Accumulation of p16(INK4a) in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status

Oncogene

Volumn 15, Issue 5, 1997, Pages 495-503

  Palmero, Ignacio ^a,c   McConnell, Beth ^a   Parry, David ^a,d   Brookes, Sharon ^a   Hara, Eiji ^a   Bates, Stewart ^a,e   Jat, Parmjit ^b   Peters, Gordon ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^d MERCK RESEARCH LABORATORIES   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cdk inhibitor; CDKN2a; Replicative lifespan; Retinoblastoma protein; SV40 T antigen; Tumor suppressor

Indexed keywords

MESSENGER RNA; PROTEIN P16; RETINOBLASTOMA PROTEIN; VIRUS T ANTIGEN; CARRIER PROTEIN; CDK4 PROTEIN, HUMAN; CDK4 PROTEIN, MOUSE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLINE; ONCOPROTEIN; PROTEIN P16INK4A;

ANIMAL CELL; ARTICLE; CELL AGING; CELL IMMORTALIZATION; CELL TRANSFORMATION; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST; FIBROBLAST CULTURE; GENE EXPRESSION; LIFESPAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENESCENCE; SIMIAN VIRUS 40; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CULTURE; CELL LINE; CELL STRAIN 3T3; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; SPECIES DIFFERENCE; VIROLOGY;

ANIMALIA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

3T3 CELLS; ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CARRIER PROTEINS; CELL AGING; CELL LINE, TRANSFORMED; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; CYCLINS; EMBRYO; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MICE; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 0030612753     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201212     Document Type: Article

References (52)

1. Aagaard L, Lukas J, Bartkova J, Kjerulff A-A, Strauss M and Bartek J. (1995). Int. J. Cancer, 61, 115-120.
2. Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D and Barrett JC. (1996). Proc. Natl. Acad. Sci. USA. 93, 13742-13747.
3. Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C and Peters G. (1994a). Oncogene, 9, 71-79.
4. Bates S, Parry D, Bonetta L, Vousden K, Dickson C and Peters G. (1994b). Oncogene, 9, 1633-1640.
5. Chomczynski P and Saachi N. (1987). Anal. Biochem., 162, 156-159.
6. England NI, Cuthbert AP, Trott DA, Jezzard S, Nobori T, Carson DA and Newbold RF. (1996). Carcinogenesis, 17, 1567-1575.
7. Fåhraeus R, Paramio JM, Ball KL, Lain S and Lane DP. (1996). Curr. Biol., 6, 84-91.
8. Guan K-L, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG and Xiong Y. (1994). Genes Dev., 8, 2939-2952.
9. Hall M and Peters G. (1996). Adv. Cancer Res., 68, 67-108.
10. Hara E, Smith R, Parry D, Tahara H, Stone S and Peters G. (1996). Mol. Cell. Biol., 16, 859-867.
11. Hegi ME, Devereux TR, Dietrich WF, Cochran CJ, Lander ES, Foley JF, Maronpot RR, Anderson MW and Wiseman RW. (1994). Cancer Res., 54, 6257-6264.
12. Herzog CR, Wiseman RW and You M. (1994). Cancer Res., 54, 4007-4010.
13. Ikram Z, Norton T and Jat PS. (1994). Proc. Natl. Acad. Sci. USA, 91, 6448-6452.
14. Jiang P, Stone S, Wagner R, Wang S, Dayananth P, Kozak CA, Wold B and Kamb A. (1995). J. Mol. Evol., 41, 795-802.
15. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS III, Johnson BE and Skolnick MH. (1994). Science, 264, 436-440.
16. Knapek DF, Serrano M, Beach D, Trono D and Walker CL. (1995). Cancer Res., 55, 1607-1612.
17. Koh J, Enders GH, Dynlacht BD and Harlow E. (1995). Nature, 375, 506-510.
18. Li Y, Nichols MA, Shay JW and Xiong Y. (1994). Cancer Res., 54, 6078-6082.
19. Linardopoulos S, Street AJ, Quelle DE, Parry D, Peters G, Sherr CJ and Balmain A. (1995). Cancer Res., 55, 5168-5172.
20. Loughran O, Edington KG, Berry IJ, Clark LJ and Parkinson EK. (1994). Cancer Res., 54, 5045-5049.
21. Loughran O, Malliri A, Owens D, Gallimore PH, Stanley MA, Ozanne B, Frame MC and Parkinson EK. (1996). Oncogene, 13, 561-568.
22. Lukas J, Bartkova J, Rohde M, Strauss M and Bartek J. (1995a). Mol. Cell. Biol., 15, 2600-2611.
23. Lukas J, Müller H, Spitkovsky D, Kjerulff AA, Jansen-Dürr P, Strauss M and Bartek J. ( 1994). J. Cell Biol., 125, 625-638.
24. Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G and Bartek J. (1995b). Nature, 375, 503-506.
25. Medema R, Herrera RE, Lam F and Weinberg RA. (1995). Proc. Natl. Acad. Sci. USA, 92, 6289-6293.
26. Noble JR, Rogan EM, Neumann AA, Maclean K, Bryan TM and Reddel RR. (1996). Oncogene, 13, 1259-1268.
27. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K and Carson DA. (1994). Nature, 368, 753-756.
28. Noda A, Ning Y, Venable SF, Pereira-Smith OM and Smith JR. (1994). Exp. Cell Res., 211, 90-98.
29. Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH and Harris CC. (1994). Proc. Natl. Acad. Sci. USA, 91, 11045-11049.
30. Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M, Xiong Y, Beach DH, Yokota J and Harris CC. (1995). Cancer Res., 55, 1448-1451.
31. Otterson GA, Kratzke RA, Coxon A, Kim YW and Kaye FJ. (1994). Oncogene, 9, 3375-3378.
32. Palmero I, Holder A, Sinclair AJ, Dickson C and Peters G. (1993). Oncogene, 8, 1049-1054.
33. Pardee AB. (1989). Science, 246, 603-608.
34. Parry D, Bates S, Mann DJ and Peters G. (1995). EMBO J., 14, 503-511.
35. Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ and Serrano M. (1995a). Oncogene, 11, 635-645.
36. Quelle DE, Zindy F, Ashmun RA and Sherr CJ. (1995b). Cell, 83, 993-1000.
37. Reznikoff CA, Yeager TR, Belair CA, Savelieva E, Puthenveettil JA and Stadler WM. (1996). Cancer Res., 56, 2886-2890.
38. Rogan EM, Bryan TM, Hukku B, Maclean K, Chang AC-M, Moy EL, Englezou A, Warneford SG, Dalla-Pozza L and Reddel RR. (1995). Mol. Cell. Biol., 15, 4745-4753.
39. Serrano M, Gómez-Lahoz E, DePinho RA, Beach D and Bar-Sagi D. (1995). Science, 267, 249-252.
40. Serrano M, Hannon GJ and Beach D. (1993). Nature, 366, 704-707.
41. Serrano M, Lee H-W, Chin L, Cordon-Cardo C, Beach D and DePinho RA. (1996). Cell, 85, 27-37.
42. Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ and Rollins BJ. (1995). Cancer Res., 55, 505-509.
43. Sherr CJ. (1994). Cell, 79, 551-555.
44. Strauss M, Lukas J and Bartek J. (1995). Nature Med., 1, 1245-1246.
45. Tam SW, Theodoras AM, Shay JW, Draetta GF and Pagano M. (1994). Oncogene, 9, 2663-2674.
46. Tsuyama N, Miura M, Kitahira M, Ishibashi S and Ide T. (1991). Cell Struct. Funct., 16, 55-62.
47. Washimi O, Nagatake M, Osada H, Ueda R, Koshikawa T, Seki T, Takahashi T and Takahashi T. (1995). Cancer Res., 55, 514-517.
48. Weinberg RA. (1995). Cell, 81, 323-330.
49. Wong H and Riabowol K. (1996). Exp. Gerentol., 31, 311-325.
50. Wright WE and Shay JW. (1992). Trends Genet., 8, 193-197.
51. Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D and Tlsty TD. (1996). J. Virol., 70, 999-1008.
52. Xiong Y, Zhang H and Beach D. (1993). Genes Dev., 7, 1572-1583.