메뉴 건너뛰기




Volumn 19, Issue 6, 1997, Pages 395-405

Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice

Author keywords

4' Chlordiazepam; Allopregnanolone; Anxiety; BZD tolerance and withdrawal; Dehydroepiandrosterone sulfate; Diazepam; Motor activity; Neurosteroids; Pregnenolone sulfate; Progesterone; Triazolam

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIAZEPAM; FLUMAZENIL; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NEUROSTEROID; PRASTERONE SULFATE; TETRAHYDRODEOXYCORTICOSTERONE; TRIAZOLAM;

EID: 0030782071     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (52)

References (48)
  • 1
    • 0025930826 scopus 로고
    • Neurosteroids: Biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain
    • Akwa, Y., Young, J., Kabbadj, K. et al. Neurosteroids: Biosynthesis, metabolism and function of pregnenolone and dehydroepiandrosterone in the brain. J Steroid Biochem Mol Biol 1991, 40: 71-81.
    • (1991) J Steroid Biochem Mol Biol , vol.40 , pp. 71-81
    • Akwa, Y.1    Young, J.2    Kabbadj, K.3
  • 2
    • 0026579057 scopus 로고
    • Neuroactive steroids
    • Paul, S.V., Purdy, R.H. Neuroactive steroids. FASEB J 1992, 6: 2311-22.
    • (1992) FASEB J , vol.6 , pp. 2311-2322
    • Paul, S.V.1    Purdy, R.H.2
  • 3
    • 0028865904 scopus 로고
    • Neurosteroids: A new class of neuromodulators
    • Kulkarni, S.K., Reddy, D.S. Neurosteroids: A new class of neuromodulators. Drugs Today 1995, 31: 433-55.
    • (1995) Drugs Today , vol.31 , pp. 433-455
    • Kulkarni, S.K.1    Reddy, D.S.2
  • 4
  • 5
    • 0025882967 scopus 로고
    • Diazepam binding inhibitor (DBI): A peptide with multiple biological actions
    • Costa, E., Guidotti, A. Diazepam binding inhibitor (DBI): A peptide with multiple biological actions. Life Sci 1991, 49: 325-44.
    • (1991) Life Sci , vol.49 , pp. 325-344
    • Costa, E.1    Guidotti, A.2
  • 6
    • 0027428732 scopus 로고
    • Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo
    • Korneyev, A., Pan, B.S., Polo, A., Romeo, E., Guidotti, A., Costa, E. Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo. J Neurochem 1993, 61: 1515-24.
    • (1993) J Neurochem , vol.61 , pp. 1515-1524
    • Korneyev, A.1    Pan, B.S.2    Polo, A.3    Romeo, E.4    Guidotti, A.5    Costa, E.6
  • 7
    • 0026635087 scopus 로고
    • Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlordiazepam
    • Guarneri, P., Papadopoulos, V., Pan, P., Costa, E. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlordiazepam. Proc Natl Acad Sci USA 1992, 89: 5118-22.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5118-5122
    • Guarneri, P.1    Papadopoulos, V.2    Pan, P.3    Costa, E.4
  • 8
    • 0027488935 scopus 로고
    • Participation of mitochondrial diazepam binding inhibitor receptor in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives
    • Auta, J., Romeo, A., Kozikowski, A., Ma, D., Costa, E., Guidotti, A. Participation of mitochondrial diazepam binding inhibitor receptor in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives. J Pharmacol Exp Ther 1993, 265: 649-56.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 649-656
    • Auta, J.1    Romeo, A.2    Kozikowski, A.3    Ma, D.4    Costa, E.5    Guidotti, A.6
  • 9
    • 0026509649 scopus 로고
    • A-A receptor. Mechanism of action and physiological significance
    • A-A receptor. Mechanism of action and physiological significance. Prog Neurobiol 1992, 38: 379-96.
    • (1992) Prog Neurobiol , vol.38 , pp. 379-396
    • Majewska, M.D.1
  • 11
    • 0025329137 scopus 로고
    • Inverse modulation of γ-aminobutyric acid and glycine-induced currents by progesterone
    • Wu, F-S., Gibbs, T.T., Farb, D.H. Inverse modulation of γ-aminobutyric acid and glycine-induced currents by progesterone. Mol Pharmacol 1990, 37: 597-602.
    • (1990) Mol Pharmacol , vol.37 , pp. 597-602
    • Wu, F.-S.1    Gibbs, T.T.2    Farb, D.H.3
  • 12
    • 0028213566 scopus 로고
    • Neurosteroids modulate calcium currents in hippocampal CAI neurons via a pertussis toxin-sensitive G-protein-coupled mechanism
    • Ffrench-Mullen, J.M.H., Danks, P., Spence, K.T. Neurosteroids modulate calcium currents in hippocampal CAI neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. J Neurosci 1994, 14: 1963-77.
    • (1994) J Neurosci , vol.14 , pp. 1963-1977
    • Ffrench-Mullen, J.M.H.1    Danks, P.2    Spence, K.T.3
  • 13
    • 0025995802 scopus 로고
    • Pregnenolone sulfate: A positive allosteric modulator at the NMDA receptor
    • Wu, F-S., Gibbs, T.T., Farb, D.H. Pregnenolone sulfate: A positive allosteric modulator at the NMDA receptor. Mol Pharmacol 1991, 40: 333-6.
    • (1991) Mol Pharmacol , vol.40 , pp. 333-336
    • Wu, F.-S.1    Gibbs, T.T.2    Farb, D.H.3
  • 14
    • 0026747649 scopus 로고
    • Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular calcium in cultured rat hippocampal neurons
    • Irwin, R.P., Maragakis, N.J., Rogawski, M.A., Purdy, R.H., Farb, D.H., Paul, S.M. Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular calcium in cultured rat hippocampal neurons. Neurosci Lett 1994, 141: 30-4.
    • (1994) Neurosci Lett , vol.141 , pp. 30-34
    • Irwin, R.P.1    Maragakis, N.J.2    Rogawski, M.A.3    Purdy, R.H.4    Farb, D.H.5    Paul, S.M.6
  • 15
    • 0025999108 scopus 로고
    • The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block calcium currents in acutely isolated hippocampal CAI neurons
    • Spence, K.T., Plata-Salaman, C.R., Ffrench-Mullen, J.M.H. The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block calcium currents in acutely isolated hippocampal CAI neurons. Life Sci 1991, 49: PL235-9.
    • (1991) Life Sci , vol.49
    • Spence, K.T.1    Plata-Salaman, C.R.2    Ffrench-Mullen, J.M.H.3
  • 16
    • 0022871695 scopus 로고
    • 2-agonists of diazepam withdrawal hyperactivity in rats
    • 2-agonists of diazepam withdrawal hyperactivity in rats. Psychopharmacology 1986, 90: 198-202.
    • (1986) Psychopharmacology , vol.90 , pp. 198-202
    • Kunchandy, J.1    Kulkarni, S.K.2
  • 17
    • 0026878098 scopus 로고
    • Benzodiazepines: Use, abuse and consequences
    • Woods, J.H., Katz, J.L., Winger, G. Benzodiazepines: Use, abuse and consequences. Pharmacol Rev 1992, 44: 151-347.
    • (1992) Pharmacol Rev , vol.44 , pp. 151-347
    • Woods, J.H.1    Katz, J.L.2    Winger, G.3
  • 19
    • 0023584428 scopus 로고
    • Abuse liability of benzodiazepines
    • Woods, J.H., Katz, J.L., Winger, G. Abuse liability of benzodiazepines. Pharmacol Rev 1990, 39: 251-419.
    • (1990) Pharmacol Rev , vol.39 , pp. 251-419
    • Woods, J.H.1    Katz, J.L.2    Winger, G.3
  • 20
    • 0023762604 scopus 로고
    • Chronic benzodiazepine administration.I. Tolerance is associated with decreased benzodiazepine receptor down-regulation and decreased gamma-aminobutyric acid A receptor function
    • Miller, L.G., Greenblatt, D.J., Barnhill, J.G., Shader, R.I. Chronic benzodiazepine administration.I. Tolerance is associated with decreased benzodiazepine receptor down-regulation and decreased gamma-aminobutyric acid A receptor function. J Pharmacol Exp Ther 1988, 246: 170-6.
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 170-176
    • Miller, L.G.1    Greenblatt, D.J.2    Barnhill, J.G.3    Shader, R.I.4
  • 21
    • 0029852005 scopus 로고    scopus 로고
    • A and mitochondrial diazepam binding inhibitor (MDR) receptors in the antistress activity of neurosteroids in mice
    • A and mitochondrial diazepam binding inhibitor (MDR) receptors in the antistress activity of neurosteroids in mice. Psychopharmacology 1996, 128: 280-92.
    • (1996) Psychopharmacology , vol.128 , pp. 280-292
    • Reddy, D.S.1    Kulkarni, S.K.2
  • 22
    • 0030896347 scopus 로고    scopus 로고
    • Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice
    • Reddy, D.S., Kulkarni, S.K. Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice. Brain Res 1997, 752: 61-71.
    • (1997) Brain Res , vol.752 , pp. 61-71
    • Reddy, D.S.1    Kulkarni, S.K.2
  • 23
    • 0023255981 scopus 로고
    • The use of a plus-maze to measure anxiety in the mouse
    • Lister, R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 1987, 92: 180-5.
    • (1987) Psychopharmacology , vol.92 , pp. 180-185
    • Lister, R.G.1
  • 24
    • 0030048392 scopus 로고    scopus 로고
    • Animal behavioral models for testing anti-anxiety agents
    • Kulkarni, S.K., Reddy, D.S. Animal behavioral models for testing anti-anxiety agents. Meth Find Exp Clin Pharmacol 1996, 18: 219-30.
    • (1996) Meth Find Exp Clin Pharmacol , vol.18 , pp. 219-230
    • Kulkarni, S.K.1    Reddy, D.S.2
  • 25
    • 0024414966 scopus 로고
    • Neurosteroids: Biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells
    • Jumg-Testas, I., Hu, Z.Y., Baulieu, E.E., Robel, P. Neurosteroids: biosynthesis of pregnenolone and progesterone in primary cultures of rat glial cells. Endocrinology 1989, 125: 2083-91.
    • (1989) Endocrinology , vol.125 , pp. 2083-2091
    • Jumg-Testas, I.1    Hu, Z.Y.2    Baulieu, E.E.3    Robel, P.4
  • 26
    • 0027182055 scopus 로고
    • Diazepam dependence prevented by glutamate antagonists
    • Steppuhn, K.G., Turski, L. Diazepam dependence prevented by glutamate antagonists. Proc Natl Acad Sci USA 1993, 90: 6889-93.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6889-6893
    • Steppuhn, K.G.1    Turski, L.2
  • 27
    • 0027270720 scopus 로고
    • Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: A review of supporting neurochemical and behavioral evidence
    • Andrews, N., File, S.E. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioral evidence. Psychopharmacology 1993, 112: 21-5.
    • (1993) Psychopharmacology , vol.112 , pp. 21-25
    • Andrews, N.1    File, S.E.2
  • 28
    • 0029928522 scopus 로고    scopus 로고
    • Altered behavioral and neurochemical response to stress in benzodiazepine-withdrawn rats
    • Martigena, I.D., Tupia, M., Molina, V.A. Altered behavioral and neurochemical response to stress in benzodiazepine-withdrawn rats. Brain Res 1996, 712: 239-44.
    • (1996) Brain Res , vol.712 , pp. 239-244
    • Martigena, I.D.1    Tupia, M.2    Molina, V.A.3
  • 29
    • 0028801074 scopus 로고
    • A receptor complex: The pharmacological properties and therapeutic potentials of epalons
    • A receptor complex: The pharmacological properties and therapeutic potentials of epalons. Crit Rev Neurobiol 1995, 9: 207-27.
    • (1995) Crit Rev Neurobiol , vol.9 , pp. 207-227
    • Gee, K.W.1    McCauley, L.D.2    Lan, N.C.3
  • 30
    • 0028906188 scopus 로고
    • A/benzodiazepine receptor complex in mammalian cortical neurons
    • A/benzodiazepine receptor complex in mammalian cortical neurons. Mol Pharmacol 1995, 47: 603-10.
    • (1995) Mol Pharmacol , vol.47 , pp. 603-610
    • Yu, R.1    Ticku, M.K.2
  • 31
    • 0027181570 scopus 로고
    • +-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: A semiquantitative immunocytochemical study
    • +-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: A semiquantitative immunocytochemical study. Brain Res 1993, 623, 329-33.
    • (1993) Brain Res , vol.623 , pp. 329-333
    • Tauboll, E.1    Ottersen, O.P.2    Gjerstad, L.3
  • 32
    • 0029919873 scopus 로고    scopus 로고
    • Neurosteroids - Molecular mechanisms of action and psychopharmacological significance
    • Rupprecht, R., Hauser C.A.E., Trapp, T., Holsboer, F. Neurosteroids - Molecular mechanisms of action and psychopharmacological significance. J Steroid Biochem Mol Biol 1996, 56: 163-8.
    • (1996) J Steroid Biochem Mol Biol , vol.56 , pp. 163-168
    • Rupprecht, R.1    Hauser, C.A.E.2    Trapp, T.3    Holsboer, F.4
  • 33
    • 0030036766 scopus 로고    scopus 로고
    • Development and regeneration of the nervous system - A role for neurosteroids
    • Schumacher, M., Robel, P., Baulieu, E-E. Development and regeneration of the nervous system - A role for neurosteroids. Dev Neurosci 1996, 18: 6-21.
    • (1996) Dev Neurosci , vol.18 , pp. 6-21
    • Schumacher, M.1    Robel, P.2    Baulieu, E.-E.3
  • 34
    • 0024321145 scopus 로고
    • Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one
    • Belelli, D., Bolger, M.B., Gee, K.W. Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur J Pharmacol 1989, 166: 325-9.
    • (1989) Eur J Pharmacol , vol.166 , pp. 325-329
    • Belelli, D.1    Bolger, M.B.2    Gee, K.W.3
  • 35
    • 0028973110 scopus 로고
    • The neurosteroid 3α-5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy
    • Frye, C.A. The neurosteroid 3α-5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy. Brain Res 1995, 696: 113-20.
    • (1995) Brain Res , vol.696 , pp. 113-120
    • Frye, C.A.1
  • 37
    • 0027381920 scopus 로고
    • Anxiolytic metabolites of progesterone: Correlation with mood and performance measures following oral progesterone administration to healthy female volunteers
    • Freeman, E.W., Purely, R. H., Coutitaris, C., Rickels, K., Paul, S.M. Anxiolytic metabolites of progesterone: Correlation with mood and performance measures following oral progesterone administration to healthy female volunteers. Neuroendocrinology 1993, 58: 478-84.
    • (1993) Neuroendocrinology , vol.58 , pp. 478-484
    • Freeman, E.W.1    Purely, R.H.2    Coutitaris, C.3    Rickels, K.4    Paul, S.M.5
  • 39
    • 0343943881 scopus 로고
    • A receptor function observed in progesterone-treated ovariectomized rats
    • A receptor function observed in progesterone-treated ovariectomized rats. Soc Neurosci Abstr 1993, 19: 373-83.
    • (1993) Soc Neurosci Abstr , vol.19 , pp. 373-383
    • Bitran, D.1    McLeod, M.2    Shiekh, M.3
  • 41
    • 0029056668 scopus 로고
    • Anti-anxiety effects of progesterone and some of its reduced metabolites: An evaluation using the burying behavior test
    • Picazo, O., Fernandez-Guasti, A. Anti-anxiety effects of progesterone and some of its reduced metabolites: An evaluation using the burying behavior test. Brain Res 1995, 680: 135-41.
    • (1995) Brain Res , vol.680 , pp. 135-141
    • Picazo, O.1    Fernandez-Guasti, A.2
  • 42
    • 0001219433 scopus 로고
    • The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalamic sites
    • Fidia Research Foundation Symposium Series, E. Costa and S.M. Paul (Eds.). Thieme Medical Publishers: New York
    • Smith, S.S. The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalamic sites. In: Neurosleroids and Brain Function. Fidia Research Foundation Symposium Series, Vol. 8. E. Costa and S.M. Paul (Eds.). Thieme Medical Publishers: New York 1991, 87-94.
    • (1991) Neurosleroids and Brain Function , vol.8 , pp. 87-94
    • Smith, S.S.1
  • 43
    • 0026502243 scopus 로고
    • Evidence that 5α-pregnan-3α-hydroxy-20-one is the metabolites responsible for anesthesia induced by 5α-pregnanedione in the mouse
    • Mok, W.M. Krieger, N.R. Evidence that 5α-pregnan-3α-hydroxy-20-one is the metabolites responsible for anesthesia induced by 5α-pregnanedione in the mouse. Neurosci Lett 1990, 135: 145-8.
    • (1990) Neurosci Lett , vol.135 , pp. 145-148
    • Mok, W.M.1    Krieger, N.R.2
  • 44
    • 0021126939 scopus 로고
    • Progesterone and estrogens in rat brain: Modulation of GABA receptor activity
    • Maggi, A., Perez, J. Progesterone and estrogens in rat brain: Modulation of GABA receptor activity. Eur J Pharmacol 1984, 103: 165-8.
    • (1984) Eur J Pharmacol , vol.103 , pp. 165-168
    • Maggi, A.1    Perez, J.2
  • 45
    • 0028951505 scopus 로고
    • Progesterone co-administration in patients discontinuing long-term benzodiazepine therapy effects on withdrawal severity and taper outcome
    • Schwerzer, E., Case, W.W., Garcia-Espana, F., Greenblatt, D.J., Rickels, K. Progesterone co-administration in patients discontinuing long-term benzodiazepine therapy effects on withdrawal severity and taper outcome. Psychopharmacology 1995, 117: 424-9.
    • (1995) Psychopharmacology , vol.117 , pp. 424-429
    • Schwerzer, E.1    Case, W.W.2    Garcia-Espana, F.3    Greenblatt, D.J.4    Rickels, K.5
  • 46
    • 0026649978 scopus 로고
    • Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: Regulation by mitochondrial diazepam binding inhibitor receptor
    • Papadopoulos, V., Guarneri, P., Krueger, K.E., Guidotti, A., Costa, E. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: Regulation by mitochondrial diazepam binding inhibitor receptor. Proc Natl Acad Sci USA 1992, 89: 5113-7.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5113-5117
    • Papadopoulos, V.1    Guarneri, P.2    Krueger, K.E.3    Guidotti, A.4    Costa, E.5
  • 47
    • 0028796547 scopus 로고
    • Cortisol inhibition of calcium currents in guinea pig hippocampal CAI neurons via G-protein-coupled activation of protein kinase C
    • Ffrench-Mullen, J.M.H. Cortisol inhibition of calcium currents in guinea pig hippocampal CAI neurons via G-protein-coupled activation of protein kinase C. J Neurosci 1995, 15: 303-11.
    • (1995) J Neurosci , vol.15 , pp. 303-311
    • Ffrench-Mullen, J.M.H.1
  • 48
    • 0025918575 scopus 로고
    • Neurosteroids block calcium channel current in freshly isolated hippocampal CAI neurons
    • Ffrench-Mullen, J.M.H., Spence, K.T. Neurosteroids block calcium channel current in freshly isolated hippocampal CAI neurons. Eur J Pharmacol 1991, 202: 269-72.
    • (1991) Eur J Pharmacol , vol.202 , pp. 269-272
    • Ffrench-Mullen, J.M.H.1    Spence, K.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.