Soporific effect of the neurosteroid pregnanolone in relation to the substance’s plasma level: A pilot study

Neuropsychobiology

Volumn 34, Issue 2, 1996, Pages 106-112

  Schulz, H ^a   Jobert, M ^a   Gee, K W ^b   Ashbrook, D W ^c  

^a PAREXEL INTERNATIONAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

EEG; Neuroactive steroid; Pregnanolone; Sedation

Indexed keywords

ELTANOLONE; PROGESTERONE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELTA RHYTHM; DRUG BLOOD LEVEL; DRUG FORMULATION; ELECTROCARDIOGRAM; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; HUMAN; HUMAN EXPERIMENT; MALE; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SLEEP;

ADULT; ELECTROENCEPHALOGRAPHY; HUMANS; MALE; PREGNANOLONE; SLEEP;

EID: 0029736545     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000119300     Document Type: Article

References (17)

1. Arafat ES, Hargrove JT, Maxson WS, Deside-rio DM, Wentz AC, Andersen RN: Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites, Am J Obstet Gynecol 1988:159:1203-1209.
2. Mok MM, Krieger NR: Evidence that 5a-preg-nan-3a-ol-20-onc is the metabolite responsible for progesterone anesthesia, Brain Res 1990; 533:42-45.
3. Majewska MD, Harrison NL, Schwartz RD, Barker JL, Paul SM: Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor, Science 1986:232:1004-1007.
4. Gee KW, Bolger MB, Brinlon RE, Coirini H, McEwen BS: Steroid modulation of the chloride ionophorc in rat brain: Structurc-activity requirements, regional dependence and mechanism of action, J Pharmacol Exp Ther 1988: 246:803-812.
5. Peters JA, Kirkness EF, Callachan H, Lambert JJ, Turner AJ: Modulation of the GABAa receptor by depressant barbiturates and pregnane steroids, BrJ Pharmacol 1988:94:1257-1269.
6. a receptors, Ther Implications Drug News Perspcc 1992;5:145-152.
7. Gee KW, McCauley L, Lan NC: A putative receptor for neurostcroids on the GABAa receptor complex: The pharmacological properties and therapeutic potential of epalons, Crit Rev Ncurobiol, in press.
8. Ramsay MAE, Savcge IM, Simpson BRJ, Goodwin R: Controlled sedation with alphaxa-lone-alphadolone, Br Med J 1974:2:656-659.
9. Carl P, Hogsklidc S, Nielsen JW, Sorensen MB, Lindholm M, Karlen B, Backstrom T: Pregna-nolone emulsion, A preliminary' pharmacokinetic and pharmacodynamic study of a new intravenous anesthetic agent, Anesthesia 1990: 45:189-197.
10. A-receptor modulation, Brain Res 1993:615:267-274.
11. Herrmann WM: Development and critical evaluation of an objective procedure for the electrocncephalographic classification of psychotropic drugs; in Hermann WM (ed): Electroencephalography in Drug Research, Stuttgart, Fischer, 1982, pp 249-351
12. Hermann WM, Fichte K, Kubicki St: Definition von EEG-Frequenzbandem aufgrund strukturanalytischer Betrachtungen: in Kubicki S, Hermann WM, Laudahn G (Hrsg.): Faklorenanalysc und Variablcnbildung aus dem Elektroencephalogramm, Stuttgart, Fischer, 1980.
13. Rechtschaffen A, Kales A: A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects, Brain Information Service/Brain Research Institute, Los Angeles, University of California, 1968.
14. Rosenberger JL, Gasko M: Comparing location estimators-trimmed means, medians, and trimean; in Hoaglin DC, Mosteller F, Tukcy JW (eds): Understanding Robust and Exploratory Data Analvsis, New York, Wiley, 1983, pp 297-333
15. Herrmann WM, Kubicki St, Röhmel J: Vigilance classification system: Development, sample values and applications in nootropic drug research, Z Gcrontopsychol Gerontopsychiatr 1988;1:1-33.
16. Schulz H, Jobcrt M, Coppola R, Herrmann WM, Pantev M: The use of diurnal vigilance changes in the EEG to verify vigilance-enhancing effects of Memantine in a clinical pharmacological study, Neuropsvchobiology, 1996:33: 32-40.
17. Steiger A, Rupprecht R, Spengler D, Guldner J, Hemmeter U, Rothe B, Damm K, Holsboer Y: Functional properties of deoxycorticosterone and spirolactone: Molecular characterization and effects on sleep-endocrine activity, J Psy-chiatrRes 1993;27:275-284.