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Volumn 15, Issue 8, 1996, Pages 1914-1923

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor

Author keywords

Cytotoxicity; IL 6; MAP kinases; NF B; TNF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOKINE; ENZYME INHIBITOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR;

EID: 0029983730     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00542.x     Document Type: Article
Times cited : (611)

References (64)
  • 1
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle, P A, and Henkel, T. (1994) Function and activation of NF-κB in the immune system. Annu. Rev. Immunol , 12, 141-179.
    • (1994) Annu. Rev. Immunol , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 2
    • 0028806565 scopus 로고
    • Identification of novel phosphorylation sites required for the activation of MAPKAP kinase-2
    • Ben-Levy, R., Leighton, I.A., Doza, Y.N., Attwood, P., Morrice, N., Marshall, C.J and Cohen, P. (1995) Identification of novel phosphorylation sites required for the activation of MAPKAP kinase-2. EMBO J., 14, 5920-5930.
    • (1995) EMBO J. , vol.14 , pp. 5920-5930
    • Ben-Levy, R.1    Leighton, I.A.2    Doza, Y.N.3    Attwood, P.4    Morrice, N.5    Marshall, C.J.6    Cohen, P.7
  • 3
    • 0028349539 scopus 로고
    • Molecular mechanisms of tumor necrosis factor-induced cytotoxicity: What we do understand and what we do not
    • Beyaert, R. and Fiers, W. (1994) Molecular mechanisms of tumor necrosis factor-induced cytotoxicity: what we do understand and what we do not. FEBS Lett., 340, 9-16.
    • (1994) FEBS Lett. , vol.340 , pp. 9-16
    • Beyaert, R.1    Fiers, W.2
  • 4
    • 0025260405 scopus 로고
    • Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement
    • Beyaert, R., Suffys, P. Van Roy, F. and Fiers, W. (1990) Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement. FEBS Lett., 262, 93-96.
    • (1990) FEBS Lett. , vol.262 , pp. 93-96
    • Beyaert, R.1    Suffys, P.2    Van Roy, F.3    Fiers, W.4
  • 5
    • 0026198734 scopus 로고
    • Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression
    • Beyaert, R., Schulze-Osthoff, K., Van Roy, F. and Fiers, W. (1991) Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression. Cytokine, 3, 284-291.
    • (1991) Cytokine , vol.3 , pp. 284-291
    • Beyaert, R.1    Schulze-Osthoff, K.2    Van Roy, F.3    Fiers, W.4
  • 7
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian MAPKs
    • Cano, E. and Mahadevan, L C. (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci. 20, 117-122.
    • (1995) Trends Biochem Sci. , vol.20 , pp. 117-122
    • Cano, E.1    Mahadevan, L.C.2
  • 8
    • 0028988138 scopus 로고
    • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R. and Lee, J C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364, 229-233.
    • (1995) FEBS Lett. , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6    Young, P.R.7    Lee, J.C.8
  • 9
    • 0028935974 scopus 로고
    • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
    • Dérijard, B , Raingeaud, J., Barrett, T., Wu, I, Han, J , Ulevitch, R.J. and Davis, R.J. (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 267, 682-685.
    • (1995) Science , vol.267 , pp. 682-685
    • Dérijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 10
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • Dignam, J.D., Lebovitz, R.M and Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res , 11, 1475-1489.
    • (1983) Nucleic Acids Res , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 11
    • 0028969480 scopus 로고
    • Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells
    • Doza, Y.N., Cuenda, A., Thomas, G.M., Cohen, P. and Nebreda, A.R. (1995) Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. FEBS Lett., 364, 223-228.
    • (1995) FEBS Lett. , vol.364 , pp. 223-228
    • Doza, Y.N.1    Cuenda, A.2    Thomas, G.M.3    Cohen, P.4    Nebreda, A.R.5
  • 12
    • 0027296741 scopus 로고
    • Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements
    • Du, W., Thanos, D. and Maniatis, T (1993) Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell, 74, 887-898
    • (1993) Cell , vol.74 , pp. 887-898
    • Du, W.1    Thanos, D.2    Maniatis, T.3
  • 13
    • 0001903141 scopus 로고
    • Biologic therapy with TNF: Preclinical studies
    • DeVita, V.T., Jr. Hellman, S. and Rosenberg, S.A (eds), J.B. Lippincott, Philadelphia, PA
    • Fiers, W. (1995) Biologic therapy with TNF: preclinical studies In DeVita, V.T., Jr. Hellman, S. and Rosenberg, S.A (eds), Biologic Therapy of Cancer, 2nd edn J.B. Lippincott, Philadelphia, PA, pp. 295-327.
    • (1995) Biologic Therapy of Cancer, 2nd Edn , pp. 295-327
    • Fiers, W.1
  • 14
    • 0028015872 scopus 로고
    • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
    • Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J. and Saklatvala, J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27. Cell, 78, 1039-1049.
    • (1994) Cell , vol.78 , pp. 1039-1049
    • Freshney, N.W.1    Rawlinson, L.2    Guesdon, F.3    Jones, E.4    Cowley, S.5    Hsuan, J.6    Saklatvala, J.7
  • 15
    • 0027994002 scopus 로고
    • An osmosensing signal transduction pathway in mammalian cells
    • Galcheva-Gargova, Z., Dérijard, B., Wu, I.H. and Davis, R.J. (1994) An osmosensing signal transduction pathway in mammalian cells. Science, 265, 806-808.
    • (1994) Science , vol.265 , pp. 806-808
    • Galcheva-Gargova, Z.1    Dérijard, B.2    Wu, I.H.3    Davis, R.J.4
  • 16
    • 0027516631 scopus 로고
    • Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and β-casein
    • Guesdon, R. Freshney, N., Waller, R.J., Rawlinson, L. and Saklatvala, J. (1993) Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and β-casein. J. Biol. Chem , 268, 4236-4243.
    • (1993) J. Biol. Chem , vol.268 , pp. 4236-4243
    • Guesdon, R.1    Freshney, N.2    Waller, R.J.3    Rawlinson, L.4    Saklatvala, J.5
  • 17
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • Gupta, S., Campbell, D., Dérijard, B. and Davis, R.J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science, 267, 389-393.
    • (1995) Science , vol.267 , pp. 389-393
    • Gupta, S.1    Campbell, D.2    Dérijard, B.3    Davis, R.J.4
  • 18
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han, J., Lee, J.-D., Bibbs, L. and Ulevitch, R.J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265, 808-811.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.-D.2    Bibbs, L.3    Ulevitch, R.J.4
  • 19
    • 0027176524 scopus 로고
    • Rapid proteolysis of IκB-α is necessary for actuation of transcription factor NF-αB
    • Henkel, T., Machleidt, T., Alkalay, I., Krönke, M., Ben-Neriah, Y. and Baeuerle, P.A. (1993) Rapid proteolysis of IκB-α is necessary for actuation of transcription factor NF-αB. Nature, 365, 182-185.
    • (1993) Nature , vol.365 , pp. 182-185
    • Henkel, T.1    Machleidt, T.2    Alkalay, I.3    Krönke, M.4    Ben-Neriah, Y.5    Baeuerle, P.A.6
  • 20
    • 0023829530 scopus 로고
    • Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor
    • Hepburn, A., Demolle, D , Boeynaems, J.M., Fiers, W. and Dumont, G.E. (1988) Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor. FEBS Lett , 227, 175-178.
    • (1988) FEBS Lett , vol.227 , pp. 175-178
    • Hepburn, A.1    Demolle, D.2    Boeynaems, J.M.3    Fiers, W.4    Dumont, G.E.5
  • 21
    • 0029002899 scopus 로고
    • A role for phosphorylation and degradation in the control of NF-κB activity
    • Israël, A. (1995) A role for phosphorylation and degradation in the control of NF-κB activity. Trends Genet., 11, 203-205.
    • (1995) Trends Genet. , vol.11 , pp. 203-205
    • Israël, A.1
  • 22
    • 0026703222 scopus 로고
    • Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity
    • Jäättelä, M., Wissing, D., Bauer, P.A. and Li, G.C. (1992) Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity EMBO J., 11, 3507-3512.
    • (1992) EMBO J. , vol.11 , pp. 3507-3512
    • Jäättelä, M.1    Wissing, D.2    Bauer, P.A.3    Li, G.C.4
  • 23
    • 0028322193 scopus 로고
    • Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors
    • Karin, M. (1994) Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr. Opin. Cell Biol., 6, 415-424
    • (1994) Curr. Opin. Cell Biol. , vol.6 , pp. 415-424
    • Karin, M.1
  • 25
    • 0027454228 scopus 로고
    • Association between protooncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB
    • Kerr, L.D , Ransone, L.J., Wamsley, P., Schmitt, M.J., Boyer, T G., Zhou, Q., Berk, A.J and Verma, I.M. (1993) Association between protooncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-κB. Nature, 365, 412-419
    • (1993) Nature , vol.365 , pp. 412-419
    • Kerr, L.D.1    Ransone, L.J.2    Wamsley, P.3    Schmitt, M.J.4    Boyer, T.G.5    Zhou, Q.6    Berk, A.J.7    Verma, I.M.8
  • 26
    • 0027957356 scopus 로고
    • Stress-and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance
    • Knauf, U., Jakob, U., Engel, K., Buchner, J. and Gaestel, M (1994) Stress-and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance. EMBO J, 13, 54-60.
    • (1994) EMBO J , vol.13 , pp. 54-60
    • Knauf, U.1    Jakob, U.2    Engel, K.3    Buchner, J.4    Gaestel, M.5
  • 28
    • 0027482463 scopus 로고
    • Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27
    • Lavoie, J.N., Hickey, E., Weber, L.A. and Landry, J. (1993) Modulation of actin microfilament dynamics and fluid phase pinocytosis by phosphorylation of heat shock protein 27. J. Biol. Chem., 268, 24210-24214.
    • (1993) J. Biol. Chem. , vol.268 , pp. 24210-24214
    • Lavoie, J.N.1    Hickey, E.2    Weber, L.A.3    Landry, J.4
  • 29
    • 0028924759 scopus 로고
    • Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
    • Lavoie, J.N., Lambert, H., Hickey, E., Weber, L.A. and Landry, J. (1995) Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol. Cell. Biol , 15, 505-516.
    • (1995) Mol. Cell. Biol , vol.15 , pp. 505-516
    • Lavoie, J.N.1    Lambert, H.2    Hickey, E.3    Weber, L.A.4    Landry, J.5
  • 30
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee, J.C. et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372, 739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1
  • 31
    • 0024475227 scopus 로고
    • NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
    • Lenardo, M.J. and Baltimore, D. (1989) NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell, 58, 227-229.
    • (1989) Cell , vol.58 , pp. 227-229
    • Lenardo, M.J.1    Baltimore, D.2
  • 32
    • 0025343895 scopus 로고
    • Activation of interleukin-6 gene expression through the NF-κB transcription factor
    • Libermann, T.A. and Baltimore, D (1990) Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol Cell. Biol., 10, 2327-2334.
    • (1990) Mol Cell. Biol. , vol.10 , pp. 2327-2334
    • Libermann, T.A.1    Baltimore, D.2
  • 34
    • 0029034251 scopus 로고
    • ATF-2 contains a phosphorylation-dependent transcriptional activation domain
    • Livingstone, C., Patel, G. and Jones, N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J , 14, 1785-1797
    • (1995) EMBO J , vol.14 , pp. 1785-1797
    • Livingstone, C.1    Patel, G.2    Jones, N.3
  • 35
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall, C.J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80, 179-185.
    • (1995) Cell. , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 36
    • 0025889011 scopus 로고
    • Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor α
    • Mathias, S., Dressler, K.A. and Kolesnick, R.N. (1991) Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor α. Proc. Natl Acad. Sci. USA, 88, 10009-10013.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 10009-10013
    • Mathias, S.1    Dressler, K.A.2    Kolesnick, R.N.3
  • 37
    • 0028817419 scopus 로고
    • Constitutive expression of human hsp27, Drosophila hsp27, or human αB-crystallin confers resistance to TNF-and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts
    • Mehlen, P. Preville, X., Chareyron, P., Briolay, J., Klemenz, R. and Arrigo, A.-P (1995) Constitutive expression of human hsp27, Drosophila hsp27, or human αB-crystallin confers resistance to TNF-and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts. J. Immunol., 154, 363-374
    • (1995) J. Immunol. , vol.154 , pp. 363-374
    • Mehlen, P.1    Preville, X.2    Chareyron, P.3    Briolay, J.4    Klemenz, R.5    Arrigo, A.-P.6
  • 38
    • 0025813543 scopus 로고
    • A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein
    • Miron, T., Vancompernolle, K., Vandekerckhove, J., Wilchek, M. and Geiger, B. (1991) A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J. Cell Biol., 114, 255-261.
    • (1991) J. Cell Biol. , vol.114 , pp. 255-261
    • Miron, T.1    Vancompernolle, K.2    Vandekerckhove, J.3    Wilchek, M.4    Geiger, B.5
  • 39
    • 0029003788 scopus 로고
    • PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid
    • Müller, G., Ayoub, M., Storz, P. Rennecke, J., Fabbro, D and Pfizenmaier, K. (1995) PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J., 14, 1961-1969.
    • (1995) EMBO J. , vol.14 , pp. 1961-1969
    • Müller, G.1    Ayoub, M.2    Storz, P.3    Rennecke, J.4    Fabbro, D.5    Pfizenmaier, K.6
  • 40
    • 0028170265 scopus 로고
    • Activation of NF-κB in vivo is regulated by multiple phosphorylations
    • Naumann, M. and Scheidereit, C. (1994) Activation of NF-κB in vivo is regulated by multiple phosphorylations. EMBO J., 13, 4597-1607.
    • (1994) EMBO J. , vol.13 , pp. 4597-11607
    • Naumann, M.1    Scheidereit, C.2
  • 41
    • 0027746269 scopus 로고
    • Activation of the nuclear factor κB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression
    • Patestos, N.P., Haegeman, G , Vandevoorde, V. and Fiers, W. (1993) Activation of the nuclear factor κB is not sufficient for regulation of tumor necrosis factor-induced interleukin-6 gene expression. Biochimie, 75, 1007-1018.
    • (1993) Biochimie , vol.75 , pp. 1007-1018
    • Patestos, N.P.1    Haegeman, G.2    Vandevoorde, V.3    Fiers, W.4
  • 42
    • 0344627945 scopus 로고
    • Oligonucleotide that binds nuclear factor NF-κB acts as a lymphoid-specific and inducible enhancer element
    • Pierce, J. W., Lenardo, M. and Baltimore, D. (1988) Oligonucleotide that binds nuclear factor NF-κB acts as a lymphoid-specific and inducible enhancer element Proc. Natl Acad. Sci. USA, 85, 1482-1486.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 1482-1486
    • Pierce, J.W.1    Lenardo, M.2    Baltimore, D.3
  • 43
    • 0029090620 scopus 로고
    • Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha
    • Prichett, W., Hand, A., Sheilds, J. and Dunnington, D. (1995) Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. J. Inflamm., 45, 97-105.
    • (1995) J. Inflamm. , vol.45 , pp. 97-105
    • Prichett, W.1    Hand, A.2    Sheilds, J.3    Dunnington, D.4
  • 44
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J. and Davis, R.J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem , 270, 7420-7426.
    • (1995) J. Biol. Chem , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 45
    • 0025047444 scopus 로고
    • On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: Enhancer, TATA box, and RNA start site (Inr motif) occlusion
    • Ray, A., LaForge, K.S. and Sehgal, P.B (1990) On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion. Mol. Cell. Biol., 10, 5736-5746.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5736-5746
    • Ray, A.1    LaForge, K.S.2    Sehgal, P.B.3
  • 46
    • 0027451924 scopus 로고
    • In vivo control of NF-κB activation by IκBα
    • Rice, N.R and Ernst, M.K. (1993) In vivo control of NF-κB activation by IκBα. EMBO J., 12, 4685-4695.
    • (1993) EMBO J. , vol.12 , pp. 4685-4695
    • Rice, N.R.1    Ernst, M.K.2
  • 47
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse, J , Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A , Zamanillo, D., Hunt, T. and Nebreda, A.R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins Cell, 78, 1027-1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 48
    • 0028960452 scopus 로고
    • Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators
    • Schmitz, M L., Stelzer, G., Altmann, H., Meisterernst, M. and Baeuerle, P.A. (1995a) Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators. J. Biol Chem., 270, 7219-7226
    • (1995) J. Biol Chem. , vol.270 , pp. 7219-7226
    • Schmitz, M.L.1    Stelzer, G.2    Altmann, H.3    Meisterernst, M.4    Baeuerle, P.A.5
  • 50
    • 0024506455 scopus 로고
    • Tumor necrosis factor signal transduction: Tissue-specific serine phosphorylation of a 26-kDa cytosolic protein
    • Schütze, S , Scheurich, P., Pfizenmaier, K. and Krönke, M. (1989) Tumor necrosis factor signal transduction: tissue-specific serine phosphorylation of a 26-kDa cytosolic protein J. Biol. Chem. 264, 3562-3567.
    • (1989) J. Biol. Chem. , vol.264 , pp. 3562-3567
    • Schütze, S.1    Scheurich, P.2    Pfizenmaier, K.3    Krönke, M.4
  • 51
    • 0027739284 scopus 로고
    • The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
    • Stokoe, D, Caudwell, B., Cohen, P.T. and Cohen, P. (1993) The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem. J , 296, 843-849.
    • (1993) Biochem. J , vol.296 , pp. 843-849
    • Stokoe, D.1    Caudwell, B.2    Cohen, P.T.3    Cohen, P.4
  • 53
    • 0024157116 scopus 로고
    • Genomic structure of the murine IL-6 gene High degree conservation of potential regulatory sequences between mouse and human
    • Tanabe, O., Akira, S., Kamiya, T., Wong, G.G., Hirano, T. and Kishimoto, T. (1988) Genomic structure of the murine IL-6 gene High degree conservation of potential regulatory sequences between mouse and human. J. Immunol , 141, 3875-3881.
    • (1988) J. Immunol , vol.141 , pp. 3875-3881
    • Tanabe, O.1    Akira, S.2    Kamiya, T.3    Wong, G.G.4    Hirano, T.5    Kishimoto, T.6
  • 55
    • 0029030855 scopus 로고
    • ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents
    • van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P. and Angel, P (1995) ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J., 14, 1798-1811
    • (1995) EMBO J. , vol.14 , pp. 1798-1811
    • Van Dam, H.1    Wilhelm, D.2    Herr, I.3    Steffen, A.4    Herrlich, P.5    Angel, P.6
  • 56
  • 57
    • 0025942531 scopus 로고
    • Tumor nectosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells
    • Vandevoorde, V., Haegeman, G. and Fiers, W. (1991) Tumor nectosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells. Biochem. Biophys. Res. Commun., 178, 993-1001.
    • (1991) Biochem. Biophys. Res. Commun. , vol.178 , pp. 993-1001
    • Vandevoorde, V.1    Haegeman, G.2    Fiers, W.3
  • 58
    • 0027076644 scopus 로고
    • Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway
    • Van Lint, J., Agostinis, P., Vandevoorde, V., Haegeman, G., Fiers, W., Merlevede, W. and Vandenheede, J.R. (1992) Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway. J. Biol. Chem., 267, 25916-25921.
    • (1992) J. Biol. Chem. , vol.267 , pp. 25916-25921
    • Van Lint, J.1    Agostinis, P.2    Vandevoorde, V.3    Haegeman, G.4    Fiers, W.5    Merlevede, W.6    Vandenheede, J.R.7
  • 59
    • 0025260903 scopus 로고
    • Interleukin-6: An overview
    • Van Snick, J. (1990) Interleukin-6: an overview. Annu. Rev. Immunol., 8, 253-278.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 253-278
    • Van Snick, J.1
  • 60
    • 0027209271 scopus 로고
    • Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts
    • Vietor, I., Schwenger, P, Li, W., Schlessinger, J. and Vilček, J. (1993) Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts. J. Biol. Chem., 268, 18994-18999.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18994-18999
    • Vietor, I.1    Schwenger, P.2    Li, W.3    Schlessinger, J.4    Vilček, J.5
  • 61
    • 0023837807 scopus 로고
    • 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines
    • 2/B cell differentiation factor BSF-2/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J. Immunol., 140, 974-977.
    • (1988) J. Immunol. , vol.140 , pp. 974-977
    • Walther, Z.1    May, L.T.2    Sehgal, P.B.3
  • 63
    • 0141929200 scopus 로고
    • Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts, role in the induction of interleukin 6
    • Zhang, Y., Lin, J.-X , Yip, Y.K. and Vilček, J. (1988) Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts, role in the induction of interleukin 6. Proc. Natl Acad. Sci. USA, 85, 6802-6805.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 6802-6805
    • Zhang, Y.1    Lin, J.-X.2    Yip, Y.K.3    Vilček, J.4
  • 64
    • 0025280023 scopus 로고
    • Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblast involves activation of a nuclear factor binding to a κB-like sequence
    • Zhang, Y., Lin, J.-X. and Vilček, J. (1990) Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblast involves activation of a nuclear factor binding to a κB-like sequence. Mol. Cell. Biol., 10, 3818-3823.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3818-3823
    • Zhang, Y.1    Lin, J.-X.2    Vilček, J.3


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