The state of the STATs: Recent developments in the study of signal transduction to the nucleus

Current Opinion in Cell Biology

Volumn 9, Issue 2, 1997, Pages 233-239

  Horvath, Curt M ^a   Darnell Jr , James E ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; POLYPEPTIDE;

CELL NUCLEUS; CYTOPLASM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSACTIVATION;

EID: 0030962017     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80067-1     Document Type: Article

References (72)

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37. Heim MH, Kerr IM, Stark GR, Darnell JE Jr: STAT SH2 groups contribute to specific interferon signalling by the Jak-STAT pathway. Science 1995, 267:1347-1349. Demonstrates that the STAT SH2 domain distinguishes between receptor phosphotyrosines to allow specificity in activation.
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40. Li X, Leung S, Darnell JE Jr, Kerr IM, Stark GR: Functional domains of STAT2 required for pre-association with the interferon alpha receptor and for signaling. Mol Cell Biol 1996, 271:5790-5794.
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44. David M, Petricon E III, Benjamin C, Pine R, Weber MJ, Larner AC: Requirement for MAP kinase (ERK2) activity in interferon alpha and interferon beta stimulated gene expression through Stat proteins. Science 1995, 269:1721-1723. Together with [43••], this paper suggests a convergence between the tyrosine- and serine-phosphorylation pathways in regulating STAT protein transcriptional output.
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63. Look DC, Pelletier MR, Tidwell RM, Roswit WT, Holtzman MJ: Stat1 depends on transcriptional synergy with Sp1. J Biol Chem 1995, 270:30264-30267 Demonstrates a requirement for interactions between STAT factors and non-STAT factors for transcriptional activity.
64. Schaefer TS, Sanders LK, Nathans D: Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc Natl Acad Sci USA 1995, 92:9097-9101. Demonstrates the existence of an alternatively spliced form of Stat3 that associates with Jun to activate transcription.
65. Bugno M, Graeve L, Gatsios P, Koj A, Heinrich PC, Travis J, Kordula T: Identification of the interleukin 6/ oncostatin M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter. Nucleic Acids Res 1995, 23:5041-5047.
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67. Xu XA, Sun YL, Hoey T: Cooperative DNA binding and sequence selective recognition conferred by the Stat amino terminal domain. Science 1996, 273:794-797. Together with [68••], this paper demonstrates the importance of the STAT protein amino-terminal domain for stabilizing adjacent dimers on tandemly arranged STAT-binding elements in promoters. This tetrameric arrangement allows for enhanced transcriptional ablility.
68. Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, Darnell JE Jr: DNA binding of in vitro activated Statla, Statt1b, and truncated Stat1: interaction between NH2 terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J 1996, 15:5616-5626. Together with [67••], this paper demonstrates the importance of the STAT protein amino-terminal domain for stabilizing adjacent dimers on tandemly arranged STAT-binding elements in promoters. The authors of this paper also characterized Stat1-DNA interactions, defining 'strong' and 'weak' binding sites as a reflection of different dissociation rates.
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