Synthesis and in vitro activity of 3β-substituted-3α-hydroxypregnan- 20-ones: Allosteric modulators of the GABA(A) receptor

Journal of Medicinal Chemistry

Volumn 40, Issue 1, 1997, Pages 61-72

  Hogenkamp, Derk J ^a   Tahir, S Hasan ^a   Hawkinson, Jon E ^a   Upasani, Ravi B ^a   Alauddin, Mian ^b   Kimbrough, Catherine L ^a   Acosta Burruel, Manuel ^a   Whittemore, E R ^a   Woodward, R M ^a   Lan, Nancy C ^a   Gee, Kelvin W ^c   Bolger, Michael B ^b  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 3BETA (TRIFLUOROMETHYL) 5ALPHA PREGNAN 20 ONE; 3BETA (AZIDOMETHYL) 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; GANAXOLONE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; DRUG POTENCY; DRUG SYNTHESIS; NEUROMODULATION; NONHUMAN; OOCYTE; RAT; RECEPTOR BLOCKING; XENOPUS;

ANIMALS; ANTI-ANXIETY AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CONVULSANTS; DESOXYCORTICOSTERONE; ELECTROPHYSIOLOGY; FEMALE; MODELS, MOLECULAR; OOCYTES; RATS; RECEPTORS, GABA-A; XENOPUS;

EID: 8044255267     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960021x     Document Type: Article

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