GABAA-receptor-mediated effects of progesterone, its ring-A-reduced metabolites and synthetic neuroactive steroids on neurogenic oedema in the rat meninges

British Journal of Pharmacology

Volumn 117, Issue 1, 1996, Pages 99-104

  Limmroth, Volker ^a   Lee, Won Suk ^a   Moskowitz, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

GABAA receptors; Headache; Migraine; Neurogenic inflammation; Neurosteroids; Progesterone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BICUCULLINE; BOVINE SERUM ALBUMIN; ELTANOLONE; PROGESTERONE; SUBSTANCE P; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; ALFAXALONE; BICUCULLINE METHIODIDE; CORTICOSTERONE DERIVATIVE; DEOXYCORTICOSTERONE DERIVATIVE; MUSCIMOL; PHACLOFEN; PREGNENOLONE; PROMEGESTONE; STEROID; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL; ARTICLE; BRAIN EDEMA; CAPILLARY PERMEABILITY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; ISOMERISM; MALE; MENINX; METABOLISM; RAT; SPRAGUE DAWLEY RAT; ANGIONEUROTIC EDEMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD BRAIN BARRIER; CLUSTER HEADACHE; CONJUNCTIVA; CONTROLLED STUDY; ELECTROSTIMULATION; EXTRAVASATION; HEART RATE; INTRAPERITONEAL DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; MIGRAINE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TONGUE; TRIGEMINUS GANGLION;

ANIMALS; BICUCULLINE; BRAIN EDEMA; CAPILLARY PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA ANTAGONISTS; ISOMERISM; MALE; MENINGES; PREGNANOLONE; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SERUM ALBUMIN, BOVINE; SUBSTANCE P;

EID: 0029671013     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15160.x     Document Type: Article

References (34)

1. BLAKIE, N.H. & HOSSACK, J.C. (1932). The treatment of migraine with emmenin. A preliminary report. Canad. Med. Ass. J., 27, 45-47.
2. BRADLEY, W.G., HUDGSON, J.B., FOSTER, J.B. & NEWELL, D.J. (1968). Double-blind controlled trial of a micronized preparation of Flumedroxone (Demigran) in prophylaxis of migraine. Br. Med. J., 3, 531-533.
3. BUZZI, M.G. & MOSKOWITZ, M.A. (1990). The antimigraine drug, sumatriptan (GR43175) selectively blocks neurogenic plasma extravasation from blood vessels in dura mater. Br. J. Pharmacol., 99, 202-206.
4. BUZZI, M.G., CARTER, W.B., SHIMITZU, T., HEATH III, H. & MOSKOWTIZ, M.A. (1991). Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion. Neuropharmacology, 30, 1193-1200.
5. BUZZI, M.G., SAKAS, D.E. & MOSKOWITZ, M.A. (1989). Indomethacin and acetylsalicylic acid block neurogenic plasma protein extravasation in rat dura mater. Eur. J. Pharmacol., 165, 251-258.
6. CRAWLEY, J.N., GLOWA, J.R., MAJEWSKA, M.D. & PAUL, S.M. (1986). Anxiolytic activity of an endogenous adrenal steroid. Brain Res., 389, 382-385.
7. deLIGNIERS, B., VINCENS, M., MAUVAIS-JARVIS, P., MAS J.I., TOUBOUL, P.J. & BOUSSER, M.G. (1986). Prevention of menstrual migraine by percutaneous oestradiol. Br. Med. J., 293, 1540.
8. DIMITRIADOU, V., BUZZI, M.G., MOSKOWITZ, M.A. & THEOHARIES, T.C. (1991). Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells. Neuroscience, 44, 97-112.
9. A-receptor complex attenuate pain sensitivity in rats. Brain Res., 643, 194-203.
10. A-receptor complex in rat cortex. Eur. J. Pharmacol., 288, 157-162.
11. GRAY, L.A. (1941). The use of progesterone in nervous tension states. Southern Med. J., 34, 1004-1005.
12. HOBBIGER, R. (1958). Effects of gamma-aminobutyric acid on the isolated mammalian ileum. J. Physiol., 142, 147-164.
13. KAVALIERS, M. & WIEBE, J.P. (1987). Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one and possible modes of action in mice. Brain Res., 415, 393-398.
14. LAMBERT, J.J., HILL-VENNING, C., PETERS, J.A., STURGESS, N.C. & HALES, T.G. (1991). The action of anaesthetics steroids on inhibitory and excitatory amino acid receptors. In FIDIA RF Symposium Series, Vol. 6 ed. Costa, E. & Barnard, E. pp. 219-236. New York: Thieme medical publishers.
15. A, receptors mediated effects of sodium valproate on dural plasma protein extravasation to substance P and trigeminal stimulation. Br. J. Pharmacol., 116, 1661-1667.
16. LEE, W.S., MOUSSAOUI, S.M. & MOSKOWITZ, M.A. (1994). Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva. Br. J. Pharmacol., 112, 920-924.
17. LUNDBERG, P.O. (1968). Prophylactic treatment of migraine with flumedroxone. Acta Neurol. Scand., 45, 309-326.
18. A-receptor. Mechanism of action and physiological significance. Prog. Neurobiol., 38, 379-395.
19. MAJEWSKA, M.D., HARRISON, N.L., SCHWARTZ, R.D., BARKER, J.L. & PAUL, S.M. (1986). Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science, 232, 1004-1007.
20. McEWEN, B.S. (1991). Non-genomic and genomic effects of steroids on neural activity. Trends Pharmacol. Sci., 12, 141-147.
21. MARKOWITZ, S., SAITO, K. & MOSKOWITZ, M.A. (1987). Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J. Neurosci., 7, 4129-4136.
22. MENDELSON, W.B., MARTIN, J.V., PERLIS, M., WAGNER, R., MAJEWSKA, M.D. & PAUL, S.M. (1987). Sleep induction by an adrenal steroid in the rat. Psychopharmacology, 93, 226-229.
23. MOSKOWITZ, M.A. (1991). The visceral organ brain: implications for the pathophysiology of vascular head pain. Neurology, 41, 182-186.
24. MOSKOWITZ, M.A., BUZZI, M.G., SAKAS, D.E. & LINNIK, M.D. (1989). Pain mechanisms underlying vascular headaches. Rev. Neurol., 145, 181-193.
25. MOSKOWITZ, M.A., REINHARD, J.F. Jr., ROMERO, J., MELAMED, E. & PETTIBONE, D.J. (1979). Neurotransmitters and the fifth cranial nerve: is there a relation to the headache phase of migraine? Lancet, ii, 883-886.
26. PAUL, S.M. & PURDY, R.H. (1992). Neuroactive steroids. FASEB J., 6, 2311-2322.
27. PFAFFENRATH, V. (1993). Efficacy and safety of percutaneous estradiol vs. placebo in menstrual migraine. Cephalalgia, 13 (Suppl.), 244.
28. PONG, S.F. & GRAHAM, L.T.Jr. (1972). N-methyl-bicuculline, a convulsant more potent than bicuculline. Brain Res., 42, 486-490.
29. PURDY, R.H., MOORE, P.H.Jr., RAO, P.N., HAGINO, N., YAMAGUCHI, T., SCHMIDT, P., RUBINOW, D.R., MORROW, A.L. & PAUL, S.M. (1990). Radioimmunoassay of 3α-Hydroxy-5α-pregnan-20-one in rat and human plasma. Steroids. 55, 290-296.
30. PURDY, R.H., MORROW, A.L., MOORE, P.H.Jr. & PAUL, S.M. (1991). Stress-induced levels of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc. Natl. Acad. Sci. U.S.A., 88, 4553-4557.
31. RUPPRECHT, R., REUL, J.H., TRAPP, T., VAN, STEENSEL, B., WETZEL, C., DAMM, K., ZIEGLGANSBERGER, W. & HOLSBOER, F. (1993). Progesterone receptor-mediated effects of neuroactive steroids. Neuron., 11, 523-530.
32. SELYE, H, (1941). The anaesthetic effect of steroid hormones. Proc. Soc. Exp. Biol. Med., 46, 116-121.
33. SINGH, I., SINGH, I. & SINGH, D. (1947). Progesterone in the treatment of migraine. Lancet, i, 745-747.
34. SOMMERVILLE, B.W. (1971). The role of progesterone in menstrual migraine. Neurnology, 21, 853-859.