4 Development of Neurosteroid-Based Novel Psychotropic Drugs

Progress in Medicinal Chemistry

Volumn 37, Issue C, 2000, Pages 135-175

  Reddy, Doodipala S ^a   Kulkarni, Shrinivas K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; PSYCHOTROPIC AGENT; STEROID;

BIOSYNTHESIS; BRAIN; EPILEPSY; HUMAN; MENTAL DISEASE; METABOLISM; PHYSIOLOGY; REVIEW;

BRAIN; EPILEPSY; HUMANS; MENTAL DISORDERS; PSYCHOTROPIC DRUGS; RECEPTORS, GABA-A; STEROIDS;

EID: 0033644935     PISSN: 00796468     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6468(08)70059-6     Document Type: Chapter

References (249)

1. Baulieu, E-E.; (1981) in Steroid Hormone Regulation of the Brain (Fuxe, K., Gustafson, J.A. and Wetterberg, L., eds), Wenner-Green Center International Symposium Series, Vol., 34, pp-3-14, Pergamon Press, Oxford.
2. Kulkarni S.K., and Reddy D.S. Drugs Today 31 (1995) 433-455
3. Selye H. Proc. Soc. Exp. Biol. Med. 46 (1941) 116-121
4. Selye H. Endocrinology 30 (1942) 437-453
5. McEven B.S. Trends Pharmacol. Sci. 12 (1991) 141-147
6. Morgan M., and Whitman J.G. Anaesthesia 40 (1985) 121-123
7. Paul S.M., and Purdy R.H. FASEB J. 6 (1992) 2311-2322
8. Baulieu E.-E., and Robel P. J. Steroid Biochem. Mol. Biol. 37 (1990) 395-403
9. Robel P., and Baulieu E.-E. Crit. Rev. Neurobiol. 9 (1995) 385-394
10. Schumacher M., Robel P., and Baulieu E.E. Dev. Neurosci. 18 (1996) 16-21
11. Cheney D.L., Uzunov D., Costa E., and Guidotti A. J. Neurosci. 15 (1995) 4641-4650
12. Guidotti A., Uzumovv D.P., Auta J., and Costa E. In: Genazzani A.R., Petraglia F., and Purdy R.H. (Eds). The Brain, Source and Target for Sex Steroid Hormones (1996), Parthenon Publishing Group, Pearl River, New York 25-41
13. Shimada K., Fukuda N., and Nakagi T. J. Chromatogr. Sci. 35 (1997) 71-74
14. Jo D.H., Abdallah M.A., Young J., Baulieu E.E., and Robel P. Steroids 54 (1989) 287-297
15. Corpechot C., Synguelakis M., Talha S., Axelson M., Sjovall J., Vihko R., Baulieu E.-E., and Robel P. Brain Res. 270 (1983) 119-125
16. Hu Z.Y., Jung-Testas I., Robel P., and Baulieu E.-E. Biochem. Biophys. Res. Commun. 161 (1987) 917-922
17. Jung-Testas I., Alliot F., Pessac B., Robel P., and Baulieu E.-E. C. R. Acad. Sci. D. 308 (1989) 165
18. Baulieu E.-E. Recent Prog. Horm. Res. 52 (1997) 1-32
19. Gustafsson J.A. Front. Neuroendocrinol. 16 (1995) 224-236
20. Akwa Y., Sanane's N., Gue'zou M., Robel P., Baulieu E.-E., and Le Goascogne C. J. Cell Biol. 121 (1993) 135-143
21. Kabbadj K., El-Etr M., Baulieu E.-E., and Robel P. Glia 7 (1993) 170-175
22. Guennoun R., Fiddes R.J., Gouezou M., Lombes M., and Baulieu E.-E. Mol. Brain. Res. 30 (1996) 287-300
23. Weidenfeld J., Siegel R.A., and Chowers I. J. Steroid. Biochem. 13 (1980) 961-963
24. Jung-Testas I., Hu Z.Y., Baulieu E.-E., and Robel P. J. Steroid Biochem. 34 (1989) 511-519
25. Melcangi R.C., Celotti F., Ballabio M., Castano P., Massarelli R., Poletti A., and Martini L. Brain Res. 516 (1990) 229-236
26. Krieger N.R., and Scott R.G. J. Neurochem. 52 (1989) 1866-1870
27. Negri-Cesi P., Poletti A., and Celotti F. J. Steroid Biochem. Molec. Biol. 58 (1996) 455-566
28. Mellon S.H. J. Clin. Endocrinol. Metab. 78 (1994) 1003-1008
29. Robel P., Young J., Corpechot C., Mayo W., Perche F., Haug M., Simon H., and Baulieu E.-E. J. Steroid Biochem. Mol. Biol. 53 (1995) 335-360
30. Mellon S.H., and Deschepper C.F. Brain Res. 629 (1993) 283-292
31. Corpechot C., Robel P., Axelson M., Sjovall J., Vikh B., and Beulieu E.-E. Proc. Natl. Acad. Sci. U.S.A. 78 (1981) 4704-4707
32. Robel P., Akwa Y., Corpechot C., Hu Z.Y., Jung-Testas I., Kabbadj K., Le Goascogne C., Morfin R., Vourch C., Young J., and Baulieu E.-E. In: Motta M. (Ed). Brain Endocrinology (1986), Raven Press, New York 105-132
33. Rose K.A., Stapleton G., Dott K., Kieny H.P., Best R., Schwarz H., Russel D.W., Bjorkhem I., Seckl J., and Lathe R. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 4925-4930
34. Akwa Y., Morfin R.F., Robel P., and Baulieu E.-E. Biochem. J. 288 (1992) 959-964
35. Guarneri P., Guarneri R., Cascio C., Pavasant P., Piccoli F., and Papadopoulos V. J. Neurochem. 63 (1994) 86-96
36. Guarneri P., Guarneri R., Cascio C., Piccoli F., and Papadopoulos V. Brain Res. 683 (1995) 65-72
37. Koenig H., Schumacher M., Ferzaz B., Do-Thi A.N., Ressouches A., Guennoun R., Jung-Testas I., Robel P., Akwa Y., and Baulieu E.-E. Science (Washington, D.C.) 268 (1995) 1500-1503
38. Stocco D.M., and Clark B.J. Endocrinology 17 (1996) 221-244
39. Krueger K.E., and Papadopoulos V. Annu. Rev. Pharmacol. Toxicol. 32 (1992) 211-237
40. Costa E., and Guidotti A. Life Sci. 49 (1991) 325-344
41. Guarneri P., Papadopoulos V., Pan B., and Costa E. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 5118-5122
42. Papadopoulos V., Guarneri P., Krueger K.E., Guidotti A., and Costa E. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 5113-5117
43. Kozikowski A.P., Ma D., Brewer J., Sun S., Costa E., Romeo E., and Guidotti A. J. Med. Chem. 36 (1993) 2908-2920
44. McEnery M.W., Snowman A.M., Trifletti R.R., and Snyder S.H. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 3170-3174
45. Sprengel R., Werner P., Seeburg P.H., Mukhin A.G., Santi M.R., Grayson D.R., Guidotti A., and Krueger K.E. J. Biol. Chem. 264 (1989) 20415-20421
46. Papadopoulos V., Boujrad N., Ikonomovic M.D., Ferrara P., and Vidic B. Mol. Cell. Endocrinol. 104 (1994) R5-R9
47. Auta J., Romeo E., Kozikowski A.P., Ma D., Costa E., and Guidotti A. J. Pharmacol. Exp. Ther. 265 (1993) 649-656
48. Romeo E., Auta J., Kozikowski A., Ma D., Papadopoulos V., Puia G., and Guidotti A. J. Pharmacol. Exp. Ther. 262 (1992) 971-978
49. Olsen R.W., and Tobin A.J. FASEB J. 4 (1990) 1469-1480
50. Harrison N.L., and Simmonds M.A. Brain Res. 323 (1984) 287-292
51. Cottrell G.A., Lambert J.J., and Peters J.A. Br. J. Pharmacol. 90 (1987) 491-500
52. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., and Paul S.M. Science (Washington, D.C.) 232 (1986) 1004-1007
53. Marrow A.L., Ssuzdak P.D., and Paul S.M. Eur. J. Pharmacol. 142 (1987) 483-485
54. Lambert J.J., Peters J.A., and Cottrell G.A. Trends Pharmacol. Sci. 8 (1987) 224-227
55. Lambert J.J., Belelli D., Hill-Venning C., and Peters J.A. Trends Pharmacol. Sci. 16 (1995) 295-303
56. Gee K.W., Bolger M.B., Brinton R.E., Coirini H., and Mceven B.S. J. Pharmacol. Exp. Ther. 246 (1988) 803-812
57. Purdy R.H., Morrow A.L., Blinn J.R., and Paul S.M. J. Med. Chem. 33 (1990) 1572-1581
58. Morrow A.L., Pace J.R., Purdy R.H., and Paul S.M. Mol. Pharmacol. 37 (1990) 263-270
59. Han M., Zorumski C.F., and Covey D.F. J. Med. Chem. 39 (1996) 4218-4232
60. Turner D.M., Ransom R.W., Yang J.S.J., and Olsen R.W. J. Pharmacol. Exp. Ther. 248 (1989) 960-966
61. Lan N.C., Chen J.-S., Belelli D., Pritchett D.B., Seeburg P.H., and Gee K.W. Eur. J. Pharmacol. 188 (1990) 403-406
62. Hawkinson J.E., Kimbrough C.L., Mccauley L.D., Bolger M.B., Lan N.C., and Gee K.W. Eur. J. Pharmacol. 269 (1994) 157-163
63. McAuley J.W., Kroboth P.D., Stiff D.D., and Reynolds I.J. Pharmacol. Biochem. Behav. 45 (1993) 77-83
64. Bertz R.J., Reynolds I.J., and Kroboth P.D. Neuropharmacology 34 (1995) 1169-1175
65. Gee K.W., and Lan N.C. Mol. Pharmacol. 40 (1991) 995-999
66. Gee K.W., Mccauley L.D., and Lan N.C. Crit. Rev. Neurobiol. 9 (1995) 207-227
67. Lan N.C., and Gee K.W. Drugs News Perspect. 10 (1997) 604-611
68. McCaueley L.D., and Gee K.W. J. Pharmacol. Exp. Ther. 275 (1995) 1412-1417
69. Rick C.E., Ye Q., Finn S.E., and Harrison N.L. NeuroReport 9 (1998) 379-383
70. Puia G., Santi M.R., Vicini S., Pritchett D.B., Purdy R.H., Paul S.M., Seeburg P.H., and Costa E. Neuron 4 (1990) 759-765
71. Prince R.J., and Simmonds M.A. Neuropharmacology 32 (1993) 59-63
72. Shingai R., Sutherland M.L., and Barnard E.A. Eur. J. Pharmacol. 206 (1991) 77-80
73. Lan N.C., Gee K.W., Bolger M.B., and Chen J.S. J. Neurochem. 57 (1991) 1818-1821
74. Hauser C.A.E., Chesnoy-Marchais D., Robel P., and Baulieu E.E. Eur. J. Pharmacol. 289 (1995) 249-257
75. Hadingham K.L., Wingrove P.B., Warlord K.A., Bain C., and Kemp J.A. Mol. Pharmacol. 44 (1993) 1211-1218
76. Davies P.A., Hanna M.C., Hales T.G., and Kirkness E.F. Nature (London) 385 (1997) 820-823
77. Zhu W.J., Wang J.F., Krueger K.E., and Vicini S. J. Neurosci. 16 (1996) 6648-6656
78. Jones M.V., and Westbrook G.L. Neuron 15 (1995) 181-191
79. Jones M.W., and Westbrook G.L. Trends Neurosci. 19 (1996) 96-101
80. Zhu W.J., and Vicini S. J. Neurosci. 17 (1997) 4022-4031
81. McCauley L.D., Liu V., Chen J.S., Hawkinson J.E., Lan N.C., and Gee K.W. Mol. Pharmacol. 47 (1995) 354-362
82. Xue B.G., Whittemore E.E., Park C.H., Woodward R.M., Lan N.C., and Gee K.W. J. Pharmacol. Exp. Ther. 281 (1997) 1095-1101
83. Majewska M.D., Mienville J.M., and Vicini S. Neurosci. Lett. 90 (1988) 279-284
84. Majewska M.D., Demirgoren S., Spivak C.E., and London E.D. Brain Res. 526 (1990) 143-146
85. Majewska M.D., and Schwartz R.D. Brain Res. 404 (1987) 355-360
86. Spivak C.E. Synapse (N.Y.) 16 (1994) 113-122
87. Steiger A., Trachsel L., Guldner J., Hemmeter U., Rothe B., Rupprecht R., Vedder H., and Holsboer F. Brain Res. 615 (1993) 267-274
88. Majewska M.D. Prog. Neurobiol. 38 (1992) 379-395
89. Mienville J.M., and Vicini S. Brain Res. 489 (1989) 190-194
90. Roberts E. Biochem. Pharmacol. 49 (1995) 1-16
91. Demirgoren S., Majewska M.D., Spivak C.E., and London E.D. Neuroscience 45 (1991) 127-135
92. Sousa A., and Ticku M.K. J. Pharmacol. Exp. Ther. 282 (1997) 827-833
93. Friedman L., Gibbs T.T., and Farb D.H. Mol. Pharmacol. 44 (1993) 191-197
94. Yu R., and Ticku M.K. J. Pharmacol. Exp. Ther. 275 (1995) 784-789
95. Yu R., and Ticku M.K. Mol. Pharmacol. 47 (1995) 603-610
96. Yu R., Hay M., and Ticku M.K. Brain Res. 706 (1996) 160-162
97. Johnson J.W., and Ascher P. Nature (London) 325 (1987) 529-531
98. Wu F.-S., Gibbs T.T., and Farb D.H. Mol. Pharmacol. 40 (1991) 333-336
99. Bowlby M.R. Mol. Pharmacol. 43 (1993) 813-819
100. Irwin R.P., Maragakis N.J., Rogawski M.A., Purdy R.H., Farb D.H., and Paul S.M. Neurosci. Lett. 141 (1992) 30-34
101. Irwin R.P., Lin S.-Z., Rogawski M.A., Purdy R.H., and Paul S.M. J. Pharmacol. Exp. Ther. 271 (1994) 677-682
102. Fahey J.M., Lindquist D.G., Pritchard G.A., and Miller L.G. Brain Res. 669 (1995) 183-188
103. Smith S.S. Neuroscience 42 (1991) 309-320
104. Walker J.M., Bowen W.D., Walker F.O., Matsumoto R.R., De Costa B., and Rice K.C. Pharmacol. Rev. 42 (1990) 355-402
105. Quirion R., Bowen W.D., Itzhak Y., Junien J.L., Musacchio J.M., Rothman R.B., Su T.R., Tam S.W., and Taylor D.P. Trends Pharmacol. Sci. 13 (1992) 85-86
106. Maurice T., and Lockhart B.P. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 21 (1997) 69-102
107. Hanner M., Moebius F.F., Flandorfer A., Knaus H.G., Striessnig J., Kempner E., and Glossman H. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 8072-8077
108. London Su.T.P.E.D., and Jaffe J.H. Science (Washington, D.C.) 240 (1988) 219-221
109. Yamada M., Nishigami T., Nakasho K., Nishimoto Y., and Miyaji H. Hepatology 20 (1994) 1271-1280
110. Maurice T., Roman F.J., and Privat A. J. Neurosci. Res. 46 (1996) 734-743
111. Monnet F.P., Mahe V., Robel P., and Baulieu E.E. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 3774-3778
112. Bergeron R., De Montigny C., and Debonnel G. J. Neurosci. 16 (1996) 1193-1202
113. Maurice T., Junien J.-L., and Privat A. Behav. Brain Res. 83 (1997) 159-164
114. Wu F.-S., Gibbs T.T., and Farb D.H. Mol. Pharmacol. 37 (1990) 597-602
115. Wu F.-S., Chen S.-C., and Tsai J.-J. Brain Res. 750 (1997) 318-320
116. Ffrench-Mullen J.M.H., and Spence K.T. Eur. J. Pharmacol. 202 (1991) 269-272
117. Ffrench-Mullen J.M.H., Danks P., and Spence K.T. J. Neurosci. 14 (1994) 1963-1977
118. Spence K.T., Plata-Salaman C.R., and Ffrench-Mullen J.M.H. Life Sci. 49 (1991) PL-235-PL-239
119. Zylinska L., Rebas E., Gromadzinska E., and Lachowicz L. Biochem. Biophys Res. Commun. 212 (1995) 178-183
120. Luntz-Leybman V., Freund R.K., and Collins A.C. Eur. J. Pharmacol. 185 (1990) 239-242
121. Ke L., and Lukas R.J. J. Neurochem. 67 (1996) 1100-1112
122. Valera S., Ballivet M., and Bertrand D. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 9949-9953
123. Bullock A.E., Clark A.L., Grady S.R., Robinson S.F., Slobe B.S., Marks M.J., and Collins A.C. J. Neurochem. 68 (1997) 2412-2423
124. Rupprecht R., Reul J.M.H.M., Trapp T., Van Steensel B., Wetzel C., Damm K., Ziegl-gansberger W., and Holsboer F. Neuron 11 (1993) 523-530
125. Purdy R.H., Morrow A.L., Moore Jr. P.H., and Paul S.M. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 4553-4557
126. Barbaccia M.L., Roscetti G., Trabucchi M., Cuccheddu T., Concas A., and Biggio G. Eur. J. Pharmacol. 261 (1994) 317-320
127. Barbaccia M.L., Roscetti G., Trabucchi M., Mostallino M.C., Concas A., Purdy R.H., and Biggio G. Neuroendocrinology 63 (1996) 166-172
128. Barbaccia M.L., Roscetti G., Bolacchi E., Concas A., Mostallino M.C., Purdy R.H., and Biggio G. Pharmacol. Biochem. Behav. 54 (1996) 205-210
129. Patchev V.K., Shoaib M., Holsboer F., and Almeida O.F.K. Neuroscience 62 (1994) 265-268
130. Reddy D.S., and Kulkarni S.K. Psychopharmacology 128 (1996) 280-292
131. Belelli D., Bolger M.B., and Gee K.W. Eur. J. Pharmacol. 166 (1989) 325-329
132. Belelli D., Lan N.C., and Gee K.W. Neurosci. Biobehav. Rev. 14 (1990) 315-322
133. Landigren S., Assly J., Backstrom T., Dubrovsky B., and Danielsson E. Acta Physiol. Scand. 131 (1987) 33-43
134. Kokate T.G., Svennson B.E., and Rogawski M.A. J. Pharmacol. Exp. Ther. 279 (1994) 1223-1229
135. Wieland S., Belluzzi J.D., Stein L., and Lan N.C. Psychopharmacology 118 (1995) 65-71
136. Frye C.A. Brain Res. 696 (1995) 113-120
137. Devaud L.L., Purdy R.H., and Morrow A.L. Alcohol Clin. Exp. Res. 19 (1995) 350-355
138. Finn D.A., Roberts A.J., and Crabbe J.C. Alcohol Clin. Exp. Res. 19 (1995) 410-415
139. Deutsch S.I., Rosse R.B., Steinberg K., Koetzner L., Riggs R., and Mastropaolo J. Pharmacol. Biochem. Behav. 55 (1996) 423-426
140. Gasior M., Carter R.B., Goldberg S.R., and Witkin J.M. J. Pharmacol. Exp. Ther. 282 (1997) 543-553
141. Budziszewska B., Siwanowicz J., Leskiewicz M., Jaworska-Feil L., and Lason W. Eur. Neuropsychopharmacol. 8 (1998) 7-12
142. Rosciszewska D., Buntner B., Guz I., and Zawisza I. J. Neurol. Neurosurg. Psychiatry. 49 (1986) 47-51
143. Reddy D.S., and Kulkarni S.K. Indian J. Pharmacol. 29 (1997) 381-392
144. Phillipps G.H. J. Steroid Biochem. 94 (1975) 1257-1269
145. Hogenkamp D.J., Tahir S.H., Hawkinson J.E., Upasani R.B., Alauddin M., Lan N.C., Gee K.W., and Bolger M.B. J. Med. Chem. 40 (1997) 61-72
146. Carter R.R., Wood P.L., Wieland S., et al. J. Pharmacol. Exp. Ther. 280 (1997) 1284-1295
147. Marshall F.H., Stratton S.C., Mullings J., Ford E., Worton S.P., Oakley N.R., and Hagan R.M. Pharmacol. Biochem. Behav. 58 (1997) 1-8
148. Carette B., and Poulain P. Neurosci. Lett. 45 (1984) 205-210
149. Heuser G., and Eidelberg E. Endocrinology 69 (1961) 915-924
150. Maione S., Berrino L., Vitagliano S., Leyva J., and Rossi F. Eur. J. Pharmacol. 219 (1992) 477-479
151. Reddy D.S., and Kulkarni S.K. Eur. J. Pharmacol. 345 (1998) 55-59
152. Crawley J.N., Glowa Jr., Majewska M.D., and Paul S.M. Brain Res. 398 (1986) 382-385
153. Mendelson W.B., Martin J.V., Perlis M., Wagner R., Majewska M.D., and Paul S.M. Psychopharmacology 93 (1987) 226-229
154. Bitran D., Hilvers R.J., and Kellogg C.K. Brain Res. 561 (1991) 157-161
155. Bitran D., Hilvers R.J., and Kellogg C.K. Behav. Neurosci. 105 (1991) 651-660
156. Britton K.T., Page M., Baldwin H., and Koob G.F. J. Pharmacol. Exp. Ther. 258 (1991) 124-129
157. Wieland S., Lan N.C., Mirasedeghi S., and Gee K.W. Brain Res. 565 (1991) 263-268
158. Picazo O., and Fernadez-Guasti A. Brain Res. 680 (1995) 135-141
159. Zimmerberg B., Brunelli S.A., and Hofer M.A. Pharmacol. Biochem. Behav. 47 (1994) 735-738
160. Reddy D.S., and Kulkarni S.K. Brain Res. 752 (1997) 61-71
161. Reddy D.S., and Kulkarni S.K. Methods Find. Exp. Clin. Pharmacol. 19 (1997) 665-681
162. Melchior C.L., and Ritzmann R.F. Pharmacol. Biochem. Behav. 47 (1994) 437-441
163. Melchior C.L., and Ritzmann R.F. Pharmacol. Biochem. Behav. 48 (1994) 893-897
164. Wang M.D., Wahlstrom G., and Backstrom T. J. Steroid Biochem. Mol. Biol. 62 (1997) 299-306
165. Zimmerberg B., Drucker P.C., and Weider J.M. Pharmacol. Biochem. Behav. 51 (1995) 463-468
166. Uzunov D.P., Cooper T.B., Costa E., and Guidotti A. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 12599-12604
167. Mayo W., Dellu F., Robel P., Cherkaoui J., Le Moal M., Baulieu E.-E., and Simon H. Brain Res. 607 (1993) 324-328
168. Isaacson R.L., Varner J.A., Baars J.-M., and De Wied D. Brain Res. 689 (1995) 79-84
169. Frye C.A., and Sturgis J.D. Neurobiol. Learn. Mem. 64 (1995) 83-96
170. Flood J.F., Smith G.E., and Roberts E. Brain Res. 447 (1989) 269-278
171. Flood J.F., Morley J.E., and Roberts E. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 1567-1571
172. Flood J.F., Morley J.E., and Roberts E. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 10806-10810
173. Kinsella D.M., Kavaliers M., Ossenkopp K.P., and Shivers R. Soc. Neurosci. Abstr. 20 (1994) 1362
174. Isaacson R.L., Yoder P.E., and Varner J. Behav. Neural Biol. 61 (1994) 170-176
175. Zimmerberg B., and Mcdonald B.C. Pharmacol. Biochem. Behav. 55 (1996) 531-547
176. Meziane H., Mathis C., Paul S.M., and Ungerer A. Psychopharmacology 126 (1996) 323-330
177. Cheney D.I., Uzunov D., and Guidotti A. NeuroReport 6 (1995) 1697-1700
178. Mathis C., Paul S.M., and Crawley J.N. Psychopharmacology 11 (1994) 201-206
179. Melchior C.L., and Ritzmann R.F. Pharmacol. Biochem. Behav. 53 (1997) 51-56
180. Orentretch N., Brind J.L., Rizer R.L., and Vogelman J.H. J. Clin. Endocrinol. Metab. 59 (1984) 551-555
181. Pickles K.R. Med. Hypoth. 42 (1994) 243-244
182. Flood J.F., and Roberts E. Brain Res. 448 (1988) 178-181
183. Maurice T., Su T.-P., and Privat A. Neuroscience 83 (1998) 413-428
184. Reddy D.S., and Kulkarni S.K. Brain Res. 791 (1998) 108-116
185. Li P.-K., Rhodes M.E., Jagannathan S., and Johnson D.A. Cognit. Brain Res. 2 (1995) 251-254
186. Li P.-K., Rhodes M.E., Burke A.M., and Johnson D.A. Life Sci. 60 (1997) PL45-PL51
187. Reddy D.S., and Kulkarni S.K. Brain Res. 799 (1998) 215-229
188. Kostowski W., Rewerski W., and Piechocki T. Neuroendocrinology 6 (1970) 311-318
189. Kavaliers M. Psychopharmacology 95 (1988) 488-492
190. Schlega M.L., Spetz L.F., Robel P., and Haung M. Physiol. Behav. 34 (1985) 867-870
191. Young J., Corpechot C., Haug M., Gobaile S., Baulieu E.-E., and Robel P. Biochem. Biophys. Res. Commun. 174 (1991) 892-897
192. Haug M., Young J., Robel P., and Baulieu E.-E. C.R. Acad. Sci. Paris 312 (1991) 511-516
193. George M.S., Guidotti A., Rubinow D., Pan B., Mikalauskas K., and Post R.M. Biol. Psychiatry 35 (1994) 775-780
194. Roberts E., and Fitten L.J. In: Kalimi M., and Regelson W. (Eds). The Biologic Role of Dehydroepiandrosterone (DHEA) (1990), Walter de Gruyter, Berlin 43-64
195. Bonnet K.A., and Brown R.P. In: Kalimis M., and Regelson W. (Eds). The Biologic Role of Dehydroepiandrosterone (DHEA) (1990), Walter de Gruyter, Berlin 65-80
196. Strauss E.B., and Stevenson W.A.H. J. Neurol. Neurosurg. Psychiatry 18 (1955) 137-144
197. Morales A.J., Nolan J.J., Nelson J.C., and Yen S.S.C. J. Clin. Endocrinol. Metab. 78 (1994) 1360-1367
198. Wolkowitz O.M., Reus V.I., Roberts E., Manfredi F., Chan T., Raum W.J., Ormiston S., Johnson R., Canick J., Brizendine L., and Weingartner H. Biol. Psychiatry 41 (1997) 311-318
199. Reddy D.S., Kaur G., and Kulkarni S.K. NeuroReport 9 (1998) 3069-3073
200. Matsuno K., Kobayashi T., Tanaka M.K., and Mita S. Eur. J. Pharmacol. 32 (1996) 267-271
201. Marrow A.L., Uzuno D.P., Biggio G., Zimmerberg B., and Backstrom T. Alcohol Clin. Exp. Res. 8 (1996) 250A-255A
202. Devaud L.L., Purdy R.H., Finn D.A., and Morrow A.L. J. Pharmacol. Exp. Ther. 278 (1996) 510-517
203. Lancaster F.E. Alcohol Clin. Exp. Res. 18 (1994) 740-746
204. Devaud L.L., and Morrow A.L. NIAAA Monogr. 29 (1995) 219-240
205. Melchior, C.L. (1995) RSA Abstracts 44.
206. Majewska M.D., Bluet-Pajot M.T., Robel P., and Baulieu E.-E. Pharmacol. Biochem. Behav. 33 (1989) 701-703
207. Lancel M., Cronlein T.A.M., Muller-Preub P., and Holsboer F. Brain Res. 646 (1994) 85-94
208. Steffensen S.C. Hippocampus 5 (1995) 320-328
209. Friess E., Trachsel L., Guldner J., Schier T., Steiger A., and Holsboer F. Am. J. Physiol. 268 (1995) E107-E113
210. Schul H., Jobert M., Gee K.W., and Ashbrook D.W. Neuropsychobiology 34 (1996) 106-112
211. Gandolfo G., Scherschlicht R., and Gottesmann C. Pharmacol. Biochem. Behav. 49 (1994) 921-927
212. Lancel M., Faulhaber J., Holsboer F., and Rupprecht R. Am. J. Physiol. 271 (1996) E763-E772
213. Lancel M., Faulhaber J., Schiffelholz T., Romeo E., Michele F.D., Holsboer F., and Rupprecht R. J. Pharmacol. Exp. Ther. 282 (1997) 1213-1218
214. Friess E., Tagaya H., Trachsel L., Holsboer F., and Rupprecht R. Am. J. Physiol. 272 (1997) E885-E891
215. Edgar D.M., Siedel W.F., Gee K.W., Lan N.C., Field G., Xia H., Hawkinson J.F., Wieland S., Carter R.B., and Wood P.L. J. Pharmacol. Exp. Ther. 282 (1997) 420-429
216. Lancel M., Faulhaber J., Schiffelholz T., Romeo E., Di Michele F., Holsboer F., and Rupprecht R. J. Pharmacol. Exp. Ther. 282 (1997) 1213-1218
217. Chen S.-W., Rodriguez E., Davies M.F., and Loew G.H. Pharmacol. Biochem. Behav. 53 (1996) 777-782
218. Reddy D.S., and Kulkarni S.K. Psychopharmacology 137 (1998) 391-400
219. Reddy D.S., and Kulkarni S.K. Pharmacol. Biochem. Behav. 62 (1999) 53-60
220. Reddy D.S., and Kulkarni S.K. Eur. J. Pharmacol. 337 (1997) 19-25
221. Reddy D.S., and Kulkarni S.K. Indian J. Pharmacol. 30 (1998) 6-15
222. Reddy D.S., and Kulkarni S.K. Methods Find. Exp. Clin. Pharmacol. 19 (1997) 395-405
223. Dewied D., and Jolles J. Physiol. Rev. 62 (1982) 976-1059
224. Pranzatelli M.R. Exp. Neurol. 125 (1994) 125
225. Limmmroth V., Lee W.S., and Moskowitz. Br. J. Pharmacol. 117 (1996) 99-104
226. Reddy D.S., and Kulkarni S.K. Asia Pac. J. Pharmacol (1999) (in press)
227. Laiprasert J.D., Rogers R.C., and Heesch C.M. Am. J. Physiol. 274 (1998) R903-R911
228. Reddy D.S., and Kulkarni S.K. Mol. Cell. Biochem. (1998) 183
229. Frye C.A., and Duncan J.E. Brain Res. 643 (1994) 194-203
230. Kavaliers M., and Wiebe J.P. Brain Res. 415 (1987) 393-398
231. Winfree C.J., Coombs D.W., Deleo J.A., and Colburn R.W. Life Sci. 50 (1992) 1007-1012
232. Caba M., Gonzalez-Mariscal G., and Beyer C. Pharmacol. Biochem. Behav. 47 (1994) 177-182
233. Gintzler, A.R.; (1980) Science (Washingon, D.C.), 210, 193-195.
234. Frye C.A., Van Keuren K.R., Rao P.N., and Erskine M.S. Brain Res. 709 (1996) 1-9
235. Cutrer F.M., and Moskowitz M.A. Headache 36 (1996) 579-585
236. Gray L.A. South. Med. J. 34 (1941) 1004-1005
237. Sing I., Singh I., and Singh D. Lancet 1 (1947) 745-747
238. Chen T.C., and Leviton A. Headache 34 (1994) 107-110
239. Baulieu E.-E. J. Clin. Endocrinol. Metab. 81 (1996) 3147-3151
240. Vallee M., Mayo W., Darnaudery M., Corpechot C., Young J., Koehl M., Le Moal M., Baulieu E.E., Robel P., and Simon H. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 14865-14870
241. Bolga L., Sharma J., and Roberts E. J. Neurosci. Res. 17 (1987) 225-234
242. Yu W.H. Brain Res. 491 (1989) 379-382
243. Roof R.L., Duvdevani R., Braswell L., and Stein D.G. Exp. Neurol. 129 (1994) 64-69
244. Guth L., Zhang Z., and Roberts E. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 12308-12312
245. Jung-Testas I., Schumacher M., Robel P., and Baulieu E.-E. Cell. Mol. Neurobiol. 16 (1996) 439-443
246. Del-Cerro S., Garcia-Estrada J., and Garcia-Segura L.M. Glia 14 (1995) 65-71
247. Hildebrand C., Bowe C.M., and Nilsson Romahl I. Prog. Neurobiol. 43 (1994) 85-141
248. Jiang N., Chopp M., Stein D., and Feit H. Brain Res. 735 (1996) 101-107
249. Waters S.L., Miller G.W., Aleo M.D., and Schnellmann R.G. Am. J. Physiol. 273 (1997) F869-F876