Progesterone induces changes in sleep comparable to those of agonistic GABA(A) receptor modulators

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 4 34-4, 1996, Pages

  Lancel, Marike ^a   Faulhaber, Johannes ^a   Holsboer, Florian ^a   Rupprecht, Rainer ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

electroencephalography; neurosteroids; sleep state; spectral analysis; aminobutyric acid A receptor

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ELTANOLONE; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; LATENT PERIOD; MALE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; REM SLEEP; SPECTROSCOPY;

EID: 0029911349     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.4.e763     Document Type: Article

References (33)

1. Belelli, D., M. B. Bolger, and K. W. Gee. Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 166: 325-329, 1989
2. A receptor function. Pharmacol. Biochem. Behav. 45: 423-428, 1993.
3. A receptors J. Neuroendocrinol 1: 171-177, 1995.
4. Bixo, M., and T. Bäckström. Regional distribution of progesterone and 5α-pregnane-3,20-dione in rat brain during progesterone-induced "anesthesia." Psychoneuroendocrinology 15: 159-162, 1990.
5. Borbély, A. A., P. Mattmann, M. Loepfe, I. Strauch, and D. Lehmann. Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum. Neurobiol. 4: 189-194, 1985.
6. Brunner, D. P., D. J. Dijk, M. Münch, and A. A. Borbély. Effect of zolpidem on sleep and sleep EEG spectra in healthy young men. Psychopharmacology 104: 1-5, 1991.
7. Brunner, D. P., M. Münch, K. Biedermann, R. Huch, A. Huch, and A. A. Borbély. Changes in sleep and sleep electroencephalogram during pregnancy. Sleep 17: 576-582, 1994.
8. Corpéchot, C., J. Young, M. Calvel, C. Wehrey C, J. N. Veltz, G. Touyer, M. Mouren, V. V. K. Prasad, C. Banner, J. Sjövall, E. E. Baulieu, and P. Robel. Neurosteroids: 3α-hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma and steroidogenic organs of male and female rats. Endocrinology 133: 1003-1009, 1993.
9. Dijk, D. J., D. G. M. Beersma, S. Daan, and R. H. van den Hoofdakker. Effects of seganserin, a 5-HT antagonist, and temazepam on human sleep stages and EEG power spectra. Eur. J. Pharmacol. 171: 207-218, 1989.
10. Driver, H. S., D. J. Dijk, E. Werth, K. Biedermann, and A. A. Borbäly. Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women. J. Clin. Endocrinol. Metab. 81: 728-735, 1996.
11. Driver, H. S., and C. M. Shapiro. A longitudinal study of sleep stages in young women during pregnancy and postpartum. Sleep 15: 449-453, 1992.
12. Gandolfo, G., R. Scherschlicht, and C. Gottesmann. Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat. Pharmacol. Biochem. Behav 49: 921-927, 1994.
13. Gottesmann, C. Données sur l'activité corticale au cours du sommeil chez le rat. C. R. Soc. Biol. Paris 158: 1829-1834, 1964.
14. Holzbauer, M. Physiological aspects of steroids with anaestethic properties. Med. Biol. 54: 227-242, 1976.
15. Kleinlogel, H. The female rat's sleep during oestrous cycle. Neuropsychobiology 10: 228-237, 1983.
16. A receptors in sleep regulation: differential effects of muscimol and midazolam on sleep in rats. Neuropsychopharmacology 15: 63-74, 1996.
17. Lancel, M., T. A. M. Crönlein, P. Müller-Preuß, and F. Holsboer. Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat, in contrast to midazolam. Brain Res. 646: 85-94, 1994.
18. Landgren, S., J. Aasly, T. Bäckström, B. Dubrovsky, and E. Danielsson. The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol. Scand. 131: 33-42, 1987.
19. Leibenluft, E., P. L. Fiero, and D. R. Rubinow. Effects of the menstrual cycle on dependent variables in mood disorder research. Arch. Gen. Psychiatry 51: 761-781, 1994.
20. A receptor channels. Annu. Rev. Neurosci. 17: 569-602, 1994.
21. Mendelson, W. B., J. V. Martin, M. Perils, R. Wagner, M. D. Majewska, and S. M. Paul. Sleep induction by an adrenal steroid in the rat. Psychopharmacology 93: 226-229, 1987.
22. Mok, W. M., C. Bukusoglu, and N. R. Krieger. 3α-Hydroxy-5α-pregnan-20-one is the only active anesthetic steroid in anesthetized mouse brain. Steroids 58: 112-114, 1993.
23. Neckelmann, D., and R. Ursin. Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat. Sleep 16: 467-477, 1993.
24. Paul, S. M., and R. H. Purdy. Neuroactive steroids. FASEB J. 6: 2311-2322, 1992.
25. Rupprecht, R., J. M. H. M. Reul, T. Trapp, B. van Steensel, C. Wetzel, K. Damm, W. Zieglgänsberger, and F. Holsboer. Progesterone receptor-mediated effects of neuroactive steroids. Neuron 11: 523-530, 1993.
26. Rupprecht, R., J. M. H. M. Reul, B. van Steensel, D. Spengler, M. Süder, B. Berning, F. Holsboer, and K. Damm. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur. J. Pharrnacol. 247: 145-154, 1993
27. Selye, H. Correlations between the chemical structure and the pharmacological actions of the steroids. Endocrinology 3: 437-453, 1942.
28. Steiger, A., R. Rupprecht, D. Spengler, J. Guldner, U. Hemmeter, B. Rothe, K. Damm, and F. Holsboer. Functional properties of deoxycorticosterone and spironolactone: molecular characterization and effects on sleep-endocrine activity. J. Psychiatr. Res. 27: 275-284, 1993.
29. Trachsel, L., D. J. Dijk, D. P. Brunner, C. Klene, and A. A. Borbély. Effect of zopiclone and midazolam on sleep and EEG spectra in a phase-advanced sleep schedule. Neuropsychopharmacology 3: 11-18, 1990.
30. Wiedemann, K., M. Hirschmann, and F. Seier. Sleep endocrine effects of different dosages of the progesterone derivative megestrol acetate in man (Abstract). Pharmacopsychiatry 28: 227, 1995.
31. Yamamoto, K. R. Steroid receptor regulated transcription of specific genes and gene networks. Annu. Rev. Genet. 19: 209-252, 1985.
32. Young, J., C. Corpéchot, F. Perché, M. Haug, E. E. Baulieu, and P. Robel. Neurosteroids: pharmacological effects of 3β-hydroxy-steroid dehydrogenase inhibitor. Endocrine 2: 505-509, 1994.
33. Zhang, S. Q., M. Kimura, and S. Inoué. Sleep patterns in cyclic and pseudopregnant rats. Neurosci. Lett. 193: 125-128, 1995.