메뉴 건너뛰기




Volumn 18, Issue 5, 1998, Pages 1633-1641

Extracellular signal-regulated kinase and p38 subgroups of mitogen- activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures

Author keywords

Astrocytes; Extracellular signal regulated kinase; Inducible nitric oxide synthase; Microglia; p38 MAP kinase; TNF

Indexed keywords

ENDOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0032032424     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-05-01633.1998     Document Type: Article
Times cited : (708)

References (67)
  • 2
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cylokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock, and immune function
    • Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE (1996) Pharmacological profile of SB 203580, a selective inhibitor of cylokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock, and immune function. J Pharmacol Exp Ther 279:1453-1461.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 4
    • 0002937623 scopus 로고
    • Role of cytokines in multiple sclerosis, autoimmune encephalitis, and other neurological disorders
    • Aggarwal B, Puri R, eds. Boston: Blackwell Scientific
    • Benveniste EN (1995) Role of cytokines in multiple sclerosis, autoimmune encephalitis, and other neurological disorders. In: Human cytokines: their role in research and therapy (Aggarwal B, Puri R, eds), p 195. Boston: Blackwell Scientific.
    • (1995) Human Cytokines: Their Role in Research and Therapy , pp. 195
    • Benveniste, E.N.1
  • 5
    • 0025069619 scopus 로고
    • Regulation of cachectin biosynthesis occurs at multiple levels
    • Beutler B (1990) Regulation of cachectin biosynthesis occurs at multiple levels. Prog Clin Biol Res 349:229-240.
    • (1990) Prog Clin Biol Res , vol.349 , pp. 229-240
    • Beutler, B.1
  • 7
    • 0029872654 scopus 로고    scopus 로고
    • Activation of MAP kinases in oligodendrocytes
    • Bhat NR, Zhang P (1996) Activation of MAP kinases in oligodendrocytes. J Neurochem 66:1986-1994.
    • (1996) J Neurochem , vol.66 , pp. 1986-1994
    • Bhat, N.R.1    Zhang, P.2
  • 8
    • 0028807912 scopus 로고
    • Expression of MARCKS in oligodendrocytes is developmentally regulated
    • Bhat NR, Zhang P, Bhat AN (1995a) Expression of MARCKS in oligodendrocytes is developmentally regulated. Dev Neurosci 17:256-263.
    • (1995) Dev Neurosci , vol.17 , pp. 256-263
    • Bhat, N.R.1    Zhang, P.2    Bhat, A.N.3
  • 9
    • 0028864592 scopus 로고
    • Thrombin activates MAP kinase in astrocytes
    • Bhat NR, Zhang P, Hogan EL (1995b) Thrombin activates MAP kinase in astrocytes. J Cell Physiol 165:417-424.
    • (1995) J Cell Physiol , vol.165 , pp. 417-424
    • Bhat, N.R.1    Zhang, P.2    Hogan, E.L.3
  • 10
    • 0345195078 scopus 로고    scopus 로고
    • MAP kinase cascades and microglial activation
    • Bhat NR, Lee JC, Zhang P (1997) MAP kinase cascades and microglial activation. J Neurochem 69:S206D.
    • (1997) J Neurochem , vol.69
    • Bhat, N.R.1    Lee, J.C.2    Zhang, P.3
  • 11
    • 0038233014 scopus 로고    scopus 로고
    • Nitric oxide-mediated mitochondrial damage in the brain - Mechanisms and implications for neurodegenerative diseases
    • Bolanos JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB, Heales SJR (1997) Nitric oxide-mediated mitochondrial damage in the brain - mechanisms and implications for neurodegenerative diseases. J Neurochem 68:2227-2240.
    • (1997) J Neurochem , vol.68 , pp. 2227-2240
    • Bolanos, J.P.1    Almeida, A.2    Stewart, V.3    Peuchen, S.4    Land, J.M.5    Clark, J.B.6    Heales, S.J.R.7
  • 12
    • 0028926263 scopus 로고
    • Parallel signal processing among mammalian MAPKs
    • Cano E, Mahadevan LC (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122.
    • (1995) Trends Biochem Sci , vol.20 , pp. 117-122
    • Cano, E.1    Mahadevan, L.C.2
  • 13
    • 0000370303 scopus 로고
    • Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
    • Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, Cerami A (1986) Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci USA 83:1670-1674.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 1670-1674
    • Caput, D.1    Beutler, B.2    Hartog, K.3    Thayer, R.4    Brown-Shimer, S.5    Cerami, A.6
  • 14
    • 0028577356 scopus 로고
    • Tumor necrosis factor-α potentiates glutamate neurotoxicity in human fetal brain cell cultures
    • Chao CC, Hu S (1994) Tumor necrosis factor-α potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev Neurosci 16:172-179.
    • (1994) Dev Neurosci , vol.16 , pp. 172-179
    • Chao, C.C.1    Hu, S.2
  • 15
    • 0028788194 scopus 로고
    • AU-rich elements: Characterization and importance in mRNA degradation
    • Chen CYA, Shyu AB (1995) AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci 20:465-470.
    • (1995) Trends Biochem Sci , vol.20 , pp. 465-470
    • Chen, C.Y.A.1    Shyu, A.B.2
  • 16
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb MH, Goldsmith EJ (1995) How MAP kinases are regulated. J Biol Chem 270:14843-14846.
    • (1995) J Biol Chem , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 18
    • 0028073283 scopus 로고
    • MAPKs: New JNK expands the group
    • Davis RJ (1994) MAPKs: new JNK expands the group. Trends Biochem Sci 19:170-173.
    • (1994) Trends Biochem Sci , vol.19 , pp. 170-173
    • Davis, R.J.1
  • 20
    • 0028089896 scopus 로고
    • Expression of inducible nitric oxide synthase causes delayed neurodegeneration in primary neuronal-glial cortical cultures
    • Dawson VL, Brahbhatt HP, Mong JA, Dawson TM (1994) Expression of inducible nitric oxide synthase causes delayed neurodegeneration in primary neuronal-glial cortical cultures. Neuropharmacology 33:1425-1430.
    • (1994) Neuropharmacology , vol.33 , pp. 1425-1430
    • Dawson, V.L.1    Brahbhatt, H.P.2    Mong, J.A.3    Dawson, T.M.4
  • 21
    • 0029730637 scopus 로고    scopus 로고
    • Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells
    • Díaz-Guerra MJM, Bodelón OG, Velasco M, Whelan R, Parker PJ, Boscá L (1996) Up-regulation of protein kinase C-epsilon promotes the expression of cytokine-inducible nitric oxide synthase in RAW 264.7 cells. J Biol Chem 271:32028-32033.
    • (1996) J Biol Chem , vol.271 , pp. 32028-32033
    • Díaz-Guerra, M.J.M.1    Bodelón, O.G.2    Velasco, M.3    Whelan, R.4    Parker, P.J.5    Boscá, L.6
  • 23
    • 0031013368 scopus 로고    scopus 로고
    • Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway
    • Folti IN, Lee JC, Young PR, Schrader JW (1997) Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway. J Biol Chem 272:3296-3301.
    • (1997) J Biol Chem , vol.272 , pp. 3296-3301
    • Folti, I.N.1    Lee, J.C.2    Young, P.R.3    Schrader, J.W.4
  • 24
    • 0030977270 scopus 로고    scopus 로고
    • MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
    • Fukunaga R, Hunter T (1997) MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J 16:1921-1933.
    • (1997) EMBO J , vol.16 , pp. 1921-1933
    • Fukunaga, R.1    Hunter, T.2
  • 25
    • 0004156838 scopus 로고
    • Cloning and expression of inducible nitric oxide synthase from rat astrocytes
    • Galea E, Reis DJ, Feinstein DL (1994) Cloning and expression of inducible nitric oxide synthase from rat astrocytes. J Neurosci Res 266:3172-3177.
    • (1994) J Neurosci Res , vol.266 , pp. 3172-3177
    • Galea, E.1    Reis, D.J.2    Feinstein, D.L.3
  • 26
    • 0030951146 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1β
    • Guan Z, Baier LD, Morrison AR (1997) p38 mitogen-activated protein kinase down-regulates nitric oxide and up-regulates prostaglandin E2 biosynthesis stimulated by interleukin-1β. J Biol Chem 272:8083-8089.
    • (1997) J Biol Chem , vol.272 , pp. 8083-8089
    • Guan, Z.1    Baier, L.D.2    Morrison, A.R.3
  • 27
    • 0025828480 scopus 로고
    • Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions
    • Han J, Huez G, Beutler B (1991) Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions. J Immunol 146:1843-1848.
    • (1991) J Immunol , vol.146 , pp. 1843-1848
    • Han, J.1    Huez, G.2    Beutler, B.3
  • 28
    • 0030932875 scopus 로고    scopus 로고
    • Differential regulation of cylokine-induced major histocompatibility complex class II expression and nitric oxide release in rat microglia and astrocytes by effectors of tyrosine kinase, protein kinase C. and cAMP.
    • Hellendall RP, Ting JP (1997) Differential regulation of cylokine-induced major histocompatibility complex class II expression and nitric oxide release in rat microglia and astrocytes by effectors of tyrosine kinase. protein kinase C. and cAMP. J Neuroimmunol 74:19-29.
    • (1997) J Neuroimmunol , vol.74 , pp. 19-29
    • Hellendall, R.P.1    Ting, J.P.2
  • 29
    • 0028843589 scopus 로고
    • Cytokine mRNA expression in postischemic/reperfused myocardium
    • Herskowitz A, Choi S, Ansari AA, Wesselingh S (1995) Cytokine mRNA expression in postischemic/reperfused myocardium. Am J Pathol 146:419-428.
    • (1995) Am J Pathol , vol.146 , pp. 419-428
    • Herskowitz, A.1    Choi, S.2    Ansari, A.A.3    Wesselingh, S.4
  • 30
    • 0028897113 scopus 로고
    • Transcriptional regulation by extracellular signals: Mechanisms and specificity
    • Hill CS, Treisman R (1995) Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211.
    • (1995) Cell , vol.80 , pp. 199-211
    • Hill, C.S.1    Treisman, R.2
  • 31
    • 0028345042 scopus 로고
    • Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells
    • Imai T, Hirata Y, Kanno K, Marumo F (1994) Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells. J Clin Invest 93:543-549.
    • (1994) J Clin Invest , vol.93 , pp. 543-549
    • Imai, T.1    Hirata, Y.2    Kanno, K.3    Marumo, F.4
  • 32
    • 0027275266 scopus 로고
    • Cytoplasmic regulation of mRNA function: The importance of the 3′-untranslated region
    • Jackson RJ (1993) Cytoplasmic regulation of mRNA function: the importance of the 3′-untranslated region. Cell 74:9-14.
    • (1993) Cell , vol.74 , pp. 9-14
    • Jackson, R.J.1
  • 33
    • 0028991950 scopus 로고
    • Transcriptional regulation of the tumor necrosis factor alpha gene
    • Jongeneel CV (1995) Transcriptional regulation of the tumor necrosis factor alpha gene. Immunobiology 193:210-216.
    • (1995) Immunobiology , vol.193 , pp. 210-216
    • Jongeneel, C.V.1
  • 35
    • 0029032249 scopus 로고
    • The regulation of AP-1 activity by mitogen-activated protein kinases
    • Karin M (1995) The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483-16486.
    • (1995) J Biol Chem , vol.270 , pp. 16483-16486
    • Karin, M.1
  • 37
    • 0030570790 scopus 로고    scopus 로고
    • Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures
    • Kong LY, McMillian MK, Maronpot R, Hong JS (1996) Protein tyrosine kinase inhibitors suppress the production of nitric oxide in mixed glia, microglia-enriched or astrocyte-enriched cultures. Brain Res 729:102-109.
    • (1996) Brain Res , vol.729 , pp. 102-109
    • Kong, L.Y.1    McMillian, M.K.2    Maronpot, R.3    Hong, J.S.4
  • 38
    • 0031029871 scopus 로고    scopus 로고
    • Cytokine- And endotoxin-induced nitric oxide synthase in rat astroglial cultures: Differential modulation by angiotensin II
    • Kopnisky KL, Sumners C, Chandler LJ (1997) Cytokine- and endotoxin-induced nitric oxide synthase in rat astroglial cultures: differential modulation by angiotensin II. J Neurochem 68:935-944.
    • (1997) J Neurochem , vol.68 , pp. 935-944
    • Kopnisky, K.L.1    Sumners, C.2    Chandler, L.J.3
  • 40
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kruetzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kruetzberg, G.W.1
  • 41
    • 0029744885 scopus 로고    scopus 로고
    • Sounding the alarm: Protein kinase cascades activated by stress and inflammation
    • Kyriakis JM, Avruch J (1996) Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem 271:24313-24316.
    • (1996) J Biol Chem , vol.271 , pp. 24313-24316
    • Kyriakis, J.M.1    Avruch, J.2
  • 42
    • 0030980917 scopus 로고    scopus 로고
    • Roles of tyrosine kinases in the regulation of nitric oxide synthesis in murine liver cells: Modulation of NF-κB activity by tyrosine kinases
    • Lee BS, Rang HS, Pyun KH, Choi I (1997) Roles of tyrosine kinases in the regulation of nitric oxide synthesis in murine liver cells: modulation of NF-κB activity by tyrosine kinases. Hepatology 25:913-919.
    • (1997) Hepatology , vol.25 , pp. 913-919
    • Lee, B.S.1    Rang, H.S.2    Pyun, K.H.3    Choi, I.4
  • 43
    • 0029664650 scopus 로고    scopus 로고
    • Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms
    • Lee JC, Young PR (1996) Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J Leukoc Biol 59:152-157.
    • (1996) J Leukoc Biol , vol.59 , pp. 152-157
    • Lee, J.C.1    Young, P.R.2
  • 45
    • 0027298505 scopus 로고
    • Cytokine production by human fetal microglia and astrocytes Differential induction by lipopolysaccharide and IL-1β
    • Lee SC, Liu W, Dickson DW, Brosnan CF, Herman JW (1993) Cytokine production by human fetal microglia and astrocytes Differential induction by lipopolysaccharide and IL-1β. J Immunol 150:2659-2667.
    • (1993) J Immunol , vol.150 , pp. 2659-2667
    • Lee, S.C.1    Liu, W.2    Dickson, D.W.3    Brosnan, C.F.4    Herman, J.W.5
  • 46
    • 0001139213 scopus 로고
    • Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
    • Lieberman AP, Pitha PM, Shin HS, Shin ML (1989) Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci USA 86:6348-6352.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6348-6352
    • Lieberman, A.P.1    Pitha, P.M.2    Shin, H.S.3    Shin, M.L.4
  • 47
    • 0028126506 scopus 로고
    • PHAS-I as a link between mitogen-activated protein kinase and translation initiation
    • Lin T, Kong X, Haystead TAJ, Pause A, Belsham G, Sonenberg N, Lawrence JC (1994) PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 260:653-656.
    • (1994) Science , vol.260 , pp. 653-656
    • Lin, T.1    Kong, X.2    Taj, H.3    Pause, A.4    Belsham, G.5    Sonenberg, N.6    Lawrence, J.C.7
  • 49
    • 0029013929 scopus 로고
    • Interactions of the nervous system and immune system development, normal brain homeostasis and disease
    • Merrill JF, Jonakait GM (1995) Interactions of the nervous system and immune system development, normal brain homeostasis and disease. FASEB J 9:611-618.
    • (1995) FASEB J , vol.9 , pp. 611-618
    • Merrill, J.F.1    Jonakait, G.M.2
  • 50
    • 0027367945 scopus 로고
    • Astrocytes in infectious and immune-mediated diseases of the central nervous system
    • Mucke L, Eddleston M (1993) Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASER J 7:1226-1232.
    • (1993) FASER J , vol.7 , pp. 1226-1232
    • Mucke, L.1    Eddleston, M.2
  • 51
    • 0031568088 scopus 로고    scopus 로고
    • An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-γ-treated macrophages
    • Mullet D, Fertel RH, Kniss D, Cox GW (1997) An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-γ-treated macrophages. J Immunol 158:897-904.
    • (1997) J Immunol , vol.158 , pp. 897-904
    • Mullet, D.1    Fertel, R.H.2    Kniss, D.3    Cox, G.W.4
  • 53
    • 0030997409 scopus 로고    scopus 로고
    • Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21
    • Nishiya T, Uehara T, Edamatsu H, Kaziro Y, Itoh H, Nomura Y (1997) Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21. FFBS Lett 408:33-38.
    • (1997) FFBS Lett , vol.408 , pp. 33-38
    • Nishiya, T.1    Uehara, T.2    Edamatsu, H.3    Kaziro, Y.4    Itoh, H.5    Nomura, Y.6
  • 54
    • 0030972480 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase in Theiler's murine encephalitis virus infection
    • Oleszak EL, Katsetos CD, Kuzmak J, Varadhachary A (1997) Inducible nitric oxide synthase in Theiler's murine encephalitis virus infection. J Virol 71:3228-3235.
    • (1997) J Virol , vol.71 , pp. 3228-3235
    • Oleszak, E.L.1    Katsetos, C.D.2    Kuzmak, J.3    Varadhachary, A.4
  • 55
    • 0027996636 scopus 로고
    • Cytokines and metabolic dysfunction after severe head injury
    • Ott L, McClain CJ, Gillespie M, Young B (1994) Cytokines and metabolic dysfunction after severe head injury. J Neurotrauma 11:447-472.
    • (1994) J Neurotrauma , vol.11 , pp. 447-472
    • Ott, L.1    McClain, C.J.2    Gillespie, M.3    Young, B.4
  • 56
    • 10144224274 scopus 로고    scopus 로고
    • Nitric oxide synthase type II mRNA stability is translation- and transcription-dependent
    • Park SK, Murphy S (1996) Nitric oxide synthase type II mRNA stability is translation- and transcription-dependent. J Neurochem 67:1766-1769.
    • (1996) J Neurochem , vol.67 , pp. 1766-1769
    • Park, S.K.1    Murphy, S.2
  • 57
    • 0030948467 scopus 로고    scopus 로고
    • The role of nitric oxide in multiple sclerosis
    • Parkinson JF, Mitrovic B, Merrill JE (1997) The role of nitric oxide in multiple sclerosis. J Mol Med 75:174-186.
    • (1997) J Mol Med , vol.75 , pp. 174-186
    • Parkinson, J.F.1    Mitrovic, B.2    Merrill, J.E.3
  • 58
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause A, Belsham GJ, Gingra A, Donxe O, Lin T, Lawrence JC, Sonenberg N (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371:762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingra, A.3    Donxe, O.4    Lin, T.5    Lawrence, J.C.6    Sonenberg, N.7
  • 59
    • 0027245888 scopus 로고
    • Macrophages and inflammation in the central nervous system
    • Perry VH, Andersson PB, Gordon S (1993) Macrophages and inflammation in the central nervous system. Trends Neurosci 16:268-273.
    • (1993) Trends Neurosci , vol.16 , pp. 268-273
    • Perry, V.H.1    Andersson, P.B.2    Gordon, S.3
  • 60
    • 84993913357 scopus 로고
    • Multiple sclerosis: TNF revisited, with promise
    • Raine CS (1995) Multiple sclerosis: TNF revisited, with promise. Nat Med 1:211-214.
    • (1995) Nat Med , vol.1 , pp. 211-214
    • Raine, C.S.1
  • 61
    • 0030988138 scopus 로고    scopus 로고
    • Nitric oxide synthase in models of focal ischemia
    • Samdani AF, Dawson TM, Dawson VL (1997) Nitric oxide synthase in models of focal ischemia. Stroke 28:1283-1288.
    • (1997) Stroke , vol.28 , pp. 1283-1288
    • Samdani, A.F.1    Dawson, T.M.2    Dawson, V.L.3
  • 62
    • 0030026354 scopus 로고    scopus 로고
    • Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha
    • Singh K, Balligand JL, Fischer TA, Smith TW, Kelly RA (1996) Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha. J Biol Chem 271:1111-1117.
    • (1996) J Biol Chem , vol.271 , pp. 1111-1117
    • Singh, K.1    Balligand, J.L.2    Fischer, T.A.3    Smith, T.W.4    Kelly, R.A.5
  • 63
    • 0024584020 scopus 로고
    • Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
    • Stuehr DJ, Nathan CF (1989) Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 169:1543-1555.
    • (1989) J Exp Med , vol.169 , pp. 1543-1555
    • Stuehr, D.J.1    Nathan, C.F.2
  • 64
    • 0030938587 scopus 로고    scopus 로고
    • Neuronal (type I) nitric oxide synthase regulates nuclear factor KB activity and immunologie (type II) nitric oxide synthase expression
    • Togashi H, Sasaki M, Frohman E, Taira E, Ratan RR, Dawson TM, Dawson VL (1997) Neuronal (type I) nitric oxide synthase regulates nuclear factor KB activity and immunologie (type II) nitric oxide synthase expression. Proc Natl Acad Sci USA 94:2676-2680.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2676-2680
    • Togashi, H.1    Sasaki, M.2    Frohman, E.3    Taira, E.4    Ratan, R.R.5    Dawson, T.M.6    Dawson, V.L.7
  • 65
    • 0030977269 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
    • Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997) Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J 16:1909-1920.
    • (1997) EMBO J , vol.16 , pp. 1909-1920
    • Waskiewicz, A.J.1    Flynn, A.2    Proud, C.G.3    Cooper, J.A.4
  • 66
    • 0027255749 scopus 로고
    • Promoter of the mouse gene-encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide
    • Xie QW, Wishnan R, Nathan C (1993) Promoter of the mouse gene-encoding calcium-independent nitric oxide synthase confers inducibility by interferon-γ and bacterial lipopolysaccharide. J Exp Med 177:1779-1784.
    • (1993) J Exp Med , vol.177 , pp. 1779-1784
    • Xie, Q.W.1    Wishnan, R.2    Nathan, C.3
  • 67
    • 0031885806 scopus 로고    scopus 로고
    • Activation of JNK/SAPK in primary glial cultures. II. Differential activation of kinase isoforms corresponds to their differential expression
    • Zhang P, Hogan EL, Bhat NR (1998) Activation of JNK/SAPK in primary glial cultures. II. Differential activation of kinase isoforms corresponds to their differential expression. Neurochem Res 23:219-225.
    • (1998) Neurochem Res , vol.23 , pp. 219-225
    • Zhang, P.1    Hogan, E.L.2    Bhat, N.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.