Microenvironmental regulation of hematopoietic stem cells

Stem Cells

Volumn 15, Issue SUPPL. 1, 1997, Pages 63-68

  Lemischka, Ihor R ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

AFT024; Competitive repopulation; Delta like protein; Hematopoietic microenvironment; Self renewal; Stem cells

Indexed keywords

CELL ACTIVITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; DIAGNOSTIC ACCURACY; HEMATOPOIESIS; STEM CELL;

ANIMALS; CELL LINE; HEMATOPOIETIC STEM CELLS; LIVER; MICE; STROMAL CELLS;

EID: 0030722695     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.5530150810     Document Type: Article

References (28)

1. Lemischka IR. The haematopoietic stem cell and its clonal progeny: mechanisms regulating the hierarchy of primitive haematopoietic cells. Cancer Surv 1992;15:3-18.
2. Metcalf D. Hematopoietic regulators: redundancy or subtlety? Blood 1993;82:3515-3523.
3. Ogawa M. Differentiation and proliferation of hemopoietic stem cells. Blood 1993; 81:2844-2853.
4. Wolf NS. The haemopoietic microenvironment. Clin Hematol 1979;8:469-500.
5. Weiss L, Geduldig U. Barrier cells: stromal regulation of hematopoiesis and blood cell release in normal and stressed murine bone marrow. Blood 1991;78:975-990.
6. Spangrude GJ, Heimfield S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988;241:58.
7. Mulder AH, Visser JWM. Separation and functional analysis of bone marrow cells separated by rhodamine-123 fluorescence. Exp Hematol 1987;15:99-104.
8. Lemischka IR. Purification and properties of fetal hematopoietic stem cells. Dev Biol 1993;4:379-385.
9. Flanagan JG, Leder P. The kit ligand: a cell surface molecule steel mutant fibroblasts. Cell 1990;63:185-194.
10. Matthews W, Jordan CT, Wiegand GW et al. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 1991;65:1143-1152.
11. Shivdasani RA, Orkin SH. The transcriptional control of hematopoiesis. Blood 1996;87:4025-4039.
12. Georgopoulos K, Bigby M, Wang J-H et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 1994;79:143-156.
13. Mackarehtschian K, Hardin JD, Moore KA et al. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 1995;3:147-161.
14. + progenitor cells by stem cell factor, interleukin-1 (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin. Blood 1993;81:2579-2584.
15. Koller MR, Emerson SG, Palsson BO. Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood 1993;82:378-384.
16. Knobel KM, McNally MA, Berson AE et al. Long-term reconstitution of mice after ex vivo expansion of bone marrow cells: differential activity of cultured bone marrow and enriched stem cell populations. Exp Hematol 1994;22:1227-1235.
17. Peters SO, Kittler ELW, Ramshaw HS et al. Murine marrow cells expanded in culture with IL-3, Il-6, IL-11, and SCF acquire an engraftment defect in normal hosts. Exp Hematol 1995;23:461-469.
18. Fraser CC, Szilvassy SJ, Eaves CJ et al. Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability. Proc Natl Acad Sci USA 1992;89:1968-1972.
19. Holyoake TL, Freshney MG, McNair L et al. Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery post-transplant and the ability to serially transplant marrow. Blood 1996;87:4589-4595.
20. Kodama H, Nose M, Yamaguchi Y et al. In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit and its ligand. J Exp Med 1992;176:351-361.
21. - progenitor cells in long-term cultures and semisolid assays. Blood 1993;81:2916-2924.
22. Szilvassy SJ, Weller KP, Lin W et al. Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Blood 1996;87:4618-4628.
23. Wineman JP, Moore KA, Lemischka IR et al. Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells. Blood 1996;87:4082-4090.
24. Moore KA, Ema H, Lemischka IR. In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 1997;89:4337-4347.
25. Artavanis-Tsakonas D, Matsuno K, Fortini ME. Notch signaling. Science 1995;268:225-232.
26. Laborda J, Sausville EA, Hoffman T et al. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 1993;268:3817-3820.
27. Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993;73:725-734.
28. Moore KA, Pytowski B, Witte L et al. Hematopoietic activity of a stromal cell-derived transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 1997;94:4011-4015.