CCD-3693: An orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 1, 1997, Pages 420-429

  Edgar, Dale M ^a,d   Seidel, Wesley F ^a   Gee, Kelvin W ^b   Lan, Nancy C ^c   Field, George ^c   Xia, Haiji ^c   Hawkinson, Jon E ^c   Wieland, Scott ^c   Carter, Richard B ^c   Wood, Paul L ^c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Department of Pharmacokinetics and Drug Metabolism   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 3ALPHA HYDROXY 3BETA TRIFLUOROMETHYL 19 NOR 5BETA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BENZODIAZEPINE RECEPTOR; CLONAZEPAM; ELTANOLONE; FLUNITRAZEPAM; HYPNOTIC SEDATIVE AGENT; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; TRIAZOLAM; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; BIOASSAY; BODY TEMPERATURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ALCOHOL INTERACTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MOUSE; NEOCORTEX; NONHUMAN; NONREM SLEEP; ORAL DRUG ADMINISTRATION; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; REM SLEEP; RIGHTING REFLEX; SEDATION; SLEEP WAKING CYCLE; TRANQUILIZING ACTIVITY; WAKEFULNESS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BODY TEMPERATURE; HYPNOTICS AND SEDATIVES; MALE; MICE; MOTOR ACTIVITY; PREGNANOLONE; PREGNENOLONE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SLEEP;

EID: 15144359114     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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