Extracellular Signal-regulated Kinase (ERK) interacts with Signal Transducer and Activator of Transcription (STAT) 5a

Molecular Endocrinology

Volumn 13, Issue 4, 1999, Pages 555-565

  Pircher, T J ^a   Petersen, H ^a   Gustafsson, J A ^a   Haldosen, L A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE; MITOGEN ACTIVATED PROTEIN KINASE; SERINE; STAT5 PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA BINDING; GENE EXPRESSION; GENETIC TRANSFECTION; MOLECULAR INTERACTION; NONHUMAN; PHOSPHORYLATION; POLYMERIZATION; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0033330660     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.4.0263     Document Type: Article

References (41)

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4. Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components
5. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription
6. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
7. Insulin stimulates the serine phosphorylation of the signal transducer and activator of transcription (STAT3) isoform
8. Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated jak2 kinase
9. STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation
10. Mapping of stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of stat1 and stat3
11. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins
12. Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/Star 5
13. Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5
14. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
15. How MAP kinases are regulated
16. Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes
17. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
18. Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism
19. Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells
20. Association of mitogen-activated protein kinase with the microtubule cytoskeleton
21. Nuclear localization and regulation of erk- and rsk-encoded protein kinases
22. Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts
23. In vitro interaction between STAT5 and JAK2: Dependence upon phosphorylation status of STAT5 and JAK2
24. Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements
25. Identification of MAP kinase domains by redirecting stress signals into growth factor responses
26. Regulation of transcription by MAP kinase cascades
27. The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif
28. Mitogen-activated protein kinases activate the serine/ threonine kinases Mnk1 and Mnk2
29. Evidence that inactive p42 mitogen-activated protein kinase and inactive Rsk exist as a heterodimer in vivo
30. Requirement of serine phosphorylation for formation of STAT-promoter complexes
31. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple stat5 isoforms in nb2 lymphocytes
32. Growth hormone-induced reorganization of the actin cytoskeleton is not required for STAT5 (signal transducer and activator of transcription-5)-mediated transcription
33. Stat3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor
34. Signal transducer and activator of transcription-3 serine phosphorylation by insulin is mediated by a Ras/Raf/MEK-dependent pathway
35. Insulin activates Stat3 independently of p21 ras-ERK and PI-3K signal transduction
36. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser(725) of Stat5a and Ser(730) of Stat5b in prolactin-sensitive cells
37. Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue
38. Lactogenic hormone activation of stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 erk2 mitogen-activated protein kinase activity
39. Two discrete regions of interleukin-2 (il2) receptor beta independently mediate IL2 activation of a pd98059/rapamycin/ wortmannin-insensitive stat5a/b serine kinase
40. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
41. Early events in signalling by interferons