Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 6005-6013

  Marshall, Lisa A ^a,b   Hansbury, Michael J ^b   Bolognese, Brian J ^b   Gum, Rebecca J ^b   Young, Peter R ^b   Mayer, Ruth J ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Department of Immunopharmacology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 METHOXYPHENYL)IMIDAZO[2,1 B]THIAZOLE 1 OXIDE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; BATIMASTAT; CD23 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 4; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE;

ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CELL CULTURE; DATA ANALYSIS; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MONOCYTE; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; WESTERN BLOTTING;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL MEMBRANE; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; IMIDAZOLES; INTERLEUKIN-4; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RECEPTORS, IGE; SOLUBILITY; U937 CELLS;

EID: 0032400931     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Bonnefoy, J. Y., S. Lecoanet-Henchoz, J.-P. Aubry, J.-F. Gauchet, and P. Graber. 1995. CD23 and B-cell activation. Curr. Opin. Immunol. 7:355.
2. Yokota, A., H. Kikutani, R. Sato, E. L. Barsumian, M. Suemura, and T. Kishimoto. 1988. Two species of human Fc∈ receptor II (Fc∈RII/CD23): tissue specific and IL-4-specific regulation of gene expression. Cell 55:611.
3. Sutton, B. J., and H. J. Gould. 1993. The human IgE network. Nature 366:421.
4. Luo, H., H. Hofstetter, J. Banchereau, and G. Delespesse. 1991. Cross-linking of CD23 antigen by its natural ligand (IgE) or by anti-CD23 antibody prevent B lymphocyte proliferation and differentiation. J. Immunol. 146:2122.
5. Ludin, C., H. Hofstetter, M. Sarfati, C. Levy, U. Suter, D. Alaimo, E. Kilchherr, H. Frost, and G. Delespesse. 1987. Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. EMBO J. 6:109.
6. Conrad, D. H., K. A. Campbell, W. C. Bartlett, C. M. Squire, and S. E. Dierks. 1994. Structure and function of the low affinity IgE receptor. Adv. Exp. Med. Biol. 347:17.
7. Barnes, P. J. 1991. Biochemistry of asthma. Trends Biochem. Sci. 16:365.
8. Liu, Y., J. A. Cairns, M. J. Holder, S. D. Abbot, K. U. Jansen, J. Bonnefoy, J. Gordon, and I. C. M. MacLennan. 1991. Recombinant 25-kDa CD23 and interleukin-1α promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis. Eur. J. Immunol. 21:1107.
9. Pene, J., I. Chretien, F. Rousset, J. Y. Bonnefoy, and J. E. de Vries. 1989. Modulation of IL-4-induced human IgE production in vitro by IFN-γ and IL-5: the role of soluble CD23 (s-CD23). J. Cell. Biochem. 39:253.
10. Sarfati, M., B. Bettler, M. Letellier, S. Fournier, M. Rubio-Trujillo, H. Hofstetter, and G. Delespesse. 1992. Native and recombinant soluble CD23 fragments with IgE suppressive activity. Immunology 76:662.
11. Armant, M., H. Ishihara, M. Rubio, G. Delespesse, and M. Sarfati. 1994. Regulation of cytokine production by soluble CD23: costimulation of interferon γ secretion and triggering of tumor necrosis factor α release. J. Exp. Med. 180: 1005.
12. Armant, M., M. Rubio, G. Delespesse, and M. Sarfati. 1995. Soluble CD23 directly activates monocytes to contribute to the antigen-independent stimulation of resting T cells. J. Immunol. 155:4868.
13. Fujiwara, H., H. Kikutani, S. Suematsu, T. Naka, K. Yoshida, T. Tanaka, M. Suemura, N. Matsumoto, S. Kojima, T. Kishimoto, et al. 1996. The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice. Proc. Natl. Acad. Sci. USA 91:6835.
14. Bonnefoy, J. Y., C. Plater-Zyberk, S. Lecoanet-Henchoz, J. F. Gauchet, J. P. Aubry, and P. Graber. 1996. A new role for CD23 in inflammation. Immunol. Today 17:418.
15. Lecoanet-Henchoz, S., J. Aubry, P. Graber, P. Life, N. Paul-Eugene, B. Ferrua, C. Plater-Zuberk, and J. Bonnefoy. 1995. CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18. Immunity 3:119.
16. Plater-Zyberk, C., and J. Y. Bonnefoy. 1995. Marked amelioration of established collagen-induced arthritis by treatment with antibodies to CD23 in vivo. Nat. Med. 1:781.
17. Kawabe, T., M. Takami, M. Hosoda, Y. Maeda, S. Sato, M. Mayumi, H. Mikawa, K. I. Arai, and J. Yodoi. 1988. Regulation of Fc∈RII/CD23 gene expression by cytokines and specific ligands (IgE and anti-Fc∈RII monoclonal antibody). J. Immunol. 141:1376.
18. Spittler, A., C. Schiller, M. Willheim, C. Tempfer, S. Winkler, and G. Boltz-Nitulescu. 1995. IL-10 augments CD23 expression on U937 cells and down-regulates IL-4 driven CD23 expression on cultured human blood monocytes: effects of IL-10 and other cytokines on cell phenotype and phagocytosis. Immunology 85:311.
19. Wu, C. Y., M. Sarfati, C. Heusser, S. Fournier, M. Rubio-Trujillo, R. Peleman, and G. Delespesse. 1991. Glucocorticoids increase the synthesis of IgE by interleukin-4-stimulated human leukocytes. J. Clin. Invest. 87:870.
20. Hornung, N., and D. Degiannis. 1993. Up-regulation by cyclosporine (CsA) of the in vitro release of soluble CD23 (sCD23) and of the in vitro production of IL-6 and IgM. Scand. J. Immunol. 38:287.
21. Degiannis, D., and N. Hornung. 1995. Rapamycin inhibits the in vitro release of soluble CD23 by SAC/IL-2/IL-4 activated human peripheral blood lymphocytes. Transplantation 59:1076.
22. Christie, G., A. Barton, B. Bolognese, D. R. Buckle, R. M. Cook, M. Hansbury, G. P. Harper, L. A. Marshall, M. E. McCord, K. Moulder, et al. 1997. IgE secretion is attenuated by an inhibitor of proteolytic processing of CD23 (Fc∈RII). Eur. J. Immunol. 27:3228.
23. Lee, J., U. Prabhakar, D. Griswold, D. Dunnington, P. Young, and A. Badger. 1995. Low-molecular weight TNF biosynthesis inhibitors: strategies and perspectives. Circ. Shock 44:97.
24. Lee, J., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, et al. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739.
25. Lee, J. C., A. M. Badger, D. E. Griswold, D. Dunnington, A. Truneh, B. Votta, J. H. White, P. R. Young, and P. E. Bender. 1993. Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. Ann. NY Acad. Sci. 696:149.
26. Badger, A. M., J. N. Bradbeer, B. Votta, J. C. Lee, J. L. Adams, and D. E. Griswold. 1996. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279:1453.
27. Cohen, P. 1997. The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol. 7:353.
28. Cuenda, A., J. Rouse, R. Doza, R. Meier, P. Cohen, T. Gallagher, P. Young, and J. Lee. 1995. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364:229.
29. Kumar, S., P. C. McDonnell, R. J. Gum, A. T. Hand, J. C. Lee, and P. R. Young. 1997. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem. Biophys. Res. Commun. 235:533.
30. Lee, J., D. E. Griswold, B. Votta, and N. Hanna. 1988. Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002. Int. J. Immunopharmacol. 10:836.
31. Marshall, L. A., and A. K. Roshak. 1993. Coexistence of two biochemically distinct phospholipase A2 activities in human platelet, monocyte and neutrophil. Biochem. Cell Biol. 71:331.
32. Vercelli, D., H. H. Jabara, B. W. Lee, N. Woodland, R. S. Geha, and D. Y. M. Leung. 1988. Human recombinant interleukin-4 induces Fc∈RII/CD23 on normal human monocytes. J. Exp. Med. 167:1406.
33. Morre, J. D., and D. M. Morre. 1989. Preparation of mammalian plasma membranes by aqueous two-phase partition. BioTechniques 7:946.
34. Marolewski, A. E., D. R. Buckle, G. Christie, D. L. Eamshaw, P. L. Flamberg, L. A. Marshall, D. G. Smith, and R. J. Mayer. 1998. CD23 (Fc∈RII) release from cell membranes is mediated by a membrane-bound metalloprotease. Biochem. J. 333:573.
35. Bonnefoy, J. Y., J. Shields, and J. J. Mermod. 1990. Inhibition of human interleukin 4-induced IgE synthesis by a subset of anti-CD23/Fc∈RII monoclonal antibodies. Eur. J. Immunol. 20:139.
36. Roshak, A., G. Sathe, and L. A. Marshall. 1994. Suppression of monocyte 85 kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis. J. Biol. Chem. 269:25999.
37. McLaughlin, M. M., S. Kumar, P. C. McDonnell, S. Van Horn, J. C. Lee, G. P. Livi, and P. R. Young. 1996. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J. Biol. Chem. 271:8488.
38. Waterman, W. H., T. F. P. Molski, C. K. Huang, J. L. Adams, and R. I. Sha'afi. 1996. Tumour necrosis factor-α-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils. Biochem. J. 319:17.
39. 2 is a 100 kDa protein in human monoblast U937 cells. J. Biol. Chem. 266:5268.
40. 2 induction in neonatal parietal bone cultures. J. Bone Miner. Res. 11:358.
41. Bansal, A., T. Roberts, E. M. Hay, R. S. H. Pumphrey, and P. B. Wilson. 1992. Soluble CD23 levels are elevated in the serum of patients with primary Sjogren's syndrome and systemic lupus erythematosus. Clin. Exp. Immunol. 89:452.
42. Hellen, E. A., D. C. Rowlands, T. T. Hansel, G. D. Kitas, and J. Crocker. 1991. Immunohistochemical demonstration of CD23 expression on lymphocytes in rheumatoid synovitis. J. Clin. Pathol. 44:293.
43. Paul-Eugene, N., D. Mossalayi, M. Sarfati, K. Yamaoka, J. Aubry, J. Bonnefoy, B. Dugas, and J. Kolb. 1995. Evidence for a role of Fc∈RII/CD23 in the IL-4-induced nitric oxide production by normal human mononuclear phagocytes. Cell. Immunol. 163:314.
44. Grenier-Brossette, N., I. Bourget, C. Akoundi, J. Bonnefoy, and J. Cousin. 1992. Spontaneous and ligand-induced endocytosis of CD23 (Fc∈ receptor II) from the surface of B lymphocytes generates a 16-kDa intracellular fragment. Immunology 22:1573.
45. Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420.
46. Foltz, I. N., J. C. Lee, P. R. Young, and J. W. Schrader. 1997. Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. J. Biol. Chem. 272:3296.
47. Lee, J. C., and P. R. Young. 1996. Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J. Leukocyte Biol. 59:152.
48. Badger, A. M., M. N. Cook, M. W. Lark, T. M. Newman-Tarr, B. A. Swift, A. H. Nelson, F. C. Barone, and S. Kumar. 1998. SB 203580 inhibits p38 MAP kinase, nitric oxide production and inducible nitric oxide synthase in bovine cartilage-derived chondrocytes. J. Immunol. 161:467.
49. Pucillo, C., S. Salzano, S. Pepe, M. Vitale, S. Formisano, and G. Rossi. 1990. Regulation of the expression of the low-affinity IgE receptor (Fc∈RII) in the human monocyte-like cell line U937 by phorbol esters and IgE. Int. Arch. Allergy Appl. Immunol. 93:330.
50. Reichel, M., B. H. Nelson, P. D. Greenberg, and P. B. Rothman. 1997. The IL-4 receptor α-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4 specific gene transcription. J. Immunol. 158: 5860.
51. Han, H., T. Brown, and B. Beutler. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med. 71:465.
52. Waskiewicz, A. J., A. Flynn, C. G. Proud, and J. A. Cooper. 1997. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16:1909.