Allopregnanolone affects sleep in a benzodiazepine-like fashion

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1213-1218

  Lancel, Marike ^a   Faulhaber, Johannes ^a   Schiffelholz, Thomas ^a   Romeo, Elena ^b   Di Michele, Flavia ^b   Holsboer, Florian ^a   Rupprecht, Rainer ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTROENCEPHALOGRAM; ELECTROMYOGRAM; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; PROGESTERONE METABOLISM; RAT; REM SLEEP; SLEEP;

ANALYSIS OF VARIANCE; ANIMALS; BENZODIAZEPINES; BRAIN; ELECTROENCEPHALOGRAPHY; GABA MODULATORS; MALE; PREGNANOLONE; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SLEEP;

EID: 0030930864     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. BARBACCIA, M. L., ROSCETTI, G., BOLACCHI, F., CONCAS, A., MOSTALLINO, M. C., PURDY, R. H. AND BIGGIO, G.: Stress-induced increase in brain neuroactive steroids: Antagonism by abecarnil. Pharmacol. Biochem. Behav. 54: 205-210, 1996.
2. BELELLI, D., BOLGER, M. B. AND GEE, K. W.: Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Eur. J. Pharmacol. 166: 325-329, 1989.
3. A receptor function. Pharmacol. Biochem. Behav. 45: 423-428, 1993.
4. A receptors. J. Neuroendocrinology 7: 171-177, 1995.
5. BORBÉLY, A. A., MATTMANN, P., LOEPFE, M., STRAUCH, I. AND LEHMANN, D.: Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Human Neurobiol. 4: 189-194, 1985.
6. CAMPBELL, J. S. AND KARAVOLAS, H. J.: The kinetic mechanism of the hypothalamic progesterone 5α-reductase. J. Steroid Biochem. 32: 283-289, 1989.
7. CORPÉCHOT, C., YOUNG, J., CALVEL, M., WEHREY, C., VELTZ, J. N., TOUYER, G., MOUREN, M., PRASAD, V. V. K., BANNER, C., SJÖVALL, J., BAULIEU, E. E. AND ROBEL, P.: Neurosteroids: 3α-Hydroxy-5α-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats. Endocrinology 133: 1003-1009, 1993.
8. A receptor complex, attenuate pain sensitivity in rats. Brain Res. 643: 194-203, 1994.
9. FRIESS, E., TAGAYA, H., TRACHSEL, L., HOLSBOER, F. AND RUPPRECHT, R.: Progesterone-induced changes in sleep in male subjects. Am. J. Physiol., 272: E885-E891, 1997.
10. GANDOLFO, G., SCHERSCHLICHT, R. AND GOTTESMANN, C.: Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat. Pharmacol. Biochem. Behav. 49: 921-927, 1994.
11. KORNEYEV, A. AND COSTA, E.: Allopregnanolone (THP) mediates anesthetic effects of progesterone in rat brain. Horm. Behav. 30: 37-43, 1996.
12. A receptors in sleep regulation: Differential effects of muscimol and midazolam on sleep in rats. Neuropsychopharmacology 15: 63-74, 1996a.
13. A receptor modulators. Am. J. Physiol. 271: E763-E772, 1996b.
14. LANCEL, M., FAULHABER, J., SCHIFFELHOLZ, T., MATHIAS, S. AND DEISZ, R. A.: Muscimol and midazolam do not potentiate each others effects on sleep-EEG in the rat. J. Neurophysiol. 77: 1624-1629, 1997.
15. LANDGREN, S., AASLY, J., BÄCKSTRÖM, T., DUBROVSKY, B. AND DANIELSSON, E.: The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex. Acta Physiol. Scand. 131: 33-42, 1987.
16. A receptor: Mechanism of action and physiological significance. Prog. Neurobiol. 38: 379-395, 1992.
17. MENDELSON, W. B., MARTIN, J. V., PERLIS, M., WAGNER, R., MAJEWSKA, M. D. AND PAUL, S. M.: Sleep induction by an adrenal steroid in the rat. Psychopharmacology 93: 226-229, 1987.
18. MOK, W. M., BUKUSOGLU, C. AND KRIEGER, N. R.: 3α-Hydroxy-5α-pregnan-20-one is the only active anesthetic steroid in anesthetized mouse brain. Steroids 58: 112-114, 1993.
19. NECKELMANN, D. AND URSIN, R.: Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat. Sleep 16: 467-477, 1993.
20. PAUL, S. M. AND PURDY, R. H.: Neuroactive steroids. FASEB J. 6: 2311-2322, 1992.
21. PICAZO, O. AND FERNÄNDEZ-GUASTI, A.: Anti-anxiety effects of progesterone and some of its reduced metabolites: An evaluation using the burying behavior test. Brain Res. 680: 135-141, 1995.
22. ROREL, P. AND BAULIEU, E. E.: Neurosteroids: Biosynthesis and function. TEM 5: 1-8, 1994.
23. ROMEO, E., CHENEY, D. L., ZIVKOVIC, I., COSTA, E. AND GUIDOTTI, A.: Mitochondrial DBI receptor complex (MDRC) agonists antagonize dizocilpine amnesia: Putative role for allopregnanolone. J. Pharmacol. Exp. Ther. 270: 89-96, 1994.
24. RUPPRECHT, R., REUL, J. M. H. M., TRAPP, T., VAN STEENSEL, B., WETZEL, C., DAMM, K., ZIEGLGÄNSBERGER, W. AND HOLSBOER, F.: Progesterone receptor-mediated effects of neuroactive steroids. Neuron 11: 523-530, 1993.
25. SELYE, H.: Correlations between the chemical structure and the pharmacological actions of the steroids. Endocrinology 30: 437-453, 1942.
26. WIELAND, S., BELLUZZI, J. D., STEIN, L. AND LAN, N. C.: Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5α-pregnan-20-one in rodents. Psychopharmacology 118: 65-71, 1995.