Development of tolerance in mice to the sedative effects of the neuroactive steroid minaxolone following chronic exposure

Pharmacology Biochemistry and Behavior

Volumn 58, Issue 1, 1997, Pages 1-8

  Marshall, Fiona H ^a   Stratton, Sharon C ^a   Mullings, Joanne ^a   Ford, Elaine ^a   Worton, Stella P ^a   Oakley, Nigel R ^a   Hagan, Russell M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

GABA; GABA(A)receptor; Locomotor activity; Mice; Minaxolone; Neurosteroid; Temazepam; Tolerance

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FLUNITRAZEPAM; MINAXOLONE; MUSCIMOL; NEUROSTEROID; TEMAZEPAM; TERT BUTYLBICYCLOORTHOBENZOATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG CROSS TOLERANCE; DRUG RECEPTOR BINDING; DRUG TOLERANCE; LIQUID SCINTILLATION COUNTING; LOCOMOTION; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SEDATION;

ANESTHETICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; FLUNITRAZEPAM; GABA AGONISTS; GABA MODULATORS; HYPNOTICS AND SEDATIVES; MALE; MEMBRANES; MICE; MICE, INBRED STRAINS; MOTOR ACTIVITY; MUSCIMOL; PREGNANOLONE; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; TEMAZEPAM;

ANIMALIA;

EID: 0030862828     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(96)00132-3     Document Type: Article

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