The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice

Brain Research

Volumn 791, Issue 1-2, 1998, Pages 108-116

  Reddy, D S ^a   Kulkarni, S K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Receptor; Dehydroepiandrosterone sulfate; Haloperidol; Learning and memory; Mouse; Neurosteroid; Passive avoidance performance; Pregnenolone sulfate

Indexed keywords

DRUG VEHICLE; HALOPERIDOL; NEUROSTEROID; OPIATE ANTAGONIST; PRASTERONE SULFATE; PREGNENOLONE SULFATE;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; FACILITATION; INTRAPERITONEAL DRUG ADMINISTRATION; LATENT PERIOD; LEARNING; MALE; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; AVOIDANCE LEARNING; DEHYDROEPIANDROSTERONE SULFATE; DOPAMINE ANTAGONISTS; HALOPERIDOL; MALE; MICE; PREGNENOLONE; RECEPTORS, SIGMA; REPRODUCIBILITY OF RESULTS; RETENTION (PSYCHOLOGY);

EID: 0032571741     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00085-7     Document Type: Article

References (40)

1. 1 binding sites in guinea pig brain. Eur. J. Pharmacol. 251:1994;R1-R2.
2. Costa E., Auta J., Guidotti A., Korneyev A., Romeo E. The pharmacology of neurosteroidogenesis. J. Steroid Biochem. Mol. Biol. 49:1994;385-389.
3. Fleshneret al. Behav. Neurosci. 111:1997;512-517.
4. Flood J.F., Morley J.E., Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc. Natl. Acad. Sci. U.S.A. 89:1992;1567-1571.
5. Flood J.F., Morley J.E., Roberts E. Pregnenolone sulfate enhances posttraining memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive. Proc. Natl. Acad. Sci. U.S.A. 92:1995;10806-10810.
6. Flood J.F., Roberts E. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res. 448:1988;178-181.
7. Frye C.A., Sturgis J.D. Neurosteroids affect spatial/reference, working, and long-term memory of female rats. Neurobiol. Learn. Mem. 64:1995;83-96.
8. Hellewell S.B., Bowen W.D. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res. 527:1990;244-253.
9. Ichihara K., Nabeshima T., Kameyama T. Opposite effects induced by low and high doses of apomorphine on single-trial passive-avoidance learning in mice. Pharmacol. Biochem. Behav. 30:1988;107-113.
10. 2 receptors. Eur. J. Pharmacol. 213:1992;243-250.
11. 2+ responses: structure-activity studies. J. Pharmacol. Exp. Ther. 271:1994;677-682.
12. Isaacson R.C., Varner J.A., Baars J.-M., de Wied D. The effects of pregnenolone sulfate and ethylestrenol on retention of a passive-avoidance task. Brain Res. 689:1995;79-84.
13. Itzhak Y., Alerhand S. Differential regulation of σ and PCP receptors after chronic administration of haloperidol and phencyclidine in mice. FASEB J. 3:1989;1868-1872.
14. Kulkarni S.K., Reddy D.S. Neurosteroids: A new class of neuromodulators. Drugs Today. 31:1995;433-455.
15. Li P.-K., Rhodes M.E., Jagannathan S., Johnson D.A. Reversal of scopolamine induced amnesia in rats by the steroid sulfatase inhibitor estrone-3-O-sulfamate. Cogn. Brain. Res. 2:1995;251-254.
16. Majewska M.D. Neurosteroids: Endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38:1992;379-395.
17. Mathis C., Paul S.M., Crawley J.N. The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive-avoidance memory task. Psychopharmacology. 11:1994;201-206.
18. Matsuno K., Matsunaga K., Senda T., Mita S. Increase in extracellular acetylcholine level by sigma ligands in rat frontal cortex. J. Pharmacol. Exp. Ther. 265:1993;851-859.
19. 1-receptors. Behav. Brain Res. 83:1997;159-164.
20. Maurice T., Lockhart B.P. Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 21:1997;69-102.
21. 1 receptors in the mouse forebrain. J. Neurosci. Res. 46:1996;734-743.
22. Mayo W., Dellu F., Robel P., Cherkaoui J., Le Moal M., Baulieu E.-E., Simon H. Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat. Brain Res. 607:1993;324-328.
23. McGough J.L. Preserving the presence of the past: Hormonal influences on memory storage. Am. Psychologist. 38:1983;161-174.
24. Mondadori C., Ducret T., Borkowski J. How long does 'memory consolidation' take? New compounds can improve retention performance, even if administered upto 24 hours after the learning experience. Brain Res. 555:1991;107-111.
25. 3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc. Natl. Acad. Sci. U.S.A. 92:1995;3774-3778.
26. Reddy D.S. Assessment of nootropic and amnestic activity of centrally acting agents. Indian J. Pharmacol. 29:1997;208-221.
27. Reddy D.S., Kulkarni S.K. Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the antistress activity of neurosteroids in mice. Psychopharmacology. 128:1996;280-292.
28. Reddy D.S., Kulkarni S.K. Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice. Brain Res. 752:1997;61-71.
29. Reddy D.S., Kulkarni S.K. Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice. Methods Find. Exp. Clin. Pharmacol. 19:1997;395-405.
30. Reddy D.S., Kulkarni S.K. Chronic neurosteroid treatment prevents development of morphine tolerance and attenuates abstinence behavior in mice. Eur. J. Pharmacol. 337:1997;19-25.
31. Reddy D.S., Kulkarni S.K. Neuroprotective effects of neurosteroids against hypoxic stress-induced neurotoxicity in naive and FG 7142-treated mice. Indian J. Pharmacol. 29:1997;381-392.
32. D.S. Reddy, S.K. Kulkarni, Reversal of benzodiazepine inverse agonist FG 7142-induced anxiety syndrome by neurosteroids in mice, Methods Find. Exp. Clin. Pharmacol. 19 (1997) (in press).
33. Roberts E. Pregnenolone: From Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABA-A receptor. Biochem. Pharmacol. 49:1995;1-16.
34. Schumacher M., Robel P., Baulieu E.-E. Development and regeneration of the nervous system: A role for neurosteroids. Dev. Neurosci. 18:1996;6-21.
35. Senda T., Kiyoshi M., Kobayashi T., Mita S. Reduction of the scopolamine-induced impairment of passive-avoidance performance by σ receptor agonist in mice. Physiol. Behav. 61:1997;257-264.
36. Sharma A.C., Kulkarni S.K. Effects of MK-801 and Ketamine on short-term memory deficits in passive-avoidance step-down task paradigm in mice. Methods Find. Exp. Clin. Pharmacol. 13:1991;155-159.
37. Stone W.S., Rudd R.J., Gold P.E. Amphetamine, epinephrine and glucose enhancement of memory retrieval. Psychobiology. 18:1990;227-230.
38. Su T.P., London E.D., Jaffe J.H. Steroid binding at σ receptors suggests a link between endocrine, nervous and immune systems. Science. 240:1988;219-221.
39. Walker J.M., Bowen W.D., Walker F.O., Matsumoto R.R., De Costa B., Rice K.C. Sigma receptors: biology and function. Pharmacol. Rev. 42:1990;355-402.
40. Wu F.S., Gibbs T.T., Farb D.H. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol. Pharmacol. 40:1991;333-336.