Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the anti stress activity of neurosteroids in mice

Psychopharmacology

Volumn 128, Issue 3, 1996, Pages 280-292

  Reddy, Doodipala Samba ^a   Kulkarni, S K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

4' Chlordiazepam; GABA A; Mitochondrial DBI receptor; Neurosteroids; Progesterone; Stress

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4' CHLORODIAZEPAM; ASCORBIC ACID; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BICUCULLINE; FLUMAZENIL; HYDROCORTISONE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NALOXONE; NEUROSTEROID; PICROTOXIN; PROGESTERONE; RNA; TRIAZOLAM;

ADRENAL GLAND; ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ANXIETY; ARTICLE; ATAXIA; BEHAVIOR; BRAIN; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; IMMOBILIZATION STRESS; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MAZE TEST; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TISSUE LEVEL;

ANALYSIS OF VARIANCE; ANIMALS; ASCORBIC ACID; BEHAVIOR, ANIMAL; BINDING SITES; CEREBELLUM; CEREBRAL CORTEX; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA ANTAGONISTS; GABA MODULATORS; ISOQUINOLINES; MALE; MICE; MITOCHONDRIA; MOTOR ACTIVITY; PAIN MEASUREMENT; PICROTOXIN; PROGESTERONE; RECEPTORS, GABA-A; RNA; STRESS, PSYCHOLOGICAL; TRIAZOLAM;

EID: 0029852005     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050136     Document Type: Article

References (54)

1. Akwa Y, Young J, Kabbadj K, Sancho J, Zucman D. Vourch C, Jung-Testas I, Hu ZY, Le Goascogne C, Jo DH, Corpechot C, Simon C, Baulieu EE, Robel P (1991) Neurosteroids: biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J Steroid Biochem Mol Biol 40 : 71-81
2. Auta J, Romeo A, Kozikowski A, Ma D, Costa E, Guidotti A (1993) Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide, and imidazopyridine derivatives. J Pharmacol Exp Ther 265 : 649-656
3. Baulieu EE, Robel P (1990) Neurosteroids: a new brain function. J Steroid Biochem Mol Biol 37 : 395-403
4. Belelli D, Bolger MB, Gee KW (1989) Anticonvulsant profile of the progesterone metabolite 5x-pregnan-3x-ol-20-one. Eur J Pharmacol 166 : 325-329
5. Bing G, Filer D, Miller JC, Stone EA (1991) Noradrenergic activation of immediate early genes in rat cerebral cortex. Mol Brain Res 11 : 43-46
6. Bitran D, Sheikh M, McLeod M (1995) Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone of brain GABA-A receptor. J Neuroendocrinol 7 : 171-178
7. Challachan H, Cottrell GA, Hather NY, Lambert JJ, Nooney JM, Peters JA (1987) Modulation of the GABA-A receptor by progesterone metabolites. Proc R Soc Lond B 231 : 359-369
8. Costa E, Guidotti A (1991) Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. Life Sci 49 : 325-344
9. Dandiya PC, Varma RR, Sogani RK, Khuteta KP (1967) Effect of reserpine and chlorpromazine in some cold stress-induced biochemical alteration. J Pharm Sci 56 : 300-301
10. D'Armour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72 : 74-79
11. El-Etre M, Akwa Y, Fiddes RJ, Robel P, Baulieu EE (1995) A progesterone metabolite stimulate the release of gonadotropin-releasing hormone from GTI-1 hypothalamic neurons via the GABA-A receptor. Proc Natl Acad Sci USA 92 : 3769-3773
12. Ffrench-Mullen JMH, Danks P, Spence KT (1994) Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. J Neurosci 14 : 1963-1977
13. Finn DA, Gee KW (1993) The influence of estrus cycle on neurosteroid potency at the GABA-A receptor complex. J Pharmacol Exp Ther 265 : 1375-1379
14. Finn DA, Gee KW (1994) The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther 271 : 164-170
15. Frye CA (1995) The neurosteroid 3x-5x-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy. Brain Res 696 : 113-120
16. Gruen RJ, Wenberg K, Elahi R, Friedhoff AJ (1995) Alterations in GABA-A receptor binding in the prefrontal cortex following exposure to chronic stress. Brain Res 684 : 112-114
17. Guarneri P, Papadopoulos V, Pan P, Costa E (1992) Regulation of pregnenolone synthesis in C6-2B glioma cells by 4′-chlordiazepam. Proc Natl Acad Sci USA 89 : 5118-5122
18. Harrison NL, Majewska MD, Harrington JW, Barker JL (1987) Structure-activity relationships for steroid interaction with the GABA-A receptor complex. J Pharmacol Exp Ther 241 : 346-353
19. Holzbauer M, Birmingham M, De Nicole AAF, Olivier JT (1985) In vivo secretion of 3α-hydroxy-5α-pregnane-20-one, a potent anesthetic steroid by adrenal gland in rat. J Steroid Biochem 22 : 97-102
20. Irwin RP, Maragakis NJ, Rogawski MA, Purdy RH, Farb DH, Paul SM (1994) Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular calcium in cultured rat hippoeampal neurons. Neurosci Lett 141 : 30-34
21. Jung-Testas I, Hu ZY, Baulieu EE, Robel P (1989) Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 125 : 2083-2091
22. 3H] 5x-dihydroprogesterone by rat brain and pituitary and effects of estradiol and time: tissue concentration of progesterone itself or specific metabolites? Endocrinology 104 : 1418-1425
23. Karavaolas HN, Betries PJ, Hodges D, Rudie N (1984) Progesterone processing by neuroendocrine structures. In: Celotti F, Nastolin F, Martini L (eds) Metabolism of harmonal steroids in the neuroendocrine structures. Raven Press, New York, pp 149-170
24. 3H to 5B-pregnane-3,20-dione in brain tissue. Steroids 25 : 459-463
25. Kokate TG, Svensson BE, Rogawski MA (1994) Anticonvulsant activity of neurosleroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation. J Pharmacol Exp Ther 270 : 1223-1229
26. Korneyev A, Pan BS, Polo A, Romeo E, Guidotti A, Costa E (1993) Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo. J Neurochem 61 : 1515-1524
27. Kulkarni SK (1980) Heat and other physiological stress-induced analgesia: catecholamine mediated and naloxone reversible response. Life Sci 27 : 185-188
28. Kulkarni SK (1989) Stress, steroids and GABA-benzodiazepine receptor interaction. Drugs Today/Med Actul 25 : 555-565
29. Kulkarni SK (1993) Handbook of experimental pharmacology 2nd edn. Vallabh Prakashan, New Delhi, pp 61-63
30. Kulkarni SK, Kunchandy J (1988) Endogenous regulators and stress-induced behavioral changes in rats and mice. In: Sharma KN, Selvamurthy W, Bhattacharya N (eds) Brain and psychophysiology of stress. ICMR, New Delhi, pp 191-199
31. Kulkarni SK, Reddy DS (1995) Neurosteroids: a new class of neuromodulators. Drugs Today/Med Actul 31 : 433-455
32. Kulkarni SK, Reddy DS (1996) Animal behavioral models for testing antianxiety agents. Meth Find Exp Clin Pharmacol 18 : 219-230
33. Kulkarni SK, Sharma A (1994) Reversal of diazepam withdrawal induced hyperactivity in mice by BR 16-A (Mentat), a herbal preparation. Ind J Exp Biol 32 : 886-888
34. Lambert JJ. Belelli D, Hill-Venning C, Peters JA (1995) Neurosteroids and GABA-A receptor function. Trends Pharmacol Sci 16 : 295-303
35. Lan NC, Gee KW, Bolger MB, Chen JS (1991) Differential responses of expressed recombinant human γ-aminobutyric acid-A receptors to neurosteroids. J Neurochem 57 : 1818-1821
36. Lister RG (1987) The use of plus-maze to measure anxiety in the mouse. Psychopharmacology 92 : 180-185
37. Maggi A, Perez J (1984) Progesterone and estrogens in rat brain: modulation of GABA receptor activity. Eur J Pharmacol 103 : 165-168
38. Majewska MD (1992) Neurosteroids: endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance. Prog Neurobiol 38 : 379-396
39. Monro HN, Fleck A (1966) The determination of nucleic acids. In: Click D (ed) Methods in biochemical analysis, vol. 14. Wiley, New York, pp 114-176
40. Natelson S (1963) Routine determinations: ascorbic acid (with dinitrophenyl hydrazine). In: Nalelson S (ed) Microtechniques of clinical chemistry 2nd edn Springfield, Illinois, USA. p 121
41. Papadopoulos V, Guarneri P, Krueger KE, Guidotti A, Costa E (1992) Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by mitochondrial diazepam binding inhibitor receptor. Proc Nalt Acad Sci USA 89 : 5113-5117
42. Paul SV, Purdy RH (1992) Neuroactive steroids. FASEB J 6 : 2311-2322
43. Post RM (1992) Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am J Psychiatry 149 : 999-1010
44. Puia G, Santi MR, Vicini S, Pritchett DB, Seeburg PH, Costa E (1989) Differences in the negative allosteric modulation of GABA receptors elicited by 4′-chlordiazepam and by a β-carboline-3-carboxylate ester: a study with natural and reconstituted receptors. Proc Natl Acad Sci USA 86 : 7275-7279
45. Puia G, Santi M, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E (1990) Neurosteroids act on recombinant human GABA-A receptors. Neuron 4 : 759-765
46. Purdy RH, Morrow AL, Moore PH Jr, Paul SM (1991) Stress-induced elevations of γ-aminobutyric acid type-A receptor-active steroids in rat brain. Proc Natl Acad Sci USA 88 : 4553-4557
47. Robel P, Baulieu EE (1994) Neurosteroids: biosynthesis and function. Trends Endocrinol Metab 5 : 1-8
48. Smith SS (1991) The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalamic sites. In: Costa E, Paul SM (eds) Neurosteroids and brain function, Fidia Research Foundation Symposium Series, vol. 8. Thieme New York, pp 87 94
49. Smith SS, Waterhouse BD, Woodward DJ (1985) Progesterone modulates cerebellar purkinje cell responsiveness to GABA and glutamate. Soc Neurosci Abstr 11 : 164.4
50. Smith SS, Waterhouse BD, Chapin JK, Woodward DJ (1987) Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic function. Brain Res 400 : 353-359
51. Turner DM, Ransom RW, Yang JS-J, Olsen RW (1989) Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates. J Pharmacol Exp Ther 248 : 960-966
52. Wieland S, Belluzzi JD, Stein L, Lan NC (1995) Comparative behavioural characterization of the neuroactive steroids 3x-OH, 5x-pregnan-20-one and 3a-OH, 5β-pregnan-20-one in rodents. Psychopharmacology 118 : 65-71
53. Wu F-S, Gibbs TT, Farb DH (1990) Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone. Mol Pharmacol 37 : 597-602
54. Wu F-S, Gibbs TT, Farb DH (1991) Pregnenolone sulfate: a positive allosteric modulator at the NMDA receptor. Mol Pharmacol 40 : 333-336