Notch as a mediator of cell fate determination in hematopoiesis: Evidence and speculation

Blood

Volumn 93, Issue 8, 1999, Pages 2431-2448

  Milner, Laurie A ^a   Bigas, Anna ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; CELL FATE; CELL INTERACTION; CELL MATURATION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HEMATOPOIESIS; LIGAND BINDING; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION REGULATION;

EID: 0033561454     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.8.2431     Document Type: Review

References (189)

1. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993
2. Orkin SH: Hematopoiesis: How does it happen? Curr Biol 7:870, 1995
3. Shivdasani RA, Orkin SH: The transcriptional control of hematopoiesis. Blood 87:4025, 1996
4. Metcalf D: Regulatory mechanisms controlling hematopoiesis: Principles and problems. Stem Cells 16:3, 1998 (suppl 1)
5. Morrison SJ, Uchida N, Weissman IL: The biology of hematopoietic stem cells. Annu Rev Cell Dev Biol 11:35, 1995
6. Morrison SJ, Shah NM, Anderson DJ: Regulatory mechanisms in stem cell biology. Cell 88:287, 1997
7. Metcalf D, Enver T, Heyworth CM, Dexter TM: Controversies in hematology: Growth factors and hematopoietic cell fate. Blood 92:345, 1998
8. Fortini ME, Artavanis-Tsakonas S: Notch: Neurogenesis is only part of the picture. Cell 75:1245, 1993
9. Artavanis-Tsakonas S, Matsuno K, Fortini ME: Notch signaling. Science 268:225, 1995
10. Egan SE, St Pierre B, Leow CC: Notch receptors, partners and regulators: From conserved domains to powerful functions. Curr Top Microbiol Immunol 228:273, 1998
11. + hernatopoietic precursors. Blood 83:2057, 1994
12. Cross MA, Enver T: The lineage commitment of haemopoietic progenitor cells. Curr Opin Genet Dev 7:609, 1997
13. Dainiak N: Surface membrane-associated regulation of cell assembly, differentiation, and growth. Blood 78:264, 1991
14. Greenwald I, Rubin GM: Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68:271, 1992
15. Zon LI: Developmental biology of hematopoiesis. Blood 86: 2876, 1995
16. Kopan R, Turner DL: The Notch pathway: Democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol 6:594, 1996
17. Honjo T: The shortest path from the surface to the nucleus: RBP-Jκ/Su(H) transcription factor. Genes Cells 1:1, 1996
18. Lewis J: A short cut to the nucleus. Nature 393:304, 1998
19. Kimble J, Simpson P: The Lin-12/Notch signaling pathway and its regulation. Annu Rev Cell Dev Biol 13:333, 1997
20. Weinmaster G, Roberts VJ, Lemke G: A homolog of Drosophila Notch expressed during mammalian development. Development 113: 199, 1991
21. Franco del Amo F, Smith DE, Swiatek PJ, Gendron-Maguire M, Greenspan RJ, McMahon AP, Gridley T: Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115:737, 1992
22. Kopan R, Weintraub H: Mouse Notch: Expression in hair follicles correlates with cell fate determination. J Cell Biol 121:631, 1993
23. Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J: TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649, 1991
24. Weinmaster G, Roberts VJ, Lemke G: Notch2: A second mammalian Notch gene. Development 116:931, 1992
25. Lardelli M, Lendahl U: Motch A and Motch B - Two mouse Notch homologues coexpressed in a wide variety of tissues. Exp Cell Res 204:364, 1993
26. Lardelli M, Dahlstrand J, Lendahl U: The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium. Mech Dev 46:123, 1994
27. Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J: Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development 122:2251, 1996
28. Robey E: Notch in vertebrates. Curr Opin Genet Dev 7:551, 1997
29. Weinmaster G: Notch signaling: Direct or what? Curr Opin Genet Dev 8:436, 1998
30. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S: Specific EGF repeats of Notch mediate interactions with Delta and Serrate: Implications for Notch as a multifunctional receptor. Cell 67:687, 1991
31. Rebay I, Fehon RG, Artavanis-Tsakonas S: Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74:319, 1993
32. Lieber T, Kidd S, Alcamo E, Corbin V, Young MW: Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei. Genes Dev 7:1949, 1993
33. Roehl H, Kimble J: Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Nature 364:632, 1993
34. Kopan R, Nye JS, Weintraub H: The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120:2385, 1994
35. Roehl H, Bosenberg M, Blelloch R, Kimble J: Roles of the RAM and ANK domains in signaling by the C.elegans GLP-1 receptor. EMBOJ 15:7002, 1996
36. Zhong W, Feder JN, Jiang M, Jan LY, Jan YN: Asymmetric localization of a mammalian Numb homolog during mouse cortical neurogenesis. Neuron 17:43, 1996
37. Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N: Interaction between Wingless and Notch signaling pathways mediated by Dishevelled. Science 271:1826, 1996
38. Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J: Oncogentic forms of NOTCH1 lacking either the primary binding site for RBP-Jκ or nuclear localization sequences retain the ability to associate with RBP-Jκ and activate transcription. J Biol Chem 272: 11336, 1997
39. Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T: Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H). Curr Biol 5:1416, 1995
40. Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD: Truncated mammalian Notch1 activates CBF1/RBPJκ-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2. Mol Cell Biol 16:952, 1996
41. Kato H, Taniguchi Y, Kurooka H, Minoguchi S, Sakai T, Nomura-Okazaki S. Tamura K, Honjo T: Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives. Development 124:4133, 1997
42. Bigas A, Martin DIK, Milner LA: Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol 18:2324, 1998
43. Simpson P: Notch signalling in development: On equivalence groups and asymmetric developmental potential. Curr Opin Genet Dev 7:537, 1997
44. Greenwald I: LIN-12/Notch signaling: Lessons from worms and flies. Genes Dev 12:1751, 1998
45. Heitzler P, Simpson P: The choice of cell fate in the epidermis of Drosophila. Cell 64:1083, 1991
46. Muskavitch MAT: Delta-Notch signaling and Drosophila cell fate choice. Dev Biol 166:415, 1994
47. Washburn T, Schweighoffer E, Gridley T, Chang D, Fowlkes BJ, Cado D, Robey E: Notch activity influences the αβ versus γδ T cell lineage decision. Cell 88:833, 1997
48. Lu B, Jan LY, Jan Y: Asymmetric cell division: Lessons from flies and worms. Curr Opin Genet Dev 8:392, 1998
49. Fleming RJ, Gu Y, Hukriede NA: Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124:2873, 1997
50. Micchelli CA, Rulifson EJ, Blair SS: The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development 124:1485, 1997
51. de Celis JF, Bray S: Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development 124:3241, 1997
52. Neumann CJ, Cohen SM: A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing. Development 122:3477, 1996
53. de Celis JF, Garcia-Bellido A, Bray SJ: Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development 122:369, 1996
54. Gaunt SJ: Chick limbs, fly wings and homology at the fringe. Nature 386:324, 1997
55. Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T: Notch1 is essential for postimplantation development in mice. Genes Dev 8:707, 1994
56. Conlon RA, Reaume AG, Rossant J: Notch1 is required for the coordinate segmentation of somites. Development 121:1533, 1995
57. Gridley T: Notch signaling in mice, in Notch/Lin-12 Signalling. Proceedings from the Instituto Juan March de Estudios e Investigaciones, vol 78. Madrid, Spain, Centro de Reuniones Internacionales Sobre Biologia, 1998, p 24
58. Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T: Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev 12:1046, 1998
59. Hrabe de Angelis M, McIntyre J II, Gossler A: Maintenance of somite borders in mice requires the Delta homologue Dill. Nature 386:717, 1997
60. Li L, Milner LA, Deng Y, Iwata M, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B: The human homolog of rat Jagged, hJagged1, is expressed by marrow stroma and inhibits differentiation of 32D cells through interaction with Notchl. Immunity 8:43, 1998
61. Shawber C, Boulter J, Lindsell CE, Weinmaster G: Jagged2: A Serrate-like gene expressed during rat embryogenesis. Dev Biol 180:370, 1996
62. Luo B, Aster JC, Hasserjian RP, Kuo F, Sklar J: Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol 17:6057, 1997
63. Mitsiadis TA, Lardelli M, Lendahl U, Thesleff I: Expression of Notch1,2, and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J Cell Biol 130:407, 1995
64. Lindsell CE, Boulter J, diSibio G, Gossler A, Weinmaster G: Expression patterns of Jagged, Delta1, Notch1, Notch2 and Notch3 genes identify ligand-receptor pairs that may function in neural development. Mol Cell Neurosci 8:14, 1996
65. Socolovsky M, Lodish HF, Daley GQ: Control of hematopoietic differentiation: Lack of specificity in signaling by cytokine receptors. Proc Natl Acad Sci USA 95:6573, 1998
66. Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID: The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood 91: 4084, 1998
67. Jones P, May G, Healy L, Brown J, Hoyne G, Delassus S, Enver T: Stromal expression of Jagged1 promotes colony formation by fetal hematopoietic progenitor cells. Blood 92:1505, 1998
68. Milner LA, Bigas A, Kopan R, Brashem-Stein C, Black M, Bernstein ID, Martin DIK: Inhibition of granulocytic differentiation by mNotch1. Proc Natl Acad Sci USA 93:13014, 1996
69. Migliaccio G, Migliaccio AR, Kreider BL, Rovera G, Adamson JW: Selection of lineage-restricted cell lines immortalized at different stages of hematopoietic differentiation from the murine cell line 32D. J Cell Biol 109:833, 1989
70. von Boehmer H: T-cell development: Is Notch a key player in lineage decisions? Curr Biol 7:R308, 1997
71. Hasserjian RP, Aster JC, Davi F, Weinberg DS, Sklar J: Modulated expression of Notch1 during thymocyte development. Blood 88:970, 1996
72. Robey E, Chang D, Itano A, Cado D, Alexander H, Lans D, Weinmaster G, Salmon P; An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87:483, 1996
73. Hsieh JJ-D, Nofziger DE, Weinmaster G, Hayward SD: Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol 71:1938, 1997
74. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T: T cell leukemia-associated human Notch/TAN-1 has IκB-like activity and physically interacts with NF-κB proteins in T cells. J Exp Med 183:2025, 1996
75. Oswald F, Liptay S, Adler G, Schmid RM: NF-κB2 is a putative target gene of activated Notch-1 via RBP-Jκ. Mol Cell Biol 18:2077, 1998
76. Siebenlist U, Franzoso G, Brown K: Structure, regulation, and function of NF-κB. Annu Rev Cell Biol 10:405, 1994
77. Baeuerle PA, Henkel T: Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12:141, 1994
78. Baeuerle P, Baltimore D: NF-κB: Ten years after. Cell 87:13, 1996
79. Baldwin ASJ: The NF-κB and IκB proteins: New discoveries and insights. Annu Rev Immunol 14:649, 1996
80. Henkel T, Ling PD, Hayward SD, Peterson MG: Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jκ. Science 265:92, 1994
81. Ordentlich P, Lin A, Shen C, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T: Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol 18:2230, 1998
82. Rohn JL, Lauring AS, Linenberger ML, Overbaugh J: Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J Virol 70:8071, 1996
83. D/myc transgeneic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes Dev 10:1930, 1996
84. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM: Neoplastic transformation by truncated alleles of human Notch1/TAN1 and Notch2. Mol Cell Biol 17:6265, 1997
85. Robbins J, Blondel BJ, Gallahan D, Callahan R: Mouse mammary tumor gene int-3: A member of the Notch gene family transforms mammary epithelial cells. J Virol 66:2594, 1992
86. Fortini ME, Rebay I, Caron LA, Artavanis-Tsakonas S: An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature 365:555, 1993
87. Struhl G, Fitzgerald K, Greenwald I: Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74:331, 1993
88. Coffman CR, Skoglund P, Harris WA, Kintner CR: Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73:659, 1993
89. Nye JS, Kopan R, Axel R: An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 120:2421, 1994
90. Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, Baltimore D: Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 183:2283, 1996
91. Zagouras P, Stifani S, Blaumueller CM, Carcangiu ML, Artavanis-Tsakonas S: Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci USA 92:6414, 1995
92. Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S: Epithelial expression and chromosomal location of human TLE genes: Implications for Notch signaling and neoplasia. Genomics 31:58, 1996
93. Lemischka IR: Microenvironmental regulation of hematopoietic stem cells. Stem Cells 15:63, 1997 (suppl 1)
94. Fleming RJ, Purcell K, Artavanis-Tsakonas S: The NOTCH receptor and its ligands. Trends Cell Biol 7:437, 1997
95. Fitzgerald K, Greenwald I: Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Development 121:4275, 1995
96. Sun X, Artavanis-Tsakonas S: The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.. Development 122:2465, 1996
97. Roecklein BA, Torok-Storb B: Functionally distinct human marrow stromal cell lines immortalized by transduction with the human Papilloma virus E6/E7 genes. Blood 85:1005, 1995
98. Bettenhausen B, Hrabe de Angelis M, Simon D, Guenet J, Gossler A: Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121:2407, 1995
99. Dunwoodie SL, Henrique D, Harrison SM, Beddington RSP: Mouse Dll3; A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 124:3065, 1997
100. Moore KA, Ema H, Lemisehka IR: In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 89: 4337, 1997
101. Moore KA, Pytowski B, Witte L, Hicklin D, Lemischka IR: Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 94:4011, 1997
102. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S: Intracellular cleavage of notch leads to a heterodimeric receptor on the plasma membrane. Cell 90:281, 1997
103. Sotillos S, Roch F, Campuzano S: The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development 124:4769, 1997
104. Pan D, Rubin GM: Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90:271, 1997
105. Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israel A: The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 95:8108, 1998
106. Kopan R, Schroeter EH, Weintraub H, Nye J: Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 93:1683, 1996
107. Schroeter EH, Kisslinger JA, Kopan R: Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382, 1998
108. Aster J, Pear W, Hasserjian R, Davi F, Luo B, Scott M, Baltimore D, Sklar J: Functional analysis of the TAN-1 gene, a human homolog of Drosophila Notch. Cold Spring Harb Symp Quant Biol 59:125, 1994
109. Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A: Signalling downstream of activated mammalian Notch. Nature 377:355, 1995
110. Struhl G, Adachi A: Nuclear access and action of Notch in vivo. Cell 93:649, 1998
111. Lecourtois M, Schweisguth F: Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos. Curr Biol 8:771, 1998
112. Fortini ME, Artavanis-Tsakonas S: The suppressor of Hairless protein participates in Notch receptor signaling. Cell 79:273, 1994
113. de la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ, Nakano T, Honjo T, Mak TW, Rossant J, Conlon RA: Conservation of the Notch signaling pathway in mammalian neurogenesis. Development 124:1139, 1997
114. Lu FM, Lux SE: Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc Natl Acad Sci USA 93:5663, 1996
115. Gho M, Lecourtois M, Geraud G, Posakony JW, Schweisguth F: Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signaling. Development 122:1673, 1996
116. Lecourtois M, Schweisguth F: The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by Notch signaling. Genes Dev 9:2598, 1995
117. Bailey AM, Posakony JW: Suppressor of Hairless directly activates transcription of Enhancer of split complex genes in response to Notch receptor activity. Genes Dev 9:2609, 1995
118. Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S: Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes Dev 6:2620, 1992
119. Martin-Bermudo MD, Carmena A, Jimenez F: Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesoectoderm specification. Development 121: 219, 1995
120. Oellers N, Dehio M, Knust E: bHLH proteins encoded by the Enhancer of split complex of Drosophila negatively interfere with transcriptional activation mediated by proneural genes. Mol Genet 117:1113, 1994
121. Hsieh JJ, Hayward SD: Masking of the CBF1/RBP-Jκ transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268:560, 1995
122. Dou S, Zeng X, Cortes P, Erdjument-Bromage H, Tempst P, Honjo T, Vales LD: The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol Cell Biol 14:3310, 1994
123. Plaisance S, Vanden Berghe W, Boone E, Fiers W, Haegeman G: Recombination signal sequence binding protein Jκ is constitutively bound to the NF-κB site of the interleukin-6 promoter and acts as a negative regulatory factor. Mol Cell Biol 17:3733, 1997
124. Chen Y, Fischer WH, Gill GN: Regulation of the ERBB-2 promoter by RBPJς and NOTCH. J Biol Chem 272:14110, 1997
125. Eastman DS, Slee R, Skoufos E, Bangalore L, Bray S, Delidakis C: Synergy between Suppressor of Hairless and Notch in regulation of Enhancer of split mγ and mδ expression. Mol Cell Biol 17:5620, 1997
126. de Celis JF, de Celis J, Ligoxygakis P, Preiss A, Delidakis C, Bray S: Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: The E(spl) genes mediate only a subset of Notch activities during imaginal development. Development 122:2719, 1996
127. Shawber C, Nofzige D, Hsieh JJ-D, Lindsell C, Bogler O, Hayward D, Weinmaster G: Notch signaling inhibits muscle differentiation through a CBF1-independent pathway. Development 122:3765, 1996
128. Matsuno K, Go MJ, Sun X, Eastman DS, Artavanis-Tsakonas S: Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development 124:4265, 1997
129. Diederich RJ, Matsuno K, Hing H, Artavanis-Tsakonas S: Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development 120:473, 1994
130. Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S: Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121:2633, 1995
131. Sieweke MH, Graf T: A transcription party during blood cell differentiation. Curr Opin Genet Dev 8:545, 1998
132. Zhang M, Sun S, Bell L, Miller BA: NF-κB transcription factors are involved in normal erythropoiesis. Blood 91:4136, 1998
133. Liou H-C, Baltimore D: Regulation of the NF-κB/rel transcription factor and IκB inhibitor system. Curr Opin Cell Biol 5:477, 1993
134. Gilmore TD, Morin PJ: The IκB proteins: Members of a multifunctional family. Trends Genet 9:427, 1993
135. Hatada EN, Nieters A, Wulczyn FG, Naumann M, Meyer R, Nucifora G, McKeithan TW, Scheidereit C: The ankyrin repeat domains of the NF-κB precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-κB DNA binding. Proc Natl Acad Sci USA 89:2489, 1992
136. Hubbard EJA, Dong Q, Greenwald I: Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans. Science 273:112, 1996
137. Smoller D, Friedel C, Schmid A, Bettler D, Lam L, Yedvobnick B: The Drosophila neurogenic locus mastermind encodes a nuclear protein unusually rich in amino acid homopolymers. Genes Dev 4:1688, 1990
138. Paroush Z, Finley RLJ, Kidd T, Wainwright SM, Ingham PW, Brent R, Ish-Horowicz D: Groucho is required for Drosophila neurogenesis, segmentation and sex-determination, and interacts directly with Hairy-related bHLH proteins. Cell 79:805, 1994
139. Bettler D, Pearson S, Yedvobnick B: The Nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions. Genetics 143:859, 1996
140. Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S: Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet 2:119, 1992
141. Jimenez G, Paroush Z, Ish-Horowicz D: Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev 11:3072, 1997
142. Fisher AL, Caudy M: Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates. Genes Dev 12:1931, 1998
143. Palaparti A, Baratz A, Stifani S: The Groucho/Transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of Histone H3. J Biol Chem 42:26604, 1997
144. Levitan D, Greenwald I: Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351, 1995
145. Irvine KD, Wieschaus E: Fringe, a boundary-specific molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. Cell 79:595, 1994
146. Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF: A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development 124: 2245, 1997
147. Panin VM, Papayannopoulos V, Wilson R, Irvine KD: Fringe modulates Notch-ligand interactions. Nature 387:908, 1997
148. Zhang N, Gridley T: Defects in somite formation in lunatic fringe-deficient mice. Nature 394:374, 1998
149. Evrard YA, Lun Y, Aulehla A, Gan L, Johnson RL: lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394:377, 1998
150. Laufer E, Dahn R, Orozco OE, Yeo C, Pisenti J, Henrique D, Abbott UK, Fallon JF, Tabin C: Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation. Nature 386:366, 1997
151. Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher WW, Leow CC, Whiting E, Ryan D, Zinyk D, Boulianne G, Hui C, Gallie B, Phillips RA, Lipshitz HD, Egan SE: Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet 16:283, 1997
152. Lin H, Schagat T: Neuroblasts: A model for the asymmetric division of stem cells. Trends Genet 13:33, 1997
153. Guo M, Jan LY, Jan YN: Control of daughter cell fates during asymmetric division: Interaction of Numb and Notch. Neuron 17:27, 1996
154. Spana EP, Doe CQ: Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron 17:21, 1996
155. Frise E, Knoblich JA, Younger-Shepherd S, Jan LY, Jan YN: The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci USA 93:11925, 1996
156. Chenn A, McConnell SK: Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell 82:631, 1995
157. Duffy JB, Perrimon N: Recent advances in understanding signal transduction pathways in worms and flies. Curr Opin Cell Biol 8:231, 1996
158. Kim SK, Fraser SE: Pattern formation and developmental mechanisms: Converging views of diverging pathways. Curr Opin Genet Dev 8:383, 1998
159. van der Geer P, Hunter T, Lindberg RA: Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol 10:251, 1994
160. Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF: Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol 12:91, 1996
161. Price JV, Savenye ED, Lum D, Breitkreutz A: Dominant enhancers of Egfr in Drosophila melanogaster. Genetic links between the Notch and Egfr signaling pathways. Genetics 147:1139, 1997
162. Freeman M: Complexity of EGF receptor signalling revealed in Drosophila. Curr Opin Genet Dev 8:407, 1998
163. Freeman M: Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87:651, 1996
164. Cagan RL, Ready DF: Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev 3:1099, 1989
165. Wasserman DA, Themen M, Rubin GM: The Ras signaling pathway in Drosophila. Curr Opin Genet Dev 5:44, 1995
166. Treisman R: Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8:205, 1996
167. Kuriyama M, Harada N, Kuroda S, Yamamoto T, Nakafuku M, Iwamatsu A, Yamamoto D, Prasad R, Croce C, Canaani E, Kaibuchi K: Identification of AF-6 and Canoe as putative targets for Ras. J Biol Chem 271:607, 1996
168. Matsuo T, Takahashi K, Kondo S, Kaibuchi K, Yamamoto D: Regulation of cone formation by Canoe and Ras in the developing Drosophila eye. Development 124:2671, 1997
169. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O: Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol 13:369, 1995
170. Nusse R,Varmus HE: Wnt genes. Cell 69:1073, 1992
171. Cadigan KM, Nusse R: Wnt signaling: A common theme in animal development. Genes Dev 11:3286, 1997
172. Austin TW, Solar GP, Ziegler FC, Liem L, Matthews W: A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells. Blood 89:3624, 1997
173. Van Den Berg DJ, Sharma AK, Bruno E, Hoffman R: Role of members of the Wnt gene family in human hematopoiesis. Blood 92:3189, 1998
174. Couso JP, Martinez Arias A: Notch is required for wingless signaling in the epidermis of Drosophila. Cell 79:259, 1994
175. Blair SS: Notch and Wingless signals collide. Science 271: 1822, 1996
176. Johnson RL, Tabin CJ: Molecular models for vertebrate limb development. Cell 90:979, 1997
177. Klingensmith J, Nusse R, Perrimon N: The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev 8:118, 1994
178. Theisen H, Purcell J, Bennett M, Kansagara D, Syed A, Marsh JL: dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Development 120:347, 1994
179. Go MJ, Eastman DS, Artavanis-Tsakonas S: Cell proliferation control by Notch signaling in Drosophila development. Development 125:2031, 1998
180. Speicher SA, Thomas U, Hinz U, Knust E: The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: Control of cell proliferation. Development 120:535, 1994
181. Johnston LA, Edgar BA: Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature 394:82, 1998
182. Hogan BL: Bone morphogenic proteins in development. Curr Opin Genet Dev 6:432, 1996
183. Baylies MK, Bate M, Gomez MR: Myogenesis: A view from Drosophila. Cell 93:921, 1998
184. Spradling AC, Xie T: decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94:251, 1998
185. Wu JY, Wen L, Zhang W, Rao Y: The secreted product of Xenopus gene lunatic Fringe, a vertebrate signaling molecule. Science 273:355, 1996
186. Dickson MC, Martin JS, Cousins FM, Kulkarni AB, Karlsson S, Akhurst RJ: Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knockout mice. Development 121:1845, 1995
187. Zhang C, Evans T: BMP-like signals are required after the midblastula transition for blood cell development. Dev Genet 18:267, 1996
188. Dzierzak E, Medvinsky A: Mouse embryonic hematopoiesis. Trends Genet 11:359, 1995
189. Mead PE, Zon LI: Molecular insights into early hematopoiesis. Curr Opin Hematol 5:156, 1998