메뉴 건너뛰기




Volumn 752, Issue 1-2, 1997, Pages 61-71

Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice

Author keywords

anxiety; GABA A receptor; mirrored chamber; motor activity; neurosteroid; progesterone

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANXIOLYTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIZOCILPINE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; NEUROSTEROID; NIFEDIPINE; PICROTOXIN; PRASTERONE; PREGNENOLONE; PROGESTERONE; TRIAZOLAM;

EID: 0030896347     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01447-3     Document Type: Article
Times cited : (170)

References (57)
  • 1
    • 0027488935 scopus 로고
    • Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives
    • Auta, J., Romeo, E., Kozikowski, A., Ma, D., Costa, E. and Guidotti, A., Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives, J. Pharmacol Exp. Ther., 265 (1993) 9649-9656.
    • (1993) J. Pharmacol Exp. Ther. , vol.265 , pp. 9649-9656
    • Auta, J.1    Romeo, E.2    Kozikowski, A.3    Ma, D.4    Costa, E.5    Guidotti, A.6
  • 2
    • 0024321145 scopus 로고
    • Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one
    • Belelli, D., Bolger, M.B. and Gee, K.W., Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one, Eur. J. Pharmacol., 166 (1989) 125-329.
    • (1989) Eur. J. Pharmacol. , vol.166 , pp. 125-329
    • Belelli, D.1    Bolger, M.B.2    Gee, K.W.3
  • 3
    • 0025918687 scopus 로고
    • Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: Endogenous metabolites of progesterone that are active at the GABA-A receptor
    • Bitran, D., Hilvers, R.J. and Kellogg, C.K., Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABA-A receptor, Brain Res., 561 (1991) 157-161.
    • (1991) Brain Res. , vol.561 , pp. 157-161
    • Bitran, D.1    Hilvers, R.J.2    Kellogg, C.K.3
  • 4
    • 0343943881 scopus 로고
    • Blockade of the bioconversion of progesterone to allopregnanolone prevents the anxiolytic effect and potentiation of cortical GABA-A receptor function observed in progesterone-treated overiectomized rats
    • Bitran, D., McLeod, M. and Shiekh, M., Blockade of the bioconversion of progesterone to allopregnanolone prevents the anxiolytic effect and potentiation of cortical GABA-A receptor function observed in progesterone-treated overiectomized rats, Soc. Neurosc. Abstr., 19 (1993) 373-373.
    • (1993) Soc. Neurosc. Abstr. , vol.19 , pp. 373-373
    • Bitran, D.1    McLeod, M.2    Shiekh, M.3
  • 5
    • 0027312304 scopus 로고
    • Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABA-A receptor function
    • Bitran, D., Purdy, R.H. and Kellogg, C.K., Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABA-A receptor function, Pharmacol. Biochem. Behav., 45 (1993) 423-428.
    • (1993) Pharmacol. Biochem. Behav. , vol.45 , pp. 423-428
    • Bitran, D.1    Purdy, R.H.2    Kellogg, C.K.3
  • 6
    • 0028916048 scopus 로고
    • Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABA-A receptors
    • Bitran, D., Shiekh, M. and McLeod, M., Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABA-A receptors, J. Neuroendocrinol., 7 (1995) 171-177.
    • (1995) J. Neuroendocrinol. , vol.7 , pp. 171-177
    • Bitran, D.1    Shiekh, M.2    McLeod, M.3
  • 7
    • 0026749909 scopus 로고
    • Biochemical and behavioral effects of steroids on GABA-A receptor function in long- and short-sleep mice
    • Bowers, B.J. and Wehner, J.M., Biochemical and behavioral effects of steroids on GABA-A receptor function in long- and short-sleep mice, Brain Res. Bull., 29 (1992) 57-68.
    • (1992) Brain Res. Bull. , vol.29 , pp. 57-68
    • Bowers, B.J.1    Wehner, J.M.2
  • 8
    • 0027155274 scopus 로고
    • Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons
    • Bowlby, M.R., Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons, Mol. Pharmacol., 43 (1993) 813-819.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 813-819
    • Bowlby, M.R.1
  • 9
    • 0023022470 scopus 로고
    • Anxiolytic activity of an endogenous adrenal steroid
    • Crawley, J.N., Glowa, J.R., Majewska, M.D. and Paul, S.M., Anxiolytic activity of an endogenous adrenal steroid, Brain Res., 398 (1986) 382-385.
    • (1986) Brain Res. , vol.398 , pp. 382-385
    • Crawley, J.N.1    Glowa, J.R.2    Majewska, M.D.3    Paul, S.M.4
  • 10
    • 0025941858 scopus 로고
    • Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABA-A receptor
    • Demirgoren, S., Majewska, M.D., Spivak, C.E. and London, E.D., Receptor binding and electrophysiological effects of dehydroepiandrosterone sulfate, an antagonist of the GABA-A receptor, Neuroscience, 45 (1991) 127-135.
    • (1991) Neuroscience , vol.45 , pp. 127-135
    • Demirgoren, S.1    Majewska, M.D.2    Spivak, C.E.3    London, E.D.4
  • 12
    • 0026662235 scopus 로고
    • GABA-active steroids: Endogenous modulators of GABA-gated chloride ion conductance
    • Deutsch, S.I., Mastropaolo, J. and Hitri, A., GABA-active steroids: endogenous modulators of GABA-gated chloride ion conductance, Clin. Neuropharmacol., 15 (1992) 352-364.
    • (1992) Clin. Neuropharmacol. , vol.15 , pp. 352-364
    • Deutsch, S.I.1    Mastropaolo, J.2    Hitri, A.3
  • 13
    • 0027095758 scopus 로고
    • Changes in burying behavior during the estrous cycle: Effect of estrogen and progesterone
    • Fernandez-Guasti, A. and Picazo, O., Changes in burying behavior during the estrous cycle: effect of estrogen and progesterone, Psychoneuroendocrinology, 17 (1992) 681-689.
    • (1992) Psychoneuroendocrinology , vol.17 , pp. 681-689
    • Fernandez-Guasti, A.1    Picazo, O.2
  • 14
    • 0028213566 scopus 로고
    • Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism
    • Ffrench-Mullen, J.M.H., Danks, P. and Spence, K.T., Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism, J. Neurosci., 14 (1994) 1963-1977.
    • (1994) J. Neurosci. , vol.14 , pp. 1963-1977
    • Ffrench-Mullen, J.M.H.1    Danks, P.2    Spence, K.T.3
  • 15
    • 0027426171 scopus 로고
    • The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acid A receptor complex
    • Finn, D.A. and Gee, K.W., The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acid A receptor complex, J. Pharmacol Exp. Ther., 265 (1993) 1374-1379.
    • (1993) J. Pharmacol Exp. Ther. , vol.265 , pp. 1374-1379
    • Finn, D.A.1    Gee, K.W.2
  • 16
    • 0028973110 scopus 로고
    • The neurosteroid 3α,5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy
    • Frye, C.A., The neurosteroid 3α,5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy, Brain Res., 696 (1995) 113-120.
    • (1995) Brain Res. , vol.696 , pp. 113-120
    • Frye, C.A.1
  • 17
    • 0014389604 scopus 로고
    • Mirror-image stimulation
    • Gallup Jr., G.G., Mirror-image stimulation, Psychol. Bull., 70 (1968) 782-793.
    • (1968) Psychol. Bull. , vol.70 , pp. 782-793
    • Gallup G.G., Jr.1
  • 18
    • 0023681634 scopus 로고
    • Steroid modulation of the chloride ionophore in rat brain: Structure activity requirements, regional dependence and mechanism of action
    • Gee, K.W., Bolger, MB., Brinton, R.E., Coirini, H. and McEven, B.S., Steroid modulation of the chloride ionophore in rat brain: structure activity requirements, regional dependence and mechanism of action, J. Pharmacol. Exp. Ther., 246 (1988) 803-812.
    • (1988) J. Pharmacol. Exp. Ther. , vol.246 , pp. 803-812
    • Gee, K.W.1    Bolger, M.B.2    Brinton, R.E.3    Coirini, H.4    McEven, B.S.5
  • 19
    • 0028801074 scopus 로고
    • A putative receptor for neurosteroids on the GABA-A receptor complex: The pharmacological properties and therapeutic potential of epalons
    • Gee, K.W., McCauley, L.D. and Lan, N.C., A putative receptor for neurosteroids on the GABA-A receptor complex: the pharmacological properties and therapeutic potential of epalons, Crit. Rec. Neurobiol., 9 (1995) 207-227.
    • (1995) Crit. Rec. Neurobiol. , vol.9 , pp. 207-227
    • Gee, K.W.1    McCauley, L.D.2    Lan, N.C.3
  • 20
    • 0028981625 scopus 로고
    • 3H]muscimol binding to the GABA-A receptor complex in rat cortex
    • 3H]muscimol binding to the GABA-A receptor complex in rat cortex, Eur. J. Pharmacol., 288 (1995) 157-162.
    • (1995) Eur. J. Pharmacol. , vol.288 , pp. 157-162
    • Goodnough, D.B.1    Hawkinson, J.E.2
  • 21
    • 0028171991 scopus 로고
    • The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABA-A receptor
    • Hawkinson, I.E., Kimbrough, C.L., McCauley, L.D., Bolger, M.B., Lan, N.C. and Gee, K.W., The neuroactive steroid 3α-hydroxy-5β-pregnan-20-one is a two-component modulator of ligand binding to the GABA-A receptor, Eur. J. Pharmacol., 269 (1994) 157-163.
    • (1994) Eur. J. Pharmacol. , vol.269 , pp. 157-163
    • Hawkinson, I.E.1    Kimbrough, C.L.2    McCauley, L.D.3    Bolger, M.B.4    Lan, N.C.5    Gee, K.W.6
  • 22
    • 0023809472 scopus 로고
    • Inhibitory influences of the adrenal steroid 3α,5α-tetrahydroxycorticosterone, on aggression and defeat-induced analgesia in mice
    • Kavaliers, M., Inhibitory influences of the adrenal steroid 3α,5α-tetrahydroxycorticosterone, on aggression and defeat-induced analgesia in mice, Psychopharmacology, 95 (1988) 488-492.
    • (1988) Psychopharmacology , vol.95 , pp. 488-492
    • Kavaliers, M.1
  • 23
    • 0025896189 scopus 로고
    • Bay K-8644 potentiates the anxiolytic effect of ethanol
    • Kirac, R. and Eroglu, L., Bay K-8644 potentiates the anxiolytic effect of ethanol, Pharmacol. Biochem. Behav., 39 (1991) 30-34.
    • (1991) Pharmacol. Biochem. Behav. , vol.39 , pp. 30-34
    • Kirac, R.1    Eroglu, L.2
  • 24
    • 0028149787 scopus 로고
    • Anticonvulsant activity of neurosteroids: Correlation with gamma-aminobutyric acid-evoked chloride current potentiation
    • Kokate, T.G., Svensson, B.E. and Rogawski, M.A., Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation, J. Pharmacol. Exp. Ther., 279 (1994) 1223-1229.
    • (1994) J. Pharmacol. Exp. Ther. , vol.279 , pp. 1223-1229
    • Kokate, T.G.1    Svensson, B.E.2    Rogawski, M.A.3
  • 25
    • 0027428732 scopus 로고
    • Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo
    • Korneyev, A., Pan, B.S., Polo, A., Romeo, E., Guidotti, A. and Costa, E., Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo, J. Neurochem., 61 (1993) 1515-1524.
    • (1993) J. Neurochem. , vol.61 , pp. 1515-1524
    • Korneyev, A.1    Pan, B.S.2    Polo, A.3    Romeo, E.4    Guidotti, A.5    Costa, E.6
  • 26
  • 27
    • 0028865904 scopus 로고
    • Neurosteroids: A new class of neuromodulators
    • Kulkarni, S.K. and Reddy, D.S., Neurosteroids: a new class of neuromodulators, Drugs Today / Med. Actual., 31 (1995) 433-455.
    • (1995) Drugs Today / Med. Actual. , vol.31 , pp. 433-455
    • Kulkarni, S.K.1    Reddy, D.S.2
  • 29
    • 0025281267 scopus 로고
    • A steroid recognition site is functionally coupled to an expressed GABA-A/benzodiazepine receptor
    • Lan, N., Chen, J.S., Belelli, D., Pritchett, D., Seeburg, P.H. and Gee, K.W., A steroid recognition site is functionally coupled to an expressed GABA-A/benzodiazepine receptor, Eur. J. Pharmacol., 188 (1990) 403-406.
    • (1990) Eur. J. Pharmacol. , vol.188 , pp. 403-406
    • Lan, N.1    Chen, J.S.2    Belelli, D.3    Pritchett, D.4    Seeburg, P.H.5    Gee, K.W.6
  • 30
    • 0028578643 scopus 로고
    • Neuroactive steroid actions at the GABA-A receptor
    • Lan, N.C. and Gee, K.W., Neuroactive steroid actions at the GABA-A receptor, Horm. Behav., 28 (1994) 537-544.
    • (1994) Horm. Behav. , vol.28 , pp. 537-544
    • Lan, N.C.1    Gee, K.W.2
  • 31
    • 0023114555 scopus 로고
    • Pregnenolone-sulfate: An endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?
    • Majewska, M.D. and Schwartz, R.D., Pregnenolone-sulfate: an endogenous antagonist of the γ-aminobutyric acid receptor complex in brain?. Brain Res., 404 (1987) 355-360.
    • (1987) Brain Res. , vol.404 , pp. 355-360
    • Majewska, M.D.1    Schwartz, R.D.2
  • 33
    • 0026509649 scopus 로고
    • Neurosteroids: Endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance
    • Majewska, M.D., Neurosteroids: endogenous bimodal modulators of the GABA-A receptor. Mechanism of action and physiological significance, Prog. Neurobiol., 38 (1992) 379-395.
    • (1992) Prog. Neurobiol. , vol.38 , pp. 379-395
    • Majewska, M.D.1
  • 34
    • 0026720565 scopus 로고
    • Interaction of prenenolone sulfate with ethanol and pentobarbital
    • Melchior, C.L. and Allen, P.M., Interaction of prenenolone sulfate with ethanol and pentobarbital, Pharmacol. Biochem. Behav., 42 (1992) 605-611.
    • (1992) Pharmacol. Biochem. Behav. , vol.42 , pp. 605-611
    • Melchior, C.L.1    Allen, P.M.2
  • 35
    • 0028213506 scopus 로고
    • Dehydroepiandrosterone is an anxiolytic in mice on the plus-maze
    • Melchior, C.L. and Ritzmann, R.F., Dehydroepiandrosterone is an anxiolytic in mice on the plus-maze. Pharmacol. Biochem. Behav., 47 (1994) 437-441.
    • (1994) Pharmacol. Biochem. Behav. , vol.47 , pp. 437-441
    • Melchior, C.L.1    Ritzmann, R.F.2
  • 36
    • 0027971029 scopus 로고
    • Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze
    • Melchior, C.L. and Ritzmann, R.F., Pregnenolone and pregnenolone sulfate, alone and with ethanol, in mice on the plus-maze, Pharmacol. Biochem. Behav., 48 (1994) 893-897.
    • (1994) Pharmacol. Biochem. Behav. , vol.48 , pp. 893-897
    • Melchior, C.L.1    Ritzmann, R.F.2
  • 37
    • 0343704051 scopus 로고
    • Dehydroepiandrosterone (DHEA) improves memory in normal mice and mice with age-induced memory deficits
    • Melchior, C.L., Glasky, A. and Ritzmann, R.F., Dehydroepiandrosterone (DHEA) improves memory in normal mice and mice with age-induced memory deficits, Soc. Neurosci. Abstr., 18 (1992) 1660.
    • (1992) Soc. Neurosci. Abstr. , vol.18 , pp. 1660
    • Melchior, C.L.1    Glasky, A.2    Ritzmann, R.F.3
  • 38
    • 0024343524 scopus 로고
    • Pregnenolone sulfate antagonizes GABA-A receptor-mediated currents via a reduction of channel opening frequency
    • Mienville, J.M. and Vicini, S., Pregnenolone sulfate antagonizes GABA-A receptor-mediated currents via a reduction of channel opening frequency, Brain Res., 489 (1989) 190-194.
    • (1989) Brain Res. , vol.489 , pp. 190-194
    • Mienville, J.M.1    Vicini, S.2
  • 41
    • 0026531215 scopus 로고
    • 5α-Pregnane-3α,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism; comparison with alprazolam
    • Owens, M.J., Ritchie, J.C. and Nemerof, C.B., 5α-Pregnane-3α,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism; comparison with alprazolam, Brain Res., 573 (1992) 353-355.
    • (1992) Brain Res. , vol.573 , pp. 353-355
    • Owens, M.J.1    Ritchie, J.C.2    Nemerof, C.B.3
  • 42
    • 0026649978 scopus 로고
    • Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: Regulation by mitochondrial diazepam binding inhibitor receptor
    • Papadopoulos, V., Guarneri, P., Krueger, K.E., Guidotti, A. and Costa, E., Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by mitochondrial diazepam binding inhibitor receptor, Proc. Natl. Acad. Sci. USA, 89 (1992) 45113-45117.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 45113-45117
    • Papadopoulos, V.1    Guarneri, P.2    Krueger, K.E.3    Guidotti, A.4    Costa, E.5
  • 43
    • 0029056668 scopus 로고
    • Anti-anxiety effects of progesterone and some of its reduced metabolites: An evaluation using the burying behavior test
    • Picazo, O. and Fernandez-Guasti, A., Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test, Brain Res., 680 (1995) 135-141.
    • (1995) Brain Res. , vol.680 , pp. 135-141
    • Picazo, O.1    Fernandez-Guasti, A.2
  • 44
    • 0026463044 scopus 로고
    • Psychopharmacological properties of calcium channel inhibitors
    • Pucilowski, O., Psychopharmacological properties of calcium channel inhibitors, Psychopharmacology (Berlin), 109 (1992) 12-19.
    • (1992) Psychopharmacology (Berlin) , vol.109 , pp. 12-19
    • Pucilowski, O.1
  • 45
    • 0025882098 scopus 로고
    • Stress-induced elevations of gamma-aminobutyric acid type-A active steroids in rat brain
    • Purdy, R.H., Morrow, A.L., Moore Jr., P.H. and Paul, S.M., Stress-induced elevations of gamma-aminobutyric acid type-A active steroids in rat brain. Proc. Natl. Acad. Sci. USA, 88 (1991) 4553-4557.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4553-4557
    • Purdy, R.H.1    Morrow, A.L.2    Moore P.H., Jr.3    Paul, S.M.4
  • 46
    • 0029852005 scopus 로고    scopus 로고
    • Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the antistress activity of neurosteroids in mice
    • in press
    • Reddy, D.S. and Kulkarni, S.K., Role of GABA-A and mitochondrial diazepam binding inhibitor receptors in the antistress activity of neurosteroids in mice, Psychopharmacology, 128 (1996) (in press).
    • (1996) Psychopharmacology , vol.128
    • Reddy, D.S.1    Kulkarni, S.K.2
  • 49
    • 0022344417 scopus 로고
    • Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice lactating intruders
    • Schlega, M.L., Spetz, L.F., Robel, P. and Haung, M., Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice lactating intruders, Physiol. Behav., 34 (1985) 867-870.
    • (1985) Physiol. Behav. , vol.34 , pp. 867-870
    • Schlega, M.L.1    Spetz, L.F.2    Robel, P.3    Haung, M.4
  • 50
    • 0024565238 scopus 로고
    • A prospective one-year study of estrogen and progestin in postmenopausal women: Effects on clinical symptoms and lipoprotein lipids
    • Sherwin, B.B. and Gelfand, M.M., A prospective one-year study of estrogen and progestin in postmenopausal women: effects on clinical symptoms and lipoprotein lipids, Obstet. Gynecol., 73 (1989) 759-766.
    • (1989) Obstet. Gynecol. , vol.73 , pp. 759-766
    • Sherwin, B.B.1    Gelfand, M.M.2
  • 51
    • 0023271933 scopus 로고
    • Progesterone alters GABA and glutamate responsiveness: A possible mechanism for its anxiolytic action
    • Smith, S.S., Waterhouse, B.D., Chapin, J.K. and Woodward, D.J., Progesterone alters GABA and glutamate responsiveness: a possible mechanism for its anxiolytic action, Brain Res., 400 (1987) 759-766.
    • (1987) Brain Res. , vol.400 , pp. 759-766
    • Smith, S.S.1    Waterhouse, B.D.2    Chapin, J.K.3    Woodward, D.J.4
  • 52
    • 0025999108 scopus 로고
    • The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block calcium currents in acutely isolated hippocampal CA1 neurons
    • Spence, K.T., Plata-Salaman, C.R. and Ffrench-Mullen, J.M.H., The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block calcium currents in acutely isolated hippocampal CA1 neurons, Life Sci., 49 (1991) 235-239.
    • (1991) Life Sci. , vol.49 , pp. 235-239
    • Spence, K.T.1    Plata-Salaman, C.R.2    Ffrench-Mullen, J.M.H.3
  • 53
    • 0025014631 scopus 로고
    • Latency to enter a mirrored chamber: A novel behavioral assay for anxiolytic agents
    • Toubas, P.L., Abla, K.A., Cao, W., Logan, L.G. and Scale, T.W., Latency to enter a mirrored chamber: a novel behavioral assay for anxiolytic agents, Pharmacol. Biochem. Behav., 35 (1990) 121-126.
    • (1990) Pharmacol. Biochem. Behav. , vol.35 , pp. 121-126
    • Toubas, P.L.1    Abla, K.A.2    Cao, W.3    Logan, L.G.4    Scale, T.W.5
  • 54
    • 0028986669 scopus 로고
    • Comparative behavioral characterization of the neuroactive steroids 3α-hydroxy-5β-pregnan-20-one and 3α-hydroxy,5β-pregnan-20-one in rodents
    • Wieland, S., Belluzzi, J.D., Stein, L. and Lan, N.C., Comparative behavioral characterization of the neuroactive steroids 3α-hydroxy-5β-pregnan-20-one and 3α-hydroxy,5β-pregnan-20-one in rodents, Psychopharmacology, 118 (1995) 65-71.
    • (1995) Psychopharmacology , vol.118 , pp. 65-71
    • Wieland, S.1    Belluzzi, J.D.2    Stein, L.3    Lan, N.C.4
  • 55
    • 0025987983 scopus 로고
    • Anxiolytic activity of the progesterone metabolite 5α-hydroxy-pregnan-3α-ol-20-one
    • Wieland, S., Lan, N.C., Mirasedegi, S. and Gee, K.W., Anxiolytic activity of the progesterone metabolite 5α-hydroxy-pregnan-3α-ol-20-one, Brain Res., 565 (1991) 263-268.
    • (1991) Brain Res. , vol.565 , pp. 263-268
    • Wieland, S.1    Lan, N.C.2    Mirasedegi, S.3    Gee, K.W.4
  • 56
    • 0025995802 scopus 로고
    • Pregnenolone sulfate: A positive allosteric modulator at the N-methyl-D-aspartate receptor
    • Wu, F.S., Gibbs, T.T. and Farb, D.H., Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor, Mol. Pharmacol., 40 (1991) 333-336.
    • (1991) Mol. Pharmacol. , vol.40 , pp. 333-336
    • Wu, F.S.1    Gibbs, T.T.2    Farb, D.H.3
  • 57
    • 0025329137 scopus 로고
    • Inverse modulation of gamma-aminobutyric acid and glycine-induced currents by progesterone
    • Wu, F.S., Gibbs, T.T. and Farb, D.H., Inverse modulation of gamma-aminobutyric acid and glycine-induced currents by progesterone, Mol. Pharmacol., 37 (1990) 597-602.
    • (1990) Mol. Pharmacol. , vol.37 , pp. 597-602
    • Wu, F.S.1    Gibbs, T.T.2    Farb, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.