, P. Bourvagnet, K. Kuma, H. Hayashida, T. Miyata, and T. Honjo. 1998. The complete nucleolide sequence of the human immunoglobulin heavy chain variable region locus. J. Exp. Med 188:2151.
6. H repertoire. Immunol. Today 16:237.
7. Brezinschek, H. P., R. I. Brezinschek, and P. E. Lipsky. 1995. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol. 155:190.
8. H gene segments in the human adult antibody repertoire. J. Immunol 154:3902.
9. Kraj, P., S. P. Rao, A. M. Glas, R. R. Hardy, E. C. B. Milner, and L. E. Silberstein. 1997. The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells. J. Immunol. 158:5824.
10. + B cells. Immunogenetics 42:132.
11. H4.21) Ig gene in the normal adult human peripheral blood B cell repertoire. J. Immunol. 154:6406.
12. Schroeder, H. W., J. I. Hillson, and R M. Perlmutter. 1987. Early restriction of the human antibody repertoire. Science 238:791.
13. Schroeder, H. Y., and J. Y. Wang. 1990. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. Proc. Natl. Acad. Sci. USA 87:6146.
14. Pascual, V., L. Verkruyse, M. L. Casey, and J. D. Capra. 1993. Analysis of Ig H chain gene segment utilization in human fetal liver. J. Immunol. 151:4164.
15. Milili, M., C. Schiff, M. Fougereau, and C. Tonnelle. 1996. The VDJ repertoire expressed in human pre-B cells reflects the selection of bona fide heavy chains. Eur. J. Immunol. 26:63.
16. Bertrand, F. E. III, L. G. Billips, P. D. Burrows, G. L. Gartland, H. Kubagawa, and H. W. Schroeder Jr. 1997. Ig DH gene segment transcription and rearrangement before surface expression of the pan-B-cell marker CD19 in normal human bone marrow. Blood 90:736.
17. Dittel, B. N., and T. W. LeBien. 1995. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. J. Immunol. 154:58.
18. Pribyl, J. A. R., N. Shah, B. N. Dittel, and T. W. LeBien. 1997. Methods for purification and growth of human B cell precursors in bone marrow stromal cell-dependent cultures. In Immunonology Methods Manual: The Comprehensive Sourcebook of Techniques. I. Lefkovits, ed. Academic Press, London.
19. H3 genes. J. Immunol. 145:2751.
20. H4 gene family. J. Immunol. 150:2858.
21. Huang, S. C., R. Jiang, A. M. Glas, and E. C. B. Milner. 1996. Non-stochastic utilization of Ig V region genes in unselected human peripheral B cells. Mol. Immunol. 33:553.
22. Suzuki, I., E. C. B. Milner, A. M. Glas, W. O. Hufnagle, S. P. Rao, L. Pfister, and C. Nottenburg. 1996. Immunoglobulin heavy chain variable region gene usage in bone marrow transplant recipients: lack of somatic mutation indicates a maturational arrest. J. Immunol. 87:1873.
23. H3 repertoire among genetically disparate individuals. Exp. Clin. Immunogenet. 13:131.
24. H repertoire in human B lymphocytes stimulated by CD40 ligand and IL-4: evidence for positive and negative selection mechanisms coupled to CD40 activation. Mol. Immunol. 33:1369.
25. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
26. H genes. Ann. NY Acad Sci. 764:50.
27. Reth, M., and L. Leclercq. 1987. Assembly of immunoglobulin variable region gene segments. In Molecular Genetics of Immunoglobulin. F. Calabi and M. S. Neuberger, eds. Elsevier Science, Amsterdam.
28. - pre-B cells of newborn mice. J. Immunol. 154:1246.
29. + cells. Blood 90:4014.
30. Hillson, J. L., I. R. Oppliger, E. H. Sasso, E. C. B. Milner, and M. H. Wener. 1992. Emerging human B cell repertoire; influence of development stage and interindividual variation. J. Immunol. 149:3741.
31. Cuisinier, A. M., L. Gauthier, L. Boubli, M. Fougereau, and C. Tonnelle. 1993. Mechanisms that generate human immunoglobulin diversity operate from the 8th week of gestation in fetal liver. Eur. J. Immunol. 23:110.
32. Alt, F. W., G. D. Yancopoulos, T. K. Blackwell, C. Wood, E. Thomas, M. Boss, R. Coffman, N. Rosenberg, S. Tonegawa, and D. Baltimore. 1984. Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3:1209.
33. Loffert, D., S. Schaal, A Ehlich, R. R. Hardy, Y. R. Zou, W. Muller, and K. Rajewsky. 1994. Early B-cell development in mouse: insights from mutations introduced by gene targeting. Immunol. Rev. 137:135.
34. H structure of the μ/surrogate L chain receptor. EMBO J. 15:1524.
35. H3 genes and short diverse third complementarity-determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements. Eur. J. Immunol. 22:247.
36. Huang, C., A. K. Stewart, R. S. Schwartz, and B. D. Stellar. 1992. Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes. J. Clin. Invest. 89:1331.
37. Ehlich, A., V. Martin, W. Muller, and K. Rajewsky. 1994. Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4:573.
38. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature 381:751.
39. Berman, J. E., and F. W. Alt. 1990. Human heavy chain variable region gene diversity, organization, and expression. Int. Rev. Immunol. 5:203.
40. Hope, T. J., R. J. Aguilera, M. E. Minie, and S. Hitoshi. 1986. Endonucleolytic activity that cleaves immunoglobulin recombination sequences. Science 231:1141.
41. Cuomo, C. A., C. L. Mundy, and M. A. Oettinger. 1996. DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences. Mol. Cell. Biol. 16:5683.
42. Ramsden, D. A., J. F. McBlane, D. C. van Gent, and M. Gellert. 1996. Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage. EMBO J. 15:3197.
43. H genes. Science 227:1597.
44. H gene segments in pre-B-cell lines. Nature 311:727.
45. H6 gene in immature B lymphoid cells. Eur. J. Immunol. 21:1311.
46. H6, in the expressed immune repertoire. J. Immunol. 150:4985.
47. H region. J. Exp. Med. 167:1499.
48. H81X usage during B cell development: initial decline in usage is independent of Ig heavy chain cell surface expression. J. Immunol. 156:2077.
49. Van Dijk, W. K., H. W. Schroeder, R. G. Perlmutter, and E. C. B. Milner. 1992. Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire. Proc. Natl. Acad. Sci. USA 89: 10430.
50. H4) using deletional analysis and pulse field gel electrophoresis. J. Immunol. 148:2923.
51. Keyna, U., G. B. Beck-Engeser, J. Jongstra, S. E. Applequist, and H. M. Jack. 1995. Surrogate light chain-dependent selection of Ig heavy chain V regions. J. Immunol. 155:5536.
52. H81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains. J. Immunol. 147:1406.
53. Decker, D. J., G. H. Kline, T. A. Hayden, S. N. Zaharevitz, and N. R. Klinman. 1995. Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition. J. Immunol. 154:4924.
54. H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.